Tetrahydrobiopterin Radical Enzymology

Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp

Dougherty, D. A. (1996) · Science · doi:10.1126/science.271.5246.163 · Cited by 2,679 · see citing works

Heme-Containing Oxygenases

Sono, M., Roach, M. P., Coulter, E. D., & Dawson, J. H. (1996) · Chemical Reviews · doi:10.1021/cr9500500 · Cited by 2,445 · see citing works

Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase

Amano, M., Chihara, K., Kimura, K., Fukata, Y., Nakamura, N., Matsuura, Y., & Kaibuchi, K. (1997) · Science · doi:10.1126/science.275.5304.1308 · Cited by 1,077 · see citing works

Tetrahydrobiopterin biosynthesis, regeneration and functions

Thöny, B., Auerbach, G., & Blau, N. (2000) · Biochemical Journal · doi:10.1042/bj3470001 · Cited by 867 · see citing works

THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

Carreras, C. W., & Santi, D. V. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003445 · Cited by 789 · see citing works

Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion

Enroth, C., Eger, B. T., Okamoto, K., Nishino, T., Nishino, T., & Pai, E. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.10723 · Cited by 733 · see citing works

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

Tayeh, M. A., & Marletta, M. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47163-9 · Cited by 687 · see citing works

Structure of Nitric Oxide Synthase Oxygenase Dimer with Pterin and Substrate

Crane, B. R., Arvai, A. S., Ghosh, D. K., Wu, C., Getzoff, E. D., Stuehr, D. J., & Tainer, J. A. (1998) · Science · doi:10.1126/science.279.5359.2121 · Cited by 668 · see citing works

Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase

Raman, C. S., Li, H., Pavel Martasek, E., Král, V., Masters, B. S. S., & Poulos, T. L. (1998) · Cell · doi:10.1016/s0092-8674(00)81718-3 · Cited by 621 · see citing works

Cation-pi interactions in aromatics of biological and medicinal interest: electrostatic potential surfaces as a useful qualitative guide.

Mecozzi, S., West, A. P., & Dougherty, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10566 · Cited by 603 · see citing works

Crystal Structure of Formate Dehydrogenase H: Catalysis Involving Mo, Molybdopterin, Selenocysteine, and an Fe 4 S 4 Cluster

Boyington, J. C., Gladyshev, V. N., Khangulov, S. V., Stadtman, T. C., & Sun, P. D. (1997) · Science · doi:10.1126/science.275.5304.1305 · Cited by 596 · see citing works

MOLYBDENUM-COFACTOR–CONTAINING ENZYMES: Structure and Mechanism

Kisker, C., Schindelin, H., & Rees, D. C. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.233 · Cited by 515 · see citing works

Tetrahydropterin-Dependent Amino Acid Hydroxylases

Fitzpatrick, P. F. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.355 · Cited by 514 · see citing works

Molecular Basis of Proton Motive Force Generation: Structure of Formate Dehydrogenase-N

Jormakka, M., Törnroth‐Horsefield, S., Byrne, B., & Iwata, S. (2002) · Science · doi:10.1126/science.1068186 · Cited by 502 · see citing works

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

Milstien, S., & Katušić, Z. S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1422 · Cited by 488 · see citing works

Crystal Structure of the Xanthine Oxidase-Related Aldehyde Oxido-Reductase from D. gigas

Romão, M. J., Archer, M., Moura, I., Moura, J. J. G., LeGall, J., Engh, R. A., Schneider, M., Hof, P., & Huber, R. (1995) · Science · doi:10.1126/science.270.5239.1170 · Cited by 480 · see citing works

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.

Fischmann, T. O., Hruza, A. W., Niu, X. D., Fossetta, J. D., Lunn, C. A., Dolphin, E., Prongay, A., Reichert, P., Lundell, D. J., Narula, S. K., et al. (1999) · Nature Structural Biology · doi:10.1038/6675 · Cited by 463 · see citing works

Crystal Structure of DMSO Reductase: Redox-Linked Changes in Molybdopterin Coordination

Schindelin, H., Kisker, C., Hilton, J. C., Rajagopalan, K. V., & Rees, D. C. (1996) · Science · doi:10.1126/science.272.5268.1615 · Cited by 451 · see citing works

Oxygen Reduction by Nitric-oxide Synthases

Stuehr, D. J., Pou, S., & Rosen, G. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100011200 · Cited by 400 · see citing works

Neuronal Nitric-oxide Synthase-μ, an Alternatively Spliced Isoform Expressed in Differentiated Skeletal Muscle

