Multi-omic rejuvenation and lifespan extension on exposure to youthful circulation

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364 · see citing works

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works

Differential expression analysis for sequence count data

Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

The Molecular Signatures Database Hallmark Gene Set Collection

Liberzon, A., Birger, C., Thorvaldsdóttir, H., Ghandi, M., Mesirov, J. P., & Tamayo, P. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.004 · Cited by 13,807 · see citing works

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075 · see citing works

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549 · see citing works

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

Krueger, F., & Andrews, S. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr167 · Cited by 5,161 · see citing works

Physiological Parameters in Laboratory Animals and Humans

Davies, B., & Morris, T. (1993) · Pharmaceutical Research · doi:10.1023/a:1018943613122 · Cited by 2,930 · see citing works

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363 · see citing works

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis

Meissner, A. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki901 · Cited by 1,203 · see citing works

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine · doi:10.1038/nm.3569 · Cited by 1,081 · see citing works

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.015 · Cited by 948 · see citing works

Physiological Migration of Hematopoietic Stem and Progenitor Cells

Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L., & Weissman, I. L. (2001) · Science · doi:10.1126/science.1064081 · Cited by 933 · see citing works

Reprogramming to recover youthful epigenetic information and restore vision

Lu, Y., Brommer, B., Tian, X., Krishnan, A., Meer, M., Wang, C., Vera, D. L., Zeng, Q., Yu, D., Bonkowski, M. S., et al. (2020) · Nature · doi:10.1038/s41586-020-2975-4 · Cited by 820 · see citing works

Rejuvenation of Regeneration in the Aging Central Nervous System

Ruckh, J. M., Zhao, J.-W., Shadrach, J. L., van Wijngaarden, P., Rao, T. N., Wagers, A. J., & Franklin, R. J. M. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2011.11.019 · Cited by 649 · see citing works

Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer

Bernardes de Jesus, B., Vera, E., Schneeberger, K., Tejera, A. M., Ayuso, E., Bosch, F., & Blasco, M. A. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200245 · Cited by 548 · see citing works

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

Rando, T. A., & Chang, H. Y. (2012) · Cell · doi:10.1016/j.cell.2012.01.003 · Cited by 520 · see citing works

Universal DNA methylation age across mammalian tissues

Lu, A. T.-H., Fei, Z., Haghani, A., Robeck, T. R., Zoller, J. A., Li, C. Z., Lowe, R., Yan, Q. J., Zhang, J., Vu, H., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00462-6 · Cited by 495 · see citing works

Reversal of epigenetic aging and immunosenescent trends in humans.

Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., Leipold, M. D., Lin, D. T. S., Kobor, M. S., & Horvath, S. (2019) · Aging Cell · doi:10.1111/acel.13028 · Cited by 477 · see citing works

Inflammation and Progression of CKD: The CRIC Study

Amdur, R. L., Feldman, H. I., Gupta, J., Yang, W., Kanetsky, P., Shlipak, M., Rahman, M., Lash, J. P., Townsend, R. R., Ojo, A., et al. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.13121215 · Cited by 452 · see citing works

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

Castellano, J. M., Mosher, K. I., Abbey, R. J., McBride, A. A., James, M. L., Berdnik, D., Shen, J. C., Zou, B., Xie, X. S., Tingle, M., et al. (2017) · Nature · doi:10.1038/nature22067 · Cited by 445 · see citing works

SIRT3 Reverses Aging-Associated Degeneration

Brown, K., Xie, S., Qiu, X., Mohrin, M., Shin, J., Liu, Y., Zhang, D., Scadden, D. T., & Chen, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.005 · Cited by 436 · see citing works

Peripheral inflammatory markers in Alzheimer’s disease: a systematic review and meta-analysis of 175 studies

Lai, K. S. P., Liu, C. S., Rau, A., Lanctôt, K. L., Köhler, C. A., Pakosh, M., Carvalho, A. F., & Herrmann, N. (2017) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp-2017-316201 · Cited by 433 · see citing works

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

Elabd, C., Cousin, W., Upadhyayula, P., Chen, R. Y., Chooljian, M. S., Li, J., Kung, S., Jiang, K. P., & Conboy, I. M. (2014) · Nature Communications · doi:10.1038/ncomms5082 · Cited by 411 · see citing works

Using DNA methylation profiling to evaluate biological age and longevity interventions

Petkovich, D. A., Podolskiy, D. I., Lobanov, A. V., Lee, S.-G., Miller, R. A., & Gladyshev, V. N. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.016 · Cited by 398 · see citing works

Methionine restriction increases blood glutathione and longevity in F344 rats

Richie, J. P., Leutzinger, Y., Parthasarathy, S., Maixoy, V., Orentreich, N., & Zimmerman, J. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.15.8001743 · Cited by 363 · see citing works

Evolution of the Aging Brain Transcriptome and Synaptic Regulation

Loerch, P. M., Lu, T., Dakin, K. A., Vann, J. M., Isaacs, A., Geula, C., Wang, J., Pan, Y., Gabuzda, D. H., Li, C., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003329 · Cited by 334 · see citing works

Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells.

