Diet, metabolites, and “western-lifestyle” inflammatory diseases
Open accessAbstract
One explanation for the increased incidence of allergies, asthma, and even some autoimmune diseases has been the hygiene hypothesis. However, recent studies also highlight an important role for diet and bacterial metabolites in controlling various immune pathways, including gut and immune homeostasis, regulatory T cell biology, and inflammation. Dietary-related metabolites engage "metabolite-sensing" G-protein-coupled receptors, such as GPR43, GPR41, GPR109A, GPR120, and GPR35. These receptors are expressed on immune cells and some gut epithelial cells and generally mediate a direct anti-inflammatory effect. Insufficient intake of "healthy foodstuffs" adversely affects the production of bacterial metabolites. These metabolites and those derived directly from food drive beneficial downstream effects on immune pathways. We propose that insufficient exposure to dietary and bacterial metabolites might underlie the development of inflammatory disorders in Western countries. This review highlights what is currently known about diet, metabolites, and their associated immune pathways in relation to the development of inflammatory disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Gut microbial production of short-chain fatty acids from dietary fiber can suppress the development of several inflammatory, autoimmune, and allergic diseases in experimental animal data.
“Accumulating experimental animal data indicate that gut microbial production of these short-chain fatty acids from dietary fiber can suppress the development of several inflammatory, autoimmune, and allergic disease (92).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [92]
Some of the beneficial effects of microbiome-derived metabolites are thought to be mediated by binding to specific G-protein-coupled receptors expressed on enteroendocrine and immune cells.
“Some of the beneficial effects of these microbiome-derived metabolites are thought to be mediated by the binding to specific G-protein–coupled receptors expressed on enteroendocrine and immune cells (92).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [92]
Multigenerational exposure to a Western diet poor in 'microbiota-accessible carbohydrates' results in the extinction of specific bacterial lineages.
“In contrast, multigenerational exposure to a Western diet poor in “microbiota-accessible carbohydrates” result in the extinction of specific bacterial lineages, which might negatively influence the maturation and function of the immune system, and increase the risk of developing a range of metabolic, inflammatory, allergic, and autoimmune diseases (92,94,98).”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [92]
Cites
1 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257 · see citing works
RetractedDe Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054 · see citing works
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, C., Kumar, C., Gnad, F., Nielsen, M. L., Rehman, M., Walther, T. C., Olsen, J. V., & Mann, M. (2009) · Science · doi:10.1126/science.1175371 · Cited by 4,040 · see citing works
Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710 · see citing works
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · see citing works
Self-citationTopping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091 · see citing works
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works
Gut Microbiota Metabolism of Dietary Fiber Influences Allergic Airway Disease and Hematopoiesis
Trompette, A., Gollwitzer, E. S., Yadava, K., Sichelstiel, A. K., Sprenger, N., Ngom-Bru, C., Blanchard, C., Junt, T., Nicod, L. P., Harris, N. L., et al. (2014) · Nature Medicine · doi:10.1038/nm.3444 · Cited by 2,862 · see citing works
Zelante, T., Iannitti, R. G., Cunha, C., De Luca, A., Giovannini, G., Pieraccini, G., Zecchi, R., D’Angelo, C., Massi-Benedetti, C., Fallarino, F., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.003 · Cited by 2,614 · see citing works
Human nutrition, the gut microbiome and the immune system
Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
The Placenta Harbors a Unique Microbiome
Aagaard, K., Ma, J., Antony, K. M., Ganu, R., Petrosino, J., & Versalovic, J. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008599 · Cited by 2,494 · see citing works
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428 · see citing works
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425 · see citing works
Self-citationBifidobacteria can protect from enteropathogenic infection through production of acetate
Fukuda, S., Toh, H., Hase, K., Oshima, K., Nakanishi, Y., Yoshimura, K., Tobe, T., Clarke, J. M., Topping, D. L., Suzuki, T., et al. (2011) · Nature · doi:10.1038/nature09646 · Cited by 2,387 · see citing works
Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368 · see citing works
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277 · see citing works
Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322269111 · Cited by 2,175 · see citing works
Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works
Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases
Simopoulos, A. P. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719248 · Cited by 2,014 · see citing works
Regulation of inflammation by short chain fatty acids
Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011) · Nutrients · doi:10.3390/nu3100858 · Cited by 1,724 · see citing works
Eder, W., Ege, M. J., & von Mutius, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054308 · Cited by 1,621 · see citing works
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564 · see citing works
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., & Tsujimoto, G. (2004) · Nature Medicine · doi:10.1038/nm1168 · Cited by 1,551 · see citing works
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538 · see citing works
Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K., Kashihara, D., Hirano, K., Tani, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2852 · Cited by 1,512 · see citing works
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., et al. (2012) · Nature · doi:10.1038/nature11228 · Cited by 1,271 · see citing works
Diet, gut microbiota and immune responses
Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261 · see citing works
Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation
Chen, L., Fischle, W., Verdin, E. M., & Greene, W. C. (2001) · Science · doi:10.1126/science.1062374 · Cited by 1,231 · see citing works
