Färkkilä, Martti

The mutational constraint spectrum quantified from variation in 141,456 humans

Karczewski, K. J., Francioli, L. C., Tiao, G., Cummings, B. B., Alföldi, J., Wang, Q., Collins, R. L., Laricchia, K. M., Ganna, A., Birnbaum, D. P., et al. (2020) · Nature

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 9,434

FinnGen provides genetic insights from a well-phenotyped isolated population

Kurki, M. I., Karjalainen, J., Palta, P., Sipilä, T. P., Kristiansson, K., Donner, K. M., Reeve, M. P., Laivuori, H., Aavikko, M., Kaunisto, M. A., et al. (2023) · Nature

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 4,233

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., et al. (2022) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 2,498

A genomic mutational constraint map using variation in 76,156 human genomes

Chen, S., Francioli, L. C., Goodrich, J. K., Collins, R. L., Kanai, M., Wang, Q., Alföldi, J., Watts, N. A., Vittal, C., Gauthier, L. D., et al. (2024) · Nature

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 1,727

A structural variation reference for medical and population genetics

Collins, R. L., Brand, H., Karczewski, K. J., Zhao, X., Alföldi, J., Francioli, L. C., Khera, A. V., Lowther, C., Gauthier, L. D., Wang, H., et al. (2020) · Nature

Genomic variations and chromosomal abnormalitiesGenomics and Rare Diseases

Cited by 1,037

Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis

Weismüller, T. J., Trivedi, P. J., Bergquist, A., Imam, M., Lenzen, H., Ponsioen, C. Y., Holm, K., Gotthardt, D., Färkkilä, M. A., Marschall, H.-U., et al. (2017) · Gastroenterology

Liver Diseases and ImmunityInflammatory Bowel Disease

Cited by 533

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

The UK-PSCSC Consortium, Liu, J. Z., The International IBD Genetics Consortium, The International PSC Study Group, Hov, J. R., Folseraas, T., Ellinghaus, E., Rushbrook, S. M., Doncheva, N. T., Andreassen, O. A., et al. (2013) · Nature Genetics

Liver Diseases and ImmunityGenetic Associations and Epidemiology

Cited by 391

A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention

KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R. (2005) · Alimentary Pharmacology & Therapeutics

Gastrointestinal motility and disordersProbiotics and Fermented Foods

Cited by 361

norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis

Fickert, P., Hirschfield, G. M., Denk, G., Marschall, H.-U., Altorjay, I., Färkkilä, M., Schramm, C., Spengler, U., Chapman, R., Bergquist, A., et al. (2017) · Journal of Hepatology

Liver Diseases and ImmunityInflammatory Bowel Disease

Cited by 297

Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population

Åberg, F., Helenius‐Hietala, J., Puukka, P., Färkkilä, M., & Jula, A. (2018) · Hepatology

Alcohol Consumption and Health EffectsLiver Disease Diagnosis and Treatment

Cited by 267

Role of endoscopy in primary sclerosing cholangitis: European society of gastrointestinal endoscopy (ESGE) and European association for the study of the liver (EASL) clinical guideline

Aabakken, L., Karlsen, T., Albert, J., Arvanitakis, M., Chazouilleres, O., Dumonceau, J.-M., Färkkilä, M., Fickert, P., Hirschfield, G., Laghi, A., et al. (2017) · Endoscopy

Liver Diseases and ImmunityGallbladder and Bile Duct Disorders

Cited by 255

Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: A three‐year randomized trial†

Rautiainen, H., Kärkkäinen, P., Karvonen, A., Nurmi, H., Pikkarainen, P., Nuutinen, H., & Färkkilä, M. (2005) · Hepatology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 222

Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis: a randomized placebo-controlled trial

Färkkilä, M., Karvonen, A., Nurmi, H., Nuutinen, H., Taavitsainen, M., Pikkarainen, P., & Kärkkäinen, P. (2004) · Hepatology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 218

Risks of light and moderate alcohol use in fatty liver disease: follow-up of population cohorts

Åberg, F., Puukka, P., Salomaa, V., Männistö, S., Lundqvist, A., Valsta, L., Perola, M., Färkkilä, M., & Jula, A. (2020) · Hepatology

Alcohol Consumption and Health EffectsLiver Disease Diagnosis and Treatment

Cited by 176

Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis

Vesterhus, M., Hov, J. R., Holm, A., Schrumpf, E., Nygård, S., Godang, K., Andersen, I. M., Næss, S., Thorburn, D., Saffioti, F., et al. (2015) · Hepatology

Liver Diseases and ImmunityLiver Disease Diagnosis and Treatment

Cited by 138

No superiority of stents vs balloon dilatation for dominant strictures in patients with primary sclerosing cholangitis

Ponsioen, C. Y., Arnelo, U., Bergquist, A., Rauws, E. A., Paulsen, V., Cantú, P., Parzanese, I., De Vries, E. M., van Munster, K. N., Said, K., et al. (2018) · Gastroenterology

Liver Diseases and ImmunityGallbladder and Bile Duct Disorders

Cited by 112

A placebo-controlled randomised trial of budesonide for PBC following an insufficient response to UDCA

Hirschfield, G. M., Beuers, U., Kupcinskas, L., Ott, P., Bergquist, A., Färkkilä, M., Manns, M. P., Parés, A., Spengler, U., Stiess, M., et al. (2021) · Journal of Hepatology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 108

Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline

Aabakken, L., Karlsen, T. H., Albert, J., Arvanitakis, M., Chazouilleres, O., Dumonceau, J.-M., Färkkilä, M., Fickert, P., Hirschfield, G. M., Laghi, A., et al. (2017) · Journal of Hepatology

Liver Diseases and ImmunityGallbladder and Bile Duct Disorders

Cited by 107

Defining primary sclerosing cholangitis: results from an International Primary Sclerosing Cholangitis Study Group consensus process

Ponsioen, C. Y., Assis, D. N., Boberg, K. M., Bowlus, C. L., Deneau, M., Thorburn, D., Aabakken, L., Färkkilä, M., Petersen, B., Rupp, C., et al. (2021) · Gastroenterology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 95

Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study

de Vries, E. M. G., Färkkilä, M., Milkiewicz, P., Hov, J. R., Eksteen, B., Thorburn, D., Chazouillères, O., Pares, A., Nygård, S., Gilja, O. H., et al. (2017) · Liver International

Liver Diseases and ImmunityLiver Disease Diagnosis and Treatment

Cited by 83

Epidemiology, risk of malignancy and patient survival in primary sclerosing cholangitis: a population-based study in Finland

Barner-Rasmussen, N., Pukkala, E., Jussila, A., & Färkkilä, M. (2020) · Scandinavian Journal of Gastroenterology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 80

Prevalence and incidence of primary biliary cirrhosis are increasing in Finland

Rautiainen, H., Salomaa, V., Niemelä, S., Karvonen, A.-L., Nurmi, H., Isoniemi, H., & Färkkilä, M. (2007) · Scandinavian Journal of Gastroenterology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 65

Interaction between alcohol use and metabolic risk factors for liver disease: a critical review of epidemiological studies

Åberg, F., Färkkilä, M., & Männistö, V. (2020) · Alcoholism Clinical and Experimental Research

Alcohol Consumption and Health EffectsLiver Disease Diagnosis and Treatment

Cited by 63

Screening primary sclerosing cholangitis and biliary dysplasia with endoscopic retrograde cholangiography and brush cytology: risk factors for biliary neoplasia

Boyd, S., Tenca, A., Jokelainen, K., Mustonen, H., Krogerus, L., Arola, J., & Färkkilä, M. (2016) · Endoscopy

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 50