Sarkar, T. J., Quarta, M., Mukherjee, S., Colville, A., Paine, P., Doan, L., Tran, C. M., Chu, C. R., Horvath, S., Qi, L. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15174-3 · Cited by 308 · see citing works

A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood

Rebo, J., Mehdipour, M., Gathwala, R., Causey, K., Liu, Y., Conboy, M. J., & Conboy, I. M. (2016) · Nature Communications · doi:10.1038/ncomms13363 · Cited by 291 · see citing works

Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity

Conboy, M. J., Conboy, I. M., & Rando, T. A. (2013) · Aging Cell · doi:10.1111/acel.12065 · Cited by 265 · see citing works

Ageing: from inflammation to cancer

Leonardi, G. C., Accardi, G., Monastero, R., Nicoletti, F., & Libra, M. (2018) · Immunity &amp; Ageing · doi:10.1186/s12979-017-0112-5 · Cited by 241 · cited 1× · see citing works

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

Conboy, I. M., & Rando, T. A. (2012) · Cell Cycle · doi:10.4161/cc.20437 · Cited by 239 · see citing works

A mammalian methylation array for profiling methylation levels at conserved sequences

Arneson, A., Haghani, A., Thompson, M. J., Pellegrini, M. A., Kwon, S. B., Vu, H., Maciejewski, E., Yao, M., Li, C. Z., Lu, A. T.-H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28355-z · Cited by 219 · see citing works

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

Baht, G. S., Silkstone, D., Vi, L., Nadesan, P., Amani, Y., Whetstone, H., Wei, Q., & Alman, B. A. (2015) · Nature Communications · doi:10.1038/ncomms8131 · Cited by 211 · see citing works

A multi-tissue full lifespan epigenetic clock for mice

Thompson, M. J., Chwiałkowska, K., Rubbi, L., Lusis, A. J., Davis, R. C., Srivastava, A., Korstanje, R., Churchill, G. A., Horvath, S., & Pellegrini, M. (2018) · Aging · doi:10.18632/aging.101590 · Cited by 203 · see citing works

DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: the DAMA study

Fiorito, G., Caini, S., Palli, D., Bendinelli, B., Saieva, C., Ermini, I., Valentini, V., Assedi, M., Rizzolo, P., Ambrogetti, D., et al. (2021) · Aging Cell · doi:10.1111/acel.13439 · Cited by 202 · see citing works

Oxidative phosphorylation and aging

Lesnefsky, E. J., & Hoppel, C. L. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.04.001 · Cited by 190 · see citing works

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

Olova, N. N., Simpson, D. J., Marioni, R. E., & Chandra, T. (2018) · Aging Cell · doi:10.1111/acel.12877 · Cited by 179 · see citing works

A whole lifespan mouse multi-tissue DNA methylation clock

Meer, M. V., Podolskiy, D. I., Tyshkovskiy, A., & Gladyshev, V. N. (2018) · eLife · doi:10.7554/elife.40675 · Cited by 176 · see citing works

The Increase of IFN-γ Production through Aging Correlates with the Expanded CD8+highCD28−CD57+ Subpopulation

Bandrés, E., Merino, J., Vázquez, B., Inogés, S., Moreno, C., Subirá, M. L., & Sánchez-Ibarrola, A. (2000) · Clinical Immunology · doi:10.1006/clim.2000.4894 · Cited by 174 · see citing works

Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism

Baht, G., Bareja, A., Lee, D. E., Rao, R. R., Huang, R., Huebner, J., Bartlett, D. B., Hart, C., Gibson, J. R., Lanza, I., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0184-y · Cited by 168 · see citing works

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., Khaitovich, P., Clish, C. B., Miller, R. A., & Gladyshev, V. N. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.018 · Cited by 167 · see citing works

Pathobiology of Aging Mice and GEM

Brayton, C. F., Treuting, P. M., & Ward, J. M. (2012) · Veterinary Pathology · doi:10.1177/0300985811430696 · Cited by 167 · see citing works

Distinct longevity mechanisms across and within species and their association with aging

Tyshkovskiy, A., Ma, S., Shindyapina, A. V., Tikhonov, S., Lee, S.-G., Bozaykut, P., Castro, J. P., Seluanov, A., Schork, N. J., Gorbunova, V., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.002 · Cited by 162 · see citing works

Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice

Donskoy, E., & Goldschneider, I. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.6.1604 · Cited by 162 · see citing works

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

Middeldorp, J., Lehallier, B., Villeda, S. A., Miedema, S. S. M., Evans, E., Czirr, E., Zhang, H., Luo, J., Stan, T., Mosher, K. I., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3185 · Cited by 153 · see citing works

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature · doi:10.1038/s41586-022-04461-2 · Cited by 153 · see citing works

Profiling epigenetic age in single cells

Trapp, A., Kerepesi, C., & Gladyshev, V. N. (2021) · Nature Aging · doi:10.1038/s43587-021-00134-3 · Cited by 150 · see citing works

Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice

Vi, L., Baht, G. S., Soderblom, E. J., Whetstone, H., Wei, Q., Furman, B., Puviindran, V., Nadesan, P., Foster, M., Poon, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07666-0 · Cited by 140 · see citing works

Universal DNA methylation age across mammalian tissuesPreprint

Lu, A. T., Fei, Z., Haghani, A., Robeck, T. R., Zoller, J. A., Li, C., Lowe, R., Yan, Q. J., Zhang, J., Vu, H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.18.426733 · Cited by 139 · see citing works

Epigenetic clocks reveal a rejuvenation event during embryogenesis followed by aging

Kerepesi, C., Zhang, B., Lee, S., Trapp, A., & Gladyshev, V. N. (2021) · Science Advances · doi:10.1126/sciadv.abg6082 · Cited by 123 · see citing works