Silvagno, F., Xia, H., & Bredt, D. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.19.11204 · Cited by 354 · see citing works

The Structure of Nitric Oxide Synthase Oxygenase Domain and Inhibitor Complexes

Crane, B. R., Arvai, A. S., Gachhui, R., Wu, C., Ghosh, D. K., Getzoff, E. D., Stuehr, D. J., & Tainer, J. A. (1997) · Science · doi:10.1126/science.278.5337.425 · Cited by 348 · see citing works

Biochemistry of Mitochondrial Nitric-oxide Synthase

Elfering, S. L., Sarkela, T. M., & Giulivi, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205256200 · Cited by 346 · see citing works

Evidence for Nuclear Emissions During Acoustic Cavitation

Taleyarkhan, R. P., West, C. D., Cho, J. S., et al. (2002) · Science · doi:10.1126/science.1067589 · Cited by 326 · see citing works

Pterin-Dependent Amino Acid Hydroxylases

Kappock, T. J., & Caradonna, J. P. (1996) · Chemical Reviews · doi:10.1021/cr9402034 · Cited by 325 · see citing works

Contribution of mitochondria to oxidative stress associated with alcoholic liver disease1 1This article is part of a series of reviews on “Alcohol, Oxidative Stress and Cell Injury”. The full list of papers may be found on the homepage of the journal.

Bailey, S. M., & CUNNINGHAM, C. C. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00769-9 · Cited by 301 · see citing works

Advances in Protein Chemistry.

Moore, S. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01552a084 · Cited by 287 · see citing works

Crystal structure and mechanism of CO dehydrogenase, a molybdo iron-sulfur flavoprotein containing S -selanylcysteine

Dobbek, H., Gremer, L., Meyer, O. O., & Huber, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.8884 · Cited by 255 · see citing works

Crystal Structure of Dimethyl Sulfoxide Reductase fromRhodobacter capsulatusat 1.88 Å Resolution

Schneider, F., Löwe, J., Huber, R., Schindelin, H., Kisker, C., & Knäblein, J. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0555 · Cited by 251 · see citing works

Cross polarization and magic angle sample spinning NMR spectra of model organic compounds. 3. Effect of the carbon-13-proton dipolar interaction on cross polarization and carbon-proton dephasing

Alemany, L. B., Grant, D. M., Alger, T. D., et al. (1983) · Journal of the American Chemical Society · doi:10.1021/ja00360a025 · Cited by 245 · see citing works

Nitric oxide synthase: models and mechanisms

Groves, J. T. (2000) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(00)00146-0 · Cited by 213 · see citing works

Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen

Hurshman, A. R., Krebs, C., Edmondson, D. E., Huynh, B. H., & Marletta, M. A. (1999) · Biochemistry · doi:10.1021/bi992026c · Cited by 208 · see citing works

Theory and Practice of Electron Transfer within Protein−Protein Complexes: Application to the Multidomain Binding of Cytochromecby CytochromecPeroxidase

Nocek, J. M., Zhou, J. S., Forest, S. D., Priyadarshy, S., Beratan, D. N., Onuchic, J. N., & Hoffman, B. M. (1996) · Chemical Reviews · doi:10.1021/cr9500444 · Cited by 198 · see citing works

Intrinsic and Extrinsic Modulation of Nitric Oxide Synthase Activity

Roman, L. J., Pavel Martasek, E., & Masters, B. S. S. (2002) · Chemical Reviews · doi:10.1021/cr000661e · Cited by 195 · see citing works

Tetrahydrobiopterin Biosynthesis, Utilization and Pharmacological Effects

Werner‐Felmayer, G., Golderer, G., & Werner, E. R. (2002) · Current Drug Metabolism · doi:10.2174/1389200024605073 · Cited by 187 · see citing works

Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase

Rusche, K. M., Spiering, M. M., & Marletta, M. A. (1998) · Biochemistry · doi:10.1021/bi9813936 · Cited by 179 · see citing works

Tetrahydrobiopterin-dependent Inhibition of Superoxide Generation from Neuronal Nitric Oxide Synthase

Vasquez-Vivar, J. M., Hogg, N., Pavel Martasek, E., Karoui, H., Pritchard, K. A., & Kalyanaraman, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.26736 · Cited by 174 · see citing works

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

Hevel, J. M., & Marletta, M. A. (1992) · Biochemistry · doi:10.1021/bi00146a019 · Cited by 173 · see citing works

