Cited by 123Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level

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Lin, Qian, Manley, Jason, Helmreich, Magdalena, Schlumm, Friederike, Li, Jennifer M., Robson, Drew N., Engert, Florian, Schier, Alexander +2 more·2020·Cell

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Abstract

Goal-directed behavior requires the interaction of multiple brain regions. How these regions and their interactions with brain-wide activity drive action selection is less understood. We have investigated this question by combining whole-brain volumetric calcium imaging using light-field microscopy and an operant-conditioning task in larval zebrafish. We find global, recurring dynamics of brain states to exhibit pre-motor bifurcations toward mutually exclusive decision outcomes. These dynamics arise from a distributed network displaying trial-by-trial functional connectivity changes, especially between cerebellum and habenula, which correlate with decision outcome. Within this network the cerebellum shows particularly strong and predictive pre-motor activity (>10 s before movement initiation), mainly within the granule cells. Turn directions are determined by the difference neuroactivity between the ipsilateral and contralateral hemispheres, while the rate of bi-hemispheric population ramping quantitatively predicts decision time on the trial-by-trial level. Our results highlight a cognitive role of the cerebellum and its importance in motor planning.

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Authors
Lin, Q., Manley, J., Helmreich, M., Schlumm, F., Li, J. M., Robson, D. N., Engert, F., Schier, A., Nöbauer, T., & Vaziri, A.
Affiliations
  • Rockefeller University (US)
  • Research Institute of Molecular Pathology (AT)
  • Harvard University (US)
Corresponding author
Vaziri, Alipasha
Venue
Cell
Publisher
Elsevier BV
Published
2020-02
Volume
180
Issue
3
Pages
536-551.e17
ISSN
0092-8674 (ISSN-L)
OpenAlex
W3000696985
Cited by
122
References
140
Citations by year
2026: 11 · 2025: 16 · 2024: 16 · 2023: 16 · 2022: 31 · 2021: 22 · 2020: 9 · 2018: 1
FWCI
10.54
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • edoc (University of Basel) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • Gordon and Betty Moore Foundation (2919.01)
  • Intelligence Advanced Research Projects Activity (D16PC00002)
  • National Institutes of Health (1RF1NS110501, DP1HD094764, R24NS086601, 1RF1 NS113251, R25GM067110, R01NS049319, 5U01NS103488, U19NS104653, 2R44OD024879)
  • Simons Foundation (SCGB 542973)
  • National Science Foundation (DBI-1707408, PHY-1748958)
  • Leon Levy Foundation
  • Kavli Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
cerebellum, decision timing, decision outcomes, zebrafish larvae, calcium imaging, light field microscopy, cerebellar granule cells, habenula, bifurcation dynamics, functional connectivity, hemispheric lateralization, motor planning, action selection, operant conditioning
MeSH terms
Animals, Behavior, Animal, Brain Mapping, Cerebellum, Cognition, Conditioning, Operant, Decision Making, Goals, Hot Temperature, Larva, Motor Activity, Movement, Neurons, Psychomotor Performance, Reaction Time, Rhombencephalon, Zebrafish, Habenula, Cerebrum

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