Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
Open accessAbstract
Immune dysfunction is commonly associated with several neurological and mental disorders. Although the mechanisms by which peripheral immunity may influence neuronal function are largely unknown, recent findings implicate meningeal immunity influencing behaviour, such as spatial learning and memory. Here we show that meningeal immunity is also critical for social behaviour; mice deficient in adaptive immunity exhibit social deficits and hyper-connectivity of fronto-cortical brain regions. Associations between rodent transcriptomes from brain and cellular transcriptomes in response to T-cell-derived cytokines suggest a strong interaction between social behaviour and interferon-γ (IFN-γ)-driven responses. Concordantly, we demonstrate that inhibitory neurons respond to IFN-γ and increase GABAergic (γ-aminobutyric-acid) currents in projection neurons, suggesting that IFN-γ is a molecular link between meningeal immunity and neural circuits recruited for social behaviour. Meta-analysis of the transcriptomes of a range of organisms reveals that rodents, fish, and flies elevate IFN-γ/JAK-STAT-dependent gene signatures in a social context, suggesting that the IFN-γ signalling pathway could mediate a co-evolutionary link between social/aggregation behaviour and an efficient anti-pathogen response. This study implicates adaptive immune dysfunction, in particular IFN-γ, in disorders characterized by social dysfunction and suggests a co-evolutionary link between social behaviour and an anti-pathogen immune response driven by IFN-γ signalling.
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The immune environment can affect behavior.
“Given the ability of the immune environment to affect behavior (Filiano et al, 2016)”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Filiano et al, 2016
Severe combined immunodeficiency mice have impaired social preference.
“Further, severe combined immunodeficiency mice have impaired social preference [195].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [195]
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R: A Language and Environment for Statistical Computing
R Core Team (2000) · doi:10.32614/r.manuals · Cited by 355,811 · see citing works
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works
Circos: An information aesthetic for comparative genomicsPreprint
Krzywinski, M. I., Schein, J. E., Birol, İ., Connors, J. M., Gascoyne, R. D., Horsman, D. E., Jones, S. J. M., & Marra, M. A. (2009) · Genome Research · doi:10.1101/gr.092759.109 · Cited by 10,838 · see citing works
MEME SUITE: tools for motif discovery and searching
Bailey, T. L., Boden, M., Buske, F. A., Frith, M., Grant, C. E., Clementi, L., Ren, J., Li, W. W., & Noble, W. S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp335 · Cited by 10,648 · see citing works
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429 · see citing works
A reproducible evaluation of ANTs similarity metric performance in brain image registration
Avants, B. B., Tustison, N. J., Song, G., Cook, P. A., Klein, A., & Gee, J. C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.025 · Cited by 4,796 · see citing works
Self-citationA component based noise correction method (CompCor) for BOLD and perfusion based fMRI
Behzadi, Y., Restom, K., Liau, J., & Liu, T. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.042 · Cited by 4,502 · see citing works
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works
The neuropathic pain triad: neurons, immune cells and glia
Scholz, J., & Woolf, C. J. (2007) · Nature Neuroscience · doi:10.1038/nn1992 · Cited by 1,738 · see citing works
Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin
Yednock, T. A., Cannon, C., Fritz, L. C., Sánchez‐Madrid, F., Steinman, L., & Karin, N. (1992) · Nature · doi:10.1038/356063a0 · Cited by 1,737 · see citing works
Moy, S. S., Nadler, J. J., Perez, A., Barbaro, R. P., Johns, J. M., Magnuson, T. R., Piven, J., & Crawley, J. N. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-1848.2004.00076.x · Cited by 1,545 · see citing works
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Zhan, Y., Paolicelli, R. C., Sforazzini, F., Weinhard, L., Bolasco, G., Pagani, F., Vyssotski, A. L., Bifone, A., Gozzi, A., Ragozzino, D., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3641 · Cited by 1,236 · see citing works
Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders
Nelson, S. B., & Valakh, V. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.033 · Cited by 1,001 · see citing works
The social brain in psychiatric and neurological disorders
Kennedy, D. P., & Adolphs, R. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.09.006 · Cited by 846 · see citing works
Regulation of learning and memory by meningeal immunity: a key role for IL-4
Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800 · see citing works
Self-citationTing, J. T., Daigle, T. L., Chen, Q., & Feng, G. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1096-0_14 · Cited by 631 · see citing works
Toward a neurology of loneliness
Cacioppo, S., Capitanio, J. P., & Cacioppo, J. T. (2014) · Psychological Bulletin · doi:10.1037/a0037618 · Cited by 623 · see citing works
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615 · see citing works
Zebrafish in The Wild: A Review of Natural History And New Notes from The Field
Engeszer, R. E., Patterson, L. B., Rao, A. A., & Parichy, D. M. (2007) · Zebrafish · doi:10.1089/zeb.2006.9997 · Cited by 612 · see citing works
Brain hyperconnectivity in children with autism and its links to social deficits
Supekar, K., Uddin, L. Q., Khouzam, A., Phillips, J., Gaillard, W. D., Kenworthy, L. E., Yerys, B. E., Vaidya, C. J., & Menon, V. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.001 · Cited by 538 · see citing works
Inhibitory role for GABA in autoimmune inflammation
Bhat, R., Axtell, R., Mitra, A., Miranda, M., Lock, C., Tsien, R. W., & Steinman, L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915139107 · Cited by 509 · see citing works
β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
Smith, L. K., He, Y., Park, J.-S., Bieri, G., Snethlage, C. E., Lin, K., Gontier, G., Wabl, R., Plambeck, K. E., Udeochu, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3898 · Cited by 500 · see citing works
Selective Modulation of Tonic and Phasic Inhibitions in Dentate Gyrus Granule Cells
Nusser, Z., & Módy, I. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.5.2624 · Cited by 487 · see citing works
Immune–neural connections: how the immune system’s response to infectious agents influences behavior
McCusker, R. H., & Kelley, K. W. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.073411 · Cited by 429 · see citing works
Regulation of cortical microcircuits by unitary GABA-mediated volume transmission
Oláh, S., Füle, M., Komlósi, G., Varga, C., Báldi, R., Barzó, P., & Tamás, G. (2009) · Nature · doi:10.1038/nature08503 · Cited by 386 · see citing works
Saverino, C., & Gerlai, R. T. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.013 · Cited by 373 · see citing works
Quantification of shoaling behaviour in zebrafish (Danio rerio)
Miller, N. Y., & Gerlai, R. T. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.007 · Cited by 326 · see citing works
IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair
Kunis, G., Baruch, K., Rosenzweig, N., Kertser, A., Miller, O., Berkutzki, T., & Schwartz, M. (2013) · Brain · doi:10.1093/brain/awt259 · Cited by 321 · see citing works
PHEROMONE-MEDIATED AGGREGATION IN NONSOCIAL ARTHROPODS: An Evolutionary Ecological Perspective
Wertheim, B., van Baalen, E.-J. A., Dicke, M., & Vet, L. E. M. (2004) · Annual Review of Entomology · doi:10.1146/annurev.ento.49.061802.123329 · Cited by 312 · see citing works
IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic pain
Tsuda, M., Masuda, T., Kitano, J., Shimoyama, H., Tozaki‐Saitoh, H., & Inoue, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810420106 · Cited by 296 · see citing works
Behavioral syndromes and the evolution of correlated behavior in zebrafish
Moretz, J. A., Martins, E. P., & Robison, B. D. (2007) · Behavioral Ecology · doi:10.1093/beheco/arm011 · Cited by 287 · see citing works
Altered T cell responses in children with autism
Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I. N., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.09.002 · Cited by 281 · see citing works
An Asymptotic χ2Test for the Equality of Two Correlation Matrices
Jennrich, R. I. (1970) · Journal of the American Statistical Association · doi:10.1080/01621459.1970.10481133 · Cited by 265 · see citing works
Waxholm Space: An image-based reference for coordinating mouse brain research
