Liver homeostasis is maintained by midlobular zone 2 hepatocytes
Open accessAbstract
Zoning in on liver growth: For organ homeostasis or regrowth after injury or disease, one or more stem cell populations is needed to rebuild lost tissue. There is considerable debate about the source of new cells in the liver. Two groups now identify the source of new hepatocytes (see the Perspective by Andersson). Although the liver may seem to lack major variation across its structure, its lobule is organized into concentric zones where hepatocytes express different metabolic enzymes. Wei et al. sought to systematically define the source of new liver cells by comparing 14 fate-mapping mice that label different liver cell types. They found that different regions of the liver lobule exhibit differences in hepatocyte turnover, with zone 2 representing a primary source of new hepatocytes during homeostasis and regeneration. Similarly, He et al. designed a genetic approach to record cell proliferation in vivo with high spatial and temporal resolution to enable continuous recording of proliferative events of any specific cell type at the whole-cell population level. Using this method, they identified zone 2 as having the highest proliferative activity and contributing the most to liver regrowth. These findings have implications for the cellular basis of chronic disease pathogenesis, cancer development, and regenerative medicine strategies. Science , this issue p. eabb1625 , p. eabc4346 ; see also p. 887
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Clusters were annotated by zone and cell type using known marker genes, including markers for hepatic zones, bile duct cells, Kupffer cells, endothelial cells, hepatic stellate cells, and lymphocytes.
“To annotate clusters by zone and cell type, known marker genes were used (18), including markers for hepatic zones (zone-specific genes), bile duct cells, Kupffer cells, endothelial cells, hepatic stellate cells, and lymphocytes.”
From The origin of hepatocellular carcinoma depends on metabolic zonation (2026) · cites this paper as [18]
In “Zone 2 proliferation is driven by the IGFBP2-mTOR-CCND1 axis” (page unavailable), the paper describes clustering hepatocytes by zone and identifies zone-specific genes. The available passages do not describe using marker genes to annotate clusters of bile duct, Kupffer, endothelial, hepatic stellate, or lymphocyte cells. (LLM, conf=0.86)
Experimental — accuracy not yet measuredKnocking CreERT2 into the endogenous Axin2 locus increases proliferation of hepatocytes due to heterozygous Axin2 deletion.
“Instead, EdU incorporation suggested that knocking CreERT2 into the endogenous Axin2 locus increases proliferation of hepatocytes due to heterozygous Axin2 deletion.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
In “Zone 3 cells near the CV do not repopulate during normal homeostasis” (page unavailable), EdU labeling shows that Axin2-CreER mice had the highest relative proliferation rate in zone 3, unlike the comparison strains. The passage does not establish that hepatocyte proliferation increased overall or that heterozygous Axin2 deletion caused the difference. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSparsely labelled hepatocytes, marked by novel Cre-expressing transgenes from the Hamp2 and Mup3 promoters, also expanded during homeostasis, demonstrating that proliferation is not limited to the high telomerase-expressing population.
“Additionally, sparsely labelled hepatocytes, marked by novel Cre-expressing transgenes from the Hamp2 and Mup3 promoters, also expanded during homeostasis, demonstrating that proliferation is not limited to the high telomerase-expressing population.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
The sections on Hamp2-positive clones and Mup3-CreER tracing report that sparsely labeled hepatocyte clones expanded during homeostasis. However, the section on hepatocytes marked in other ways says Tert-positive cells may overlap with the Hamp2 and Mup3 populations, so these results do not establish that proliferation occurs outside the high-telomerase-expressing population. Page numbers were not available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredInjury to zone 1 by allyl alcohol injection or DDC diet was compensated by proliferation of hepatocytes in zones 2 and 3.
“Additionally, injury to zone 1 by allyl alcohol injection or 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet was compensated by proliferation of hepatocytes in zones 2 and 3.85,86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
In “Midlobular cells contribute to regeneration after chronic biliary and centrilobular injuries” (Fig. 5), the paper reports that zone 1 cell populations contracted during DDC treatment while zone 2 and 3 populations expanded. It does not report an allyl alcohol injection experiment, so that part of the attributed claim is unsupported by this source. (LLM, conf=0.88)
Experimental — accuracy not yet measuredZone 2 hepatocytes labelled by AAV8-TBG-Cre or CreERT2 expressed from the Hamp2 or Mup3 promoters proliferated and clonally expanded.
“Zone 2 hepatocytes labelled by AAV8-TBG-Cre or CreERT2 expressed from the Hamp2 or Mup3 promoters also proliferated and clonally expanded.86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
The sections on Hamp2-positive clones and Mup3-CreER tracing report proliferation and clonal expansion, and the section on other labeling methods reports that expanded AAV-TBG-Cre-labeled clones were predominantly in zone 2. Our copy calls the viral method AAV-TBG-Cre, not AAV8-TBG-Cre, so it does not verify the specified AAV8 serotype. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Hepatocytes traced from the Hamp2 and Mup3 promoters readily gave rise to hepatocyte clusters after CCl4 and DDC injury.
“Additionally, hepatocytes traced from the Hamp2 and Mup3 promoters readily gave rise to hepatocyte clusters after CCl4 and DDC injury.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
In “Midlobular cells contribute to regeneration after chronic biliary and centrilobular injuries” (Fig. 5, M and N), the paper reports significant increases in both traced populations after chronic CCl4 injury. After DDC injury, however, Hamp2-traced cells expanded while Mup3-traced cells contracted significantly (Fig. 5, E to G; fig. S11, A to D). The claim is therefore not supported for Mup3-traced hepatocytes after DDC injury. (LLM, conf=0.90)
Experimental — accuracy not yet measuredRecent studies have demonstrated that hepatocytes are primarily maintained by the proliferation of pre-existing hepatocytes during liver homeostasis and regeneration.
