Fritsche, Ellen

Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation

Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences

Toxic Organic Pollutants ImpactSkin Protection and Aging

Cited by 437

The hallmarks of fibroblast ageing

Tigges, J., Krutmann, J., Fritsche, E., Haendeler, J., Schaal, H., Fischer, J. W., Kalfalah, F., Reinke, H., Reifenberger, G., Stühler, K., et al. (2014) · Mechanisms of Ageing and Development

Telomeres, Telomerase, and SenescenceSkin Protection and Aging

Cited by 250

Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

Waldera Lupa, D. M., Kalfalah, F., Safferling, K., Boukamp, P., Poschmann, G., Volpi, E., Götz-Rösch, C., Bernerd, F., Haag, L., Huebenthal, U., et al. (2015) · Journal of Investigative Dermatology

Telomeres, Telomerase, and SenescenceSkin Protection and Aging

Cited by 224

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Fritsche, E., Grandjean, P., Crofton, K. M., Aschner, M., Goldberg, A., Heinonen, T., Hessel, E. V. S., Hogberg, H. T., Bennekou, S. H., Lein, P. J., et al. (2018) · Toxicology and Applied Pharmacology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 124

OECD/EFSA workshop on developmental neurotoxicity (DNT): the use of non-animal test methods for regulatory purposes

Fritsche, E. (2017) · ALTEX

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 118

Putative adverse outcome pathways relevant to neurotoxicity

Bal-Price, A., Crofton, K. M., Sachana, M., Shafer, T. J., Behl, M., Forsby, A., Hargreaves, A., Landesmann, B., Lein, P. J., Louisse, J., et al. (2015) · Critical Reviews in Toxicology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 114

Establishment of an a priori protocol for the implementation and interpretation of an in-vitro testing battery for the assessment of developmental neurotoxicity

Masjosthusmann, S., Blum, J., Bartmann, K., Dolde, X., Holzer, A., Stürzl, L., Keßel, E. H., Förster, N., Dönmez, A., Klose, J., et al. (2020) · EFSA Supporting Publications

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 110

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals

Blum, J., Masjosthusmann, S., Bartmann, K., Bendt, F., Dolde, X., Dönmez, A., Förster, N., Holzer, A.-K., Hübenthal, U., Keßel, H. E., et al. (2023) · Chemosphere

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 105

Role of the aryl hydrocarbon receptor in tobacco smoke extract–induced matrix metalloproteinase‐1 expression

Ono, Y., Torii, K., Fritsche, E., Shintani, Y., Nishida, E., Nakamura, M., Shirakata, Y., Haarmann‐Stemmann, T., Abel, J., Krutmann, J., et al. (2013) · Experimental Dermatology

Skin Protection and AgingToxic Organic Pollutants Impact

Cited by 87

Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events

Baumann, J., Gassmann, K., Masjosthusmann, S., DeBoer, D., Bendt, F., Giersiefer, S., & Fritsche, E. (2016) · Archives of Toxicology

Animal testing and alternativesNeurogenesis and neuroplasticity mechanisms

Cited by 85

The AhR–Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention?

Haarmann-Stemmann, T., Abel, J., Fritsche, E., & Krutmann, J. (2012) · Journal of Investigative Dermatology

Genomics, phytochemicals, and oxidative stressDermatology and Skin Diseases

Cited by 85

https://www.altex.org/index.php/altex/article/view/1339

Krebs, A., Waldmann, T., Wilks, M. F., van Vugt-Lussenburg, B. M. A., van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., et al. (2019) · ALTEX

Animal testing and alternativesAgricultural safety and regulations

Cited by 77

miR-23a-3p Causes Cellular Senescence by Targeting Hyaluronan Synthase 2: Possible Implication for Skin Aging

Röck, K., Tigges, J., Sass, S., Schütze, A., Florea, A.-M., Fender, A. C., Theis, F. J., Krutmann, J., Boege, F., Fritsche, E., et al. (2015) · Journal of Investigative Dermatology

Telomeres, Telomerase, and SenescenceMicroRNA in disease regulation

Cited by 72

Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery

Klose, J., Pahl, M., Bartmann, K., Bendt, F., Blum, J., Dolde, X., Förster, N., Holzer, A.-K., Hübenthal, U., Keßel, H. E., et al. (2022) · Cell Biology and Toxicology

Toxic Organic Pollutants ImpactFlame retardant materials and properties

Cited by 58

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Tal, T., Myhre, O., Fritsche, E., Rüegg, J., Craenen, K., Aiello-Holden, K., Agrillo, C., Babin, P. J., Escher, B. I., Dirven, H., et al. (2024) · Frontiers in Toxicology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 58

Evidence for a novel anti-apoptotic pathway in human keratinocytes involving the aryl hydrocarbon receptor, E2F1, and checkpoint kinase 1

Frauenstein, K., Sydlik, U., Tigges, J., Majora, M., Wiek, C., Hanenberg, H., Abel, J., Esser, C., Fritsche, E., Krutmann, J., et al. (2013) · Cell Death & Differentiation

Skin Protection and AgingCell death mechanisms and regulation

Cited by 56

Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation

Koch, K., Bartmann, K., Hartmann, J., Kapr, J., Klose, J., Kuchovská, E., Pahl, M., Schlüppmann, K., Zühr, E., & Fritsche, E. (2022) · Frontiers in Toxicology

Animal testing and alternativesNeurogenesis and neuroplasticity mechanisms

Cited by 48

Molecular and functional characterization of different BrainSphere models for use in neurotoxicity testing on microelectrode arrays

Hartmann, J., Henschel, N., Bartmann, K., Dönmez, A., Brockerhoff, G., Koch, K., & Fritsche, E. (2023) · Cells

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 31