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

Salpeter, S. J., Khalaileh, A., Weinberg-Corem, N., Ziv, O., Glaser, B., & Dor, Y. (2013) · Diabetes · doi:10.2337/db13-0160 · Cited by 122 · see citing works

Asynchronous, contagious and digital aging

Rando, T. A., & Wyss-Coray, T. (2021) · Nature Aging · doi:10.1038/s43587-020-00015-1 · Cited by 121 · see citing works

Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin

Mehdipour, M., Skinner, C. M., Wong, N., Lieb, M., Liu, C., Etienne, J., Kato, C., KIPROV, D. D., Conboy, M. J., & Conboy, I. M. (2020) · Aging · doi:10.18632/aging.103418 · Cited by 113 · see citing works

Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

Benigni, A., Cassis, P., Conti, S., Perico, L., Corna, D., Cerullo, D., Zentilin, L., Zoja, C., Perna, A., Lionetti, V., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7703 · Cited by 106 · see citing works

Increased oxidative phosphorylation in response to acute and chronic DNA damage

Brace, L. E., Vose, S. C., Stanya, K. J., Gathungu, R. M., Marur, V. R., Longchamp, A., Treviño-Villarreal, H., Mejia, P., Vargas, D., Inouye, K., et al. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.22 · Cited by 105 · see citing works

The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104 · see citing works

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

Ho, T. T., Dellorusso, P. V., Verovskaya, E. V., Bakker, S. T., Flach, J., Smith, L. K., Ventura, P. B., Lansinger, O. M., Hérault, A., Zhang, S. Y., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20210223 · Cited by 101 · see citing works

Survival Characteristics and Age-Adjusted Disease Incidences in C57BL/6 Mice Fed a Commonly Used Cereal-Based Diet Modulated by Dietary Restriction

Turturro, A., Duffy, P. H., Hass, B. S., Kodell, R. L., & Hart, R. W. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.11.b379 · Cited by 101 · see citing works

The Fountain of Youth: A tale of parabiosis, stem cells, and rejuvenation

Conese, M., Carbone, A., Beccia, E., & Angiolillo, A. (2017) · Open Medicine · doi:10.1515/med-2017-0053 · Cited by 62 · see citing works

Dynamics of epigenetic age following hematopoietic stem cell transplantation

Stölzel, F., Brosch, M., Horvath, S., Krämer, M., Thiede, C., Bonin, M. V., Ammerpohl, O., Middeke, M., Schetelig, J., Ehninger, G., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.160481 · Cited by 42 · see citing works

Reversing age: dual species measurement of epigenetic age with a single clockPreprint

Horvath, S., Singh, K., Raj, K., Khairnar, S. I., Sanghavi, A., Shrivastava, A., Zoller, J. A., Li, C. Z., Hereñú, C. B., Canatelli-Mallat, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.07.082917 · Cited by 40 · see citing works

Experimental prolongation of the life span.

McCay, C. M., Pope, F., & Lunsford, W. (1956) · PubMed · Cited by 29 · see citing works

Experimental prolongation of the life span

Pope, F., Lunsford, W., & McCay, C. M. (1956) · Journal of Chronic Diseases · doi:10.1016/0021-9681(56)90015-7 · Cited by 27 · see citing works

Parabiosis as a Method for Studying Factors which Affect Aging in Rats

Lunsford, W., McCay, C. M., Lupien, P. J., Pope, F., & Sperling, G. A. (2009) · Gerontologia · doi:10.1159/000211170 · Cited by 23 · see citing works

Blood glutathione: a biochemical index of life span enhancement in the diet restricted Lobund-Wistar rat.

LANG, C. A., Wu, W. K., Chen, T., & Bj, M. (1989) · PubMed · Cited by 23 · see citing works

Three-Month Heterochronic Parabiosis Has a Deleterious Effect on the Lifespan of Young Animals, Without a Positive Effect for Old Animals

Yankova, T., Dubiley, T. A., Shytikov, D. W., & Pishel, I. (2022) · Rejuvenation Research · doi:10.1089/rej.2022.0029 · Cited by 15 · see citing works

Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis

Huffman, K. M., Andonian, B. J., Abraham, D., Bareja, A., Lee, D. E., Katz, L. H., Huebner, J. L., Kraus, W. E., & White, J. P. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00576.2020 · Cited by 14 · see citing works

Molecular hallmarks of heterochronic parabiosis at single cell resolutionPreprint

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Webber, J. T., McGeever, A., Bonanno, L. N., Pisco, A. O., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.06.367078 · Cited by 14 · see citing works

Alive and well? Exploring disease by studying lifespan

Brett, J. O., & Rando, T. A. (2014) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2014.05.004 · Cited by 12 · see citing works

Residual Blood Volumes in Organs of Pregnant Mice and Fetuses

Satoh, H. (1979) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.129.41 · Cited by 3 · see citing works

The role of SIRT3 in regulating cancer cell metabolism

Herrera, K. N. G., Finley, L. W. S., & Haigis, M. C. (2012) · BMC Proceedings · doi:10.1186/1753-6561-6-s3-p18 · Cited by 2 · see citing works

Biological age is increased by stress and restored upon recovery

Poganik, J. R., Zhang, B., Baht, G. S., Tyshkovskiy, A., Deik, A., Kerepesi, C., Yim, S. H., Lu, A. T., Haghani, A., Gong, T., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.03.015 · Cited by 246 · see citing works

