The hallmarks of fibroblast ageing

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075 · see citing works

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · see citing works

Telomeres shorten during ageing of human fibroblasts

Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works

The senescence-associated secretory phenotype: the dark side of tumor suppression

Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · cited 1× · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Mitochondria, Oxidants, and Aging

Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388 · see citing works

Frailty Consensus: A Call to Action

Morley, J. E., Vellas, B. J., van Kan, G. A., Anker, S. D., Bauer, J. M., Bernabei, R., Cesari, M., Chumlea, W. C., Doehner, W., Evans, J., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.03.022 · Cited by 4,078 · see citing works

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 4× · see citing works

Molecular chaperones in protein folding and proteostasis

Hartl, F. U., Bracher, A., & Hayer-Hartl, M. K. (2011) · Nature · doi:10.1038/nature10317 · Cited by 3,525 · see citing works

Mitochondria: In Sickness and in Health

Nunnari, J., & Suomalainen, A. (2012) · Cell · doi:10.1016/j.cell.2012.02.035 · Cited by 3,479 · see citing works

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · cited 3× · see citing works

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · cited 3× · see citing works

DNA damage, aging, and Cancer

Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

Understanding the odd science of aging

Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

Chen, H., & Chan, D. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp326 · Cited by 1,455 · see citing works

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427 · see citing works

Molecular basis of sun-induced premature skin ageing and retinoid antagonism

Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410 · see citing works

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402 · see citing works

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works

Functions and dysfunctions of mitochondrial dynamics

Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369 · see citing works

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

Herbig, U., Jobling, W. A., Chen, B. P. C., Chen, D. J., & Sedivy, J. M. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00256-4 · Cited by 1,344 · see citing works

Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

Lemasters, J. J. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.3 · Cited by 1,342 · see citing works

The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo

Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,256 · see citing works

Lamin A-Dependent Nuclear Defects in Human Aging

Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,224 · see citing works

Circadian Control of the NAD ⁺ Salvage Pathway by CLOCK-SIRT1

Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198 · see citing works

Fusion and fission: interlinked processes critical for mitochondrial health

Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196 · see citing works

Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

Kondratov, R. V., Kondratova, A. A., Gorbacheva, V. Y., Vykhovanets, O. V., & Antoch, M. P. (2006) · Genes & Development · doi:10.1101/gad.1432206 · Cited by 1,188 · see citing works

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

Ramsey, K. M., Yoshino, J., Brace, C. S., Abrassart, D., Kobayashi, Y., Marcheva, B., Hong, H.-K., Chong, J. L., Buhr, E. D., Lee, C., et al. (2009) · Science · doi:10.1126/science.1171641 · Cited by 1,126 · see citing works

Rates of Behavior and Aging Specified by Mitochondrial Function During Development

Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121 · see citing works

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

Goldman, R. D., Shumaker, D. K., Erdos, M. R., Eriksson, M., Goldman, A. E., Gordon, L. B., Gruenbaum, Y., Khuon, S., Mendez, M., Varga, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402943101 · Cited by 1,103 · see citing works

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · cited 1× · see citing works

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Passos, J. F., Nelson, G., Wang, C., Richter, T., Simillion, C., Proctor, C. J., Miwa, S., Olijslagers, S., Hallinan, J., Wipat, A., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.5 · Cited by 1,019 · see citing works

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998 · see citing works

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., et al. (2009) · Science · doi:10.1126/science.1172156 · Cited by 958 · see citing works

Mitochondrial Dynamics in Mammalian Health and Disease

Liesa, M., Palacín, M., & Zorzano, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00030.2008 · Cited by 953 · see citing works

DNA Repair, Genome Stability, and Aging

Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944 · see citing works

Temperature as a Universal Resetting Cue for Mammalian Circadian Oscillators

Buhr, E. D., Yoo, S.-H., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195262 · Cited by 917 · see citing works

Mitochondrial Signaling

Butow, R. A., & Avadhani, N. G. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00179-0 · Cited by 882 · see citing works