Family size, infection and atopy: the first decade of the 'hygiene hypothesis'
Strachan, D. (2000) · Thorax · doi:10.1136/thorax.55.suppl_1.s2 · Cited by 1,183 · see citing works
HÆMOSTATIC FUNCTION AND PLATELET POLYUNSATURATED FATTY ACIDS IN ESKIMOS
Dyerberg, J., & Bang, H. O. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91490-9 · Cited by 1,005 · see citing works
Zaki, M. H., Boyd, K. L., Vogel, P., Kastan, M. B., Lamkanfi, M., & Kanneganti, T.-D. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.003 · Cited by 989 · see citing works
Deacetylase inhibition promotes the generation and function of regulatory T cells
Tao, R. N., de Zoeten, E. F., Özkaynak, E., Chen, C., Wang, L., Porrett, P. M., Li, B., Turka, L. A., Olson, E. N., Greene, M. I., et al. (2007) · Nature Medicine · doi:10.1038/nm1652 · Cited by 927 · see citing works
Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses
Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.021 · Cited by 840 · see citing works
IgA Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis
Peterson, D. A., McNulty, N. P., Guruge, J. L., & Gordon, J. I. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.013 · Cited by 828 · see citing works
Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 816 · see citing works
Wrzosek, L., Miquel, S., Noordine, M.-L., Bouet, S., Curt, M. J.-C., Robert, V., Philippe, C., Bridonneau, C., Cherbuy, C., Masselot, C. R., et al. (2013) · BMC Biology · doi:10.1186/1741-7007-11-61 · Cited by 807 · see citing works
Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
Kiss, E. A., Vonarbourg, C., Kopfmann, S., Hobeika, E., Finke, D., Esser, C., & Diefenbach, A. (2011) · Science · doi:10.1126/science.1214914 · Cited by 801 · see citing works
Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4466 · Cited by 789 · see citing works
Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.015 · Cited by 784 · see citing works
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 748 · see citing works
Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637002100 · Cited by 731 · see citing works
Wlodarska, M., Thaiss, C. A., Nowarski, R., Henao-Mejia, J., Zhang, J.-P., Brown, E. M., Frankel, G., Levy, M., Katz, M. N., Philbrick, W. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.026 · Cited by 708 · see citing works
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
Ichimura, A., Hirasawa, A., Poulain‐Godefroy, O., Bonnefond, A., Hara, T., Yengo, L., Kimura, I., Leloire, A., Liu, N., Iida, K., et al. (2012) · Nature · doi:10.1038/nature10798 · Cited by 663 · see citing works
Ou, J., Carbonero, F., Zoetendal, E. G., DeLany, J. P., Wang, M., Newton, K., Gaskins, H. R., & O’Keefe, S. J. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.056689 · Cited by 646 · see citing works
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., et al. (2013) · Science · doi:10.1126/science.1237910 · Cited by 642 · see citing works
Lepage, P., Häsler, R., Spehlmann, M. E., Rehman, A., Žvirblienė, A., Begun, A., Ott, S. J., Kupčinskas, L., Dore, J. M., Raedler, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.011 · Cited by 592 · see citing works
Willemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518 · see citing works
Dupaul-Chicoine, J., Yeretssian, G., Doiron, K., Bergstrom, K. S. B., McIntire, C. R., LeBlanc, P. M., Meunier, C., Turbide, C., Gros, P., Beauchemin, N., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.012 · Cited by 517 · see citing works
Does the microbiota regulate immune responses outside the gut?
Noverr, M. C., & Huffnagle, G. B. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.10.008 · Cited by 499 · see citing works
The “Perfect Storm” for Type 1 Diabetes
Vaarala, O., Atkinson, M. A., & Neu, J. (2008) · Diabetes · doi:10.2337/db08-0331 · Cited by 497 · see citing works
Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization
Herbst, T., Sichelstiel, A., Schär, C., Yadava, K., Bürki, K., Cahenzli, J., McCoy, K., Marsland, B. J., & Harris, N. L. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1574oc · Cited by 440 · see citing works
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
Sapieha, P., Sirinyan, M., Hamel, D., Zaniolo, K., Joyal, J.-S., Cho, J.-H., Honoré, J.-C., Kermorvant-Duchemin, E., Varma, D. R., Tremblay, S., et al. (2008) · Nature Medicine · doi:10.1038/nm.1873 · Cited by 359 · see citing works
Vogt, M. C., Paeger, L., Heß, S., Steculorum, S. M., Awazawa, M., Hampel, B., Neupert, S., Nicholls, H. T., Mauer, J., Hausen, A. C., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.008 · Cited by 358 · see citing works
Normand, S., Delanoye, A., Bressenot, A., Huot, L., Grandjean, T., Peyrin‐Biroulet, L., Lemoine, Y., Hot, D., & Chamaillard, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100981108 · Cited by 358 · see citing works
An Official American Thoracic Society Workshop Report: Obesity and Asthma
Dixon, A. E., Holguín, F., Sood, A., Salome, C. M., Pratley, R. E., Beuther, D. A., Celedon, J. C., & Shore, S. A. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200903-013st · Cited by 348 · see citing works
Dietary Fiber Intake and Mortality in the NIH-AARP Diet and Health Study
Park, Y., Subar, A. F., Hollenbeck, A. R., & Schatzkin, A. G. (2011) · Archives of Internal Medicine · doi:10.1001/archinternmed.2011.18 · Cited by 344 · see citing works
Inflammatory Bowel Disease as a Model for Translating the Microbiome
Huttenhower, C., Kostic, A. D., & Xavier, R. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.013 · Cited by 332 · see citing works
Toma, I., Kang, J. J., Sipos, A., Vargas, S., Bansal, E., Hanner, F., Meer, E., & Peti-Peterdi, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33293 · Cited by 322 · see citing works
Finding the Missing Links among Metabolites, Microbes, and the Host
Dorrestein, P. C., Mazmanian, S. K., & Knight, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.015 · Cited by 317 · see citing works
Identification of β-Arrestin2 as a G Protein-Coupled Receptor-Stimulated Regulator of NF-κB Pathways
Gao, H., Sun, Y., Wu, Y., Luan, B., Wang, Y., Qu, B., & Pei, G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00216-3 · Cited by 313 · see citing works
The increase in the prevalence of asthma and allergy: food for thought
Devereux, G. S. (2006) · Nature reviews. Immunology · doi:10.1038/nri1958 · Cited by 309 · see citing works
Trends in Dietary Fiber Intake in the United States, 1999-2008