Structural Insight into the Aromatic Amino Acid Hydroxylases and Their Disease-Related Mutant Forms

Flatmark, T., & Stevens, R. C. (1999) · Chemical Reviews · doi:10.1021/cr980450y · Cited by 172 · see citing works

Regulation of Neuronal Nitric Oxide Synthase through Alternative Transcripts

Brenman, J. E., Xia, H., Chao, D. S., et al. (1997) · Developmental Neuroscience · doi:10.1159/000111211 · Cited by 162 · see citing works

Renin-dependent Cardiovascular Functions and Renin-independent Blood-Brain Barrier Functions Revealed by Renin-deficient Mice

Yanai, K., Saito, T., Kakinuma, Y., Kon, Y., Hirota, K., Taniguchi-Yanai, K., Nishijo, N., Shigematsu, Y., Horiguchi, H., Kasuya, Y., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.5 · Cited by 152 · see citing works

Structure of Tetrameric Human Phenylalanine Hydroxylase and Its Implications for Phenylketonuria

Fusetti, F., Erlandsen, H., Flatmark, T., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16962 · Cited by 148 · see citing works

Comparative Functioning of Dihydro- and Tetrahydropterins in Supporting Electron Transfer, Catalysis, and Subunit Dimerization in Inducible Nitric Oxide Synthase

Presta, A., Siddhanta, U., Wu, C., Sennequier, N., Huang, L., Abu‐Soud, H. M., ERZURUM, S. C., & Stuehr, D. J. (1998) · Biochemistry · doi:10.1021/bi971944c · Cited by 145 · see citing works

Molybdenum active centre of DMSO reductase from Rhodobacter capsulatus: crystal structure of the oxidised enzyme at 1.82-Å resolution and the dithionite-reduced enzyme at 2.8-Å resolution

McAlpine, A. S., McEwan, A. G., Shaw, A. L., & Bailey, S. (1997) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s007750050185 · Cited by 145 · see citing works

Pharmacophore Mapping of a Series of 2,4-Diamino-5-deazapteridine Inhibitors of Mycobacterium avium Complex Dihydrofolate Reductase

Debnath, A. K. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm010360c · Cited by 145 · see citing works

Fluorescence of pterin, 6-formylpterin, 6-carboxypterin and folic acid in aqueous solution: pH effects

Thomas, A. H., Lorente, C., Capparelli, A. L., et al. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b202114e · Cited by 144 · see citing works

The Structural Basis of Phenylketonuria

Erlandsen, H., & Stevens, R. C. (1999) · Molecular Genetics and Metabolism · doi:10.1006/mgme.1999.2922 · Cited by 142 · see citing works

Structure of a Nitric Oxide Synthase Heme Protein from Bacillus subtilis,

Pant, K., Bilwes, A. M., Adak, S., Stuehr, D. J., & Crane, B. R. (2002) · Biochemistry · doi:10.1021/bi0263715 · Cited by 134 · see citing works

Rapid Purification and Partial Characterization of Human Platelet Glycoprotein IIIb

McGregor, J. L., Catimel, B., Parmentier, S., et al. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31286-3 · Cited by 133 · see citing works

Coordination compounds of pteridine, alloxazine and flavin ligands: structures and properties

Kaim, W., Schwederski, B. E., Heilmann, O., & Hornung, F. M. (1999) · Coordination Chemistry Reviews · doi:10.1016/s0010-8545(98)00193-3 · Cited by 133 · see citing works

Crystal Structure of Tyrosine Hydroxylase with Bound Cofactor Analogue and Iron at 2.3 Å Resolution: Self-Hydroxylation of Phe300 and the Pterin-Binding Site,

Goodwill, K. E., Sabatier, C., & Stevens, R. C. (1998) · Biochemistry · doi:10.1021/bi981462g · Cited by 130 · see citing works

Chemistry and Biology of Pteridines and Folates

(2002) · Springer eBooks · doi:10.1007/978-1-4615-0945-5 · Cited by 129 · see citing works

Tetrahydrobiopterin-Free Neuronal Nitric Oxide Synthase: Evidence for Two Identical Highly Anticooperative Pteridine Binding Sites

Gorren, A. C. F., List, B. M., Schrammel, A., Pitters, E., Hemmens, B., Werner, E. R., Schmidt, K., & Mayer, B. (1996) · Biochemistry · doi:10.1021/bi961931j · Cited by 128 · see citing works

Spectral Characterization and Effect on Catalytic Activity of Nitric Oxide Complexes of Inducible Nitric Oxide Synthase

