miR-23a-3p Causes Cellular Senescence by Targeting Hyaluronan Synthase 2: Possible Implication for Skin Aging

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 2× · see citing works

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330 · see citing works

Hyaluronan: from extracellular glue to pericellular cue

Toole, B. P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1391 · Cited by 2,125 · see citing works

Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells,

Stenderup, K. (2003) · Bone · doi:10.1016/j.bone.2003.07.005 · Cited by 1,207 · see citing works

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works

Hyaluronic acid: A key molecule in skin aging

Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012) · Dermato-Endocrinology · doi:10.4161/derm.21923 · Cited by 1,031 · see citing works

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

Tian, X., Azpurua, J., Hine, C., Vaidya, A. M., Myakishev-Rempel, M., Ablaeva, J., Mao, Z., Nevo, E., Gorbunova, V. A., & Seluanov, A. (2013) · Nature · doi:10.1038/nature12234 · Cited by 786 · see citing works

The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

Jia, K., Chen, D., & Riddle, D. L. (2004) · Development · doi:10.1242/dev.01255 · Cited by 705 · see citing works

The relationship between in vitro cellular aging and in vivo human age.

Schneider, E. L., & Mitsui, Y. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.10.3584 · Cited by 569 · see citing works

Molecular mechanisms of skin ageing

Jenkins, G. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00425-0 · Cited by 559 · see citing works

Hyaluronan-Cell Interactions in Cancer and Vascular Disease

Toole, B. P., Wight, T. N., & Tammi, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100039200 · Cited by 491 · see citing works

Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells

Evanko, S. P., Angello, J. C., & Wight, T. N. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.1004 · Cited by 487 · see citing works

Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

Wagner, W., Bork, S., Horn, P., Krunic, D., Walenda, T., Diehlmann, A., Beneš, V., Blake, J., Huber, F.-X., Eckstein, V., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005846 · Cited by 480 · see citing works

The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila

Liu, N., Landreh, M., Cao, K., Abe, M., Hendriks, G., Kennerdell, J. R., Zhu, Y., Wang, L., & Bonini, N. M. (2012) · Nature · doi:10.1038/nature10810 · Cited by 394 · see citing works

Reciprocal Regulation of MicroRNA-1 and Insulin-Like Growth Factor-1 Signal Transduction Cascade in Cardiac and Skeletal Muscle in Physiological and Pathological Conditions

Elia, L., Contu, R., Quintavalle, M., Varrone, F., Chimenti, C., Russo, M. A., Cimino, V., Marinis, L. D., Frustaci, A., Catalucci, D., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.879429 · Cited by 394 · see citing works

miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging

Hackl, M., Brunner, S. M., Fortschegger, K., Schreiner, C., Mičutková, L., Mück, C., Laschober, G. T., Lepperdinger, G., Sampson, N., Berger, P., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00549.x · Cited by 356 · see citing works

Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids

Drummond, M. J., McCarthy, J. J., Fry, C. S., Esser, K. A., & Rasmussen, B. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90562.2008 · Cited by 256 · see citing works

Hyaluronan in skin: aspects of aging and its pharmacologic modulation

Stern, R., & Maibach, H. I. (2008) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2007.09.013 · Cited by 254 · see citing works

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging

Dumble, M. L., Moore, L. M., Chambers, S. M., Geiger, H., Zant, G. E. V., Goodell, M. A., & Donehower, L. A. (2006) · Blood · doi:10.1182/blood-2006-03-010413 · Cited by 241 · see citing works

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

Kennedy, A. L., Morton, J. P., Manoharan, I., Nelson, D. M., Jamieson, N. B., Pawlikowski, J. S., McBryan, T., Doyle, B., McKay, C., Oien, K. A., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.020 · Cited by 213 · see citing works

p63–microRNA feedback in keratinocyte senescence

Cervo, P. R. D. V., Lena, A. M., Nicoloso, M. S., Rossi, S., Mancini, M., Zhou, H., Saintigny, G., Dellambra, E., Odorisio, T., Mahé, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112257109 · Cited by 181 · see citing works

