Smirnov, Igor

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature

Lymphatic System and DiseasesCerebrospinal fluid and hydrocephalus

Cited by 4,413

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

Da Mesquita, S., Louveau, A., Vaccari, A., Smirnov, I., Cornelison, R. C., Kingsmore, K. M., Contarino, C., Onengut-Gumuscu, S., Farber, E., Raper, D., et al. (2018) · Nature

Cerebrospinal fluid and hydrocephalusLymphatic System and Diseases

Cited by 1,445

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.

Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., et al. (2018) · Nature Neuroscience

Lymphatic System and DiseasesCerebrospinal fluid and hydrocephalus

Cited by 956

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., et al. (2016) · Nature

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 697

Functional characterization of the dural sinuses as a neuroimmune interface

Rustenhoven, J., Drieu, A., Mamuladze, T., de Lima, K. A., Dykstra, T., Wall, M., Papadopoulos, Z., Kanamori, M., Salvador, A. F., Baker, W., et al. (2021) · Cell

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 685

Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma

Cugurra, A., Mamuladze, T., Rustenhoven, J., Dykstra, T., Beroshvili, G., Greenberg, Z. J., Baker, W., Papadopoulos, Z., Drieu, A., Blackburn, S., et al. (2021) · Science

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 681

Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., et al. (2023) · Nature

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 609

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

Brioschi, S., Wang, W.-L., Peng, V., Wang, M., Shchukina, I., Greenberg, Z. J., Bando, J. K., Jaeger, N., Czepielewski, R. S., Swain, A., et al. (2021) · Science

Neuroinflammation and Neurodegeneration MechanismsT-cell and B-cell Immunology

Cited by 472

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

Da Mesquita, S., Papadopoulos, Z., Dykstra, T., Brase, L., Farias, F. G., Wall, M., Jiang, H., Kodira, C. D., de Lima, K. A., Herz, J., et al. (2021) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 431

Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., et al. (2020) · Nature Immunology

T-cell and B-cell ImmunologyNeuroinflammation and Neurodegeneration Mechanisms

Cited by 416

Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

Cronk, J. C., Filiano, A. J., Louveau, A., Marin, I., Marsh, R., Ji, E., Goldman, D. H., Smirnov, I., Geraci, N., Acton, S., et al. (2018) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsHematopoietic Stem Cell Transplantation

Cited by 412

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

Gadani, S. P., Walsh, J. T., Smirnov, I., Zheng, J., & Kipnis, J. (2015) · Neuron

Neuroinflammation and Neurodegeneration MechanismsIL-33, ST2, and ILC Pathways

Cited by 359

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.

Bolte, A. C., Dutta, A. B., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Ennerfelt, H. E., Shapiro, D., Nguyen, B. H., Frost, E. L., et al. (2020) · Nature Communications

Traumatic Brain Injury and Neurovascular DisturbancesCerebrospinal fluid and hydrocephalus

Cited by 357

Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., et al. (2022) · Nature

Cerebrospinal fluid and hydrocephalusNeuroinflammation and Neurodegeneration Mechanisms

Cited by 325

Identification of direct connections between the dura and the brain

Smyth, L. C. D., Xu, D., Okar, S. V., Dykstra, T., Rustenhoven, J., Papadopoulos, Z., Bhasiin, K., Kim, M. W., Drieu, A., Mamuladze, T., et al. (2024) · Nature

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 264

Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance

Jiang-Xie, L.-F., Drieu, A., Bhasiin, K., Quintero, D., Smirnov, I., & Kipnis, J. (2024) · Nature

Cerebrospinal fluid and hydrocephalusNeural dynamics and brain function

Cited by 220

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

Cronk, J. C., Derecki, N. C., Ji, E., Xu, Y., Lampano, A. E., Smirnov, I., Baker, W., Norris, G. T., Marin, I., Coddington, N., et al. (2015) · Immunity

Genetics and Neurodevelopmental DisordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 199

Features of skin-coincubated macrophages that promote recovery from spinal cord injury

Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., & Yoles, E. (2003) · Journal of Neuroimmunology

Spinal Cord Injury ResearchNerve injury and regeneration

Cited by 155

Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury

Norris, G. T., Smirnov, I., Filiano, A. J., Shadowen, H. M., Cody, K. R., Thompson, J. A., Harris, T. H., Gaultier, A., Overall, C. C., & Kipnis, J. (2018) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 109