Schier, Alexander F.

Spatial reconstruction of single-cell gene expression data

Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 7,055

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science

MicroRNA in disease regulationRNA Research and Splicing

Cited by 1,647

MicroRNAs Regulate Brain Morphogenesis in Zebrafish

Giraldez, A. J., Cinalli, R. M., Glasner, M. E., Enright, A. J., Thomson, J. M., Baskerville, S., Hammond, S. M., Bartel, D. P., & Schier, A. F. (2005) · Science

MicroRNA in disease regulationDevelopmental Biology and Gene Regulation

Cited by 1,315

Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis

Farrell, J. A., Wang, Y., Riesenfeld, S. J., Shekhar, K., Regev, A., & Schier, A. F. (2018) · Science

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 876

Whole-organism lineage tracing by combinatorial and cumulative genome editing

McKenna, A., Findlay, G. M., Gagnon, J. A., Horwitz, M. S., Schier, A. F., & Shendure, J. (2016) · Science

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 766

Brain-wide neuronal dynamics during motor adaptation in zebrafish

Ahrens, M. B., Li, J. M., Orger, M. B., Robson, D. N., Schier, A. F., Engert, F., & Portugues, R. (2012) · Nature

Motor Control and AdaptationZebrafish Biomedical Research Applications

Cited by 729

Whole-brain activity mapping onto a zebrafish brain atlas

Randlett, O., Wee, C. L., Naumann, E. A., Nnaemeka, O., Schoppik, D., Fitzgerald, J. E., Portugues, R., Lacoste, A. M. B., Riegler, C., Engert, F., et al. (2015) · Nature Methods

Zebrafish Biomedical Research ApplicationsUndergraduate Neuroscience Education and Research

Cited by 528

Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish

Prober, D. A., Rihel, J., Onah, A. A., Sung, R.-J., & Schier, A. F. (2006) · The Journal of Neuroscience

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 508

Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation

Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W. S., Robertson, E. J., et al. (1999) · Molecular Cell

Developmental Biology and Gene RegulationWnt/β-catenin signaling in development and cancer

Cited by 374

Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430

Mishima, Y., Giraldez, A. J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A. F., & Inoue, K. (2006) · Current Biology

MicroRNA in disease regulationDevelopmental Biology and Gene Regulation

Cited by 321

Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion

Dunn, T. W., Mu, Y., Narayan, S., Randlett, O., Naumann, E. A., Yang, C.-T., Schier, A. F., Freeman, J., Engert, F., & Ahrens, M. B. (2016) · eLife

Zebrafish Biomedical Research ApplicationsNeural dynamics and brain function

Cited by 312

High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies

Rabani, M., Raychowdhury, R., Jovanovic, M., Rooney, M., Stumpo, D. J., Pauli, A., Hacohen, N., Schier, A. F., Blackshear, P. J., Friedman, N., et al. (2014) · Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 226

Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia

Huang, P., & Schier, A. F. (2009) · Development

Genetic and Kidney Cyst DiseasesHedgehog Signaling Pathway Studies

Cited by 210

Kctd13 deletion reduces synaptic transmission via increased RhoA

Escamilla, C. O., Filonova, I., Walker, A. K., Xuan, Z. X., Holehonnur, R., Espinosa, F., Liu, S., Thyme, S. B., López-García, I. A., Mendoza, D. B., et al. (2017) · Nature

Genetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities

Cited by 165

Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus

Merkle, F. T., Neuhausser, W. M., Santos, D., Valen, E., Gagnon, J. A., Maas, K., Sandoe, J., Schier, A. F., & Eggan, K. (2015) · Cell Reports

CRISPR and Genetic EngineeringPluripotent Stem Cells Research

Cited by 152

The tangential nucleus controls a gravito-inertial vestibulo-ocular reflex

Bianco, I. H., Ma, L.-H., Schoppik, D., Robson, D. N., Orger, M. B., Beck, J. C., Li, J. M., Schier, A. F., Engert, F., & Baker, R. (2012) · Current Biology

Vestibular and auditory disordersZebrafish Biomedical Research Applications

Cited by 134

Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level

Lin, Q., Manley, J., Helmreich, M., Schlumm, F., Li, J. M., Robson, D. N., Engert, F., Schier, A., Nöbauer, T., & Vaziri, A. (2020) · Cell

Neural dynamics and brain functionNeuroscience and Neuropharmacology Research

Cited by 122

A Zebrafish Genetic Screen Identifies Neuromedin U as a Regulator of Sleep/Wake States

Chiu, C. N., Rihel, J., Lee, D. A., Singh, C., Mosser, E. A., Chen, S., Sapin, V., Pham, U., Engle, J., Niles, B. J., et al. (2016) · Neuron

Sleep and Wakefulness ResearchNeuropeptides and Animal Physiology

Cited by 101

Neuropeptidergic control of sleep and wakefulness

Richter, C., Woods, I. G., & Schier, A. F. (2014) · Annual Review of Neuroscience

Sleep and Wakefulness ResearchCircadian rhythm and melatonin

Cited by 75

Molecular mechanisms controlling the biogenesis of the TGF-β signal Vg1

Dingal, P. C. D. P., Carte, A. N., Montague, T. G., Lim Suan, M. B., & Schier, A. F. (2021) · Proceedings of the National Academy of Sciences

TGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

Cited by 4

Molecular mechanisms controlling the biogenesis of the TGF-β signal Vg1

Dingal, P. C. D. P., Carte, A. N., Montague, T. G., Lim Suan, M. B., & Schier, A. F. (2023) · Proceedings of the National Academy of Sciences

TGF-β signaling in diseasesDevelopmental Biology and Gene Regulation

Cited by 4