King, D. E., Mainous, A. G., & Lambourne, C. A. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.01.019 · Cited by 295 · see citing works
A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma
Wood, L. G., Garg, M. L., & Gibson, P. G. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.036 · Cited by 280 · see citing works
Lukasova, M., Malaval, C., Gille, A., Kero, J. T., & Offermanns, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41651 · Cited by 267 · see citing works
Molecules in focus: Indoleamine 2,3-dioxygenase
King, N. J. C., & Thomas, S. R. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.01.004 · Cited by 260 · see citing works
Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis
Alenghat, T., Osborne, L. C., Saenz, S. A., Kobuley, D. E., Ziegler, C. G. K., Mullican, S. E., Choi, I., Grunberg, S., Sinha, R., Wynosky-Dolfi, M. A., et al. (2013) · Nature · doi:10.1038/nature12687 · Cited by 248 · see citing works
Manipulating antioxidant intake in asthma: a randomized controlled trial
Wood, L. G., Garg, M. L., Smart, J. M., Scott, H. A., Barker, D., & Gibson, P. G. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.032623 · Cited by 247 · see citing works
Nagel, G., Weinmayr, G., Kleiner, A., García‐Marcos, L., Strachan, D. P., & the ISAAC Phase Two Study Group (2010) · Thorax · doi:10.1136/thx.2009.128256 · Cited by 234 · see citing works
Macia, L., Thorburn, A. N., Binge, L. C., Mariño, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J., & Mackay, C. R. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01080.x · Cited by 223 · see citing works
Self-citationMedium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory Receptor
Suzuki, M., Takaishi, S., Nagasaki, M., Onozawa, Y., Iino, I., Maeda, H., Komai, T., & Oda, T. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.420042 · Cited by 222 · see citing works
Digby, J. E., Martínez, F. O., Jefferson, A., Ruparelia, N., Chai, J. T., Wamil, M., Greaves, D. R., & Choudhury, R. P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.241836 · Cited by 221 · see citing works
Treatment of distal ulcerative colitis with short-chain fatty acid enemas a placebo-controlled trial
Scheppach, W. M., & German-Austrian Scfa Study Group (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02071409 · Cited by 204 · see citing works
Kanauchi, O., Suga, T., Tochihara, M., Hibi∥, T., Naganuma, M., Homma, T., Asakura, H., Nakano, H., Takahama, K., Fujiyama, Y., et al. (2002) · Journal of Gastroenterology · doi:10.1007/bf03326417 · Cited by 194 · see citing works
Boulet, L. ‐. (2012) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2012.04040.x · Cited by 192 · see citing works
Wang, L., de Zoeten, E. F., Greene, M. I., & Hancock, W. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd3031 · Cited by 186 · see citing works
Dietary influences on intestinal immunity
Veldhoen, M., & Brucklacher-Waldert, V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3299 · Cited by 164 · see citing works
Obesity and the lung: 4 {middle dot} Obesity and asthma
Sin, D. D., & Sutherland, E. R. (2008) · Thorax · doi:10.1136/thx.2007.086819 · Cited by 149 · see citing works
Berthon, B. S., MacDonald‐Wicks, L. K., Gibson, P. G., & Wood, L. G. (2012) · Respirology · doi:10.1111/resp.12015 · Cited by 146 · see citing works
Fecal Short-Chain Fatty Acids in Children with Inflammatory Bowel Disease
Treem, W. R., Ahsan, N., Shoup, M., & Hyams, J. S. (1994) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199402000-00007 · Cited by 139 · see citing works
Innate immune responses to mycobacteria and the downregulation of atopic responses
Rook, G. A. W., Martinelli, R., & Brunet, L. R. (2003) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200310000-00003 · Cited by 136 · see citing works
Mediterranean Diet as a Protective Factor for Wheezing in Preschool Children
Castro-Rodríguez, J. A., García‐Marcos, L., Rojas, J. D. A., Valverde‐Molina, J., & Sánchez‐Solís, M. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.01.003 · Cited by 126 · see citing works
Mining the human gut microbiota for effector strains that shape the immune system
Ahern, P. P., Faith, J. J., & Gordon, J. I. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.012 · Cited by 123 · see citing works
Digby, J. E., McNeill, E., Dyar, O. J., Lam, V. K. L., Greaves, D. R., & Choudhury, R. P. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.08.045 · Cited by 122 · see citing works
The role of HCA2 (GPR109A) in regulating macrophage function
Zandi‐Nejad, K., Takakura, A., Jurewicz, M. M., Chandraker, A. K., Offermanns, S., Mount, D. B., & Abdi, R. (2013) · The FASEB Journal · doi:10.1096/fj.12-223933 · Cited by 119 · see citing works
Gambhir, D., Ananth, S., Veeranan‐Karmegam, R., Elangovan, S., Hester, S., Jennings, E., Offermanns, S., Nussbaum, J. J., Smith, S. B., Thangaraju, M., et al. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8447 · Cited by 113 · see citing works
Obesity and childhood asthma – mechanisms and manifestations
Jensen, M. E., Wood, L. G., & Gibson, P. G. (2012) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e3283508df5 · Cited by 75 · see citing works
Fujita, T., Matsuoka, T., Honda, T., Kabashima, K., Hirata, T., & Narumiya, S. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.123 · Cited by 75 · see citing works
Kanauchi, O., Iwanaga, T., Andoh, A., Araki, Y., Nakamura, T., Mitsuyama, K., Suzuki, A., Hibi, T., & Bamba, T. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02427.x · Cited by 69 · see citing works
Metabolites from intestinal microbes shape Treg
Geuking, M. B., McCoy, K. D., & Macpherson, A. J. (2013) · Cell Research · doi:10.1038/cr.2013.125 · Cited by 50 · see citing works
Dietary Cycloinulooligosaccharides Enhance Intestinal Immunoglobulin A Production in Mice
Ishikawa, T., & Nanjo, F. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.80733 · Cited by 38 · see citing works
Flagged first, then by citations
1 of the 103 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works
“In colonocytes (5), butyrate is β-oxidized to Acetyl-CoA and constitutes”
BackgroundGut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409 · see citing works
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019) · Foods · doi:10.3390/foods8030092 · Cited by 1,773 · see citing works
“Interestingly, maternal prebiotics metabolites are able to cross the placenta and can affect the development of the fetal immune system [12,126].”