Hurshman, A. R., & Marletta, M. A. (1995) · Biochemistry · doi:10.1021/bi00016a038 · Cited by 120 · see citing works

Structural Diversity of Neuronal Nitric Oxide Synthase mRNA in the Nervous System

Ogura, T., Yokoyama, T., Fujisawa, H., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1726 · Cited by 115 · see citing works

Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical

Vásquez-Vivar, J., Whitsett, J., Martásek, P., Hogg, N., & Kalyanaraman, B. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00680-3 · Cited by 112 · see citing works

EPR and ENDOR Characterization of Intermediates in the Cryoreduced Oxy-Nitric Oxide Synthase Heme Domain with Bound l -Arginine or NG-Hydroxyarginine

Davydov, R. M., Ledbetter, A. P., Pavel Martasek, E., Larukhin, M., Sono, M., Dawson, J. H., Masters, B. S. S., & Hoffman, B. M. (2002) · Biochemistry · doi:10.1021/bi0260637 · Cited by 110 · see citing works

N‐terminal domain swapping and metal ion binding in nitric oxide synthase dimerization

Crane, B. R., Rosenfeld, R. J., Arvai, A. S., Ghosh, D. K., Ghosh, S., Tainer, J. A., Stuehr, D. J., & Getzoff, E. D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6271 · Cited by 110 · see citing works

High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin

Andersen, O. A., Flatmark, T., & Hough, E. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5061 · Cited by 108 · see citing works

Comparative Effects of Substrates and Pterin Cofactor on the Heme Midpoint Potential in Inducible and Neuronal Nitric Oxide Synthases

Presta, A., Weber‐Main, A. M., Stankovich, M. T., & Stuehr, D. J. (1998) · Journal of the American Chemical Society · doi:10.1021/ja9740374 · Cited by 104 · see citing works

Crystal Structure and Site-Specific Mutagenesis of Pterin-Bound Human Phenylalanine Hydroxylase ,

Erlandsen, H., Bjørgo, E., Flatmark, T., et al. (2000) · Biochemistry · doi:10.1021/bi992531+ · Cited by 101 · see citing works

Tetrahydrobiopterin in Nitric Oxide Synthesis: A Novel Biological Role for Pteridines

Gorren, A. C. F., & Mayer, B. (2002) · Current Drug Metabolism · doi:10.2174/1389200024605154 · Cited by 99 · see citing works

Tetrahydrobiopterin Binding to Macrophage Inducible Nitric Oxide Synthase: Heme Spin Shift and Dimer Stabilization by the Potent Pterin Antagonist 4-Amino-Tetrahydrobiopterin

Mayer, B., Wu, C., Gorren, A. C. F., et al. (1997) · Biochemistry · doi:10.1021/bi970144z · Cited by 97 · see citing works

Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate

Patel, K. B., Stratford, M. R. L., Wardman, P., & Everett, S. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00777-8 · Cited by 95 · see citing works

Heme Iron Reduction and Catalysis by a Nitric Oxide Synthase Heterodimer Containing One Reductase and Two Oxygenase Domains

Siddhanta, U., Wu, C., Abu‐Soud, H. M., Zhang, J., Ghosh, D. K., & Stuehr, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.13.7309 · Cited by 95 · see citing works

The auto‐oxidation of tetrahydrobiopterin

DAVIS, M. D., Kaufman, S., & Milstien, S. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14004.x · Cited by 94 · see citing works

Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy

Schmidt, P. P., Lange, R., Gorren, A. C. F., Werner, E. R., Mayer, B., & Andersson, K. K. (2001) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s007750000185 · Cited by 94 · see citing works

Intra-subunit and Inter-subunit Electron Transfer in Neuronal Nitric-oxide Synthase

Sagami, I., Daff, S. N., & Shimizu, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104123200 · Cited by 86 · see citing works

Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synthase

WERNER, E. R., PITTERS, E., SCHMIDT, K., WACHTER, H., WERNER-FELMAYER, G., & MAYER, B. (1996) · Biochemical Journal · doi:10.1042/bj3200193 · Cited by 86 · see citing works

Absolute configuration of biological tetrahydrofolates. A crystallographic determination

Fontecilla-Camps, J. C., Bugg, C. E., Temple, C., et al. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00514a041 · Cited by 77 · see citing works

Structural Comparison of Bacterial and Human Iron-dependent Phenylalanine Hydroxylases: Similar Fold, Different Stability and Reaction Rates

Erlandsen, H., Kim, J. Y., Patch, M. G., et al. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00496-5 · Cited by 76 · see citing works

