Prostaglandin D2-sensitive, sleep-promoting zone defined in the ventral surface of the rostral basal forebrain.
Open accessAbstract
The site of action for the sleep-promoting effect of prostaglandin (PG) D2 was extensively examined in the brain of adult male rats (n = 231). PGD2 was administered at 100 pmol/0.2 microliter per min for 6 hr (2300-0500 hr) through chronically implanted microdialysis probes or infusion cannulae. Among the administrations of PDG2 by dialysis probes (n = 176), only those (n = 8) to a ventro-rostral part of the basal forebrain by the probes implanted on the midline consistently increased slow-wave sleep (SWS), by 51 +/- 6 min (mean +/- SEM) above the baseline value (111 +/- 11 min). Since this area is separated by a cleft into right and left regions, the results were interpreted to mean that, through this cleft, PGD2 diffused in the subarachnoid space over the adjacent ventral surface, where it had the effect of promoting sleep. When PGD2 was directly infused into the subarachnoid space (n = 55), extraordinary increases exceeding 90 min were consistently attained for the SWS at sites located between 0.5 and 2 mm rostral to the bregma and between 0 and 1.2 mm lateral to the midline defined according to the stereotaxic coordinates adopted from the brain atlas of Paxinos and Watson [Paxinos, G. & Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates (Academic, San Diego)]. Thus, we demarcated a "PGD2-sensitive, sleep-promoting zone" within this region in the ventral surface of the rostral basal forebrain. During the bilateral infusion of PGD2 into the subarachnoid space of this zone, the hourly mean SWS level of the nocturnal animals (n = 6) in the night reached the maximum at the second hour of the infusion period; this maximum hourly SWS level, corresponding to the daytime level of the same animals, lasted until the end of PGD2 infusion.
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Cites
The rat brain in stereotaxic coordinates
Palkovits, M. (1983) · Neuropeptides · doi:10.1016/0143-4179(83)90049-5 · Cited by 28,959 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2011) · Elsevier eBooks · doi:10.1016/c2009-0-59875-3 · Cited by 5,118 · see citing works
Principles And Practice Of Sleep Medicine
Ayvazian, L. F. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/140.4.1172a · Cited by 554 · see citing works
Central chemosensitivity and the reaction theory.
Loeschcke, H. H. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014397 · Cited by 380 · see citing works
Sterman, M. B., & Clemente, C. (1962) · Experimental Neurology · doi:10.1016/0014-4886(62)90081-x · Cited by 375 · see citing works
Codistribution of GABA‐ with acetylcholine‐synthesizing neurons in the basal forebrain of the rat
Gritti, I., Mainville, L., & Jones, B. E. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903290403 · Cited by 299 · see citing works
Sleep-related neuronal discharge in the basal forebrain of cats
Szymusiak, R. S., & McGinty, D. (1986) · Brain Research · doi:10.1016/0006-8993(86)91107-8 · Cited by 259 · see citing works
Purification and characterization of rat brain prostaglandin D synthetase.
Urade, Y., Fujimoto, N., & Hayaishi, O. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38889-0 · Cited by 243 · see citing works
Self-citationUrade, Y., Kitahama, K., Ohishi, H., Kaneko, T., Mizuno, N., & Hayaishi, O. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9070 · Cited by 238 · see citing works
Self-citationHayaishi, O. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.11.1907936 · Cited by 235 · see citing works
Self-citationProstaglandin D2, a cerebral sleep-inducing substance in monkeys.
Onoe, H., Ueno, R., Fujita, I., Nishino, H., Oomura, Y., & Hayaishi, O. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.4082 · Cited by 225 · see citing works
Self-citationProstaglandin D2 induces sleep when microinjected into the preoptic area of conscious rats
Ueno, R., Ishikawa, Y., Nakayama, T., & Hayaishi, O. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)91760-0 · Cited by 172 · see citing works
Self-citationSleep suppression following kainic acid-induced lesions of the basal forebrain
Szymusiak, R. S., & McGinty, D. (1986) · Experimental Neurology · doi:10.1016/0014-4886(86)90240-2 · Cited by 153 · see citing works
Identification of β-Trace as Prostaglandin D Synthase
Watanabe, K., Urade, Y., Mäder, M., Murphy, C., & Hayaishi, O. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2297 · Cited by 142 · see citing works
Self-citationVillablanca, J. R., Marcus, R. J., & Olmstead, C. E. (1976) · Experimental Neurology · doi:10.1016/0014-4886(76)90279-x · Cited by 90 · see citing works
Effect of activation of central nervous system serotonin 1A receptors on cardiorespiratory function.
Gillis, R. A., Hill, K. J., KIRBY, J., et al. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23780-6 · Cited by 88 · see citing works
Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase.