Johnson, G. A., Badea, A., Brandenburg, J., Cofer, G. P., Fubara, B. N., Liu, S., & Nissanov, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.067 · Cited by 253 · see citing works
Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism
Gupta, S., Aggarwal, S., Rashanravan, B., & Lee, T. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00021-6 · Cited by 250 · see citing works
Resetting the Circadian Clock by Social Experience in Drosophila melanogaster
Levine, J. D., Funes, P., Dowse, H. B., & Hall, J. C. (2002) · Science · doi:10.1126/science.1076008 · Cited by 242 · see citing works
Public Versus Personal Information for Mate Copying in an Invertebrate
Mery, F., Varela, S. A. M., Danchin, É., Blanchet, S., Parejo, D., Coolen, I., & Wagner, R. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.064 · Cited by 241 · see citing works
Han, S., Tai, C., Jones, C. J., Scheuer, T., & Catterall, W. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.016 · Cited by 231 · see citing works
Hamilton's rule and the causes of social evolution
Bourke, A. F. G. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0362 · Cited by 223 · see citing works
Adaptive immunity affects learning behavior in mice
Brynskikh, A., Warren, T., Zhu, J., & Kipnis, J. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.12.008 · Cited by 221 · see citing works
Self-citationClassical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity
Datwani, A., McConnell, M. J., Kanold, P. O., Micheva, K. D., Busse, B., Shamloo, M., Smith, S. J., & Shatz, C. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.10.015 · Cited by 212 · see citing works
A common genetic target for environmental and heritable influences on aggressiveness in Drosophila
Wang, L., Dankert, H., Perona, P., & Anderson, D. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801327105 · Cited by 205 · see citing works
Krause, J., Butlin, R. K., Peuhkuri, N., & Pritchard, V. L. (2000) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2000.tb00052.x · Cited by 199 · see citing works
López‐Muñoz, A., Roca, F. J., Meseguer, J., & Mulero, V. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802528 · Cited by 188 · see citing works
Social Interactions in “Simple” Model Systems
Sokolowski, M. B. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.007 · Cited by 186 · see citing works
Filiano, A. J., Martens, L. H., Young, A. H., Warmus, B. A., Zhou, P., Diaz‐Ramirez, G., Jiao, J., Zhang, Z., Huang, E. J., Gao, F., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.6103-11.2013 · Cited by 172 · see citing works
Self-citationHoffmann, A. A. (1987) · Animal Behaviour · doi:10.1016/s0003-3472(87)80117-3 · Cited by 159 · see citing works
Social learning about egg-laying substrates in fruitflies
Sarin, S., & Dukas, R. (2009) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2009.1294 · Cited by 152 · see citing works
Innate and adaptive immune responses in the CNS
Waisman, A., Liblau, R., & Becher, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00141-6 · Cited by 151 · see citing works
Morphology and spatial distribution of GABAergic neurons in cat primary auditory cortex (AI)
Prieto, J. J., Peterson, B. A., & Winer, J. A. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903440304 · Cited by 148 · see citing works
Ruan, H., & Wu, C.-F. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711127105 · Cited by 112 · see citing works
Palop, J. J., Mucke, L., & Roberson, E. D. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-744-0_17 · Cited by 104 · see citing works
Visual social preferences of lone zebrafish in a novel environment: strain and anxiolytic effects
Barba-Escobedo, P. A., & Gould, G. G. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00770.x · Cited by 88 · see citing works
PirB regulates a structural substrate for cortical plasticity.
Djurisic, M., Vidal, G. S., Mann, M., Aharon, A., Kim, T., Ferrao Santos, A., Zuo, Y., Hübener, M., & Shatz, C. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321092110 · Cited by 79 · see citing works
Seizure resistance without parkinsonism in aged mice after tau reduction
Li, Z., Hall, A. M., Kelinske, M., & Roberson, E. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.001 · Cited by 71 · see citing works
Inflammatory Cytokines at the Summits of Pathological Signal Cascades in Brain Diseases