BackgroundDe Filippis, F., Pellegrini, N., Vannini, L., Jeffery, I. B., La Storia, A., Laghi, L., Serrazanetti, D. I., Di Cagno, R., Ferrocino, I., Lazzi, C., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309957 · Cited by 1,638 · see citing works
Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7734 · Cited by 1,439 · see citing works
Self-citationImpact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,313 · see citing works
“Recent studies have emphasized the profound effects of diet and nutrients on the localization and composition of the gutmicrobiota as well as on the connection between the gut microbiota and immunological pathways (Thorburn et al., 2014).”
BackgroundPromoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works
“G-protein-coupled receptors expressed by enteroendocrine and immune cells may be important mediators of the effects of the microbiome (Thorburn et al., 2014).”
InfluentialLinking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity
Schirmer, M., Smeekens, S. P., Vlamakis, H. C., Jaeger, M., Oosting, M., Franzosa, E. A., ter Horst, R., Jansen, T., Jacobs, L., Bonder, M. J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.10.020 · Cited by 1,159 · see citing works
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
Christ, A., Günther, P. S., Lauterbach, M. A. R., Duewell, P., Biswas, D., Pelka, K., Scholz, C. J., Oosting, M., Händler, K., Bassler, K. E., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.013 · Cited by 1,099 · see citing works
“Alterations in diets can have deleterious effects on immune responses and drive the development of a range of inflammatory diseases (Thorburn et al., 2014).”
BackgroundGut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,107 · see citing works
Marques, F. Z., Nelson, E., Chu, P.-Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024545 · Cited by 1,065 · see citing works
Self-citationMicrobiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases
Sun, M., Wu, W. H., Liu, Z., & Cong, Y. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1242-9 · Cited by 1,071 · see citing works
“SCFA might activate NALP6 through the GPCR pathway, further promoting gut goblet cells to secret mucus, which is an important barrier to separate the bacteria and epithelial cells [53, 54].”
BackgroundMicrobes, Metabolites, and the Gut-Lung Axis
Dang, A. T., & Marsland, B. J. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0160-6 · Cited by 1,028 · see citing works
“Signaling through these transmembrane receptors linked to regular G proteins is associated with an inflammatory effect through activation of mitogen-activated protein (MAP) kinases, phosphoinositide 3 (PI3K)-kinases, and mammalian target of rapamycin (mTOR).(82) Alternatively, signal transduction pathways involving th…”
BackgroundAtarashi, K., Suda, W., Luo, C., Kawaguchi, T., Motoo, I., Narushima, S., Kiguchi, Y., Yasuma, K., Watanabe, E., Tanoue, T., et al. (2017) · Science · doi:10.1126/science.aan4526 · Cited by 957 · see citing works
Microbial Regulation of Host Physiology by Short-chain Fatty Acids
van der Hee, B., & Wells, J. M. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.02.001 · Cited by 988 · see citing works
Influence of Maternal Obesity on the Long-Term Health of Offspring
Godfrey, K. M., Reynolds, R. M., Prescott, S. L., Nyirenda, M., Jaddoe, V. W. V., Eriksson, J. G., & Broekman, B. F. P. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30107-3 · Cited by 1,059 · see citing works
“39 There is preliminary evidence in humans that dietary manipulation of the maternal microbiome in pregnancy with prebiotic fibre has beneficial effects for both offspring immune function and metabolism (reviewed in [40]).”
Microbial genes and pathways in inflammatory bowel disease
Schirmer, M., Garner, A., Vlamakis, H. C., & Xavier, R. J. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0213-6 · Cited by 956 · see citing works
Thorburn, A. N., McKenzie, C. I., Shen, S., Stanley, D., Macia, L., Mason, L. J., Roberts, L. K., Wong, C. H. Y., Shim, R., Robert, R., et al. (2015) · Nature Communications · doi:10.1038/ncomms8320 · Cited by 917 · see citing works
Self-citationIddir, M., Alex Brito, O., Dingeo, G., Sosa, S., Samouda, H., Frano, M. R. L., & Bohn, T. (2020) · Nutrients · doi:10.3390/nu12061562 · Cited by 795 · see citing works
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms
Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx227 · Cited by 762 · see citing works
“Accumulating experimental animal data indicate that gut microbial production of these short-chain fatty acids from dietary fiber can suppress the development of several inflammatory, autoimmune, and allergic disease (92).”
The role of short-chain fatty acids in immunity, inflammation and metabolism
Yao, Y., Cai, X. T., Fei, W., Ye, Y., Zhao, M., & Zheng, C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1854675 · Cited by 776 · see citing works
He, Y., Fu, L., Li, Y., Wang, W., Gong, M., Zhang, J., Dong, X., Huang, J., Wang, Q., Mackay, C. R., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.002 · Cited by 729 · see citing works
Self-citationShort chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 742 · see citing works
Mariño, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., et al. (2017) · Nature Immunology · doi:10.1038/ni.3713 · Cited by 686 · see citing works
Self-citationTan, J., McKenzie, C. I., Vuillermin, P., Goverse, G., Vinuesa, C. G., Mebius, R. E., Macia, L., & Mackay, C. R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.047 · Cited by 666 · see citing works
“…of dietary fiber in the western world is well below the recommended levels, and we have argued previously that insufficient intake of dietary fiber may contribute to a range of ‘‘western lifestyle’’ inflammatory diseases (Macia et al., 2012;Maslowski andMackay, 2011; Thorburn et al., 2014).”