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

Fumagalli, M., Rossiello, F., Clerici, M., Barozzi, S., Cittaro, D., Kaplunov, J. M., Bucci, G., Dobreva, M., Matti, V., Beausejour, C. M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2466 · Cited by 851 · see citing works

Autophagy and aging: The importance of maintaining "clean" cells

Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792 · see citing works

Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

Shumaker, D. K., Dechat, T., Kohlmaier, A., Adam, S. A., Bozovsky, M. R., Erdos, M. R., Eriksson, M., Goldman, A. E., Khuon, S., Collins, F. S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602569103 · Cited by 791 · see citing works

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., & Barrett, J. C. (2004) · Nature Cell Biology · doi:10.1038/ncb1095 · Cited by 790 · see citing works

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789 · see citing works

A senescent cell bystander effect: senescence‐induced senescence

Nelson, G., Wordsworth, J., Wang, C., Jurk, D., Lawless, C., Martin‐Ruiz, C., & von Zglinicki, T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00795.x · Cited by 755 · see citing works

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

Satoh, A., Brace, C. S., Rensing, N., Cliften, P. F., Wozniak, D. F., Herzog, E. D., Yamada, K. A., & Imai, S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.013 · Cited by 734 · see citing works

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731 · see citing works

Extending life span by increasing oxidative stress

Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 718 · see citing works

Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes

Toussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713 · see citing works

Health in a 24-h society

Rajaratnam, S. M., & Arendt, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06108-6 · Cited by 711 · see citing works

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

Mao, Z., Bozzella, M. J., Seluanov, A., & Gorbunova, V. A. (2008) · Cell Cycle · doi:10.4161/cc.7.18.6679 · Cited by 695 · see citing works

Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Peek, C. B., Affinati, A. H., Ramsey, K. M., Kuo, H.-Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., et al. (2013) · Science · doi:10.1126/science.1243417 · Cited by 658 · see citing works

Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation

Parrinello, S., Coppe, J.-P., Krtolica, A., & Campisi, J. (2005) · Journal of Cell Science · doi:10.1242/jcs.01635 · Cited by 631 · see citing works

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

Chang, H.-C., & Guarente, L. (2013) · Cell · doi:10.1016/j.cell.2013.05.027 · Cited by 615 · see citing works

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

Morselli, E., Maiuri, M. C., Markaki, M., Megalou, E., Pasparaki, A., Palikaras, K., Criollo, A., Galluzzi, L., Malik, S. A., Vitale, I., et al. (2010) · Cell Death & Disease · doi:10.1038/cddis.2009.8 · Cited by 613 · see citing works

Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response

Jurk, D., Wang, C., Miwa, S., Maddick, M., Korolchuk, V., Tsolou, A., Gonos, E. S., Thrasivoulou, C., Jill Saffrey, M., Cameron, K., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00870.x · Cited by 598 · see citing works

Detectable clonal mosaicism and its relationship to aging and cancer

Jacobs, K. B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M.-J., et al. (2012) · Nature Genetics · doi:10.1038/ng.2270 · Cited by 589 · see citing works

E2F target genes: unraveling the biology

Bracken, A. P., Cirò, M., Cocito, A., & Helin, K. (2004) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2004.06.006 · Cited by 583 · see citing works

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works

p16 ^INK4A is a robust <i>in vivo</i> biomarker of cellular aging in human skin

Ressler, S., Bartkova, J., Niederegger, H., Bartek, J., Scharffetter‐Kochanek, K., Jansen‐Dürr, P., & Wlaschek, M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00231.x · Cited by 557 · see citing works

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

Trifunovic, A., Hansson, A., Wredenberg, A., Rovio, A. T., Dufour, E., Khvorostov, I., Spelbrink, J. N., Wibom, R., Jacobs, H. T., & Larsson, N.-G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508886102 · Cited by 555 · see citing works

Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation

Cristofalo, V. J., Allen, R. G., Pignolo, R. J., Martin, B. G., & Beck, J. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10614 · Cited by 554 · see citing works

Aging and Genome Maintenance: Lessons from the Mouse?