Steinman, L. (2013) · Science Signaling · doi:10.1126/scisignal.2003898 · Cited by 70 · see citing works
Shen, H. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518785112 · Cited by 69 · see citing works
The pediatric template of brain perfusion
Avants, B., Duda, J., Kilroy, E., Krasileva, K. E., Jann, K., Kandel, B. M., Tustison, N. J., Yan, L., Jog, M., Smith, R. X., et al. (2015) · Scientific Data · doi:10.1038/sdata.2015.3 · Cited by 59 · see citing works
Self-citationLópez‐Muñoz, A., Sepulcre, M. P., Roca, F. J., Figueras, A. J., Meseguer, J., & Mulero, V. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.01.015 · Cited by 46 · see citing works
Epistatic regulation of behavioural and morphological traits in the zebrafish (Danio rerio)
Wright, D., Butlin, R. K., & Carlborg, Ö. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9080-9 · Cited by 38 · see citing works
Different social-learning strategies in wild and domesticated zebrafish, Danio rerio
Zala, S. M., Määttänen, I., & Penn, D. J. (2012) · Animal Behaviour · doi:10.1016/j.anbehav.2012.03.029 · Cited by 22 · see citing works
Plasticity of Social Behavior in Drosophila
Камышев, Н. Г., Smirnova, G. P., Аркадьевна, К. Е., Никифоров, О. Н., Parafenyuk, I. V., & Пономаренко, В. В. (2002) · Neuroscience and Behavioral Physiology · doi:10.1023/a:1015832328023 · Cited by 17 · see citing works
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Research works printed but not linked: 4
- [32]Zhan Y Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior Nat Neurosci 17 400 406 10.1038/nn.3641 2014 24487234 · DOI · Paper page
- [40]Derecki NC Regulation of learning and memory by meningeal immunity: a key role for IL-4 J Exp Med 207 1067 1080 10.1084/jem.20091419 2010 20439540 PMC2867291 · DOI · Paper page
- [56]Moy SS Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice Genes Brain Behav 3 287 302 10.1111/j.1601-1848.2004.00076.x 2004 15344922 · DOI · Paper page
- [68]Wang L Dankert H Perona P Anderson DJ A common genetic target for environmental and heritable influences on aggressiveness in Drosophila Proc Natl Acad Sci U S A 105 5657 5663 10.1073/pnas.0801327105 2008 18408154 PMC2311352 · DOI
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Self-citationUnderstanding the functions and relationships of the glymphatic system and meningeal lymphatics
Louveau, A., Plog, B. A., Antila, S., Alitalo, K., Nedergaard, M., & Kipnis, J. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90603 · Cited by 640 · see citing works
Self-citationThe role of peripheral immune cells in the CNS in steady state and disease
Prinz, M., & Priller, J. (2017) · Nature Neuroscience · doi:10.1038/nn.4475 · Cited by 657 · see citing works
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Chen, X., Firulyova, M., Manis, M., Herz, J., Smirnov, I., Aladyeva, E., Wang, C., Bao, X., Finn, M. B., Hu, H., et al. (2023) · Nature · doi:10.1038/s41586-023-05788-0 · Cited by 609 · see citing works
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The Role of the Immune System in Autism Spectrum Disorder
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Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521 · see citing works
Slavich, G. M. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045159 · Cited by 502 · see citing works
“Indeed, cytokine receptors are present on virtually all neural cell types, and recent animal model work has shown that they play a critical mechanistic role in linking neuronal connectivity, immunity, and social behavior (Filiano et al. 2016).”
BackgroundPirzgalska, R. M., Seixas, E., Seidman, J. S., Link, V. M., Martínez‐Sánchez, N., Mahú, I., Mendes, R., Gres, V., Kubasova, N., Morris, I., et al. (2017) · Nature Medicine · doi:10.1038/nm.4422 · Cited by 511 · see citing works
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Self-citationImmunoneuropsychiatry — novel perspectives on brain disorders
Pape, K., Tamouza, R., Leboyer, M., & Zipp, F. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0174-4 · Cited by 455 · see citing works
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Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons
Alves de Lima, K., Rustenhoven, J., Da Mesquita, S., Wall, M., Salvador, A. F., Smirnov, I., Martelossi Cebinelli, G., Mamuladze, T., Baker, W., Papadopoulos, Z., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0776-4 · Cited by 416 · see citing works