BackgroundSelf-citationPathogenesis of autoimmune disease
Pisetsky, D. S. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00720-1 · Cited by 656 · see citing works
Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells
Li, M., van Esch, B. C. A. M., Wagenaar, G. T. M., Garssen, J., Folkerts, G., & Henricks, P. A. J. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.05.003 · Cited by 622 · see citing works
GPCR-Mediated Signaling of Metabolites
Husted, A. S., Trauelsen, M., Rudenko, O., Hjorth, S. A., & Schwartz, T. W. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.008 · Cited by 586 · see citing works
Gasaly, N., de Vos, P., & Hermoso, M. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658354 · Cited by 592 · see citing works
Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis
Sivaprakasam, S., Prasad, P. D., & Singh, N. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.007 · Cited by 573 · see citing works
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works
Immune mediators in the brain and peripheral tissues in autism spectrum disorder
Estes, M. L., & McAllister, A. K. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3978 · Cited by 514 · see citing works
Miller, F. W. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102266 · Cited by 521 · see citing works
High levels of butyrate and propionate in early life are associated with protection against atopy
Roduit, C., Frei, R., Ferstl, R., Loeliger, S., Westermann, P., Rhyner, C., Schiavi, E., Barcik, W., Rodríguez‐Pérez, N., Wawrzyniak, M., et al. (2018) · Allergy · doi:10.1111/all.13660 · Cited by 515 · see citing works
“One of the lifestyle factors thought to be important is the diet.(1) Nutritional factors and their interaction with the gut microbiota influence immunological processes, especially early in life.”
BackgroundSystemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer
Coutzac, C., Jouniaux, J.-M., Paci, A., Schmidt, J., Mallardo, D., Seck, A., Asvatourian, V., Cassard, L., Saulnier, P., Lacroix, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16079-x · Cited by 513 · see citing works
Chen, D., Jin, D., Huang, S., Wu, J., Xu, M., Liu, T., Dong, W., Liu, X., Wang, S., Zhong, W., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.019 · Cited by 495 · see citing works
Microbiome and Anticancer Immunosurveillance
Zitvogel, L., Ayyoub, M., Routy, B., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.03.001 · Cited by 478 · see citing works
The gut-skin axis in health and disease: A paradigm with therapeutic implications
O'Neill, C. A., Monteleone, G., McLaughlin, J. T., & Paus, R. (2016) · BioEssays · doi:10.1002/bies.201600008 · Cited by 449 · see citing works
“There is also good evidence that gut endocrine cells and their function are abnormal in gut infections [99, 100], in both coeliac and Crohn’s diseases [101], and also with changing gut function during ageing [102, 103].”
BackgroundDiet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Age‐related changes in the gut microbiota influence systemic inflammation and stroke outcome
Spychala, M. S., Venna, V. R., Jandzinski, M., Doran, S. J., Durgan, D. J., Ganesh, B. P., Ajami, N. J., Putluri, N., Graf, J., Bryan, R. M., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25250 · Cited by 435 · see citing works
“Working through either or both of these pathways, SCFAs stabilize the gut epithelial barrier, modulate cytokine secretion, alter Tlymphocyte populations, increase the protective mucus layer, modulate antibody secretion, and inhibit nuclear factor kappa B.(44) Additionally, SCFAs mediate the maturation and function of…”
BackgroundDietary fiber and SCFAs in the regulation of mucosal immunity
Tan, J. K., Macia, L., & Mackay, C. R. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.11.007 · Cited by 427 · see citing works
Self-citationRegulation of short-chain fatty acids in the immune system
Liu, X., Shao, J.-H., Liao, Y.-T., Wang, L., Yuan, J., Dong, P.-J., Liu, Z., He, D., Li, C., & Zhang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1186892 · Cited by 435 · see citing works
“C2 activates the GPR41 and GPR43 receptors and their downstream ERK2/1 and MAPK signal ing pathways and increases the product ion of proinflammatory factors and chemokines (72, 73) (Figure 1).”
BackgroundAmit, I., Winter, D. R., & Jung, S. (2015) · Nature Immunology · doi:10.1038/ni.3325 · Cited by 406 · see citing works
Beyond gut feelings: how the gut microbiota regulates blood pressure
Marques, F. Z., Mackay, C. R., & Kaye, D. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.120 · Cited by 397 · see citing works
Self-citationMediterranean diet and health status: Active ingredients and pharmacological mechanisms
Schwingshackl, L., Morze, J., & HOFFMANN, G. E. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14778 · Cited by 393 · see citing works
Diet in the Pathogenesis and Treatment of Inflammatory Bowel Diseases
Lee, D. Y., Albenberg, L. G., Compher, C. W., Baldassano, R. N., Piccoli, D. A., Lewis, J. D., & Wu, G. D. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.007 · Cited by 377 · see citing works
The impact of the gut microbiome on extra-intestinal autoimmune diseases
Miyauchi, E., Shimokawa, C., Steimle, A., Desai, M. S., & Ohno, H. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00727-y · Cited by 375 · see citing works
Epigenetics and DOHaD: From Basics to Birth and Beyond
Bianco-Miotto, T., Craig, J. M., Gasser, Y. P., van Dijk, S. J., & Ozanne, S. E. (2017) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174417000733 · Cited by 361 · see citing works
“In humans, FFAR2 (also known as GPR43) is activated by acetate, propionate, and to some extent, butyrate; FFAR3 (GRP41) is activated by butyrate and propionate, and NIACR (the niacin receptor or GPR109A) is activated by butyrate.(49,64,65) Cellular levels of specific SCFAs have been associated with DNA methylation lev…”
BackgroundMicrobiome-modulated metabolites at the interface of host immunity
Blacher, E., Levy, M., Tatirovsky, E., & Elinav, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601247 · Cited by 354 · see citing works
“Trp is known to undergo metabolism by Lactobacilli, giving rise to indole-3-aldehyde, which can bind to the aryl hydrocarbon receptor (AHR), followed by its transport through the epithelial cell layer by a transporter containing angiotensin I converting enzyme 2 (9, 31).”