The role of the [2Fe–2S] cluster centers in xanthine oxidoreductase

Nishino, T., & Okamoto, K. (2000) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)00165-3 · Cited by 72 · see citing works

Reactions Catalyzed by the Heme Domain of Inducible Nitric Oxide Synthase: Evidence for the Involvement of Tetrahydrobiopterin in Electron Transfer

Hurshman, A. R., & Marletta, M. A. (2002) · Biochemistry · doi:10.1021/bi012002h · Cited by 71 · see citing works

Expression and Characterization of the Catalytic Core of Tryptophan Hydroxylase

Moran, G. R., Daubner, S. C., & Fitzpatrick, P. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12259 · Cited by 71 · see citing works

Electrochemistry of Pterin Cofactors and Inhibitors of Nitric Oxide Synthase

Gorren, A. C. F., Kungl, A. J., Schmidt, K., Werner, E. R., & Mayer, B. (2001) · Nitric Oxide · doi:10.1006/niox.2001.0332 · Cited by 66 · see citing works

Chronic insulin effects on insulin signalling and GLUT4 endocytosis are reversed by metformin

Pryor, P. R., Liu, S. C. H., CLARK, A. E., et al. (2000) · Biochemical Journal · doi:10.1042/bj3480083 · Cited by 66 · see citing works

Low-Temperature Optical Absorption Spectra Suggest a Redox Role for Tetrahydrobiopterin in Both Steps of Nitric Oxide Synthase Catalysis

Gorren, A. C. F., Bec, N., Schrammel, A., Werner, E. R., Lange, R., & Mayer, B. (2000) · Biochemistry · doi:10.1021/bi0007775 · Cited by 65 · see citing works

Substitution of His59 Converts CD39 Apyrase into an ADPase in a Quaternary Structure Dependent Manner

Grinthal, A., & Guidotti, G. (1999) · Biochemistry · doi:10.1021/bi991751k · Cited by 64 · see citing works

Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity

Tóth, M. (2002) · Molecular Human Reproduction · doi:10.1093/molehr/8.3.271 · Cited by 59 · see citing works

Electron Spin Resonance of Pteridine Radicals and the Structure of Hydropteridines

Ehrenberg, A., Hemmerich, P. H., Müller, F., et al. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb01121.x · Cited by 58 · see citing works

ADP-Binding Site of Escherichia coli Succinyl-CoA Synthetase Revealed by X-ray Crystallography,

Joyce, M., Fraser, M. E., James, M. N. G., et al. (1999) · Biochemistry · doi:10.1021/bi991696f · Cited by 58 · see citing works

The Ferrous Dioxygen Complex of the Oxygenase Domain of Neuronal Nitric-oxide Synthase

Couture, M., Stuehr, D. J., & Rousseau, D. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3201 · Cited by 57 · see citing works

Peroxidase catalysed aerobic degradation of 5,6,7,8‐tetrahydrobiopterin at physiological pH

Armarego, W. L. F., Randles, D., & Taguchi, H. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07666.x · Cited by 52 · see citing works

Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein 1 1Edited by R. Huber

Musah, R. A., Jensen, G. M., Bunte, S. W., et al. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5287 · Cited by 52 · see citing works

Specificity of Mouse GM2 Activator Protein and β-N-Acetylhexosaminidases A and B

Yuziuk, J. A., Bertoni, C., Beccari, T., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.66 · Cited by 51 · see citing works

Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved

Curtius, H., Heintel, D., Ghisla, S., Küster, T., Leimbacher, W., & Niederwieser, A. (1985) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1985.tb08855.x · Cited by 50 · see citing works

Allosteric modulation of rat brain nitric oxide synthase by the pterin-site enzyme inhibitor 4-aminotetrahydrobiopterin

Pfeiffer, S., Gorren, A. C. F., Pitters, E., Schmidt, K., Werner, E. R., & Mayer, B. (1997) · Biochemical Journal · doi:10.1042/bj3280349 · Cited by 49 · see citing works

Structures of reaction intermediates of bovine cytochrome c oxidase probed by time-resolved vibrational spectroscopy

Kitagawa, T. (2000) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)00155-0 · Cited by 46 · see citing works

Dependence of an alkyl glycol-ether monooxygenase activity upon tetrahydropterins

Kaufman, S., Pollock, R. J., Summer, G. K., Das, A. K., & Hajra, A. K. (1990) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(90)90141-2 · Cited by 45 · see citing works