“recent studies have demonstrated that hepatocytes are primarily maintained by the proliferation of pre-existing hepatocytes during liver homeostasis and regeneration14–19”
From Multimodal decoding of human liver regeneration (2024) · cites this paper as [18]
The effect on liver regeneration in Rspo3ΔHSC mice was mediated by RSPO3-dependent regulation of the WNT target CCND1.
“Analysis using qPCR and IHC suggested that this effect was mediated by RSPO3-dependent regulation of the WNT target CCND1 (Fig. 4a and Extended Data Figs. 7a and 10b), a key driver of liver regeneration23,42.”
From Hepatic stellate cells control liver zonation, size and functions via R-spondin 3 (2025) · cites this paper as [42]
Alterations in proliferation and liver injury in Rspo3ΔHSC mice were most pronounced in the hepatic midzone.
“Corresponding to the predominantly midzonal alterations in WNT-target genes as a result of a condensed zone 3 and an expanded zone 1 (Fig. 3i and Extended Data Fig. 8c), the alterations in proliferation and liver injury in Rspo3ΔHSC mice were most pronounced in the hepatic midzone (Fig. 4e and Extended Data Fig. 10b), which is pivotal for hepatocyte regeneration42.”
From Hepatic stellate cells control liver zonation, size and functions via R-spondin 3 (2025) · cites this paper as [42]
Mice with Cre recombinase activity in distinct zonal populations permit induction of HCC mutations in a variety of normal cell types.
“The recent generation of mice with Cre recombinase activity in distinct zonal populations permitted us to induce HCC mutations in a variety of normal cell types (18).”
From The origin of hepatocellular carcinoma depends on metabolic zonation (2026) · cites this paper as [18]
Cyp1a2-CreER mice recombine loci in zones 2 and 3, but more frequently in zone 3.
“Cyp1a2-CreER mice recombine loci in zones 2 and 3, but more frequently in zone 3 (18).”
From The origin of hepatocellular carcinoma depends on metabolic zonation (2026) · cites this paper as [18]
During homeostasis, zone 2 hepatocytes rather than a defined subpopulation seem to have increased proliferative potential.
“During homeostasis, zone 2 hepatocytes rather than a defined subpopulation seem to have increased proliferative potential.”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Hepatocytes do not proliferate equally over time, as results obtained via three independent experimental approaches have led to the same conclusion, namely that zone 2 hepatocytes proliferate more than hepatocytes from the other zones.
“Nevertheless, hepatocytes do not proliferate equally over time, as results obtained via three independent experimental approaches have led to the same conclusion, namely that zone 2 hepatocytes proliferate more than hepatocytes from the other zones.75,86,88”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Hepatocyte proliferation in zone 2 hepatocytes is mediated by the IGFBP2-mTOR-CCND1 axis.
“Hepatocyte proliferation in zone 2 hepatocytes is mediated by the IGFBP2-mTOR-CCND1 axis.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Zone 2 hepatocytes expand during homeostasis, with a corresponding contraction of the areas originally occupied by zone 1 or 3 hepatocytes.
“A comprehensive study using several new mouse transgenic lines to label different portions of the lobule also demonstrated that zone 2 hepatocytes expand during homeostasis, with a corresponding contraction of the areas originally occupied by zone 1 or 3 hepatocytes.86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Alternative zone 3 labelling with other gene promoters also did not show that zone 3 hepatocytes give rise to hepatocytes in other zones during homeostasis.
“Alternative zone 3 labelling with other gene promoters also did not show that zone 3 hepatocytes give rise to hepatocytes in other zones during homeostasis.44,50,86”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [86]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Fast unfolding of communities in large networks
Blondel, V. D., Guillaume, J.-L., Lambiotte, R., & Lefebvre, E. (2008) · Journal of Statistical Mechanics: Theory and Experiment · doi:10.1088/1742-5468/2008/10/p10008 · Cited by 21,424 · see citing works
SCANPY: large-scale single-cell gene expression data analysis
Wolf, F. A., Angerer, P., & Theis, F. J. (2018) · Genome Biology · doi:10.1186/s13059-017-1382-0 · Cited by 8,881 · see citing works
From Louvain to Leiden: guaranteeing well-connected communities
Traag, V. A., Waltman, L., & van Eck, N. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-41695-z · Cited by 5,635 · see citing works
Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors
Haghverdi, L., Lun, A. T. L., Morgan, M. D., & Marioni, J. C. (2018) · Nature Biotechnology · doi:10.1038/nbt.4091 · Cited by 2,416 · see citing works
Epidemiology and Management of Hepatocellular Carcinoma
Kulik, L., & El‐Serag, H. B. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.08.065 · Cited by 1,738 · see citing works
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06318-7 · Cited by 1,552 · see citing works
A human liver cell atlas reveals heterogeneity and epithelial progenitors