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

Ma, S., Ji, Z., Zhang, B., Geng, L., Cai, Y., Nie, C., Li, J., Zuo, Y., Sun, Y., Xu, G., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.019 · Cited by 162 · see citing works

Distinct longevity mechanisms across and within species and their association with aging

Tyshkovskiy, A., Ma, S., Shindyapina, A. V., Tikhonov, S., Lee, S.-G., Bozaykut, P., Castro, J. P., Seluanov, A., Schork, N. J., Gorbunova, V., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.002 · Cited by 162 · see citing works

The Information Theory of Aging

Lu, Y. R., Tian, X., & Sinclair, D. A. (2023) · Nature Aging · doi:10.1038/s43587-023-00527-6 · Cited by 141 · see citing works

Stress, epigenetics, and aging: Unraveling the intricate crosstalk

Wu, Z., Qu, J. T., Zhang, W., & Liu, G. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.10.006 · Cited by 142 · see citing works

The role of cellular senescence in neurodegenerative diseases

Wang, Y., Kuča, K., Li, Y., Nepovimová, E., Heger, Z., Valko, M., Adam, V., Wu, Q., & Jomová, K. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03768-5 · Cited by 118 · see citing works

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Sun, E., Zhou, O. Y., Hauptschein, M., Rappoport, N., Xu, L., Negredo, P. N., Liu, L. A., Rando, T. A., Zou, J., & Brunet, A. (2024) · Nature · doi:10.1038/s41586-024-08334-8 · Cited by 98 · see citing works

The hallmarks of aging as a conceptual framework for health and longevity research

Tartiere, A. G., Freije, J. M. P., & López-Otı́n, C. (2024) · Frontiers in Aging · doi:10.3389/fragi.2024.1334261 · Cited by 97 · see citing works

The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review

Jang, D. S., Shin, J., Shim, E., Ohtani, N., & Jeon, O. H. (2024) · Aging Cell · doi:10.1111/acel.14315 · Cited by 84 · see citing works

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

Ximerakis, M., Holton, K. M., Giadone, R. M., Ozek, C., Saxena, M., Santiago, S., Adiconis, X., Dionne, D. A., Nguyễn, L., Shah, K. M., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00373-6 · Cited by 82 · see citing works

Nature of epigenetic aging from a single-cell perspective

Tarkhov, A. E., Lindstrom-Vautrin, T., Zhang, S., Ying, K., Moqri, M., Zhang, B., Tyshkovskiy, A., Levy, O., & Gladyshev, V. N. (2024) · Nature Aging · doi:10.1038/s43587-024-00616-0 · Cited by 83 · see citing works

The brain–body energy conservation model of aging

Shaulson, E. D., Cohen, A. A., & Picard, M. A. (2024) · Nature Aging · doi:10.1038/s43587-024-00716-x · Cited by 76 · see citing works

Emerging epigenetic insights into aging mechanisms and interventions

Wu, Z., Zhang, W., Qu, J. T., & Liu, G. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.12.002 · Cited by 74 · see citing works

Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming

Lu, J. Y., Tu, W. B., Li, R., Weng, M., Sanketi, B. D., Yuan, B., Reddy, P., Esteban, C. R., & Belmonte, J. C. I. (2025) · Cell · doi:10.1016/j.cell.2025.07.031 · Cited by 67 · see citing works

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale, L., Tual-Chalot, S., Sedej, S., Ministrini, S., Georgiopoulos, G., Grunewald, M., Bäck, M., Bochaton-Piallat, M.-L., Boon, R. A., Ramos, G. C., et al. (2025) · Nature Reviews Cardiology · doi:10.1038/s41569-025-01130-5 · Cited by 59 · see citing works

Epigenetic clocks and programmatic aging

Gems, D., Virk, R. S., & de Magalhães, J. P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102546 · Cited by 50 · see citing works

Epigenetic Regulation of Aging and its Rejuvenation

An, Y., Wang, Q., Gao, K., Zhang, C., Ouyang, Y., Li, R., Zhou, M., Wu, T., Zhou, L., Xie, Z., et al. (2025) · MedComm · doi:10.1002/mco2.70369 · Cited by 44 · see citing works

The mechanisms, hallmarks, and therapies for brain aging and age-related dementia

Jin, S., Lü, W., Zhang, J., Zhang, L., Tao, F., Zhang, Y., Hu, X., & Liu, Q. (2024) · 中国科学通报：英文版 · doi:10.1016/j.scib.2024.09.005 · Cited by 40 · see citing works

Universal transcriptomic hallmarks of mammalian ageing and mortality

Tyshkovskiy, A., Kholdina, D., Davitadze, M., Molière, A., Moldakozhayev, A., Tongu, Y., Kasahara, T., Glubokov, D., Eames, A., Kats, L., et al. (2026) · Nature · doi:10.1038/s41586-026-10542-3 · Cited by 37 · see citing works

Reversal of biological age in multiple rat organs by young porcine plasma fraction

Horvath, S., Singh, K., Raj, K., Khairnar, S. I., Sanghavi, A., Shrivastava, A., Zoller, J. A., Li, C. Z., Hereñú, C. B., Canatelli-Mallat, M., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00980-6 · Cited by 35 · see citing works

Aging insights from heterochronic parabiosis models

Lagunas‐Rangel, F. A. (2024) · npj Aging · doi:10.1038/s41514-024-00166-0 · Cited by 34 · see citing works