Mechanism of oxidation of tetrahydropterins

Archer, M. C., Vonderschmitt, D. J., & Scrimgeour, K. G. (1972) · Canadian Journal of Biochemistry · doi:10.1139/o72-160 · Cited by 45 · see citing works

Pentacarbonyl(7-.eta.1-cycloheptatrienyl)rhenium. Synthesis and fluxional behavior of a monohaptocycloheptatrienyl derivative of a transition metal

Heinekey, D. M., & GRAHAM, W. A. G. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00514a042 · Cited by 45 · see citing works

Studies on 6-methyl-5-deazatetrahydropterin and its 4a adducts

Moad, G., Luthy, C. L., Benkovic, P. A., et al. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00514a033 · Cited by 43 · see citing works

Activation of Neuronal Nitric-oxide Synthase by the 5-Methyl Analog of Tetrahydrobiopterin

Riethmüller, C., Gorren, A. C. F., Pitters, E., Hemmens, B., Habisch, H., Heales, S., Schmidt, K., Werner, E. R., & Mayer, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16047 · Cited by 42 · see citing works

Characterization of the Interaction between Manganese and Tyrosine Z in Acetate-Inhibited Photosystem II

Szalai, V. A., Kühne, H., Lakshmi, K. V., et al. (1998) · Biochemistry · doi:10.1021/bi9813025 · Cited by 42 · see citing works

Tryptophan 80 and Leucine 143 Are Critical for the Hydride Transfer Step of Thymidylate Synthase by Controlling Active Site Access,

Fritz, T. A., Liu, L., Finer-Moore, J. S., et al. (2002) · Biochemistry · doi:10.1021/bi012108c · Cited by 41 · see citing works

Why do nitric oxide synthases use tetrahydrobiopterin?

Wei, C., Wang, Z., Meade, A. L., McDonald, J. F., & Stuehr, D. J. (2002) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(02)00432-4 · Cited by 40 · see citing works

The Role of Thiols in the Apparent Activation of Rat Brain Nitric Oxide Synthase (NOS)1

Komori, Y., Hyun, J., Chiang, K. T., & Fukuto, J. M. (1995) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a124797 · Cited by 35 · see citing works

Structures of Tetrahydrobiopterin Binding-Site Mutants of Inducible Nitric Oxide Synthase Oxygenase Dimer and Implicated Roles of Trp457,

Aoyagi, M., Arvai, A. S., Ghosh, S., et al. (2001) · Biochemistry · doi:10.1021/bi011183k · Cited by 35 · see citing works

Low-temperature crystal structures of Tetrakis-μ-3,5-diisopropylsalicylatobis-dimethylformamidodicopper(II) and Tetrakis-μ-3,5-diisopropylsalicylatobis-diethyletheratodicopper(II) and their role in modulating polymorphonuclear leukocyte activity in overcoming seizures

Morgant, G., Dung, N.-H., Daran, J., et al. (2000) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)00107-0 · Cited by 33 · see citing works

Characterization of Human Liver Inducible Nitric Oxide Synthase Expressed inEscherichia coli

Gerber, N. C., Nishida, C. R., & de Montellano, P. R. O. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0187 · Cited by 32 · see citing works

Kinetic Studies on the Successive Reaction of Neuronal Nitric Oxide Synthase from l -Arginine to Nitric Oxide and l -Citrulline

Iwanaga, T., Yamazaki, T., & Kominami, S. (1999) · Biochemistry · doi:10.1021/bi991277i · Cited by 30 · see citing works

Molybdopterin Radical in Bacterial Aldehyde Dehydrogenases

Luykx, D. M. A. M., Duine, J. A., & de Vries, S. (1998) · Biochemistry · doi:10.1021/bi972972y · Cited by 28 · see citing works

Structural Basis for Pterin Antagonism in Nitric-oxide Synthase

Kotsonis, P., Fröhlich, L. G., Raman, C. S., Li, H., Berg, M., Gerwig, R., Groehn, V., Kang, Y., Al-Masoudi, N. A., Taghavi‐Moghadam, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011469200 · Cited by 28 · see citing works

Synthesis of sesquiterpene antitumor lactones. 5. Total synthesis of vernolepin. 2. Stereocontrolled synthesis of (.+-.)-vernolepin

Iio, H., Isobe, M., KAWAI, T., et al. (1979) · Journal of the American Chemical Society · doi:10.1021/ja00514a034 · Cited by 28 · see citing works