BackgroundLoss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair
Tang, T. W. H., Chen, H.-C., Chen, C.-Y., Yen, C. Y. T., Lin, C.-J., Prajnamitra, R. P., Chen, L.-L., Ruan, S.-C., Lin, J.-H., Lin, P.-J., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.035235 · Cited by 348 · see citing works
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications
Zhao, L.-Y., Mei, J.-X., Yu, G., Lei, L., Zhang, W.-H., Liu, K., Chen, X.-L., Kołat, D., Yang, K., & Hu, J.-K. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01406-7 · Cited by 359 · see citing works
“Moreover, Lactobacilli can convert tryptophan into indole-3-aldehyde that acts as an AhR agonist by increasing the expression of IL-22 and enhancing the activity of Th17 cells.(243) TMAO is metabolized in the liver from trimethylamine (TMA) synthesized by host gut microbes,(244) and it has been demonstrated to increas…”
BackgroundImpact of Mediterranean Diet on Chronic Non-Communicable Diseases and Longevity
Dominguez, L. J., Bella, G. D., Veronese, N., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13062028 · Cited by 346 · see citing works
“It has been shown that high dietary fiber intake promotes modifications of gut microbiota in both rodents and humans, with decreased Firmicutes and increased Bacteroidetes, which produces high levels of SCFAs, related with several inflammatory, autoimmune, and allergic diseases [76].”
BackgroundConnecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex
Rizzetto, L., Fava, F., Tuohy, K. M., & Selmi, C. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.05.008 · Cited by 331 · see citing works
Finding the Missing Links among Metabolites, Microbes, and the Host
Dorrestein, P. C., Mazmanian, S. K., & Knight, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.05.015 · Cited by 317 · see citing works
Microbiome in the gut-skin axis in atopic dermatitis
Lee, S.-Y., Lee, E., Park, Y. M., & Hong, S.-J. (2018) · Allergy, Asthma & Immunology Research · doi:10.4168/aair.2018.10.4.354 · Cited by 326 · see citing works
“SCFAs produced by the gut microbiome, such as Akkerman sia muciniphila,(31) play important roles in inflammatory diseases, such as AD, which might explain the association between dietary feeding, microbiome, and the skin immune system.(23,32)”
BackgroundThe Role of the Immune System in Metabolic Health and Disease
Zmora, N., Bashiardes, S., Levy, M., & Elinav, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.006 · Cited by 323 · see citing works
“…differentiation, anti-inflammatory processes (Singh et al., 2014), and inflammasome activation (Macia et al., 2015); and impact the hematopoietic repertoire (Trompette et al., 2014) through their signaling via G protein-coupled receptors, such as GPR41, GPR43, andGPR109A (Thorburn et al., 2014).”
BackgroundThe Healthy Human Blood Microbiome: Fact or Fiction?
Castillo, D. J., Rifkin, R. F., Cowan, D. A., & Potgieter, M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00148 · Cited by 314 · see citing works
Biological Function of Short-Chain Fatty Acids and Its Regulation on Intestinal Health of Poultry
Liu, L., Li, Q., Yang, Y., & Guo, A. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.736739 · Cited by 318 · see citing works
“The studies showed that the activation of GPR41/43 by SCFAs resulted in the activation of downstream mTOR, PI3K, or MAPK signaling pathways, thus exerting pro-inflammatory effects (114, 115).”
BackgroundA diet-sensitive commensal Lactobacillus strain Mediates TLR7-dependent systemic autoimmunity
Zegarra-Ruiz, D. F., El Beidaq, A., Iñiguez, A. J., Lubrano Di Ricco, M., Manfredo Vieira, S., Ruff, W. E., Mubiru, D., Fine, R. L., Sterpka, J., Greiling, T. M., et al. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.009 · Cited by 308 · see citing works
Valenta, R., Hochwallner, H., Linhart, B., & Pahr, S. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.006 · Cited by 298 · see citing works
Molecular and cellular mechanisms of food allergy and food tolerance
Chinthrajah, R. S., Hernandez, J. D., Boyd, S. D., Galli, S. J., & Nadeau, K. C. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.02.004 · Cited by 310 · see citing works
The Microbial Metabolite Butyrate Induces Expression of Th1-Associated Factors in CD4+ T Cells
Kespohl, M., Vachharajani, N., Luu, M., Harb, H., Pautz, S., Wolff, S., Sillner, N., Walker, A., Schmitt-Kopplin, P., Boettger, T., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01036 · Cited by 294 · see citing works
“Therefore, SCFAs such as butyrate, propionate, or acetate have recently been considered as potential therapeutic tool to modulate inflammatory responses (10, 11).”