Aizarani, N., Saviano, A., Sagar, Mailly, L., Durand, S., Herman, J. S., Pessaux, P., Baumert, T. F., & Grün, D. (2019) · Nature · doi:10.1038/s41586-019-1373-2 · Cited by 1,147 · see citing works
Single-cell spatial reconstruction reveals global division of labour in the mammalian liver
Halpern, K. B., Shenhav, R., Matcovitch-Natan, O., Tóth, B., Lemze, D., Golan, M., Massasa, E. E., Baydatch, S., Landen, S., Moor, A. E., et al. (2017) · Nature · doi:10.1038/nature21065 · Cited by 1,059 · see citing works
Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.722 · Cited by 830 · see citing works
Sadana, P., Geyer, R., Pezoldt, J., Helmsing, S., Huehn, J., Hust, M., Dersch, P., & Scrima, A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001068 · Cited by 723 · see citing works
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
Wang, B., Zhao, L., Fish, M., Logan, C. Y., & Nusse, R. (2015) · Nature · doi:10.1038/nature14863 · Cited by 674 · see citing works
Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration
Raven, A., Lu, W.-Y., Man, T. Y., Ferreira-Gonzalez, S., O’Duibhir, E., Dwyer, B. J., Thomson, J. P., Meehan, R. R., Bogorad, R., Koteliansky, V., et al. (2017) · Nature · doi:10.1038/nature23015 · Cited by 533 · see citing works
Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer
Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M. A., Ye, L., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.026 · Cited by 486 · see citing works
Spatial heterogeneity in the mammalian liver
Ben-Moshe, S., & Itzkovitz, S. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0134-x · Cited by 485 · see citing works
Kopp, J. L., Dubois, C. L., Schaffer, A., Hao, E., Shih, H., Seymour, P. A., Ma, J., & Sander, M. (2011) · Development · doi:10.1242/dev.056499 · Cited by 472 · see citing works
van Amerongen, R., Bowman, A. N., & Nusse, R. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.023 · Cited by 446 · see citing works
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
Malato, Y., Naqvi, S., Schürmann, N., Ng, R., Wang, B., Zape, J., Kay, M. A., Grimm, D., & Willenbring, H. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59261 · Cited by 434 · see citing works
Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation
Yanger, K., Knigin, D., Zong, Y., Maggs, L., Gu, G., Akiyama, H., Pikarsky, E., & Stanger, B. Z. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.003 · Cited by 426 · see citing works
A New Xenobiotic-Induced Mouse Model of Sclerosing Cholangitis and Biliary Fibrosis
Fickert, P., Stöger, U., Fuchsbichler, A., Moustafa, T., Marschall, H., Weiglein, A. H., Tsybrovskyy, O., Jaeschke, H., Zatloukal, K., Denk, H., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.061133 · Cited by 376 · see citing works
The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size
Planas-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3337 · Cited by 359 · see citing works
Zhu, H., Shah, S. P., Shyh‐Chang, N., Shinoda, G., Einhorn, W. S., Viswanathan, S. R., Takeuchi, A., Grasemann, C., Rinn, J. L., Lopez, M. F., et al. (2010) · Nature Genetics · doi:10.1038/ng.593 · Cited by 306 · see citing works
Self-citationIsolation and Culture of Adult Mouse Hepatocytes
Li, W., Ralphs, K. L., & Tosh, D. (2010) · Methods in molecular biology · doi:10.1007/978-1-59745-019-5_13 · Cited by 303 · see citing works
Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes
Deng, X., Zhang, X., Li, W., Feng, R.-X., Li, L., Yi, G.-R., Zhang, X.-N., Yin, C., Yu, H.-Y., Zhang, J.-P., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.022 · Cited by 289 · see citing works
Self-citationSomatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease
Zhu, M., Lu, T., Jia, Y., Luo, X., Gopal, P., Li, L., Odewole, M., Renteria, V., Singal, A. G., Jang, Y., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.026 · Cited by 250 · see citing works
Self-citationDistributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury
Lin, S., Nascimento, E. M., Gajera, C. R., Chen, L., Neuhöfer, P., Garbuzov, A., Wang, S., & Artandi, S. E. (2018) · Nature · doi:10.1038/s41586-018-0004-7 · Cited by 241 · see citing works
Choi, T., Ninov, N., Stainier, D. Y. R., & Shin, D. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.10.019 · Cited by 238 · see citing works
Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration
Chen, F., Jimenez, R. J., Sharma, K., Luu, H. Y., Hsu, B. Y., Ravindranathan, A., Stohr, B. A., & Willenbring, H. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.001 · Cited by 236 · see citing works
Clonal Tracing of Sox9+ Liver Progenitors in Mouse Oval Cell Injury
Tarlow, B., Finegold, M. J., & Grompe, M. (2014) · Hepatology · doi:10.1002/hep.27084 · Cited by 220 · see citing works
Spatial sorting enables comprehensive characterization of liver zonation
Ben-Moshe, S., Shapira, Y., Moor, A. E., Halpern, K. B., & Itzkovitz, S. (2019) · doi:10.1101/529784 · Cited by 205 · see citing works
Spatial sorting enables comprehensive characterization of liver zonation
Ben-Moshe, S., Shapira, Y., Moor, A. E., Manco, R., Veg, T., Bahar Halpern, K., & Itzkovitz, S. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0109-9 · Cited by 205 · see citing works