Differential Regulation of Hyaluronan Metabolism in the Epidermal and Dermal Compartments of Human Skin by UVB Irradiation

Averbeck, M., Gebhardt, C., Voigt, S., et al. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700614 · Cited by 171 · see citing works

Chronic Ultraviolet B Irradiation Causes Loss of Hyaluronic Acid from Mouse Dermis Because of Down-Regulation of Hyaluronic Acid Synthases

Dai, G., Freudenberger, T., Zipper, P., Melchior, A., Grether‐Beck, S., Rabausch, B., de Groot, J., Twarock, S., Hanenberg, H., Homey, B., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070136 · Cited by 162 · see citing works

Inhibition of PI3K Prevents the Proliferation and Differentiation of Human Lung Fibroblasts into Myofibroblasts: The Role of Class I P110 Isoforms

Conte, E., Fruciano, M., Fagone, E., Gili, E., Caraci, F., Iemmolo, M., Crimi, N., & Vancheri, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024663 · Cited by 161 · see citing works

Inhibition of Hyaluronan Synthesis Accelerates Murine Atherosclerosis

Nagy, N., Freudenberger, T., Melchior‐Becker, A., Roeck, K., ter Braak, M., Jastrow, H., Kinzig, M., Lucke, S., Suvorava, T., Kojda, G., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.972653 · Cited by 151 · see citing works

Stepwise up‐regulation of MicroRNA expression levels from replicating to reversible and irreversible growth arrest states in WI‐38 human fibroblasts

Maes, O. C., Sarojini, H., & Wang, E. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21834 · Cited by 124 · see citing works

Human Skin Aging Is Associated with Reduced Expression of the Stem Cell Markers β1 Integrin and MCSP

Giangreco, A., Goldie, S. J., Failla, V., Saintigny, G., & Watt, F. M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.297 · Cited by 123 · see citing works

High levels of oncomi R ‐21 contribute to the senescence‐induced growth arrest in normal human cells and its knock‐down increases the replicative lifespan

Dellago, H., Preschitz‐Kammerhofer, B., Terlecki‐Ζaniewicz, L., Schreiner, C., Fortschegger, K., Chang, M. W. ‐., Hackl, M., Monteforte, R., Kühnel, H., Schosserer, M., et al. (2013) · Aging Cell · doi:10.1111/acel.12069 · Cited by 117 · see citing works

Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes

Tzellos, T., Klagas, I., Vahtsevanos, K., Triaridis, S., Printza, A., Kyrgidis, Α., Karakiulakis, G., Zouboulis, C. C., & Papakonstantinou, E. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00889.x · Cited by 116 · see citing works

MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging

Bates, D. J., Li, N., Liang, R., Sarojini, H., An, J., Masternak, M. M., Bartke, A., & Wang, E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00529.x · Cited by 97 · see citing works

Collagen Fragments Inhibit Hyaluronan Synthesis in Skin Fibroblasts in Response to Ultraviolet B (UVB)

Roeck, K., Grandoch, M., Majora, M., Krutmann, J., & Fischer, J. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.201665 · Cited by 90 · see citing works

MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extra-cellular matrix

Mancini, M., Saintigny, G., Mahé, C., Annicchiarico‐Petruzzelli, M., Melino, G., & Candi, E. (2012) · Aging · doi:10.18632/aging.100508 · Cited by 86 · see citing works

Hyaluronan Metabolism in Human Keratinocytes and Atopic Dermatitis Skin Is Driven by a Balance of Hyaluronan Synthases 1 and 3

Malaisse, J., Bourguignon, V., Vuyst, É. D., de Rouvroit, C. L., Nikkels, A., Flamion, B., & Poumay, Y. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.147 · Cited by 82 · see citing works