Self-citationCronk, J. C., Filiano, A. J., Louveau, A., Marin, I., Marsh, R., Ji, E., Goldman, D. H., Smirnov, I., Geraci, N., Acton, S., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180247 · Cited by 412 · see citing works
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Self-citationImmune cell regulation of glia during CNS injury and disease
Greenhalgh, A. D., David, S., & Bennett, F. C. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0263-9 · Cited by 409 · see citing works
Erickson, M., & Banks, W. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014647 · Cited by 312 · see citing works
Transforming the understanding of brain immunity
Castellani, G., Croese, T., Peralta Ramos, J. M., & Schwartz, M. (2023) · Science · doi:10.1126/science.abo7649 · Cited by 386 · see citing works
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Hu, Y., Hu, Q., Li, Y., Lu, L., Xiang, Z., Yin, Z., Kabelitz, D., & Wu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01653-8 · Cited by 409 · see citing works
Multifaceted interactions between adaptive immunity and the central nervous system
Kipnis, J. (2016) · Science · doi:10.1126/science.aag2638 · Cited by 376 · see citing works
Self-citationMicroglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
Pasciuto, E., Burton, O. T., Roca, C. P., Lagou, V., Rajan, W. D., Theys, T., Mancuso, R., Tito, R. Y., Kouser, L., Callaerts-Vegh, Z., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.026 · Cited by 368 · see citing works
Alves de Lima, K., Rustenhoven, J., & Kipnis, J. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-102319-103410 · Cited by 348 · see citing works
Self-citationGut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Sanmarco, L. M., Wheeler, M. A., Gutiérrez-Vázquez, C., Polonio, C. M., Linnerbauer, M., Pinho-Ribeiro, F. A., Li, Z., Giovannoni, F., Batterman, K. V., Scalisi, G., et al. (2021) · Nature · doi:10.1038/s41586-020-03116-4 · Cited by 331 · see citing works
Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms
Sadler, R., Cramer, J. V., Heindl, S., Kostidis, S., Betz, D., Zuurbier, K. R., Northoff, B. H., Heijink, M., Goldberg, M. P., Plautz, E. J., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1359-19.2019 · Cited by 338 · see citing works
Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory
Ribeiro, M., Brigas, H. C., Temido-Ferreira, M., Pousinha, P. A., Regen, T., Santa, C., Coelho, J. E., Marques-Morgado, I., Valente, C. A., Omenetti, S., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aay5199 · Cited by 335 · see citing works
Advances in Meningeal Immunity
Rua, R., & McGavern, D. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.003 · Cited by 326 · see citing works
Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain
McCarthy, M., Nugent, B. M., & Lenz, K. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.61 · Cited by 256 · see citing works
Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior
Fan, K.-Q., Li, Y.-Y., Wang, H.-L., Mao, X.-T., Guo, J.-X., Wang, F., Huang, L.-J., Li, Y.-N., Ma, X.-Y., Gao, Z.-J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.001 · Cited by 312 · see citing works
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
Drieu, A., Du, S., Storck, S. E., Rustenhoven, J., Papadopoulos, Z., Dykstra, T., Zhong, F., Kim, K., Blackburn, S., Mamuladze, T., et al. (2022) · Nature · doi:10.1038/s41586-022-05397-3 · Cited by 325 · see citing works
Emerging roles of innate and adaptive immunity in Alzheimer’s disease
Chen, X., & Holtzman, D. M. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.016 · Cited by 297 · see citing works
Immune cells and CNS physiology: Microglia and beyond
Norris, G. T., & Kipnis, J. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180199 · Cited by 274 · see citing works
Self-citationGarber, C., Soung, A., Vollmer, L. L., Kanmogne, M., Last, A., Brown, J., & Klein, R. S. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0427-y · Cited by 272 · see citing works
Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology
Rankin, L. C., & Artis, D. (2018) · Cell · doi:10.1016/j.cell.2018.03.013 · Cited by 271 · see citing works
T cell responses in the central nervous system
Korn, T., & Kallies, A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.144 · Cited by 268 · see citing works
Neuronal regulation of immunity: why, how and where?