Formation of Nitric Oxide Synthase−Iron(II) Nitrosoalkane Complexes: Severe Restriction of Access to the Iron(II) Site in the Presence of Tetrahydrobiopterin

Renodon‐Cornière, A., Boucher, J., Wu, C., Gachhui, R., Sari, M., Mansuy, D., & Stuehr, D. J. (1998) · Biochemistry · doi:10.1021/bi972297s · Cited by 26 · see citing works

The Effect of Substrate, Dihydrobiopterin, and Dopamine on the EPR Spectroscopic Properties and the Midpoint Potential of the Catalytic Iron in Recombinant Human Phenylalanine Hydroxylase

Hagedoorn, P., Schmidt, P. P., Andersson, K. K., Hagen, W. R., Flatmark, T., & Martı́nez, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009458200 · Cited by 25 · see citing works

The amino-acid minimum for maintenance and growth, as exemplified by further experiments with lysine and tryptophane (Osborne, T. B., and Mendel, L. B. (1916) J. Biol. Chem. 25, 1-12) and The role of vitamines in the diet (Osborne, T. B., and Mendel, L. B. (1917) J. Biol. Chem. 31, 149-163).

Simoni, R., Hill, R. L., & Vaughan, M. M. (2002) · PubMed · Cited by 23 · see citing works

Combinations Against Combinations: Associations of Anti-HIV 1 Reverse Transcriptase Drugs Challenged by Constellations of Drug Resistance Mutations

Maga, G., & Spadari, S. (2002) · Current Drug Metabolism · doi:10.2174/1389200023337982 · Cited by 21 · see citing works

Binding of l -Arginine and Imidazole Suggests Heterogeneity of Rat Brain Neuronal Nitric Oxide Synthase

Gorren, A. C. F., Schmidt, K., & Mayer, B. (2002) · Biochemistry · doi:10.1021/bi025675o · Cited by 21 · see citing works

Advances in Enzymology and Related Areas of Molecular Biology

(1999) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470123195 · Cited by 21 · see citing works

A Model for Hydride Transfer in Thymidylate Synthase Based on Unnatural Amino Acid Mutagenesis

Barrett, J. E., Lucero, C., & Schultz, P. G. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991040+ · Cited by 19 · see citing works

Purification and characterization of three constitutive cytochrome P-450 isoforms from bovine olfactory epithelium

Longo, V. G., Amato, G., Santucci, A., et al. (1997) · Biochemical Journal · doi:10.1042/bj3230065 · Cited by 16 · see citing works

Zum Mechanismus der Autoxydation von Vanadium (IV)‐Komplexen

Kaden, T. (1966) · Helvetica Chimica Acta · doi:10.1002/hlca.19660490628 · Cited by 13 · see citing works

Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase

Werner, E. R., Habisch, H., Gorren, A. C. F., Schmidt, K., Canevari, L., Werner‐Felmayer, G., & Mayer, B. (2000) · Biochemical Journal · doi:10.1042/bj3480579 · Cited by 13 · see citing works

Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin

Gorren, A. C. F., Schrammel, A., RIETHMÜLLER, C., et al. (2000) · Biochemical Journal · doi:10.1042/bj3470475 · Cited by 12 · see citing works

Oxidation of tetrahydropterins by azide radical and the spectra of trihydropterin radicals

Armstrong, D. A., Farahani, M., & Surdhar, P. S. (1990) · Canadian Journal of Chemistry · doi:10.1139/v90-303 · Cited by 11 · see citing works

Proton magnetic resonance spectra of some 6‐ and 7‐substituted 2‐amino‐4‐hydroxypteridines

Storm, C. B., & Chung, H. S. (1976) · Organic Magnetic Resonance · doi:10.1002/mrc.1270080708 · Cited by 10 · see citing works

The conformational flexibility of 5,6,7,8‐tetrahydrobiopterin and 5,6,7,8‐tetrahydroneopterin: a molecular dynamical simulation

Estelberger, W., Mlekusch, W., & Reibnegger, G. J. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01302-h · Cited by 8 · see citing works

Conformational investigation of the cofactor (6R,1′R,2′S-)-5,6,7,8-tetrahydrobiopterin

Estelberger, W., Fuchs, D., Murr, C., et al. (1995) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(95)00064-2 · Cited by 8 · see citing works

The conformation of 5, 6, 7, 8-tetrahydrobiopterin and 7,8-dihydrobiopterin in solution: a 1H NMR study

Martı́nez, A., Dao, K. K., McKinney, J. A., et al. (2000) · Pteridines · doi:10.1515/pteridines.2000.11.2.32 · Cited by 8 · see citing works

Participation of Free Radicals in Photoreduction of Pterins and Folic Acid

Kritsky, M. S., Telegina, T. A., Lyudnikova, T. A., et al. (2001) · Doklady Biochemistry and Biophysics · doi:10.1023/a:1012344210189 · Cited by 7 · see citing works

[Pyridoxal kinase activity and pyridoxal-P concentration in mammalian tissues under normal and experimental conditions].

