Greenleaf, William J.

Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons

Blum, J. A., Klemm, S., Shadrach, J. L., Guttenplan, K. A., Nakayama, L., Kathiria, A., Hoang, P. T., Gautier, O., Kaltschmidt, J. A., Greenleaf, W. J., et al. (2021) · Nature Neuroscience

Single-cell and spatial transcriptomicsNeuroscience and Neuropharmacology Research

Cited by 210

Chromatin accessibility profiling methods

Minnoye, L., Marinov, G. K., Krausgruber, T., Pan, L., Marand, A. P., Secchia, S., Greenleaf, W. J., Furlong, E. E. M., Zhao, K., Schmitz, R. J., et al. (2021) · Nature Reviews Methods Primers

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 206

Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

Haney, M. S., Bohlen, C. J., Morgens, D. W., Ousey, J. A., Barkal, A. A., Tsui, C. K., Ego, B. K., Levin, R., Kamber, R. A., Collins, H., et al. (2018) · Nature Genetics

Phagocytosis and Immune RegulationCellular transport and secretion

Cited by 193

High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2

Becker, W. R., Ober-Reynolds, B., Jouravleva, K., Jolly, S. M., Zamore, P. D., & Greenleaf, W. J. (2019) · Molecular Cell

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 161

Long-range single-molecule mapping of chromatin accessibility in eukaryotes

Shipony, Z., Marinov, G. K., Swaffer, M. P., Sinnott-Armstrong, N. A., Skotheim, J. M., Kundaje, A., & Greenleaf, W. J. (2020) · Nature Methods

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 160

Transcript-indexed ATAC-seq for precision immune profiling

Satpathy, A. T., Saligrama, N., Buenrostro, J. D., Wei, Y., Wu, B., Rubin, A. J., Granja, J. M., Lareau, C. A., Li, R., Qi, Y., et al. (2018) · Nature Medicine

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 152

High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer

Pierce, S. E., Granja, J. M., & Greenleaf, W. J. (2021) · Nature Communications

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 146

NEAT-seq: simultaneous profiling of intra-nuclear proteins, chromatin accessibility and gene expression in single cells

Chen, A. F., Parks, B., Kathiria, A. S., Ober-Reynolds, B., Goronzy, J. J., & Greenleaf, W. J. (2022) · Nature Methods

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 139

An encyclopedia of enhancer-gene regulatory interactions in the human genome

Gschwind, A. R., Mualim, K. S., Karbalayghareh, A., Sheth, M. U., Dey, K. K., Jagoda, E., Nurtdinov, R. N., Xi, W., Tan, A. S., Jones, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory)

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 119

Single-cell epigenomic variability reveals functional cancer heterogeneity

Litzenburger, U. M., Buenrostro, J. D., Wu, B., Shen, Y., Sheffield, N. C., Kathiria, A., Greenleaf, W. J., & Chang, H. Y. (2017) · Genome Biology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 115

Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases

Ober-Reynolds, B., Wang, C., Ko, J. M., Rios, E. J., Aasi, S. Z., Davis, M. M., Oro, A. E., & Greenleaf, W. J. (2023) · Nature Genetics

Hair Growth and DisordersGenomics and Chromatin Dynamics

Cited by 83

Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Mor, N., Rais, Y., Sheban, D., Peles, S., Aguilera-Castrejon, A., Zviran, A., Elinger, D., Viukov, S., Geula, S., Krupalnik, V., et al. (2018) · Cell Stem Cell

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 79

Single-cell transcriptomic landscape of the developing human spinal cord

Andersen, J., Thom, N., Shadrach, J. L., Chen, X., Onesto, M. M., Amin, N. D., Yoon, S.-J., Li, L., Greenleaf, W. J., Müller, F., et al. (2023) · Nature Neuroscience

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 61

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression

Pierce, S. E., Granja, J. M., Corces, M. R., Brady, J. J., Tsai, M. K., Pierce, A. B., Tang, R., Chu, P., Feldser, D. M., Chang, H. Y., et al. (2021) · Nature Cell Biology

Chromatin Remodeling and CancerCancer Cells and Metastasis

Cited by 59

Multifaceted role for p53 in pancreatic cancer suppression

Mello, S. S., Flowers, B. M., Mazur, P. K., Lee, J. J., Müller, F., Denny, S. K., Ferreira, S., Hanson, K., Kim, S. K., Greenleaf, W. J., et al. (2023) · Proceedings of the National Academy of Sciences

Pancreatic and Hepatic Oncology ResearchCancer-related Molecular Pathways

Cited by 55

Single-molecule states link transcription factor binding to gene expression

Doughty, B. R., Hinks, M. M., Schaepe, J. M., Marinov, G. K., Thurm, A. R., Rios-Martinez, C., Parks, B. E., Tan, Y., Marklund, E., Dubocanin, D., et al. (2024) · Nature

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 42

PU.1 and BCL11B sequentially cooperate with RUNX1 to anchor mSWI/SNF to poise the T cell effector landscape

Gamble, N., Bradu, A., Caldwell, J. A., McKeever, J., Bolonduro, O., Ermis, E., Kaiser, C., Kim, Y., Parks, B., Klemm, S., et al. (2024) · Nature Immunology

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 26

Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs

Shin, J. H., Cuevas, L. M., Roy, R., Bonilla, S. L., Al-Hashimi, H., Greenleaf, W. J., & Herschlag, D. (2024) · RNA

RNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Cited by 1

Exploring the energetic and conformational properties of the sequence space connecting naturally occurring RNA tetraloop receptor motifs

Shin, J. H., Cuevas, L. M., Roy, R., Bonilla, S. L., Al-Hashimi, H., Greenleaf, W. J., & Herschlag, D. (2024) · RNA

RNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Cited by 1