Means, A. L., Xu, Y., Zhao, A., Ray, K. C., & Gu, G. (2008) · genesis · doi:10.1002/dvg.20397 · Cited by 183 · see citing works
AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration
Sun, T., Pikiolek, M., Orsini, V., Bergling, S., Holwerda, S., Morelli, L., Hoppe, P. S., Planas-Paz, L., Yang, Y., Ruffner, H., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.10.011 · Cited by 166 · see citing works
Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration
Sun, X., Chuang, J.-C., Kanchwala, M., Wu, L., Celen, C., Li, L., Liang, H., Zhang, S., Maples, T., Nguyen, L. H., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.03.001 · Cited by 161 · see citing works
Self-citationMfsd2a+ hepatocytes repopulate the liver during injury and regeneration
Pu, W., Zhang, H., Huang, X., Tian, X., He, L., Wang, Y., Zhang, L., Liu, Q., Li, Y., Li, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms13369 · Cited by 136 · see citing works
Self-citationAng, C. H., Hsu, S. H., Guo, F., Tan, C. T., Yu, V. C., Visvader, J. E., Chow, P. K. H., & Fu, N. Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908099116 · Cited by 102 · see citing works
Bowman, A. N., van Amerongen, R., Palmer, T. D., & Nusse, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305411110 · Cited by 95 · see citing works
Preferential distribution of apoptotic bodies in acinar zone 3 of normal human and rat liver
Benedetti, A., Jézéquel, A. M., & Orlandi, F. (1988) · Journal of Hepatology · doi:10.1016/s0168-8278(88)80004-7 · Cited by 88 · see citing works
Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments
Canver, M. C., Haeussler, M., Bauer, D. E., Orkin, S. H., Sanjana, N. E., Shalem, O., Yuan, G., Zhang, F., Concordet, J., & Pinello, L. (2018) · Nature Protocols · doi:10.1038/nprot.2018.005 · Cited by 87 · see citing works
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
Espeillac, C., Mitchell, C., Celton‐Morizur, S., Chauvin, C., Koka, V., Gillet, C., Albrecht, J. H., Desdouets, C., & Pende, M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44203 · Cited by 80 · see citing works
Self-citationDynamic zonation of liver polyploidy
Tanami, S., Ben-Moshe, S., Elkayam, A., Mayo, A., Bahar Halpern, K., & Itzkovitz, S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2427-5 · Cited by 77 · see citing works
A quantitative evaluation of apoptotic bodies in rat liver
Benedetti, A., Jézéquel, A. M., & Orlandi, F. (1988) · Liver International · doi:10.1111/j.1600-0676.1988.tb00987.x · Cited by 63 · see citing works
Orchestrating Wnt signalling for metabolic liver zonation
Birchmeier, W. (2016) · Nature Cell Biology · doi:10.1038/ncb3349 · Cited by 61 · see citing works
Zonation of Nitrogen and Glucose Metabolism Gene Expression upon Acute Liver Damage in Mouse
Ghafoory, S., Breitkopf‐Heinlein, K., Li, Q., Scholl, C., Dooley, S., & Wölfl, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078262 · Cited by 52 · see citing works
Bergmann, P., Militzer, K., Schmidt, P. F., & Büttner, D. (1995) · Laboratory Animals · doi:10.1258/002367795780740447 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Andrews, T. S., Atif, J., Liu, J. C., Perciani, C. T., Ma, X., Thoeni, C., Slyper, M., Eraslan, G., Segerstolpe, A., Manuel, J., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1854 · Cited by 307 · see citing works
The spatiotemporal program of zonal liver regeneration following acute injury
Ben-Moshe, S., Veg, T., Manco, R., Dan, S., Papinutti, D., Lifshitz, A., Kolodziejczyk, A. A., Bahar Halpern, K., Elinav, E., & Itzkovitz, S. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.04.008 · Cited by 224 · see citing works
The Hippo signaling pathway in development and regeneration
Zhong, Z., Jiao, Z., & Yu, F. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113926 · Cited by 204 · see citing works
Amino acid metabolism, transport and signalling in the liver revisited.
Paulusma, C., Lamers, W., Bröer, S., & van de Graaf, S. V. D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115074 · Cited by 162 · see citing works
Paris, J., & Henderson, N. C. (2022) · Hepatology · doi:10.1002/hep.32408 · Cited by 167 · see citing works
Liver Zonation – Revisiting Old Questions With New Technologies
Cunningham, R. P., & Porat‐Shliom, N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.732929 · Cited by 166 · see citing works
ECM formation and degradation during fibrosis, repair, and regeneration
Mayorca‐Guiliani, A. E., Leeming, D. J., Henriksen, K., Mortensen, J. H., Nielsen, S. H., Anstee, Q. M., Sanyal, A. J., Karsdal, M. A., & Schuppan, D. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00063-4 · Cited by 172 · see citing works
Multimodal decoding of human liver regeneration
Matchett, K. P., Wilson-Kanamori, J. R., Portman, J. R., Kapourani, C. A., Fercoq, F., May, S., Zajdel, E., Beltran, M., Sutherland, E. F., Mackey, J. B. G., et al. (2024) · Nature · doi:10.1038/s41586-024-07376-2 · Cited by 140 · see citing works
“Referee #2 (Remarks to the Author): In this study, Matchett et al aim to shed further lights on the mechanisms of liver regeneration upon Acute Liver Failure (ALF).”