Bukin, I. V. (1976) · PubMed · Cited by 5 · see citing works

Critical role of the neuronal nitric-oxide synthase heme proximal side residue, Arg418, in catalysis and electron transfer

Sato, Y., Sagami, I., & Shimizu, T. (2001) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(01)00334-8 · Cited by 4 · see citing works

[Characteristics of liver cell ribosomal material from rats poisoned with ethionine. Extraction and properties of active ribosomal subunits from individual ribosomes accmulated under the influence of ethionine].

Abakumova, O. I., Da, I., Ugarova, T. I., et al. (1974) · PubMed · Cited by 3 · see citing works

Socialists Reverse Budget Decline

Balter, M. (1997) · Science · doi:10.1126/science.278.5335.31a · Cited by 2 · see citing works

[Hydroxylation of aniline and aminoantipyrine derivatives (1-phenyl-2,3-dimethylaminopyrazolon-5) in liver endoplasmic reticulum].

Арчаков, А. И., Karuzina, I. I., Vn, T., et al. (1975) · PubMed · Cited by 1 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Tetrahydrobiopterin: biochemistry and pathophysiology

Werner, E. R., Blau, N., & Thöny, B. (2011) · Biochemical Journal · doi:10.1042/bj20110293 · Cited by 493 · see citing works

NO synthase: Structures and mechanisms

Daff, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.03.001 · Cited by 251 · see citing works

Enzymes of the l-arginine to nitric oxide pathway

Stuehr, D. J. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.10.2748s · Cited by 218 · see citing works

Myocardial ischemia results in tetrahydrobiopterin (BH ₄ ) oxidation with impaired endothelial function ameliorated by BH ₄

Dumitrescu, C., Biondi, R., Xia, Y., Cardounel, A. J., Druhan, L. J., Ambrosio, G., & Zweier, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702986104 · Cited by 192 · see citing works

Regulation of Tetrahydrobiopterin Synthesis and Bioavailability in Endothelial Cells

Shi, W., Meininger, C. J., Haynes, T. E., Hatakeyama, K., & Wu, G. (2004) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:41:3:415 · Cited by 137 · see citing works

Nitric-oxide synthase: A cytochrome P450 family foster child

Gorren, A. C. F., & Mayer, B. (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2006.08.019 · Cited by 129 · see citing works

Tetrahydrobiopterin in nitric oxide synthase

Tejero, J., & Stuehr, D. (2013) · IUBMB Life · doi:10.1002/iub.1136 · Cited by 75 · see citing works

Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation

Chen, W., Li, L., Brod, T., Saeed, O., Thabet, S., Jansen, T., Dikalov, S., Weyand, C., Goronzy, J., & Harrison, D. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.191023 · Cited by 36 · see citing works

Versatile Regulation of Neuronal Nitric Oxide Synthase by Specific Regions of Its C-Terminal Tail

Tiso, M., Tejero, J., Panda, K., Aulak, K. S., & Stuehr, D. J. (2007) · Biochemistry · doi:10.1021/bi701646k · Cited by 34 · see citing works

Molecular mechanism for pterin-mediated inactivation of tyrosine hydroxylase: Formation of insoluble aggregates of tyrosine hydroxylase

Urano, F., Hayashi, N., Arisaka, F., Kurita, H., Murata, S., & Ichinose, H. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj073 · Cited by 30 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

From attention to citation: What are altmetrics and how do they work?

Wang, X. (2014) · London School of Economics and Political Science Research Online (London School of Economics and Political Science)

An Introduction to Altmetrics

Brigham, T. (2014) · Medical Reference Services Quarterly · doi:10.1080/02763869.2014.957093 · Cited by 107 · see citing works

Do Altmetrics Work? Twitter and Ten Other Social Web Services

Thelwall, M., Haustein, S., Larivière, V., & Sugimoto, C. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064841 · Cited by 907 · see citing works

Using Altmetrics to Support Research Evaluation

Thelwall, M. A. (2018) · Communications in computer and information science · doi:10.1007/978-981-13-1053-9_2 · Cited by 19 · see citing works