Schiller, M., Ben-Shaanan, T. L., & Rolls, A. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0387-1 · Cited by 267 · see citing works
The Immune System, Cytokines, and Biomarkers in Autism Spectrum Disorder
Masi, A., Glozier, N., Dale, R. C., & Guastella, A. J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0103-8 · Cited by 260 · see citing works
Brain borders at the central stage of neuroimmunology
Rustenhoven, J., & Kipnis, J. (2022) · Nature · doi:10.1038/s41586-022-05474-7 · Cited by 253 · see citing works
Self-citationNeuro–Immune Cell Units: A New Paradigm in Physiology
Godinho‐Silva, C., Cardoso, F., & Veiga‐Fernandes, H. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041812 · Cited by 250 · see citing works
The role of T cells in age-related diseases
Carrasco, E., Heras, M. M. G. D. L., Gabandé‐Rodríguez, E., Desdín-Micó, G., Aranda, J. F., & Mittelbrunn, M. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00557-4 · Cited by 244 · see citing works
Gut reactions: how the blood-brain barrier connects the microbiome and the brain
Logsdon, A. F., Erickson, M. A., Rhea, E. M., Salameh, T. S., & Banks, W. A. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370217743766 · Cited by 235 · see citing works
Cytokines as emerging regulators of central nervous system synapses
Zipp, F., Bittner, S., & Schafer, D. P. (2023) · Immunity · doi:10.1016/j.immuni.2023.04.011 · Cited by 239 · see citing works
Infectious immunity in the central nervous system and brain function
Klein, R. S., Garber, C., & Howard, N. (2017) · Nature Immunology · doi:10.1038/ni.3656 · Cited by 235 · see citing works
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease
Brigas, H. C., Ribeiro, M. A., Coelho, J. E., Gomes, R., Gómez‐Murcia, V., Carvalho, K., Faivre, É., Costa-Pereira, S., Darrigues, J., de Almeida, A. A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109574 · Cited by 236 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
Rosenzweig, N., Dvir-Szternfeld, R., Tsitsou-Kampeli, A., Keren‐Shaul, H., Ben-Yehuda, H., Weill-Raynal, P., Cahalon, L., Kertser, A., Baruch, K., Amit, I., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08352-5 · Cited by 224 · see citing works
Peripheral immune system in aging and Alzheimer’s disease
Cao, W., & Zheng, H. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0284-2 · Cited by 214 · see citing works
Neuroimmune circuits in inter-organ communication
Huh, J. R., & Veiga‐Fernandes, H. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0247-z · Cited by 216 · see citing works
The Jak/STAT pathway: A focus on pain in rheumatoid arthritis
Simon, L. S., Taylor, P. C., Choy, E., Sebba, A. I., Quebe, A. K., Knopp, K. L., & Porreca, F. (2020) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2020.10.008 · Cited by 222 · see citing works
Comer, A. L., Carrier, M., Tremblay, M., & Cruz‐Martín, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00274 · Cited by 204 · see citing works
How and why do T cells and their derived cytokines affect the injured and healthy brain?
Filiano, A. J., Gadani, S. P., & Kipnis, J. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.39 · Cited by 199 · see citing works
Self-citationFish type I and type II interferons: composition, receptor usage, production and function
Gan, Z., Chen, S. N., Huang, B., Zou, J., & Nie, P. (2019) · Reviews in Aquaculture · doi:10.1111/raq.12349 · Cited by 196 · see citing works
Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration
Pluvinage, J. V., & Wyss-Coray, T. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0255-9 · Cited by 191 · see citing works
The interplay of immunology and cachexia in infection and cancer
Baazim, H., Antonio-Herrera, L., & Bergthaler, A. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00624-w · Cited by 192 · see citing works
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
Woo, M. S., Mayer, C., Binkle-Ladisch, L., Sonner, J. K., Rosenkranz, S. C., Shaposhnykov, A., Rothammer, N., Tsvilovskyy, V., Lorenz, S., Raich, L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.031 · Cited by 196 · see citing works
Immune cell compartmentalization for brain surveillance and protection
Croese, T., Castellani, G., & Schwartz, M. (2021) · Nature Immunology · doi:10.1038/s41590-021-00994-2 · Cited by 188 · see citing works
Circulating myeloid-derived MMP8 in stress susceptibility and depression
Cathomas, F., Lin, H.-Y., Chan, K. L., Li, L., Parise, L. F., Alvarez, J., Durand-de Cuttoli, R., Aubry, A. V., Muhareb, S., Desland, F., et al. (2024) · Nature · doi:10.1038/s41586-023-07015-2 · Cited by 189 · see citing works