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics
Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133 · see citing works
Self-citationThe Liver–Immunity Nexus and Cancer Immunotherapy
Lee, J. C., Green, M. D., Huppert, L., Chow, C., Pierce, R., & Daud, A. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1193 · Cited by 91 · see citing works
Hu, S., Liu, S., Bian, Y., Poddar, M., Singh, S., Cao, C., McGaughey, J., Bell, A., Blazer, L. L., Adams, J. J., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100754 · Cited by 118 · see citing works
Tuning Interphase Chemistry to Stabilize High‐Voltage LiCoO2Cathode Material via Spinel Coating
Liu, J., Wang, J., Ni, Y., Liu, J., Zhang, Y., Lü, Y., Yan, Z., Zhang, K., Zhao, Q. X., Cheng, F., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202207000 · Cited by 118 · see citing works
Self-citationSpatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology
Martini, T., Naef, F., & Tchorz, J. S. (2023) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-024831 · Cited by 113 · see citing works
Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01068-6 · Cited by 112 · see citing works
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3
Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., et al. (2025) · Nature · doi:10.1038/s41586-025-08677-w · Cited by 110 · see citing works
In vivo partial cellular reprogramming enhances liver plasticity and regeneration
Hishida, T., Yamamoto, M., Hishida, Y., Shao, C., Huang, L., Wang, C., Shojima, K., Xue, Y., Hang, Y., Shokhirev, M. N., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110730 · Cited by 111 · see citing works
Podapangi, S. K., Jafarzadeh, F., Mattiello, S., Korukonda, T. B., Singh, A., Beverina, L., & Brown, T. M. (2023) · RSC Advances · doi:10.1039/d3ra01692g · Cited by 105 · see citing works
Li, Z.-Y., Pai, R., Gupta, S., Currenti, J., Guo, W., Bartolomeo, A. D., Feng, H., Zhang, Z., Li, Z.-Z., Liu, L.-Q., et al. (2024) · Nature Cancer · doi:10.1038/s43018-023-00672-2 · Cited by 109 · see citing works
Spatial metabolomics and its application in the liver
Santos, A. A., Delgado, T. C., Marques, V., Ramírez-Moncayo, C., Alonso, C., Vidal‐Puig, A., Hall, Z., Martínez‐Chantar, M. L., & Rodrigues, C. M. P. (2023) · Hepatology · doi:10.1097/hep.0000000000000341 · Cited by 100 · see citing works
Poss, K. D., & Tanaka, E. M. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.07.007 · Cited by 94 · see citing works
ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation
Sun, T., Annunziato, S., Bergling, S., Sheng, C., Orsini, V., Forcella, P., Pikiolek, M., Kancherla, V., Holwerda, S., Imanci, D., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.05.013 · Cited by 84 · see citing works
Tissue CD14+CD8+T-cells reprogrammed by myeloid cells and modulated by LPS
Pallett, L., Swadling, L., Diniz, M., Maini, A. A., Schwabenland, M., Gasull, A. D., Davies, J., Kucykowicz, S., Skelton, J., Thomas, N., et al. (2023) · Nature · doi:10.1038/s41586-022-05645-6 · Cited by 68 · see citing works
A spatiotemporal atlas of mouse liver homeostasis and regeneration
Xu, J., Guo, P., Hao, S., Shangguan, S., Shi, Q., Volpe, G., Huang, K., Zuo, J., An, J., Yuan, Y., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01709-7 · Cited by 75 · see citing works
Self-citationMapping cellular interactions from spatially resolved transcriptomics data
Zhu, J. J., Wang, Y., Chang, W. Y., Malewska, A., Napolitano, F., Gahan, J. C., Unni, N. G., Zhao, M., Yuan, R., Wu, F., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02408-1 · Cited by 72 · see citing works
Self-citationDiploid hepatocytes drive physiological liver renewal in adult humans
Heinke, P., Rost, F., Rode, J., Trus, P., Simonova, I., Lázár, E., Feddema, J., Welsch, T., Alkass, K., Salehpour, M., et al. (2022) · Cell Systems · doi:10.1016/j.cels.2022.05.001 · Cited by 73 · see citing works
Multi-zonal liver organoids from human pluripotent stem cells
Reza, H. A., Santangelo, C., Iwasawa, K., Reza, A. A., Sekiya, S., Glaser, K., Bondoc, A., Merola, J., & Takebe, T. (2025) · Nature · doi:10.1038/s41586-025-08850-1 · Cited by 71 · see citing works
Harnessing reactive oxygen/nitrogen species and inflammation: Nanodrugs for liver injury
Liu, M., Huang, Q., Zhu, Y., Chen, L., Li, Y., Gong, Z., & Ai, K. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100215 · Cited by 69 · see citing works
Liver regeneration: Cellular origin and molecular mechanisms
Huang, R. C. C., Zhang, X., Gracia‐Sancho, J., & Xie, W. (2022) · Liver International · doi:10.1111/liv.15174 · Cited by 68 · see citing works
The gut–liver axis: host microbiota interactions shape hepatocarcinogenesis
Silveira, M. A. D., Bilodeau, S., Greten, T. F., Wang, X. W., & Trinchieri, G. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.02.009 · Cited by 66 · see citing works
Stabilization of Metastable Halide Perovskite Lattices in the 2D Limit
Fu, Y. (2022) · Advanced Materials · doi:10.1002/adma.202108556 · Cited by 64 · see citing works
Metabolic inflexibility promotes mitochondrial health during liver regeneration