Hasty, P., Campisi, J., Hoeijmakers, J., van Steeg, H., & Vijg, J. (2003) · Science · doi:10.1126/science.1079161 · Cited by 553 · cited 2× · see citing works

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

Rodier, F., Muñoz, D. P., Teachenor, R., Chu, V., Le, O., Bhaumik, D., Coppé, J.-P., Campeau, E., Beauséjour, C. M., Kim, S.-H., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.071340 · Cited by 535 · see citing works

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truth

Zielonka, J., & Kalyanaraman, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.028 · Cited by 535 · see citing works

DNA damage signalling guards against activated oncogenes and tumour progression

Bartek, J., Bartkova, J., & Lukas, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210881 · Cited by 521 · see citing works

Circadian Rhythms and Metabolic Syndrome

Maury, E., Ramsey, K. M., & Bass, J. T. (2010) · Circulation Research · doi:10.1161/circresaha.109.208355 · Cited by 502 · see citing works

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

Morselli, E., Mariño, G., Bennetzen, M. V., Eisenberg, T., Megalou, E. V., Schroeder, S., Cabrera, S., Bénit, P., Rustin, P., Criollo, A., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008167 · Cited by 495 · see citing works

The circadian clock and pathology of the ageing brain

Kondratova, A. A., & Kondratov, R. V. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3208 · Cited by 482 · see citing works

Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

Wagner, W., Bork, S., Horn, P., Krunic, D., Walenda, T., Diehlmann, A., Beneš, V., Blake, J., Huber, F.-X., Eckstein, V., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005846 · Cited by 480 · see citing works

Calorie restriction and sirtuins revisited

Guarente, L. (2013) · Genes &amp; Development · doi:10.1101/gad.227439.113 · Cited by 464 · see citing works

DNA mismatch repair: Molecular mechanism, cancer, and ageing

Hsieh, P., & Yamane, K. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.012 · Cited by 463 · see citing works

Epidermal Growth Factor Receptor-dependent Akt Activation by Oxidative Stress Enhances Cell Survival

Wang, X., McCullough, K. D., Franke, T. F., & Holbrook, N. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14624 · Cited by 461 · see citing works

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

De Cecco, M., Criscione, S. W., Peckham, E. J., Hillenmeyer, S., Hamm, E. A., Manivannan, J., Peterson, A. L., Kreiling, J. A., Neretti, N., & Sedivy, J. M. (2013) · Aging Cell · doi:10.1111/acel.12047 · Cited by 459 · see citing works

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

Woldt, E., Sebti, Y., Solt, L. A., Duhem, C., Lancel, S., Eeckhoute, J., Hesselink, M. K. C., Paquet, C., Delhaye, S., Shin, Y., et al. (2013) · Nature Medicine · doi:10.1038/nm.3213 · Cited by 454 · see citing works

Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation

Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701764104 · Cited by 437 · see citing works

Splicing-directed therapy in a new mouse model of human accelerated aging

Osorio, F. G., Navarro, C. L., Cadiñanos, J., López-Mejía, I. C., Quirós, P. M., Bartoli, C., Rivera, J., Tazi, J., Guzmán, G., Varela, I., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002847 · Cited by 432 · see citing works

AGEMAP: A Gene Expression Database for Aging in Mice

Zahn, J. M., Poosala, S., Owen, A. B., Ingram, D. K., Lustig, A., Carter, A., Weeraratna, A. T., Taub, D. D., Gorospe, M., Mazan-Mamczarz, K., et al. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030201 · Cited by 431 · see citing works

Can autophagy promote longevity?

