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Cited by 229Sleep and Wakefulness ResearchNeuroscience of respiration and sleepCircadian rhythm and melatonin

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The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus

Gallopin, T., Luppi, P.-H., Cauli, B., Urade, Y., Rossier, J., Hayaishi, O., Lambolez, B., Fort, P.·2005·Neuroscience
DOI 10.1016/j.neuroscience.2005.05.045
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Abstract

Recent research has shown that neurons in the ventrolateral preoptic nucleus are crucial for sleep by inhibiting wake-promoting systems, but the process that triggers their activation at sleep onset remains to be established. Since evidence indicates that sleep induced by adenosine, an endogenous sleep-promoting substance, requires activation of brain A(2A) receptors, we examined the hypothesis that adenosine could activate ventrolateral preoptic nucleus sleep neurons via A(2A) adenosine receptors in rat brain slices. Following on from our initial in vitro identification of these neurons as uniformly inhibited by noradrenaline and acetylcholine arousal transmitters, we established that the ventrolateral preoptic nucleus comprises two intermingled subtypes of sleep neurons, differing in their firing responses to serotonin, inducing either an inhibition (Type-1 cells) or an excitation (Type-2 cells). Since both cell types contained galanin and expressed glutamic acid decarboxylase-65/67 mRNAs, they potentially correspond to the sleep promoting neurons inhibiting arousal systems. Our pharmacological investigations using A(1) and A(2A) adenosine receptors agonists and antagonists further revealed that only Type-2 neurons were excited by adenosine via a postsynaptic activation of A(2A) adenosine receptors. Hence, the present study is the first demonstration of a direct activation of the sleep neurons by adenosine. Our results further support the cellular and functional heterogenei…

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Metadata

Authors
Gallopin, T., Luppi, P.-H., Cauli, B., Urade, Y., Rossier, J., Hayaishi, O., Lambolez, B., & Fort, P.
Affiliations
  • Lyon 1 Université (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Fort, P.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2005
Volume
134
Issue
4
Pages
1377-1390
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2005.05.045
OpenAlex
W1984452606
Cited by
229
References
2
Citations by year
2026: 7 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 8 · 2021: 9 · 2020: 5 · 2019: 12 · 2018: 7 · 2017: 12 · 2016: 16 · 2015: 7 · 2014: 13 · 2013: 18 · 2012: 14
FWCI
3.48
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
adenosine, adenosine A2A receptor, ventrolateral preoptic nucleus, sleep induction, serotonin, galanin, neuronal heterogeneity, arousal, norepinephrine, acetylcholine, sleep homeostasis, sleep consolidation
MeSH terms
Adenosine, Animals, Neurons, Organ Culture Techniques, Preoptic Area, Serotonin, Sleep, Rats, Sprague-Dawley, Patch-Clamp Techniques, Reverse Transcriptase Polymerase Chain Reaction, Receptor, Adenosine A2A, Rats, Adenosine A2 Receptor Agonists, Adenosine A2 Receptor Antagonists

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