Critical Neurotransmitters in the Neuroimmune Network
Hodo, T., de Aquino, M. T. P., Shimamoto, A., & Shanker, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01869 · Cited by 187 · see citing works
The neuropathobiology of multiple sclerosis
Woo, M. S., Engler, J. B., & Friese, M. A. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00823-z · Cited by 194 · see citing works
Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J. (2021) · Science Advances · doi:10.1126/sciadv.abe4601 · Cited by 172 · see citing works
Self-citationInterferon- γ and infectious diseases: Lessons and prospects
Casanova, J., MacMicking, J. D., & Nathan, C. (2024) · Science · doi:10.1126/science.adl2016 · Cited by 179 · see citing works
Dash, S., Syed, Y. A., & Khan, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.880544 · Cited by 179 · see citing works
Zhang, H.-Y., Wang, Y., He, Y., Wang, T., Huang, X.-H., Zhao, C.-M., Zhang, L., Li, S.-W., Wang, C., Qu, Y.-N., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01871-9 · Cited by 161 · see citing works
Kraynak, T. E., Marsland, A. L., Wager, T. D., & Gianaros, P. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.013 · Cited by 165 · see citing works
Social Behavior Is Modulated by Valence-Encoding mPFC-Amygdala Sub-circuitry
Huang, W., Zucca, A., Levy, J., & Page, D. T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107899 · Cited by 163 · see citing works
Beyond the gut: decoding the gut–immune–brain axis in health and disease
Park, J. C., Chang, L., Kwon, H.-K., & Im, S.-H. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01333-3 · Cited by 149 · see citing works
Fiebiger, U., Bereswill, S., & Heimesaat, M. M. (2016) · European Journal of Microbiology and Immunology · doi:10.1556/1886.2016.00036 · Cited by 165 · see citing works
Kann, O., Almouhanna, F., & Chausse, B. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.10.007 · Cited by 150 · see citing works
Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury
Gadani, S. P., Smirnov, I., Wiltbank, A. T., Overall, C. C., & Kipnis, J. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20161982 · Cited by 148 · see citing works
Self-citationNeuroimmune regulation during intestinal development and homeostasis
Veiga‐Fernandes, H., & Pachnis, V. (2017) · Nature Immunology · doi:10.1038/ni.3634 · Cited by 146 · see citing works
Madore, C., Leyrolle, Q., Lacabanne, C., Benmamar-Badel, A., Joffre, C., Nadjar, A., & Layé, S. (2016) · Neural Plasticity · doi:10.1155/2016/3597209 · Cited by 141 · see citing works
Transcriptomic and clonal characterization of T cells in the human central nervous system
Pappalardo, J. L., Zhang, L., Pecsok, M. K., Perlman, K., Zografou, C., Raddassi, K., Abulaban, A. A., Krishnaswamy, S., Antel, J. P., van Dijk, D., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb8786 · Cited by 132 · see citing works
Distal Consequences of Oral Inflammation
Konkel, J. E., O’Boyle, C., & Krishnan, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01403 · Cited by 142 · see citing works
Boehme, M., van de Wouw, M., Bastiaanssen, T. F. S., Olavarría-Ramírez, L., Lyons, K., Fouhy, F., Golubeva, A. V., Moloney, G. M., Minuto, C., Sandhu, K. V., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0425-1 · Cited by 128 · see citing works
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135 · see citing works
Hammond, B. R., Miller, L. S., Bello, M., Lindbergh, C. A., Mewborn, C. M., & Renzi‐Hammond, L. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00254 · Cited by 135 · see citing works
A Budding Relationship: Bacterial Extracellular Vesicles in the Microbiota-Gut-Brain Axis
Haas‐Neill, S., & Forsythe, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238899 · Cited by 139 · see citing works
The immune system and psychiatric disease: a basic science perspective
Bennett, F. C., & Molofsky, A. V. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13334 · Cited by 139 · see citing works
Harnessing regulatory T cell neuroprotective activities for treatment of neurodegenerative disorders
Machhi, J., Kevadiya, B. D., Muhammad, I. K., Herskovitz, J., Olson, K. E., Mosley, R. L., & Gendelman, H. E. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00375-7 · Cited by 136 · see citing works
IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry
Majumder, S., & McGeachy, M. J. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-092536 · Cited by 131 · see citing works
High-dimensional single-cell analysis reveals the immune signature of narcolepsy