Aging Fibroblasts Resist Phenotypic Maturation Because of Impaired Hyaluronan-Dependent CD44/Epidermal Growth Factor Receptor Signaling

Simpson, R., Wells, A. H., Thomas, D. W., Stephens, P., Steadman, R., & Phillips, A. O. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090802 · Cited by 79 · see citing works

Acidic glycosaminoglycans in human skin during fetal development and adult life

Breen, M., WEINSTEIN, H. G., Johnson, R. L., et al. (1970) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(70)90009-7 · Cited by 70 · see citing works

MicroRNA (miRNA)-mediated Interaction between Leukemia/Lymphoma-related Factor (LRF) and Alternative Splicing Factor/Splicing Factor 2 (ASF/SF2) Affects Mouse Embryonic Fibroblast Senescence and Apoptosis

Verduci, L., Simili, M., Rizzo, M., Mercatanti, A., Evangelista, M., Mariani, L., Rainaldi, G., & Pitto, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.114736 · Cited by 58 · see citing works

Regulation of Senescence in Cancer and Aging

Kong, Y., Cui, H., Ramkumar, C., & Zhang, H. (2011) · Journal of Aging Research · doi:10.4061/2011/963172 · Cited by 55 · see citing works

Versican/PG-M Assembles Hyaluronan into Extracellular Matrix and Inhibits CD44-mediated Signaling toward Premature Senescence in Embryonic Fibroblasts

Suwan, K., Choocheep, K., Hatano, S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806927200 · Cited by 52 · see citing works

Aryl Hydrocarbon Receptor Repressor (AhRR) Function Revisited: Repression of CYP1 Activity in Human Skin Fibroblasts Is Not Related to AhRR Expression

Tigges, J., Weighardt, H., Wolff, S., Götz, C., Förster, I., Kohne, Z., Hübenthal, U., Merk, H. F., Abel, J., Haarmann‐Stemmann, T., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.259 · Cited by 50 · see citing works

FOXA1 mediates p16INK4a activation during cellular senescence

Li, Q., Zhang, Y., Fu, J., Han, L., Xue, L., Lv, C., Wang, P., Li, G., & Tong, T. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.35 · Cited by 49 · see citing works

Fighting against Skin Aging: The Way from Bench to Bedside

Zhang, S., & Duan, E. (2018) · Cell Transplantation · doi:10.1177/0963689717725755 · Cited by 739 · see citing works

Diet and Skin Aging—From the Perspective of Food Nutrition

Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works

Boosting the Photoaged Skin: The Potential Role of Dietary Components

Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116 · see citing works

MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence

Zhang, J.-A., Zhou, B.-R., Xu, Y., Chen, X., Liu, J., Gozali, M., Wu, D., Yin, Z.-Q., & Luo, D. (2016) · Oncotarget · doi:10.18632/oncotarget.9357 · Cited by 53 · see citing works

Molecular Mechanisms to Target Cellular Senescence in Aging and Disease

Marcozzi, S., Beltrami, A. P., & Malavolta, M. (2022) · Cells · doi:10.3390/cells11233732 · Cited by 20 · see citing works

Faculty Opinions recommendation of Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts.

Avvedimento, E., & Moroncini, G. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.12523956.13748058

Cellular responses to telomere shortening: cellular senescence as a tumor suppressor mechanism.

Greider, C. W. (2002) · PubMed · Cited by 20 · see citing works

From cellular senescence towards age-related macular degeneration: the role of telomeres

Moshetova, L. K., Abramova, O. I., Turkina, K. I., Dmitrenko, O., & Karpova, N. S. (2020) · Russian Journal of Clinical Ophthalmology · doi:10.32364/2311-7729-2020-20-3-148-151 · Cited by 1 · see citing works

Cellular lifespan and senescence: a complex balance between multiple cellular pathways

Dolivo, D., Hernandez, S. J., & Dominko, T. (2016) · BioEssays · doi:10.1002/bies.201670906 · Cited by 27 · see citing works