Wang, X., Menezes, C. J., Jia, Y., Xiao, Y., Venigalla, S. S. K., Cai, F., Hsieh, M.-H., Gu, W., Du, L., Sudderth, J., et al. (2024) · Science · doi:10.1126/science.adj4301 · Cited by 64 · see citing works
Self-citationMacrophages harness hepatocyte glutamate to boost liver regeneration
Rigual, M. D. M., Angulo-Aguado, M., Zagorac, S., Álvarez-Díaz, R., Benítez-Mondéjar, M., Yi, F., Martínez-Garay, C., Santos-de-Frutos, K., Kim, E., Campos-Olivas, R., et al. (2025) · Nature · doi:10.1038/s41586-025-08778-6 · Cited by 53 · see citing works
Strain Relaxation for Perovskite Lattice Reconfiguration
Jin, B., Cao, J., Yuan, R., Cai, B., Wu, C., & Zheng, X. (2022) · Advanced Energy and Sustainability Research · doi:10.1002/aesr.202200143 · Cited by 53 · see citing works
Liver macrophages: development, dynamics, and functions
Nusse, Y., & Kubes, P. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01298-3 · Cited by 50 · see citing works
Polyploidy control in hepatic health and disease
Sladky, V. C., Eichin, F., Reiberger, T., & Villunger, A. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.06.030 · Cited by 49 · see citing works
Mueller, M., Hefti, M., Eshmuminov, D., Schuler, M. J., Silva, R. X. S. D., Petrowsky, H., Oliveira, M. L. D., Oberkofler, C. E., Hagedorn, C., Mancina, L., et al. (2021) · Annals of Surgery · doi:10.1097/sla.0000000000005102 · Cited by 50 · see citing works
Zonation in NASH – A key paradigm for understanding pathophysiology and clinical outcomes
Steinman, J. B., Salomao, M. A., & Pajvani, U. B. (2021) · Liver International · doi:10.1111/liv.15025 · Cited by 49 · see citing works
Cellular crosstalk during liver regeneration: unity in diversity
Shu, W., Yang, M., Yang, J., Lin, S., Wei, X., & Xu, X. (2022) · Cell Communication and Signaling · doi:10.1186/s12964-022-00918-z · Cited by 50 · see citing works
Single-cell and spatially resolved transcriptomics for liver biology
Lin, P., Yan, X., Jing, S., Wu, Y., Shan, Y., Guo, W., Gu, J., Li, Y., Zhang, H., & Li, H. (2023) · Hepatology · doi:10.1097/hep.0000000000000387 · Cited by 53 · see citing works
Critical Role of LSEC in Post-Hepatectomy Liver Regeneration and Failure
Rudder, M. D., Dili, A., Stärkel, P., & Leclercq, I. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158053 · Cited by 46 · see citing works
The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease
Annunziato, S., Sun, T., & Tchorz, J. S. (2022) · Hepatology · doi:10.1002/hep.32328 · Cited by 45 · see citing works
Trinh, V. Q.-H., Lee, T.-F., Lemoinne, S., Ray, K. C., Ybanez, M. D., Tsuchida, T., Carter, J. K., Agudo, J., Brown, B. D., Akat, K. M., et al. (2023) · Science Signaling · doi:10.1126/scisignal.adf6696 · Cited by 45 · see citing works
The Role of Liver Zonation in Physiology, Regeneration, and Disease
Panday, R., Monckton, C. P., & Khetani, S. R. (2022) · Seminars in Liver Disease · doi:10.1055/s-0041-1742279 · Cited by 44 · see citing works
Preservation of Mitochondrial Health in Liver Ischemia/Reperfusion Injury
Machado, I. F., Palmeira, C. M., & Rolo, A. P. (2023) · Biomedicines · doi:10.3390/biomedicines11030948 · Cited by 41 · see citing works
Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction
Zhu, L., Shao, C., Chen, H., Chen, Z., & Zhao, Y. (2021) · Research · doi:10.34133/2021/9845679 · Cited by 41 · see citing works
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury.
Wang, S., Wang, X., Shan, Y., Tan, Z., Su, Y., Cao, Y., Wang, S., Dong, J., Gu, J., & Wang, Y. (2024) · Cell Stem Cell · doi:10.1016/j.stem.2024.01.013 · Cited by 40 · see citing works
Self-citationCellular origins of regenerating liver and hepatocellular carcinoma
Holczbauer, Á., Wangensteen, K. J., & Shin, S. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100416 · Cited by 39 · see citing works
A multi-tissue single-cell expression atlas in cattle
Han, B., Li, H., Zheng, W., Zhang, Q., Chen, A., Zhu, S., Shi, T., Wang, F., Zou, D., Yu, S., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02329-5 · Cited by 36 · see citing works
Self-citationIL6 supports long-term expansion of hepatocytes in vitro
Guo, R., Jiang, M., Wang, G., Li, B., Jia, X., Ai, Y., Chen, S., Tang, P., Liu, A., Yuan, Q., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35167-8 · Cited by 36 · see citing works
The evidence-based multifaceted roles of hepatic stellate cells in liver diseases: A concise review
Kim, J., & Kim, Y. J. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122547 · Cited by 39 · see citing works
Lin, Y.-H., Wei, Y., Zeng, Q., Wang, Y., Pagani, C. A., Li, L., Zhu, M., Wang, Z., Hsieh, M.-H., Corbitt, N., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.04.007 · Cited by 33 · see citing works
Self-citationCell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis
Kurosaki, S., Nakagawa, H., Hayata, Y., Kawamura, S., Matsushita, Y., Yamada, T., Uchino, K., Hayakawa, Y., Suzuki, N., Hata, M., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100315 · Cited by 34 · see citing works
Cell metabolism-based therapy for liver fibrosis, repair, and hepatocellular carcinoma
Gilgenkrantz, H., Paradis, V., & Lotersztajn, S. (2023) · Hepatology · doi:10.1097/hep.0000000000000479 · Cited by 32 · see citing works
