Pardoll, Drew M.

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

Zeng, J., See, A. P., Phallen, J., Jackson, C. M., Belcaid, Z., Ruzevick, J., Durham, N., Meyer, C., Harris, T. J., Albesiano, E., et al. (2013) · International Journal of Radiation Oncology*Biology*Physics

Glioma Diagnosis and TreatmentCancer Immunotherapy and Biomarkers

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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Fu, J., Kanne, D. B., Leong, M., Glickman, L. H., McWhirter, S. M., Lemmens, E., Mechette, K., Leong, J. J., Lauer, P., Liu, W., et al. (2015) · Science Translational Medicine

Immunotherapy and Immune Responsesinterferon and immune responses

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Microbiota organization is a distinct feature of proximal colorectal cancers

Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences

Gut microbiota and healthBacterial biofilms and quorum sensing

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Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

Lee, H., Herrmann, A., Deng, J.-H., Kujawski, M., Niu, G., Li, Z., Forman, S., Jove, R., Pardoll, D. M., & Yu, H. (2009) · Cancer Cell

NF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

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The role of CD4+ T cell responses in antitumor immunity

Pardoll, D. M., & Topalian, S. L. (1998) · Current Opinion in Immunology

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

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The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients

Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E. M., Lazarev, M. G., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., et al. (2015) · Clinical Infectious Diseases

Clostridium difficile and Clostridium perfringens researchGut microbiota and health

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Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Sadtler, K., Estrellas, K., Allen, B. W., Wolf, M. T., Fan, H., Tam, A. J., Patel, C. H., Luber, B. S., Wang, H., Wagner, K. R., et al. (2016) · Science

Wound Healing and TreatmentsTissue Engineering and Regenerative Medicine

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Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC)

Cottrell, T. R., Thompson, E. D., Forde, P. M., Stein, J. E., Duffield, A. S., Anagnostou, V., Rekhtman, N., Anders, R. A., Cuda, J. D., Illei, P. B., et al. (2018) · Annals of Oncology

Cancer Immunotherapy and BiomarkersLung Cancer Diagnosis and Treatment

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Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

Grasso, C. S., Tsoi, J., Onyshchenko, M., Abril-Rodriguez, G., Ross-Macdonald, P., Wind-Rotolo, M., Champhekar, A., Medina, E., Torrejon, D. Y., Shin, D. S., et al. (2020) · Cancer Cell

Cancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management

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Targeting a neoantigen derived from a common TP53 mutation

Hsiue, E. H.-C., Wright, K. M., Douglass, J., Hwang, M. S., Mog, B. J., Pearlman, A. H., Paul, S., DiNapoli, S. R., Konig, M. F., Wang, Q., et al. (2021) · Science

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

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Major histocompatibility complex class II‐restricted presentation of a cytosolic antigen by autophagy

Nimmerjahn, F., Milosevic, S., Behrends, U., Jaffee, E. M., Pardoll, D. M., Bornkamm, G. W., & Mautner, J. (2003) · European Journal of Immunology

Immunotherapy and Immune ResponsesAutophagy in Disease and Therapy

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Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Lu, Z., Zou, J., Li, S., Topper, M. J., Tao, Y., Zhang, H., Jiao, X., Xie, W., Kong, X., Vaz, M., et al. (2020) · Nature

Immune cells in cancerCancer Cells and Metastasis

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Neoadjuvant immune checkpoint blockade: A window of opportunity to advance cancer immunotherapy

Topalian, S. L., Forde, P. M., Emens, L. A., Yarchoan, M., Smith, K. N., & Pardoll, D. M. (2023) · Cancer Cell

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

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TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer

Park, B. V., Freeman, Z. T., Ghasemzadeh, A., Chattergoon, M. A., Rutebemberwa, A., Steigner, J., Winter, M. E., Huynh, T. V., Sebald, S. M., Lee, S.-J., et al. (2016) · Cancer Discovery

TGF-β signaling in diseasesCancer Immunotherapy and Biomarkers

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IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

Faust, H. J., Zhang, H., Han, J., Wolf, M. T., Jeon, O. H., Sadtler, K., Peña, A. N., Chung, L., Maestas, D. R., Tam, A. J., et al. (2020) · Journal of Clinical Investigation

Osteoarthritis Treatment and MechanismsTelomeres, Telomerase, and Senescence

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Perspective: Alpha-Bugs, Their Microbial Partners, and the Link to Colon Cancer

Sears, C. L., & Pardoll, D. M. (2011) · The Journal of Infectious Diseases

Gut microbiota and healthBacterial Cancer Therapy

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Divergent immune responses to synthetic and biological scaffolds

Sadtler, K., Wolf, M. T., Ganguly, S., Moad, C. A., Chung, L., Majumdar, S., Housseau, F., Pardoll, D. M., & Elisseeff, J. H. (2019) · Biomaterials

Wound Healing and TreatmentsTissue Engineering and Regenerative Medicine

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Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotype

Trimble, C. L., Piantadosi, S., Gravitt, P., Ronnett, B., Pizer, E., Elko, A., Wilgus, B., Yutzy, W., Daniel, R., Shah, K., et al. (2005) · Clinical Cancer Research

Cervical Cancer and HPV ResearchHead and Neck Cancer Studies

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Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic

Tomkovich, S., Dejea, C. M., Winglee, K., Drewes, J. L., Chung, L., Housseau, F., Pope, J. L., Gauthier, J., Sun, X., Mühlbauer, M., et al. (2019) · Journal of Clinical Investigation

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Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade

Stein, J. E., Lipson, E. J., Cottrell, T. R., Forde, P. M., Anders, R. A., Cimino-Mathews, A., Thompson, E. D., Allaf, M. E., Yarchoan, M., Feliciano, J., et al. (2020) · Clinical Cancer Research

Cancer Immunotherapy and BiomarkersBreast Cancer Treatment Studies

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Bispecific antibodies targeting mutant RAS neoantigens

Douglass, J., Hsiue, E. H.-C., Mog, B. J., Hwang, M. S., DiNapoli, S. R., Pearlman, A. H., Miller, M. S., Wright, K. M., Azurmendi, P. A., Wang, Q., et al. (2021) · Science Immunology

Monoclonal and Polyclonal Antibodies ResearchCancer Immunotherapy and Biomarkers

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Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis

Housseau, F., Wu, S., Wick, E. C., Fan, H., Wu, X., Llosa, N. J., Smith, K. N., Tam, A., Ganguly, S., Wanyiri, J. W., et al. (2016) · Cancer Research

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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A biologic scaffold–associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy

Wolf, M. T., Ganguly, S., Wang, T. L., Anderson, C. W., Sadtler, K., Narain, R., Cherry, C., Parrillo, A. J., Park, B. V., Wang, G., et al. (2019) · Science Translational Medicine

Cancer Immunotherapy and BiomarkersImmune cells in cancer

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Stat3 Activity in Melanoma Cells Affects Migration of Immune Effector Cells and Nitric Oxide-Mediated Antitumor Effects

Burdelya, L., Kujawski, M., Niu, G., Zhong, B., Wang, T., Zhang, S., Kortylewski, M., Shain, K., Kay, H., Djeu, J., et al. (2005) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsImmune cells in cancer

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