Zhu, Hao

Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation

Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., et al. (2013) · Science

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 638

Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA

Miller, J. B., Zhang, S., Kos, P., Xiong, H., Zhou, K., Perelman, S. S., Zhu, H., & Siegwart, D. J. (2017) · Angewandte Chemie International Edition

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 540

Liver homeostasis is maintained by midlobular zone 2 hepatocytes

Wei, Y., Wang, Y. G., Jia, Y., Li, L., Yoon, J., Zhang, S., Wang, Z., Zhang, Y., Zhu, M., Sharma, T., et al. (2021) · Science

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 292

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

Zhu, M., Lu, T., Jia, Y., Luo, X., Gopal, P., Li, L., Odewole, M., Renteria, V., Singal, A. G., Jang, Y., et al. (2019) · Cell

Liver physiology and pathologyCancer Genomics and Diagnostics

Cited by 250

Enhancing CRISPR/Cas gene editing through modulating cellular mechanical properties for cancer therapy

Zhang, D., Wang, G., Yu, X., Wei, T., Farbiak, L., Johnson, L. T., Taylor, A. M., Xu, J., Hong, Y., Zhu, H., et al. (2022) · Nature Nanotechnology

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 243

Dendrimer‐Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

Cheng, Q., Wei, T., Jia, Y., Farbiak, L., Zhou, K., Zhang, S., Wei, Y., Zhu, H., & Siegwart, D. J. (2018) · Advanced Materials

RNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers

Cited by 221

De novo and salvage purine synthesis pathways across tissues and tumors

Tran, D. H., Kim, D., Kesavan, R., Brown, H., Dey, T., Soflaee, M. H., Vu, H. S., Tasdogan, A., Guo, J., Bezwada, D., et al. (2024) · Cell

Biochemical and Molecular ResearchAdenosine and Purinergic Signaling

Cited by 213

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

Zhang, S., Zhou, K., Luo, X., Li, L., Tu, H.-C., Sehgal, A., Nguyen, L. H., Zhang, Y., Gopal, P., Tarlow, B. D., et al. (2018) · Developmental Cell

Liver physiology and pathologyCancer-related Molecular Pathways

Cited by 180

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration

Sun, X., Chuang, J.-C., Kanchwala, M., Wu, L., Celen, C., Li, L., Liang, H., Zhang, S., Maples, T., Nguyen, L. H., et al. (2016) · Cell Stem Cell

Liver physiology and pathologyChromatin Remodeling and Cancer

Cited by 161

Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment

Celen, C., Chuang, J.-C., Luo, X., Nijem, N., Walker, A. K., Chen, F., Zhang, S., Chung, A. S., Nguyen, L. H., Nassour, I., et al. (2017) · eLife

Genetics and Neurodevelopmental DisordersChromatin Remodeling and Cancer

Cited by 113

Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling

Choi, E., Kikuchi, S., Gao, H., Brodzik, K., Nassour, I., Yopp, A., Singal, A. G., Zhu, H., & Yu, H. (2019) · Nature Communications

Metabolism, Diabetes, and CancerProtein Tyrosine Phosphatases

Cited by 89

SWI/SNF component ARID1A restrains pancreatic neoplasia formation

Wang, S. C., Nassour, I., Xiao, S., Zhang, S., Luo, X., Lee, J., Li, L., Sun, X., Nguyen, L. H., Chuang, J.-C., et al. (2019) · Gut

Pancreatic and Hepatic Oncology ResearchChromatin Remodeling and Cancer

Cited by 85

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

Wang, Z., Zhu, S., Jia, Y., Wang, Y., Kubota, N., Fujiwara, N., Gordillo, R., Lewis, C., Zhu, M., Sharma, T., et al. (2023) · Cell

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 72

In vivo CRISPR screening identifies BAZ2 chromatin remodelers as druggable regulators of mammalian liver regeneration

Jia, Y., Li, L., Lin, Y.-H., Gopal, P., Shen, S., Zhou, K., Yu, X., Sharma, T., Zhang, Y., Siegwart, D. J., et al. (2022) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 59

Disease Etiology and Outcomes After Atezolizumab Plus Bevacizumab in Hepatocellular Carcinoma: Post-Hoc Analysis of IMbrave150

Espinoza, M., Muquith, M., Lim, M., Zhu, H., Singal, A. G., & Hsiehchen, D. (2023) · Gastroenterology

Hepatocellular Carcinoma Treatment and PrognosisCancer Immunotherapy and Biomarkers

Cited by 55

The origins and functions of hepatic polyploidy

Zhang, S., Lin, Y.-H., Tarlow, B., & Zhu, H. (2019) · Cell Cycle

Liver physiology and pathologyChromosomal and Genetic Variations

Cited by 38

IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration

Lin, Y.-H., Wei, Y., Zeng, Q., Wang, Y., Pagani, C. A., Li, L., Zhu, M., Wang, Z., Hsieh, M.-H., Corbitt, N., et al. (2023) · Cell Stem Cell

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 33

Immune Checkpoint Inhibition is Safe and Effective for Liver Cancer Prevention in a Mouse Model of Hepatocellular Carcinoma

Chung, A. S., Mettlen, M., Ganguly, D., Lu, T., Wang, T., Brekken, R. A., Hsiehchen, D., & Zhu, H. (2020) · Cancer Prevention Research

Cancer Immunotherapy and BiomarkersHepatocellular Carcinoma Treatment and Prognosis

Cited by 29

The origin of hepatocellular carcinoma depends on metabolic zonation

Guo, J., Liang, R., Chung, A., Li, Z., Li, B., Chen, E., Li, L., Wang, J., Hsieh, M.-H., Fang, I. X., et al. (2026) · Science

Liver physiology and pathologyCancer Genomics and Diagnostics

Cited by 24

PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer

Zhu, M., Wang, Y., Lu, T., Guo, J., Li, L., Hsieh, M.-H., Gopal, P., Han, Y., Fujiwara, N., Wallace, D. P., et al. (2024) · Cell Metabolism

Liver physiology and pathologyCancer Genomics and Diagnostics

Cited by 9

Somatic mutations in TBX3 promote hepatic clonal expansion by accelerating VLDL secretion

Mannino, G., Quinn, G., Zhu, M., Wang, Z., Wang, X., Li, B., Hsieh, M.-H., Mathews, T., Zacharias, L., Gu, W., et al. (2025) · Journal of Clinical Investigation

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 4