HNF4α isoforms: the fraternal twin master regulators of liver function
Radi, S. H., Vemuri, K., Martinez-Lomeli, J., & Sladek, F. M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1226173 · Cited by 32 · see citing works
Mitosis of hepatitis B virus-infected cells in vitro results in uninfected daughter cells
Tu, T., Zehnder, B., Wettengel, J. M., Zhang, H., Coulter, S., Ho, V., Douglas, M. W., Protzer, U., George, J., & Urban, S. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100514 · Cited by 32 · see citing works
Distinct hepatocyte identities in liver homeostasis and regeneration
Chen, F., Schönberger, K., & Tchorz, J. S. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100779 · Cited by 30 · see citing works
Single-cell transcriptomics shows dose-dependent disruption of hepatic zonation by TCDD in mice
Nault, R., Saha, S., Bhattacharya, S., Sinha, S., Maiti, T., & Zacharewski, T. R. (2022) · Toxicological Sciences · doi:10.1093/toxsci/kfac109 · Cited by 30 · see citing works
Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model
Xin, J., Yang, T., Wu, X., Wu, Y., Liu, Y. F., Liu, X., Jiang, M., & Gao, W. (2023) · Communications Biology · doi:10.1038/s42003-023-04564-0 · Cited by 29 · see citing works
Recent advances in tissue stem cells
Fu, X., He, Q., Tao, Y., Wang, M., Wang, W., Wang, Y., Yu, Q. C., Zhang, F., Zhang, X., Chen, Y., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2007-8 · Cited by 29 · see citing works
Self-citationOderberg, I. M., & Goessling, W. (2023) · JCI Insight · doi:10.1172/jci.insight.163929 · Cited by 29 · see citing works
Seubnooch, P., Montani, M., Tsouka, S., Claude, E., Rafiqi, U., Perren, A. A., Dufour, J., & Masoodi, M. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100725 · Cited by 29 · see citing works
Direct mechanical exposure initiates hepatocyte proliferation
Li, W., Wu, Y. C., Hu, W., Zhou, J., Shu, X., Zhang, X., Zhang, Z., Wu, H. C., Du, Y. M., Lü, D., et al. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100905 · Cited by 28 · see citing works
Feng, D., Guan, Y.-K., Wang, Y., Maccioni, L., Mackowiak, B., & Gao, B. (2025) · eGastroenterology · doi:10.1136/egastro-2025-100189 · Cited by 29 · see citing works
Self-citationHarnessing orthogonal recombinases to decipher cell fate with enhanced precision
Weng, W., Liu, X., Lui, K. O., & Zhou, B. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.09.007 · Cited by 26 · see citing works
Hepatocyte generation in liver homeostasis, repair, and regeneration
Pu, W., & Zhou, B. (2022) · Cell Regeneration · doi:10.1186/s13619-021-00101-8 · Cited by 25 · see citing works
State-of-the-art advancements in Liver-on-a-chip (LOC): Integrated biosensors for LOC
Liu, M., Xiang, Y., Yang, Y., Long, X., Xiao, Z., Nan, Y., Jiang, Y., Qiu, Y., Huang, Q., & Ai, K. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114758 · Cited by 27 · see citing works
Is liver regeneration key in hepatocellular carcinoma development?
Rigual, M. D. M., Sánchez, P. S., & Djouder, N. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.10.005 · Cited by 27 · see citing works
Roles of Estrogens in the Healthy and Diseased Oviparous Vertebrate Liver
Tramunt, B., Montagner, A., Tan, N. S., Gourdy, P., Rémignon, H., & Wahli, W. (2021) · Metabolites · doi:10.3390/metabo11080502 · Cited by 27 · see citing works
Novel Insights Into the Mechanism of GVHD-Induced Tissue Damage
Ara, T., & Hashimoto, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.713631 · Cited by 26 · see citing works
Cell transplantation-based regenerative medicine in liver diseases
Cardinale, V., Lanthier, N., Baptista, P. M., Carpino, G., Carnevale, G., Orlando, G., Angelico, R., Manzia, T. M., Schuppan, D., Pinzani, M., et al. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.06.005 · Cited by 26 · see citing works
Ruz‐Maldonado, I., González, J. T., Zhang, H., Sun, J., Bort, A., Kabir, I., Kibbey, R. G., Suárez, Y., Greif, D. M., & Fernandez-Hernando, C. F. (2024) · Nature Communications · doi:10.1038/s41467-024-45439-0 · Cited by 26 · see citing works
The origin of hepatocellular carcinoma depends on metabolic zonation
Guo, J., Liang, R., Chung, A., Li, Z., Li, B., Chen, E., Li, L., Wang, J., Hsieh, M.-H., Fang, I. X., et al. (2026) · Science · doi:10.1126/science.adv7129 · Cited by 24 · see citing works
Self-citationSpatial regulation of glucose and lipid metabolism by hepatic insulin signaling
He, B., Copps, K. D., Stöhr, O., Liu, B., Hu, S., Joshi, S., Haigis, M. C., White, M. F., Zhu, H., & Tao, R. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.03.015 · Cited by 25 · see citing works
Self-citationNovel insights into liver homeostasis and regeneration
Michalopoulos, G. K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00454-0 · Cited by 24 · see citing works
Sarkar, A., Jin, Y., DeFelice, B. C., Logan, C. Y., Yang, Y., Anbarchian, T., Wu, P. V., Morri, M., Neff, N. F., Nguyen, H., et al. (2022) · eLife · doi:10.7554/elife.82311 · Cited by 23 · see citing works
Lipid droplet deposition in the regenerating liver: A promoter, inhibitor, or bystander?
