Hayaishi, Osamu

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

Huang, Z.-L., Qu, W.-M., Eguchi, N., Chen, J.-F., Schwarzschild, M. A., Fredholm, B. B., Urade, Y., & Hayaishi, O. (2005) · Nature Neuroscience

Adenosine and Purinergic SignalingCoffee research and impacts

Cited by 640

Indoleamine 2,3-dioxygenase. Purification and some properties

Shimizu, T., Nomiyama, S., Hirata, F., & Hayaishi, O. (1978) · Journal of Biological Chemistry

Metal-Catalyzed Oxygenation MechanismsAmino Acid Enzymes and Metabolism

Cited by 367

Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens

Lazarus, M., Shen, H.-Y., Cherasse, Y., Qu, W.-M., Huang, Z.-L., Bass, C. E., Winsky-Sommerer, R., Semba, K., Fredholm, B. B., Boison, D., et al. (2011) · Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorAdenosine and Purinergic Signaling

Cited by 327

Molecular mechanisms of sleep‐wake regulation: roles of prostaglandins D 2 and E 2

Hayaishi, O. (1991) · The FASEB Journal

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 235

The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus

Gallopin, T., Luppi, P.-H., Cauli, B., Urade, Y., Rossier, J., Hayaishi, O., Lambolez, B., & Fort, P. (2005) · Neuroscience

Sleep and Wakefulness ResearchNeuroscience of respiration and sleep

Cited by 229

Prostaglandin D2 and sleep/wake regulation

Urade, Y., & Hayaishi, O. (2011) · Sleep Medicine Reviews

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 200

Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.

Matsumura, H., Nakajima, T., Osaka, T., Satoh, S., Kawase, K., Kubo, E., Kantha, S. S., Kasahara, K., & Hayaishi, O. (1994) · Proceedings of the National Academy of Sciences

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 143

CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats

Ram, A., Pandey, H. P., Matsumura, H., Kasahara-Orita, K., Nakajima, T., Takahata, R., Satoh, S., Terao, A., & Hayaishi, O. (1997) · Brain Research

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 112

Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats.

Inoué, S., Honda, K., Komoda, Y., Uchizono, K., Ueno, R., & Hayaishi, O. (1984) · Proceedings of the National Academy of Sciences

Sleep and Wakefulness ResearchNeuroscience of respiration and sleep

Cited by 100

Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase.

Watanabe, K., Iguchi, Y., Iguchi, S., Arai, Y., Hayaishi, O., & Roberts, L. J. (1986) · Proceedings of the National Academy of Sciences

Inflammatory mediators and NSAID effectsEicosanoids and Hypertension Pharmacology

Cited by 62

Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats.

Matsumura, H., Honda, K., Choi, W. S., Inoué, S., Sakai, T., & Hayaishi, O. (1989) · Proceedings of the National Academy of Sciences

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 46