Hartmann, F. J., Bernard‐Valnet, R., Queriault, C., Mrdjen, D., Weber, L. M., Galli, E., Krieg, C., Robinson, M. D., Nguyen, X., Dauvilliers, Y. A., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160897 · Cited by 120 · see citing works
Functional immune cell–astrocyte interactions
Sanmarco, L. M., Polonio, C. M., Wheeler, M. A., & Quintana, F. J. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20202715 · Cited by 132 · see citing works
Leschak, C. J., & Eisenberger, N. I. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000685 · Cited by 122 · see citing works
Kotas, M. E., & Locksley, R. M. (2018) · Immunity · doi:10.1016/j.immuni.2018.06.002 · Cited by 116 · see citing works
T Cells as an Emerging Target for Chronic Pain Therapy
Laumet, G. O., Ma, J., Robison, A. J., Kumari, S., Heijnen, C. J., & Kavelaars, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00216 · Cited by 116 · see citing works
The zebrafish subcortical social brain as a model for studying social behavior disorders
Geng, Y., & Peterson, R. T. (2019) · Disease Models & Mechanisms · doi:10.1242/dmm.039446 · Cited by 111 · see citing works
Pathway-level information extractor (PLIER) for gene expression data
Mao, W., Zaslavsky, E., Hartmann, B., Sealfon, S. C., & Chikina, M. D. (2019) · Nature Methods · doi:10.1038/s41592-019-0456-1 · Cited by 113 · see citing works
Masi, A., Breen, E. J., Alvares, G. A., Glozier, N., Hickie, I. B., Hunt, A. M., Hui, J., Beilby, J. P., Ravine, D., Wray, J. A., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0176-2 · Cited by 110 · see citing works
The Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System
Strominger, I., Elyahu, Y., Berner, O., Reckhow, J. D., Mittal, K., Nemirovsky, A., & Monsonego, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01066 · Cited by 111 · see citing works
Joglekar, A., Hu, W., Zhang, B., Narykov, O., Diekhans, M., Marrocco, J., Balacco, J., Ndhlovu, L. C., Milner, T. A., Fedrigo, O. D., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01616-4 · Cited by 122 · see citing works
Toxoplasmosis: A pathway to neuropsychiatric disorders
Tyebji, S., Seizova, S., Hannan, A. J., & Tonkin, C. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.012 · Cited by 111 · see citing works
Jiao, W., Lin, J., Deng, Y., Ji, Y., Liang, C., Wei, S., Xi, J., & Yan, F. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03312-3 · Cited by 126 · see citing works
Laumet, G. O., Edralin, J. D., Chiang, A. C. A., Dantzer, R., Heijnen, C. J., & Kavelaars, A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0154-1 · Cited by 107 · see citing works
GABAergic neuronal IL-4R mediates T cell effect on memory
Herz, J., Fu, Z., Kim, K., Dykstra, T., Wall, M. K., Li, H., Salvador, A. F., Zou, B., Yan, N., Blackburn, S. M., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.10.022 · Cited by 109 · see citing works
Self-citationB-1a lymphocytes promote oligodendrogenesis during brain development
Tanabe, S., & Yamashita, T. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0106-4 · Cited by 107 · see citing works
- Authors
- Filiano, A. J., Xu, Y., Tustison, N. J., Marsh, R. L., Baker, W., Smirnov, I., Overall, C. C., Gadani, S. P., Turner, S. D., Weng, Z., Peerzade, S. N., Chen, H., Lee, K. S., Scott, M. M., Beenhakker, M. P., Litvak, V., & Kipnis, J.
- Affiliations
- University of Virginia (US)
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Filiano, Anthony J.
- Litvak, Vladimir
- Kipnis, Jonathan
- ORCID
- Venue
- Nature
- Published
- 2016-07
- Volume
- 535
- Issue
- 7612
- Pages
- 425-429
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4961620
- OpenAlex
- W2469685265
- Cited by
- 697
- References
- 66
- Citations by year
- 2026: 62 · 2025: 76 · 2024: 91 · 2023: 78 · 2022: 74 · 2021: 69 · 2020: 70 · 2019: 60 · 2018: 56 · 2017: 41 · 2016: 17 · 2015: 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG034113, R01AG034113, R37AG034113)
- National Institute of Allergy and Infectious Diseases (T32AI007496)
- National Institute of Neurological Disorders and Stroke (R01NS081026, NS081026)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- interferon-gamma, social behavior, meningeal immunity, GABAergic neurotransmission, prefrontal cortex, neural circuits, JAK/STAT signaling, T cell cytokines, neuroimmune interactions, social dysfunction
- MeSH terms
- Animals, Drosophila melanogaster, Female, Interferon-gamma, Male, Meninges, Mice, Inbred C57BL, Neural Pathways, Social Behavior, T-Lymphocytes, Zebrafish, Signal Transduction, Prefrontal Cortex, Mice, Rats, GABAergic Neurons, Transcriptome
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