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and RejuvenationPreprint

Tyshkovskiy, A., Kholdina, D., Ying, K., Davitadze, M., Molière, A., Tongu, Y., Kasahara, T., Kats, L., Vladimirova, A., Moldakozhayev, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.04.601982 · Cited by 30 · see citing works

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29 · see citing works

Blood-derived factors to brain communication in brain diseases

He, J., Zhang, Y., Guo, Y., Guo, J., Chen, X., Xu, S., Xu, X., Wu, C., Liu, C., Chen, J., et al. (2024) · 中国科学通报：英文版 · doi:10.1016/j.scib.2024.09.022 · Cited by 25 · see citing works

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Mitchell, W., Goeminne, L. J., Tyshkovskiy, A., Zhang, S., Chen, J. Y., Paulo, J. A., Pierce, K. A., Choy, A. H., Clish, C. B., Gygi, S. P., et al. (2024) · eLife · doi:10.7554/elife.90579 · Cited by 23 · see citing works

Intercellular communication is crucial in the regulation of healthy aging via exosomes

Sun, H., Xia, T., Ma, S., Lv, T., & Li, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107591 · Cited by 23 · see citing works

Dietary methionine restriction started late in life promotes healthy aging in a sex-specific manner

Hernández-Arciga, U., Stamenkovic, C., Yadav, S., Nicoletti, C., Albalawy, W. N., hammood, F. A., Gonzalez, T. F., Naikwadi, M. U., Graham, A., Smarz, C., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads1532 · Cited by 23 · see citing works

Systemic and local regulation of hematopoietic homeostasis in health and disease

Carpenter, R. S., & Maryanovich, M. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00482-4 · Cited by 22 · see citing works

Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics

Peng, Y., Zhao, T., Rong, S., Yang, S., Teng, W., Xie, Y., & Wang, Y. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02818-5 · Cited by 22 · see citing works

How age affects human hematopoietic stem and progenitor cells and the strategies to mitigate aging

Li, X., Wang, J., Hu, L., & Cheng, T. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.104711 · Cited by 22 · see citing works

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Yu, F., Chen, C., Liu, W., Zhao, Z., Fan, Y., Li, Z., Huang, W., Xie, T., Luo, C., Yao, Z., et al. (2025) · Aging Cell · doi:10.1111/acel.14482 · Cited by 20 · see citing works

Disorganization of secondary lymphoid organs and dyscoordination of chemokine secretion as key contributors to immune aging

Sonar, S. A., Watanabe, M., & Nikolich‐Žugich, J. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101835 · Cited by 19 · see citing works

Regeneration leads to global tissue rejuvenation in aging sexual planarians

Dai, X., Li, X., Tyshkovskiy, A., Zuckerman, C., Cheng, N., Lin, P., Paris, D., Qureshi, S., Kruglyak, L., Mao, X., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00847-9 · Cited by 19 · see citing works

Engineered Extracellular Vesicles Derived from Juvenile Mice Enhance Mitochondrial Function in the Aging Bone Microenvironment and Achieve Rejuvenation

Zheng, J., Ren, Y., Ke, J., Zhu, G., Wang, Z., Shi, X., & Wang, Y. (2025) · ACS Nano · doi:10.1021/acsnano.4c17989 · Cited by 18 · see citing works

Immune Checkpoint Inhibitors in Geriatric Oncology

Cook, S. L., Amin, M. A., Bari, S., Poonnen, P. J., Khasraw, M., & Johnson, M. O. (2024) · Current Oncology Reports · doi:10.1007/s11912-024-01528-3 · Cited by 18 · see citing works

A cellular identity crisis? Plasticity changes during aging and rejuvenationPreprint

Gorelov, R. A., & Hochedlinger, K. (2024) · Genes & Development · doi:10.1101/gad.351728.124 · Cited by 18 · see citing works

Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism

Landsberger, T., Amit, I., & Alon, U. S. (2023) · GeroScience · doi:10.1007/s11357-023-00915-1 · Cited by 16 · see citing works

Rejuvenation of young blood on aging organs: Effects, circulating factors, and mechanisms

Liu, M., Lan, Q., Wu, H., & Qiu, C.-W. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32652 · Cited by 16 · see citing works

The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk

Li, S., Wang, K., Wu, J., & Zhu, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102653 · Cited by 16 · see citing works

Interplay between aging and metabolic diseases: from molecular mechanisms to therapeutic horizons

Zhong, D., Sun, Y., Zhao, L., Hu, Z., Li, G., Li, H., & Xie, Z. (2025) · Medical Review · doi:10.1515/mr-2025-0047 · Cited by 14 · see citing works

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic ( BI01 ) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

Chambers, T. L., Wells, J. M., Koopmans, P. J., da Silva, F. M., Malik, Z. B., Greene, N. P., Filareto, A., Franti, M., Sini, P., Weinstabl, H., et al. (2025) · Aging Cell · doi:10.1111/acel.70068 · Cited by 14 · see citing works

Exosomes from young plasma stimulate the osteogenic differentiation and prevent osteoporosis via miR-142-5p

Li, Z., Yu, Q., Cui, X., Wang, Y., Xu, R., Lu, R., Chen, J., Zhou, X., Zhang, C., Li, L., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.03.012 · Cited by 13 · see citing works

Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging

Yousefzadeh, M. J., Robbins, P. D., & Huffman, D. M. (2022) · Aging · doi:10.18632/aging.204015 · Cited by 13 · see citing works

Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation

Sengstack, J., Zheng, J., Aghayev, T., Bieri, G., Mobaraki, M., Lin, J., Deng, C., Villeda, S., & Li, H. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2515183123 · Cited by 11 · see citing works

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Miyawaki, M., Hashimoto, S., Ogawa, S., & Kase, Y. (2026) · Aging Cell · doi:10.1111/acel.70385 · Cited by 10 · see citing works

Epigenetic aging of human blood cells is influenced by the age of the host body

Holland, P., Istre, M. S., Ali, M. M., Gedde‐Dahl, T., Buechner, J., Wildhagen, M., Brunvoll, S. H., Horvath, S., Matsuyama, S., Dahl, J. A., et al. (2024) · Aging Cell · doi:10.1111/acel.14112 · Cited by 10 · see citing works

Extracellular vesicle‐encapsulated miR ‐30c‐5p reduces aging‐related liver fibrosis

Rodrigues, A. C., Heng, Y. J., & Slack, F. J. (2024) · Aging Cell · doi:10.1111/acel.14310 · Cited by 10 · see citing works

Cellular senescence in age-related musculoskeletal diseases

Xiong, J., Guo, Q., & Luo, X. (2025) · Frontiers of Medicine · doi:10.1007/s11684-025-1125-7 · Cited by 10 · see citing works

AgeMeta: Quantitative Gene Expression Database of Mammalian Aging

Tikhonov, S., Batin, M., Gladyshev, V. N., Dmitriev, S. E., & Tyshkovskiy, A. (2024) · Biochemistry (Moscow) · doi:10.1134/s000629792402010x · Cited by 10 · see citing works

High-dimensional Ageome Representations of Biological Aging across Functional ModulesPreprint

Ying, K., Tyshkovskiy, A., Chen, Q., Crespo, E. L., Zhang, B., Liu, H., Matei-Dediu, B., Poganik, J. R., Moqri, M., Kirschne, K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.17.613599 · Cited by 10 · see citing works

Senescent microglia: The hidden culprits accelerating Alzheimer’s disease

Li, W., Xie, Y., Jia-Xin, M., Shu-Chao, G., & Li-Ping, H. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149480 · Cited by 9 · see citing works

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

Xiao, L., Zhang, Z., Li, T., Jiang, Y., Liu, Y., Lv, T., Qin, L., Zhu, Y., & Tang, W. (2025) · Aging Cell · doi:10.1111/acel.70327 · Cited by 9 · see citing works

Mesenchymal drift: A convergent framework for the hallmarks of aging

Lu, J. Y., Tu, W. B., Ma, S., Ma, Z., Imaz-Rosshandler, I., Weng, M., Qu, J., Esteban, C. R., Reddy, P., Liu, G.-H., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.020 · Cited by 10 · see citing works

Biological aging clocks in health and disease

Wyss‐Coray, T., & Topol, E. J. (2026) · Nature Medicine · doi:10.1038/s41591-026-04495-3 · Cited by 9 · see citing works

Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats

Kawamura, T., Kerepesi, C., Sarkar, J. P., Torma, F., Bori, Z., Zhou, L., Bakonyi, P., Kolonics, A., Balogh, L., Higuchi, M., et al. (2025) · Aging Cell · doi:10.1111/acel.70110 · Cited by 8 · see citing works

Aging and immunity: the age-old tangoPreprint

Fernández-Maestre, I., Harris, A. S., & Amor, C. (2025) · Genes & Development · doi:10.1101/gad.352644.125 · Cited by 8 · see citing works

Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics

Liu, Y., Lu, S., Yang, J., Yang, Y., Li, J., Hu, J., Li, Y., Yang, F., Pang, Y., Zhao, Y., et al. (2024) · BMC Genomics · doi:10.1186/s12864-024-10556-z · Cited by 7 · see citing works

Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial

Gaudilliere, B. L., Xue, L., Tsai, A. S., Gao, X., McAllister, T. N., Tingle, M. S., Porras, G., Feinstein, I., Feyaerts, D., Verdonk, F., et al. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06215-w · Cited by 7 · see citing works

Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis

Peng, X. F., Wang, L., Xu, F., Guo, Q., Xie, G., Sheng, L., Chen, L., Teng, J., Yang, J., Wu, X., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01293-8 · Cited by 6 · see citing works

Research progress on blood therapy for anti-aging

Liu, S., Wang, S., Dong, Y., Yang, S., & Yao, C. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.039 · Cited by 5 · see citing works

Neonatal small extracellular vesicle-loaded GelNB hydrogel reprograms the vascular-immune microenvironment for spinal cord injury repair

Yuan, F., Shi, C., Liang, X., Xu, J., Qin, Y., Xu, S., Chen, Y., Qin, T., Ding, Y., Hu, Z., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.04.026 · Cited by 5 · see citing works

Pterostilbene Targets Hallmarks of Aging in the Gene Expression Landscape in Blood of Healthy Rats

Tello‐Palencia, M. A., Yang, T., Sularz, O., Demers, L. E., Ma, Y., Boycott, C., Zhang, H. A., Lubecka, K., Kumar, S., Ramsey, B. S., et al. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400662 · Cited by 5 · see citing works

Replacement as an aging intervention

Lore, S., Poganik, J. R., Atala, A., Church, G. M., Gladyshev, V. N., Scheibye‐Knudsen, M., & Verdin, E. M. (2025) · Nature Aging · doi:10.1038/s43587-025-00858-6 · Cited by 5 · see citing works