Matsumura, H., Takahata, R., & Hayaishi, O. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9046 · Cited by 82 · see citing works
Self-citationThe pia mater at the site of the entry of blood vessels into the central nervous system
Krahn, V. (1982) · Anatomy and Embryology · doi:10.1007/bf00318509 · Cited by 80 · see citing works
Firing properties of cat basal forebrain neurones during sleep-wakefulness cycle
Détári, L., Juhász, G. D., & Kukorelli, T. (1984) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(84)90062-2 · Cited by 67 · see citing works
Effects of prostaglandin D2, lipoxins and leukotrienes on sleep and brain temperature of rats
Kantha, S. S., Matsumura, H., Kubo, E., Kawase, K., Takahata, R., Serhan, C. N., & Hayaishi, O. (1994) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/0952-3278(94)90083-3 · Cited by 56 · see citing works
Self-citationAwaking effect of prostaglandin E2 in freely moving rats
Matsumura, H., Honda, K., Goh, Y., Ueno, R., Sakai, T., Inoué, S., & Hayaishi, O. (1989) · Brain Research · doi:10.1016/0006-8993(89)90800-7 · Cited by 56 · see citing works
Self-citationPermeability of the external glial limiting membrane of rat parietal cortex
Wagner, H., Barthel, J., & Pilgrim, C. (1983) · Anatomy and Embryology · doi:10.1007/bf00305928 · Cited by 31 · see citing works
Takahata, R., Matsumura, H., Kantha, S. S., Kubo, E., Kawase, K., Sakai, T., & Hayaishi, O. (1993) · Brain Research · doi:10.1016/0006-8993(93)90010-k · Cited by 31 · see citing works
Self-citationAction of Endothelin-1 on Vasomotor Neurons in Rat Rostral Ventrolateral Medulla
Cao, W.-H., Kuwaki, T., Unekawa, M., et al. (1993) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199322008-00053 · Cited by 20 · see citing works
Endothelin-sensitive areas in the ventral surface of the rat medulla
Kuwaki, T., Cao, W.-H., Unekawa, M., Terui, N., & Kumada, M. (1991) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(91)90111-f · Cited by 17 · see citing works
Fukuda, Y., Tojima, H., Tanaka, K., et al. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90316-d · Cited by 15 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Hayaishi O. Molecular mechanisms of sleep-wake regulation: roles of prostaglandins D2 and E2. FASEB J. 1991 Aug;5(11):2575–2581. [PubMed] [Google Scholar]
- Ueno R., Honda K., Inoué S., Hayaishi O. Prostaglandin D2, a cerebral sleep-inducing substance in rats. Proc Natl Acad Sci U S A. 1983 Mar;80(6):1735–1737. doi: 10.1073/pnas.80.6.1735. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
Cited by
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Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
Activation of ventrolateral preoptic neurons during sleep
Sherin, J. E., Shiromani, P. J., McCarley, R. W., & Saper, C. B. (1996) · Science · doi:10.1126/science.271.5246.216 · Cited by 1,111 · see citing works
Neural circuitry engaged by prostaglandins during the sickness syndrome
Saper, C. B., Romanovsky, A. A., & Scammell, T. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3159 · Cited by 285 · see citing works
The Neurobiology of Sleep and Wakefulness
Schwartz, M. D., & Kilduff, T. S. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.002 · Cited by 207 · see citing works
Prostaglandin D2 and sleep/wake regulation
Urade, Y., & Hayaishi, O. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.08.003 · Cited by 200 · see citing works
Self-citationRam, A., Pandey, H. P., Matsumura, H., Kasahara-Orita, K., Nakajima, T., Takahata, R., Satoh, S., Terao, A., & Hayaishi, O. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01401-1 · Cited by 112 · see citing works
Self-citationSleep and inflammatory markers in different psychiatric disorders
Krysta, K., Krzystanek, M., Bratek, A., & Krupka-Matuszczyk, I. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-015-1492-3 · Cited by 53 · see citing works
- Authors
- Matsumura, H., Nakajima, T., Osaka, T., Satoh, S., Kawase, K., Kubo, E., Kantha, S. S., Kasahara, K., & Hayaishi, O.
- Affiliations
- Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Japan.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-12-06
- Volume
- 91
- Issue
- 25
- Pages
- 11998-12002
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC45363
- OpenAlex
- W1983238769
- Cited by
- 143
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 4 · 2019: 4 · 2018: 3 · 2017: 2 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Nippon Zoki Pharmaceutical
- Chungbuk National University
- Chiba University
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- prostaglandin D2, sleep promotion, slow-wave sleep, basal forebrain, microdialysis, sleep regulation
- MeSH terms
- Animals, Brain Mapping, Circadian Rhythm, Electroencephalography, Electromyography, Infusions, Parenteral, Male, Reference Values, Sleep, Sleep Stages, Prostaglandin D2, Prosencephalon, Rats, Sprague-Dawley, Rats
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