Hu, Y., Wang, R., Liu, J., Wang, Y., & Dong, J. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000267 · Cited by 22 · see citing works
Self-citationIn the zone for liver proliferation
Andersson, E. R. (2021) · Science · doi:10.1126/science.abg4864 · Cited by 23 · see citing works
Nagai, H., Nagai, L. A. E., Tasaki, S., Nakato, R., Umetsu, D., Kuranaga, E., Miura, M., & Nakajima, Y.-I. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.08.022 · Cited by 22 · see citing works
Kakazu, E., Mino, M., & Kanto, T. (2025) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2025.0048 · Cited by 22 · see citing works
Decoding liver fibrogenesis with single-cell technologies
Zhou, T., Musunuru, K., Lui, K. O., & Ding, Q. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac040 · Cited by 21 · see citing works
Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applications
Jiang, M., Ren, J., Belmonte, J. C. I., & Liu, G. (2023) · FEBS Journal · doi:10.1111/febs.16930 · Cited by 20 · see citing works
FoxO3 restricts liver regeneration by suppressing the proliferation of hepatocytes
Liang, C.-Q., Zhou, D., Peng, W., Chen, W.-Y., Wu, H., Zhou, Y.-M., Gu, W., Park, K., Zhao, H., Pi, L., et al. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00227-6 · Cited by 18 · see citing works
Highly stable bismuth-chloride perovskite X-ray direct detectors with an ultralow detection limit
Chen, H., Han, Q., Qin, H., Shen, Y., Lv, H., Liu, Y., Du, L., Wang, Y., He, Y., & Ning, W. (2025) · Chemical Science · doi:10.1039/d5sc00061k · Cited by 19 · see citing works
Self-citationCabanes‐Creus, M., Navarro, R. G., Liao, S. H. Y., Scott, S., Carlessi, R., Roca-Pinilla, R., Knight, M., Baltazar, G., Zhu, E., Jones, M., et al. (2023) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2022.12.014 · Cited by 19 · see citing works
Li, S., Li, C., Khan, M. I., Liu, J., Shi, Z., Gao, D. Y., Qiu, B., & Ding, W. (2023) · Microsystems & Nanoengineering · doi:10.1038/s41378-023-00544-w · Cited by 19 · see citing works
Zonation, Zonation, Zonation: The Real Estate of the Liver
Yasaka, T. M., Kim, C., Meadows, V., & Monga, S. P. (2025) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-042624-091820 · Cited by 21 · see citing works
Akiyama, S., Saku, N., Miyata, S., Ite, K., Toyoda, M., Kimura, T., Kuroda, M., Nakazawa, A., Kasahara, M., Nonaka, H., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02776-5 · Cited by 18 · see citing works
Zhang, S., Zatulovskiy, E. A., Arand, J., Sage, J., & Skotheim, J. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.965595 · Cited by 18 · see citing works
Self-citationMultiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver
Huppert, S. S., & Schwartz, R. E. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-032822-094134 · Cited by 19 · see citing works
A statistical method for quantifying progenitor cells reveals incipient cell fate commitments
Deng, S., Gong, H., Zhang, D., Zhang, M., & He, X. (2024) · Nature Methods · doi:10.1038/s41592-024-02189-7 · Cited by 19 · see citing works
ScRNA-seq and ST-seq in liver research
He, J., Deng, C., Krall, L., & Shan, Z. (2023) · Cell Regeneration · doi:10.1186/s13619-022-00152-5 · Cited by 17 · see citing works
Okada, J., Landgraf, A., Xiaoli, A. M., Liu, L. P., Horton, M., Schuster, V. L., Yang, F., Sidoli, S., Qiu, Y., Kurland, I. J., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01269-y · Cited by 16 · see citing works
Iwasawa, K., & Takebe, T. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.06.007 · Cited by 16 · see citing works
Compartmentalization, cooperation, and communication: The 3Cs of Hepatocyte zonation
Porat‐Shliom, N. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102292 · Cited by 16 · see citing works
Relationships Between Regeneration, Wound Healing, and Cancer
Maggiore, G., & Zhu, H. (2023) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-062822-123558 · Cited by 16 · see citing works
Self-citationPlata-Gómez, A. B., de Prado-Rivas, L., Sanz, A., Deleyto-Seldas, N., García, F., de la Calle Arregui, C., Silva, C., Caleiras, E., Graña-Castro, O., Piñeiro-Yáñez, E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46032-1 · Cited by 16 · see citing works
Tissue regeneration: Unraveling strategies for resolving pathological fibrosis
Li, J., Wang, S., Yuan, J., Mao, X., Wang, X., Zhang, L., Dong, Q., Chen, Z., Wang, Y., & Tang, N. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.10.002 · Cited by 16 · see citing works
Self-citationEmerging and potential use of CRISPR in human liver disease
Adlat, S., Vázquez-Salgado, A. M., Lee, M., Yin, D., & Wangensteen, K. J. (2023) · Hepatology · doi:10.1097/hep.0000000000000578 · Cited by 17 · see citing works
Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing
He, S., Guo, Z., Zhou, M., Wang, H., Zhang, Z., Shi, M., Li, X., Yang, X., & He, L. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.002 · Cited by 15 · see citing works
Yi, B., Pan, J., Yang, Z., Zhu, Z., Sun, Y., Guo, T., & Zhao, Z. (2024) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2024.101958 · Cited by 15 · see citing works
- Authors
- Wei, Y., Wang, Y. G., Jia, Y., Li, L., Yoon, J., Zhang, S., Wang, Z., Zhang, Y., Zhu, M., Sharma, T., Lin, Y.-H., Hsieh, M.-H., Albrecht, J. H., Le, P. T., Rosen, C. J., Wang, T., & Zhu, H.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- University of Minnesota (US)
- Maine Medical Center (US)
- Corresponding author
- Zhu, Hao
- ORCID
- Venue
- Science
- Published
- 2021-02-26
- Volume
- 371
- Issue
- 6532
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC8496420
- OpenAlex
- W3132549301
- Cited by
- 292
- References
- 43
- Citations by year
- 2026: 37 · 2025: 60 · 2024: 39 · 2023: 73 · 2022: 53 · 2021: 30
- FWCI
- 27.13
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01 CA251928)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK111588)
- National Institute of Environmental Health Sciences (R03ES026397-01)
- Burroughs Wellcome Fund
- Cancer Prevention and Research Institute of Texas (RP150596, RP190208)
- Stand Up To Cancer (SU2C-AACR-IRG 10-16)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- liver homeostasis, hepatocyte proliferation, liver regeneration, hepatocyte turnover, fate mapping, cell proliferation imaging, liver stem cells
- MeSH terms
- Animals, Biliary Tract, Biliary Tract Diseases, Homeostasis, Liver, Liver Regeneration, Insulin-Like Growth Factor Binding Protein 2, Cyclin D1, Hepatocytes, Cell Proliferation, Mice, Gene Knock-In Techniques, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