Epigenetic information loss is a common feature of multiple diseases and aging

Sagy, N., Chang, C., Gal, M., & Bar, D. Z. (2025) · GeroScience · doi:10.1007/s11357-025-01767-7 · Cited by 4 · see citing works

Heterochronic parabiosis uncovers AdipoR1 as a critical player in retinal rejuvenation

Liu, Y., Liu, X., Lv, J., Zhang, Q., Yang, Z., Chen, X., Gu, C., Zhang, C., Zhuo, Y., & Su, W. (2025) · Science Advances · doi:10.1126/sciadv.adv6642 · Cited by 4 · see citing works

Exosomes from small intestinal epithelium mediate cardiac fibrosis during aging

He, Y., Lu, X., Pang, S., Xia, F., Lv, Y., Yu, J., Ding, G., & Sheng, Y. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf183 · Cited by 4 · see citing works

Impact of visceral adipose tissue on longevity and metabolic health: a comparative study of gene expression in perirenal and epididymal fat of Ames dwarf mice

Zaczek, A., Lewiñski, A., Karbownik‐Lewińska, M., Lehoczki, A., & Gesing, A. (2024) · GeroScience · doi:10.1007/s11357-024-01131-1 · Cited by 4 · see citing works

Improvement of Immune Function and Redox State in Several Organs of Old and Prematurely Aging Female Mice After a Short Social Interaction With Adults

Félix, J., Cerro, E. D., & la Fuente, M. D. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae181 · Cited by 4 · see citing works

Multi-Omic Rejuvenation: A New Strategy for Lifespan Extension

Rybina, O. Y., & PASYUKOVA, E. G. (2024) · Molecular Biology · doi:10.1134/s0026893324700377 · Cited by 3 · see citing works

EXOSOMES FROM CYCLIC MICE MODULATE LIVER TRANSCRIPTOME IN ESTROUPAUSE MICE INDEPENDENT OF AGE

Zanini, B. M., Ávila, B. M., Hense, J. D., Garcia, D. N., Ashiqueali, S., Alves, P. I. C., Oliveira, T. L., Collares, T. V., Brieño‐Enríquez, M. A., Mason, J. B., et al. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112508 · Cited by 3 · see citing works

Rapamycin Reverses the Hepatic Response to Diet‐Induced Metabolic Stress That Is Amplified by Aging

Havas, A. P., Rajesh, A., Lei, X., Proulx, J. M., Miller, K. N., Field, A. E., Davis, A., Teneche, M. G., Gandhi, A., Lee, J., et al. (2026) · Aging Cell · doi:10.1111/acel.70395 · Cited by 3 · see citing works

The cell rejuvenation atlas: leveraging network biology to identify master regulators of rejuvenation strategies

Hodar, J. A., Jung, S., Soudy, M., Barvaux, S., & del Sol, A. (2024) · Aging · doi:10.18632/aging.206105 · Cited by 3 · see citing works

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice

Murach, K. A., Dungan, C. M., Chambers, T. L., Horvath, S., Nandakumar, J., Gladyshev, V. N., Pletcher, S. D., Dai, X., & Guo, L. (2025) · Aging Cell · doi:10.1111/acel.70236 · Cited by 2 · see citing works

Beyond the hallmarks of aging: Rethinking what aging is and how we measure it

Keshavarz, M., & Ehninger, D. (2025) · Genomic psychiatry : · doi:10.61373/gp025i.0119 · Cited by 2 · see citing works

Circulating Metabolites Treat Human TMJ‐OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis

Meng, B., Li, X., Yang, B., Qu, Y., He, Y., Fu, C., An, Z., Wu, A., Hei, Y., Zhang, R., et al. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70224 · Cited by 2 · see citing works

Systemic recalibration and epigenetic resetting as complementary strategies in ageing biology

Li, Y.-Y., & Tay, F. R. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103227 · Cited by 2 · see citing works

Rejuvenation Is on Its Way

Muradian, K. K., & Fraifeld, V. E. (2024) · Healthy ageing and longevity · doi:10.1007/978-3-031-64995-0_12 · Cited by 2 · see citing works

Plasma therapy: a novel intervention to improve age-induced decline in deudenal cell proliferation in female rat model

Asmaz, E. D., Ceylani, T., Genç, A. İ., Sertkaya, Z. T., & Teker, H. T. (2025) · Biogerontology · doi:10.1007/s10522-025-10197-z · Cited by 2 · see citing works

Extracellular Vesicles in Aging and Age-Related Diseases

Liu, J., Yu, H., Tian, Y., & Liu, N. (2024) · Springer eBooks · doi:10.1007/978-981-97-5536-3_14 · Cited by 2 · see citing works

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenationPreprint

Mitchell, W., Goeminne, L. J. E., Tyshkovskiy, A., Zhang, S., Paulo, J. A., Pierce, K. A., Choy, A. H., Clish, C. B., Gygi, S. P., & Gladyshev, V. N. (2023) · eLife · doi:10.7554/elife.90579.1 · Cited by 2 · see citing works

In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young bloodPreprint

Wang, X., Tazearslan, C., Kim, S., Guo, Q., Contreras, D., Yang, J., Hudgins, A. D., & Suh, Y. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.02.592258 · Cited by 2 · see citing works

