Doudna, Jennifer A.

Tunable protein synthesis by transcript isoforms in human cells

Floor, S. N., & Doudna, J. A. (2016) · eLife

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 265

Nucleosome breathing and remodeling constrain CRISPR-Cas9 function

Isaac, R. S., Jiang, F., Doudna, J. A., Lim, W. A., Narlikar, G. J., & Almeida, R. (2016) · eLife

CRISPR and Genetic EngineeringGenomics and Chromatin Dynamics

Cited by 234

A Thermostable Cas9 with Increased Lifetime in Human Plasma

Harrington, L. B., Paez-Espino, D., Staahl, B. T., Chen, J. S., Ma, E., Kyrpides, N. C., & Doudna, J. A. (2017) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 205

Ribozyme Structures and Mechanisms

Doherty, E. A., & Doudna, J. A. (2001) · Annual Review of Biophysics and Biomolecular Structure

RNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Cited by 195

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

Hultquist, J. F., Schumann, K., Woo, J. M., Manganaro, L., McGregor, M. J., Doudna, J., Simon, V., Krogan, N. J., & Marson, A. (2016) · Cell Reports

CRISPR and Genetic EngineeringHIV Research and Treatment

Cited by 170

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing

Rouet, R., Thuma, B. A., Roy, M. D., Lintner, N. G., Rubitski, D. M., Finley, J. E., Wisniewska, H. M., Mendonsa, R., Hirsh, A., de Oñate, L., et al. (2018) · Journal of the American Chemical Society

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 163

TRBP alters human precursor microRNA processing in vitro

Lee, H. Y., & Doudna, J. A. (2012) · RNA

MicroRNA in disease regulationRNA Interference and Gene Delivery

Cited by 161

Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain

Palermo, G., Chen, J. S., Ricci, C. G., Rivalta, I., Jinek, M., Batista, V. S., Doudna, J. A., & McCammon, J. A. (2018) · Quarterly Reviews of Biophysics

CRISPR and Genetic EngineeringProtein Structure and Dynamics

Cited by 123

A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis

Doudna, J. A., Couture, S., & Szostak, J. W. (1991) · Science

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 117

Improved genome editing by an engineered CRISPR-Cas12a

Ma, E., Chen, K., Shi, H., Stahl, E. C., Adler, B., Trinidad, M., Liu, J., Zhou, K., Ye, J., & Doudna, J. A. (2022) · Nucleic Acids Research

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 110

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery

Gaj, T., Staahl, B. T., Rodrigues, G. M. C., Limsirichai, P., Ekman, F. K., Doudna, J. A., & Schaffer, D. V. (2017) · Nucleic Acids Research

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 89

RNA-guided assembly of Rev-RRE nuclear export complexes

Bai, Y., Tambe, A., Zhou, K., & Doudna, J. A. (2014) · eLife

HIV Research and TreatmentRNA and protein synthesis mechanisms

Cited by 86

Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA

Doudna, J. A., Usman, N., & Szostak, J. W. (1993) · Biochemistry

RNA and protein synthesis mechanismsOrigins and Evolution of Life

Cited by 51

Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies

Carlson, L.-A., Bai, Y., Keane, S. C., Doudna, J. A., & Hurley, J. H. (2016) · eLife

HIV Research and TreatmentT-cell and Retrovirus Studies

Cited by 48

Genome expansion by a CRISPR trimmer-integrase

Wang, J. Y., Tuck, O. T., Skopintsev, P., Soczek, K. M., Li, G., Al-Shayeb, B., Zhou, J., & Doudna, J. A. (2023) · Nature

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 33

RNA language models predict mutations that improve RNA function

Shulgina, Y., Trinidad, M. I., Langeberg, C. J., Nisonoff, H., Chithrananda, S., Skopintsev, P., Nissley, A. J., Patel, J., Boger, R. S., Shi, H., et al. (2024) · Nature Communications

RNA and protein synthesis mechanismsGenomics and Phylogenetic Studies

Cited by 32

CRISPRi-ART enables functional genomics of diverse bacteriophages using RNA-binding dCas13d

Adler, B. A., Al-Shimary, M. J., Patel, J. R., Armbruster, E. G., Colognori, D., Charles, E. J., Miller, K. V., Lahiri, A., Cui, M. L., Oromí-Bosch, A., et al. (2025) · Nature Microbiology

Bacteriophages and microbial interactionsCRISPR and Genetic Engineering

Cited by 30

A phage nucleus-associated RNA-binding protein is required for jumbo phage infection

Enustun, E., Armbruster, E. G., Lee, J., Zhang, S., Yee, B. A., Malukhina, K., Gu, Y., Deep, A., Naritomi, J. T., Liang, Q., et al. (2024) · Nucleic Acids Research

Bacteriophages and microbial interactionsBacterial Genetics and Biotechnology

Cited by 27

An essential and highly selective protein import pathway encoded by nucleus-forming phage

Morgan, C. J., Enustun, E., Armbruster, E. G., Birkholz, E. A., Prichard, A., Forman, T., Aindow, A., Wannasrichan, W., Peters, S., Inlow, K., et al. (2024) · Proceedings of the National Academy of Sciences

Bacteriophages and microbial interactionsBacterial Genetics and Biotechnology

Cited by 25

An essential and highly selective protein import pathway encoded by nucleus-forming phage

Morgan, C. J., Enustun, E., Armbruster, E. G., Birkholz, E. A., Prichard, A., Forman, T., Aindow, A., Wannasrichan, W., Peters, S., Inlow, K., et al. (2024) · Proceedings of the National Academy of Sciences

Bacteriophages and microbial interactionsBacterial Genetics and Biotechnology

Cited by 25

Author response: Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

Lin, S., Staahl, B. T., Alla, R. K., & Doudna, J. A. (2014) · eLife

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 15

The Dicer-TRBP Interface Structure and Implications for Strand Selection During Microrna Biogenesis

Wilson, R. C., & Doudna, J. A. (2014) · Biophysical Journal

RNA Interference and Gene DeliveryMicroRNA in disease regulation

Cited by 1