BackgroundMetabolite-Sensing G Protein–Coupled Receptors—Facilitators of Diet-Related Immune Regulation
Tan, J. K., McKenzie, C. I., Mariño, E., Macia, L., & Mackay, C. R. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052235 · Cited by 303 · see citing works
Self-citationLi, X. O., Li, X. O., Xia, B., Jin, X., Zou, Q., Zeng, Z., Zhao, W., Yan, S., Li, L., Yuan, S., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.02.002 · Cited by 303 · see citing works
Sun, J., Furio, L., Mecheri, R., van der Does, A. M., Lundeberg, E., Saveanu, L., Chen, Y., van Endert, P., Agerberth, B., & Diana, J. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.013 · Cited by 292 · see citing works
Bridging intestinal immunity and gut microbiota by metabolites
Wang, G., Huang, S., Wang, Y., Cai, S., Yu, H., Liu, H., Zeng, X., Zhang, G., & Qiao, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03190-6 · Cited by 299 · see citing works
Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
You, M., Xie, Z., Zhang, N., Zhang, Y., Xiao, D., Liu, S., Zhuang, W., Li, L., & Tao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01442-3 · Cited by 297 · see citing works
“Acetylation can also promote the activation, nuclear translocation and DNA binding of transcription factors (such as STAT3, NF-kB, FoxP3, N-FAT and RUNX1).(118,218,219) In addition, sodium propionate (SP) affects the expression of survivin and p21, inducing cell cycle arrest especially in the G2/M phase, and then lead…”
BackgroundMiranda, P. M., Palma, G. D., Serkis, V., Lu, J., Louis-Auguste, M., McCarville, J. L., Verdu, E. F., Collins, S. M., & Berčík, P. (2018) · Microbiome · doi:10.1186/s40168-018-0433-4 · Cited by 293 · see citing works
“Strong epidemiological evidences support the concept that diet underpins the rise in chronic inflammatory diseases such as IBD, diabetes, or asthma [3, 5, 6].”
BackgroundGioia, C., Lucchino, B., Tarsitano, M. G., Iannuccelli, C., & Franco, M. D. (2020) · Nutrients · doi:10.3390/nu12051456 · Cited by 303 · see citing works
Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis
Wang, K., Yin, J., Chen, J., Ma, J., Si, H., & Xia, D. (2024) · Phytomedicine · doi:10.1016/j.phymed.2023.155258 · Cited by 301 · see citing works
Food, immunity, and the microbiome
Tilg, H., & Moschen, A. R. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.036 · Cited by 292 · see citing works
West, C. E., Renz, H. E., Jenmalm, M. C., Kozyrskyj, A. L., Allen, K. J., Vuillermin, P., Prescott, S. L., Mackay, C. R., Salminen, S., Wong, G., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.012 · Cited by 281 · see citing works
Self-citationBloomfield, S. F., Rook, G. A. W., Scott, E. A., Shanahan, F., Stanwell-Smith, R., & Turner, P. (2016) · Perspectives in Public Health · doi:10.1177/1757913916650225 · Cited by 274 · see citing works
“[77] [78] [79] Other studies show that the elderly living in the community with healthy diets 78 have higher gut microbiota diversity than those in longstay residential care who have a less diverse diet.”
BackgroundBiomarkers for monitoring intestinal health in poultry: present status and future perspectives
Ducatelle, R., Goossens, E., Meyer, F. D., Eeckhaut, V., Antonissen, G., Haesebrouck, F., & Immerseel, F. V. (2018) · Veterinary Research · doi:10.1186/s13567-018-0538-6 · Cited by 271 · see citing works
“Diet-related, either or not microbiota-derived, metabolites engage the upregulation of metabolite-sensing G-protein-coupled and other receptors on intestinal epithelial cells, as shown in laboratory animals [29].”
BackgroundThe nutrition‐gut microbiome‐physiology axis and allergic diseases
McKenzie, C. I., Tan, J., Macia, L., & Mackay, C. R. (2017) · Immunological Reviews · doi:10.1111/imr.12556 · Cited by 271 · see citing works
Self-citationBeyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology
Rankin, L. C., & Artis, D. (2018) · Cell · doi:10.1016/j.cell.2018.03.013 · Cited by 271 · see citing works
Metabolic and Vascular Effect of the Mediterranean Diet
Tuttolomondo, A., Simonetta, I., Daidone, M., Mogavero, A., Ortello, A., & Pinto, A. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194716 · Cited by 269 · see citing works
“Bacteroidetes (in particular, Bacteroides acidifaciens) have an important role in gut microbiota through the production of high levels of short-chain fatty acids, including acetate, propionate, or butyrate, in fact many experimental animal data suggest that their high levels can discontinue the progress of several inf…”
The Protective Role of Butyrate against Obesity and Obesity-Related Diseases
Coppola, S., Avagliano, C., Calignano, A., & Canani, R. B. (2021) · Molecules · doi:10.3390/molecules26030682 · Cited by 267 · see citing works
Song, Y., Li, J., & Wu, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01952-8 · Cited by 301 · see citing works
Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.29 · Cited by 250 · see citing works
Self-citationThe impact of diet on asthma and allergic diseases
Julia, V., Macia, L., & Dombrowicz, D. (2015) · Nature reviews. Immunology · doi:10.1038/nri3830 · Cited by 253 · see citing works
Self-citationMetabolic regulation of macrophage phenotype and function
Saha, S., Shalova, I. N., & Biswas, S. K. (2017) · Immunological Reviews · doi:10.1111/imr.12603 · Cited by 252 · see citing works
Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk
Ma, N., Guo, P., Zhang, J., He, T., Kim, S. W., Zhang, G., & Ma, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00005 · Cited by 249 · see citing works
“This variety of local metabolites affect on mucosal and systemic immune maturation and are involved in multiple immune signaling pathways with the participation of macrophages, dendritic cells (DCs), T cells, and innate lymphoid cells (ILCs) (110, 111).”
BackgroundEvolution, human-microbe interactions, and life history plasticity
Rook, G., Bäckhed, F., Levin, B. R., McFall-Ngai, M. J., & McLean, A. R. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30566-4 · Cited by 246 · see citing works
“Some microbiota-derived signals (Figure 3), notably those that signal via ‘‘metabolite-sensing’’ G-protein-coupled receptors (GPCR) or by inhibiting histone deacetylase (HDAC) and so driving epigenetic changes, are equally relevant to metabolism and to immunoregulation.((20)) This close link might be due to the large…”
BackgroundKaisar, M. M. M., Pelgrom, L. R., van der Ham, A. J., Yazdanbakhsh, M., & Everts, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01429 · Cited by 245 · see citing works
“Two of the most well-studied mechanisms through which butyrate has been shown to modulate immune cell function are inhibition of HDAC activity and signaling through GPRs (4, 5, 9, 10, 18).”
BackgroundPrebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence
Frei, R., Akdis, M., & O’Mahony, L. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000151 · Cited by 240 · see citing works
“Abnormalities in the production of these metabolites (because of dietary factors and dysbiosis) might play a role in the pathogenesis of type 2 diabetes, obesity, inflammatory bowel disease, colorectal cancer, and allergies [13].”
BackgroundMetabolism meets immunity: The role of free fatty acid receptors in the immune system
Alvarez‐Curto, E., & Milligan, G. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.03.017 · Cited by 240 · see citing works
Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD
Martyniak, A., Medyńska-Przęczek, A., Wędrychowicz, A., Skoczeń, S., & Tomasik, P. (2021) · Biomolecules · doi:10.3390/biom11121903 · Cited by 249 · see citing works
Kidney disease and obesity: epidemiology, mechanisms and treatment
Câmara, N. O. S., Iseki, K., Kramer, H., Liu, Z.-H., & Sharma, K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.191 · Cited by 238 · see citing works
Piazzon, M. C., Calduch-Giner, J. À., Fouz, B., Estensoro, I., Simó‐Mirabet, P., Puyalto, M., Karalazos, V., Palenzuela, O. R., Sitjà‐Bobadilla, A., & Pérez‐Sánchez, J. (2017) · Microbiome · doi:10.1186/s40168-017-0390-3 · Cited by 238 · see citing works
Hosseinkhani, F., Heinken, A., Thiele, I., Lindenburg, P. W., Harms, A. C., & Hankemeier, T. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1882927 · Cited by 244 · see citing works
“Inoculation of SCFAs producing bacteria can increase Bacteroidetes abundances while reducing Firmicutes, and improve balance in the gut bacterial structure.(34) Overall, these data have led to emerging interests in the regulatory function of SCFAs in a wide range of immune cells, including both innate and adaptive cel…”
BackgroundZhang, W., Zou, G.-L., Li, B., Du, X., Sun, Z., Sun, Y., & Jiang, X. (2020) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2002.02044 · Cited by 233 · see citing works
“8 Effects of FMT on SCFA Production SCFAs act as key bacterial metabolites, mainly composed of acetate, propionate and butyrate in the intestine, which are beneficial for human health [58, 59].”
BackgroundChen, L., Sun, M., Wu, W., Yang, W., Huang, X., Xiao, Y., Ma, C., Xu, L., Yao, S., Liu, Z., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz046 · Cited by 231 · see citing works
An exposome perspective: Early-life events and immune development in a changing world
Renz, H., Holt, P. G., Inouye, M., Logan, A. C., Prescott, S. L., & Sly, P. D. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.015 · Cited by 226 · see citing works
Jacobs, J. P., Goudarzi, M., Singh, N., Tong, M., McHardy, I. H., Ruegger, P. M., Asadourian, M., Moon, B., Ayson, A., Borneman, J., et al. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.06.004 · Cited by 230 · see citing works
“Interestingly, 19 of 90 subjects had discordant OTU type and metabotype, suggesting that other factors besides the microbiome such as diet also could influence the metabolome.(49) A strength of this study was that its central finding (a disease-related microbial community type detectable in healthy subjects) also was…”
BackgroundGut Microbiota Metabolism and Interaction with Food Components
Vernocchi, P., CHIERICO, F. D., & Putignani, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103688 · Cited by 236 · see citing works
“Hence, the principal activities of SCFAs are the following [51]: (1) triggering of Foxp3+ T regulatory (Treg) cells and tolerance; (2) induction of IgA secretion from B cells; (3) “competitive exclusion”, due to high-fiber diet that spreads commensal bacteria and limits the access of pathogenic bacteria to the gut epi…”
BackgroundInfluentialLeveraging diet to engineer the gut microbiome
Wolter, M., Grant, E. T., Boudaud, M., Steimle, A., Pereira, G. V., Martens, E. C., & Desai, M. S. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00512-7 · Cited by 211 · see citing works
Bortolin, R. C., de Vargas, A. R., Gasparotto, J., Chaves, P. R., Schnorr, C. E., Martinello, K. B., Silveira, A. K., Rabelo, T. K., Gelain, D. P., & Moreira, J. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.225 · Cited by 219 · see citing works
Ganesan, K., Chung, S. K., Vanamala, J., & Xu, B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123720 · Cited by 221 · see citing works
Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology
Priyadarshini, M., Kumar, K. U., Dudeja, P. K., & Layden, B. T. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170050 · Cited by 272 · see citing works
- Authors
- Thorburn, A. N., Macia, L., & Mackay, C. R.
- Affiliations
- Monash University (AU)
- Corresponding author
- Mackay, Charles R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 40
- Issue
- 6
- Pages
- 833-842
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2008993230
- Cited by
- 879
- References
- 103
- Citations by year
- 2026: 27 · 2025: 32 · 2024: 80 · 2023: 77 · 2022: 83 · 2021: 114 · 2020: 82 · 2019: 88 · 2018: 71 · 2017: 67 · 2016: 77 · 2015: 68 · 2014: 11 · 2013: 1
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- diet, bacterial metabolites, Western lifestyle, inflammatory diseases, hygiene hypothesis, G protein-coupled receptors, GPR43, GPR41, GPR109A, GPR120, GPR35, gut immune homeostasis, regulatory T cells, anti-inflammatory signaling, dietary metabolites, allergy, asthma, autoimmune disease
- MeSH terms
- Autoimmune Diseases, Bacterial Proteins, Diet, Humans, Hypersensitivity, Inflammation, Life Style, Gastrointestinal Tract, Receptors, G-Protein-Coupled, Metabolome, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