Avoidance of rejuvenation: a stress test for evolutionary theories of aging

Aisin, S. I., Lidskii, B. V., & Lidsky, P. V. (2026) · npj Aging · doi:10.1038/s41514-026-00365-x · Cited by 1 · see citing works

Extended heterochronic parabiosis as an approach to study rejuvenation

Zhang, B. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00681-0 · Cited by 1 · see citing works

Systemic factors in young human serum influence in vitro responses of human skin and bone marrow-derived blood cells in a microphysiological co-culture system

Ritter, J., Falckenhayn, C., Qi, M., Gather, L., Gutjahr, D., Schmidt, J. R., Simm, S., Kalkhof, S., Hildebrand, J., Bosch, T., et al. (2025) · Aging · doi:10.18632/aging.206288 · Cited by 1 · see citing works

REGENECYTE cord blood cell therapy in post-COVID syndrome: a phase IIa randomized, placebo-controlled trial

Huang, Y.-W., Chen, Y.-C., Lau, E., Su, Y.-C., Tai, L.-K., Rosenthal, J., Wang, J., & Lee, T.-Y. (2026) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103737 · Cited by 1 · see citing works

Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies

Kim, E., Kang, J. S., & Yang, Y. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01688-1 · Cited by 1 · see citing works

Gut microbiota-epigenetic interactions in systemic aging: mechanistic drivers for endocrine and reproductive network remodeling and therapeutic modulation

Birigwa, C., Tong, Q., Qu, B., Zuo, T., Yuan, W., Xiong, J., & Luo, J. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1826382 · Cited by 1 · see citing works

Biological Age Can Be Moved in Both Directions

Muradian, K. K., & Fraifeld, V. E. (2024) · Healthy ageing and longevity · doi:10.1007/978-3-031-64995-0_11 · Cited by 1 · see citing works

Feasibility Analysis of Mainstream Aging Theories and Intervention

Huang, B. (2026) · Ageing and Longevity Research · doi:10.53941/alr.2026.100001 · Cited by 1 · see citing works

Editorial: Immunosenescence in organ transplantation

Iske, J., & Zhou, H. (2024) · Frontiers in Transplantation · doi:10.3389/frtra.2024.1422358 · Cited by 1 · see citing works

As Rejuvenation Research Expands, We Need to Focus on Identifying the Most Effective, Safest Approaches

Conboy, I. M. (2023) · Rejuvenation Research · doi:10.1089/rej.2023.29009.editorial

Reviewer #2 (Public Review): Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

(2024) · eLife · doi:10.7554/elife.90579.2.sa0

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Mitchell, W., Goeminne, L. J. E., Tyshkovskiy, A., Zhang, S., Chen, J. Y., Paulo, J. A., Pierce, K. A., Choy, A. H., Clish, C. B., Gygi, S. P., et al. (2024) · doi:10.7554/elife.90579.2

Reviewer #1 (Public Review): Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

(2024) · eLife · doi:10.7554/elife.90579.3.sa1

AgeMeta: QUANTITATIVE GENE EXPRESSION DATABASE OF MAMMALIAN AGING

Tikhonov, S., Batin, M., Gladyshev, V. N., Dmitriev, S. E., & Tyshkovskiy, A. (2024) · Biochemistry (Moscow) · doi:10.31857/s0320972524020099mhqeg

Biomedical Research in Aging

González-Meljem, J. M., Haston, S., Gallage, S., Innes, A. J., & Scheckhuber, C. Q. (2024) · Springer eBooks · doi:10.1007/978-3-031-76469-1_2

A Blueprint for Curing AgingPreprint

Renteln, M. (2025) · Preprints.org · doi:10.20944/preprints202211.0255.v4

Can serial therapeutic plasma exchange remove synthetic chemicals from humans?

Savage, P. B., Anderson, P. S., She, J., Smith, P. W., Hanaway, P. J., & Basiorka, R. (2025) · Medical Hypotheses · doi:10.1016/j.mehy.2025.111630

Molecular mechanisms of ageing in cancer development and therapeutic response: Translational implications for precision oncology

Husain, L. (2025) · Clinical and Translational Discovery · doi:10.1002/ctd2.70065

BIOLOGICAL AGE REDUCTION AND LIFESPAN EXTENSION UPON YOUTHFUL CIRCULATION EXPOSURE

Zhang, B. (2023) · Innovation in Aging · doi:10.1093/geroni/igad104.1942

Chronic Exposure to Youthful Circulation Leads to Epigenetic Reprogramming and Lifespan Extension

Zhang, B., Lee, D., Tyshkovskiy, A., Bareja, A., Kerepesi, C., Horvath, S., Gladyshev, V. N., & White, J. P. (2021) · Innovation in Aging · doi:10.1093/geroni/igab046.2551 · Cited by 1 · see citing works

Prolonged heterochronic parabiosis decreases biological age and promotes longevity in old mice

(2023) · Nature Aging · doi:10.1038/s43587-023-00452-8 · Cited by 2 · see citing works

Extended heterochronic parabiosis as an approach to study rejuvenation

Zhang, B. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00681-0 · Cited by 1 · see citing works

Three-Month Heterochronic Parabiosis Has a Deleterious Effect on the Lifespan of Young Animals, Without a Positive Effect for Old Animals

Yankova, T., Dubiley, T. A., Shytikov, D. W., & Pishel, I. (2022) · Rejuvenation Research · doi:10.1089/rej.2022.0029 · Cited by 15 · see citing works