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Cited by 112Sleep and Wakefulness ResearchCircadian rhythm and melatoninSleep and Work-Related Fatigue

CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats

Ram, Arjun, Pandey, Haushila P, Matsumura, Hitoshi, Kasahara-Orita, Keiko, Nakajima, Tomoko, Takahata, Ryuichi, Satoh, Shinsuke, Terao, Akira +1 more·1997·Brain Research
DOI 10.1016/s0006-8993(96)01401-1
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Abstract

The concentration of PGD2, PGE2, and of PGF2 alpha was measured in the cerebrospinal fluid (CSF) collected from the cisterna magna of conscious rats (n = 29), which, chronically implanted with a catheter for the CSF sampling, underwent deprivation of daytime sleep. Significant elevation of the CSF level of PGD2 was observed following 2.5-h sleep deprivation (SD), and the elevation became more marked following 5- and 10-h SD, apparently reaching the maximum at 5-h SD (703 +/- 140 pg/ml (mean +/- S.E.M.) for baseline vs. 1734 +/- 363 pg/ml for SD, n = 10). The levels of PGE2, and PGF2 alpha also significantly increased following 5- and 10-h SD, but not following 2.5-h SD. It is unlikely that these changes were simply caused by some responses of the animals to stress stimuli, because stress stimuli derived from restraint of the animal at the supine position to a board for 1 h did not produce any acute responses in the CSF levels of prostaglandins (n = 13). In a different group of animals (n = 11) implanted with electrodes for recording electroencephalogram (EEG) and electromyogram (EMG) in addition to the catheter, the levels of the prostaglandins in CSF were determined for slow-wave sleep (SWS) and wakefulness in the day and for SWS and wakefulness in the night. The highest PGD2 value was obtained at daytime SWS, whereas the lowest was at night wakefulness; furthermore, a significant difference was observed between SWS and wakefulness rather than between day and night. The CSF level of PGE2 also showed a similar tendency. In an additional group of animals (n = 6), not only PGD2 but also PGE2 and PGF2 alpha significantly increased the sleeping time of the animal when applied into the subarachnoid space underlying the ventral surface area of the rostral basal forebrain, the previously defined site of action for the sleep-promoting effect of PGD2. The promotion of sleep by PGE2 applied to the subarachnoid space was an effect completely opposite to the well-established awaking effect of the same prostaglandin demonstrated in the hypothalamic region in a series of previous studies. Based on these results, we conclude that increases in CSF levels of prostaglandins, especially that of PGD2, are correlated in rats with heightened propensity towards sleep and further with the depth of sleep under normal as well as SD conditions.

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  • COX-2 products such as prostaglandin D2 promote sleep in rat cerebrospinal fluid.

    “Additionally, COX-2 products, such as prostaglandin D2, are sleep-promoting in rat cerebrospinal fluid (CSF) (45), which may support the idea that sleep-promoting molecules are elevated during sleep loss.”

    From Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt (2015) · cites this paper as [45]

  • Moderate sleep deprivation caused an increase in CSF levels of PGD2, E2, and F2α in rats.

    “moderate sleep deprivation caused an increase in CSF levels of PGD2, E2, and F2α in rats (455).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [455]

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Authors
Ram, A., Pandey, H. P., Matsumura, H., Kasahara-Orita, K., Nakajima, T., Takahata, R., Satoh, S., Terao, A., & Hayaishi, O.
Corresponding author
Matsumura, Hitoshi
ORCID
Terao, Akira
Venue
Brain Research
Publisher
Elsevier BV
Published
1997-03
Volume
751
Issue
1
Pages
81-89
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/s0006-8993(96)01401-1
OpenAlex
W2145858950
Cited by
112
References
47
Citations by year
2026: 1 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 6 · 2019: 5 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 3 · 2012: 5
FWCI
1.81
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Takeda Science Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
prostaglandin D2, prostaglandin E2, prostaglandin F2alpha, cerebrospinal fluid, sleep deprivation, slow-wave sleep, sleep-wake cycle, sleep promotion, basal forebrain, subarachnoid administration, rats, sleep propensity, hypothalamus, stress response, restraint stress, EEG, electromyography
MeSH terms
Animals, Antineoplastic Agents, Body Temperature, Consciousness, Male, Microelectrodes, Oxytocics, Prostaglandins, Synthetic, Sleep Deprivation, Stress, Physiological, Subarachnoid Space, Prostaglandin D2, Dinoprostone, Dinoprost, Prosencephalon, Rats, Sprague-Dawley, Rats

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