Madeo, F., Tavernarakis, N., & Kroemer, G. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-842 · Cited by 429 · see citing works

Human cell senescence as a DNA damage response

Zglinicki, T. V., Saretzki, G., Ladhoff, J., Fagagna, F. D. D., & Jackson, S. P. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.034 · Cited by 419 · see citing works

Photoaging is Associated with Protein Oxidation in Human Skin In Vivo

Sander, C. S., Chang, H., Salzmann, S., Müller, F. M., Ekanayake‐Mudiyanselage, S., Elsner, P. U., & Thiele, J. J. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01708.x · Cited by 416 · see citing works

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., & Walker, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.016 · Cited by 409 · see citing works

Changes in DNA repair during aging

Gorbunova, V., Seluanov, A., Mao, Z., & Hine, C. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm756 · Cited by 405 · see citing works

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

Varela, I., Pereira, S., Ugalde, A. P., Navarro, C. L., Suárez, M. F., Cau, P., Cadiñanos, J., Osorio, F. G., Foray, N., Cobo, J. L., et al. (2008) · Nature Medicine · doi:10.1038/nm1786 · Cited by 403 · see citing works

Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans

Rea, S. L., Ventura, N., & Johnson, T. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050259 · Cited by 383 · see citing works

What causes mitochondrial DNA deletions in human cells?

Krishnan, K. J., Reeve, A. K., Samuels, D. C., Chinnery, P. F., Blackwood, J. K., Taylor, R. W., Wanrooij, S., Spelbrink, J. N., Lightowlers, R. N., & Turnbull, D. M. (2008) · Nature Genetics · doi:10.1038/ng.f.94 · Cited by 380 · see citing works

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

Jiang, M., Liu, K., Luo, J., & Dong, Z. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090594 · Cited by 375 · see citing works

The Mutant Form of Lamin A that Causes Hutchinson-Gilford Progeria Is a Biomarker of Cellular Aging in Human Skin

McClintock, D., Ratner, D., Lokuge, M., Owens, D. M., Gordon, L. B., Collins, F. S., & Djabali, K. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001269 · Cited by 365 · see citing works

Matrix Metalloproteinase-1 is the Major Collagenolytic Enzyme Responsible for Collagen Damage in UV-irradiated Human Skin¶

Brennan, M. M., Bhatti, H., Nerusu, K. C., Bhagavathula, N., Kang, S., Fisher, G. J., Varani, J., & Voorhees, J. J. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0780043mmitmc2.0.co2 · Cited by 358 · see citing works

miR‐17, miR‐19b, miR‐20a, and miR‐106a are down‐regulated in human aging

Hackl, M., Brunner, S. M., Fortschegger, K., Schreiner, C., Mičutková, L., Mück, C., Laschober, G. T., Lepperdinger, G., Sampson, N., Berger, P., et al. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00549.x · Cited by 356 · see citing works

Gene expression profile of aging in human muscle

Welle, S. L., Brooks, A. I., Delehanty, J. M., Needler, N. A., & Thornton, C. A. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00049.2003 · Cited by 351 · see citing works

Transcriptional profiling of aging in human muscle reveals a common aging signature

Zahn, J. M., Sonu, R., Vogel, H., Crane, E., Mazan-Mamczarz, K., Rabkin, R., Davis, R. W., Becker, K. G., Owen, A. B., & Kim, S. K. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020115 · Cited by 351 · see citing works

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

Passos, J. F., Saretzki, G., & von Zglinicki, T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm893 · Cited by 344 · see citing works

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

Asher, G., Reinke, H., Altmeyer, M., Gutierrez-Arcelus, M., Hottiger, M. O., & Schibler, U. (2010) · Cell · doi:10.1016/j.cell.2010.08.016 · Cited by 340 · see citing works

A Transcriptional Profile of Aging in the Human Kidney

Rodwell, G. E. J., Sonu, R., Zahn, J. M., Lund, J., Wilhelmy, J., Wang, L., Xiao, W., Mindrinos, M., Crane, E., Segal, E., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020427 · Cited by 338 · see citing works

Inhibition of Type I Procollagen Synthesis by Damaged Collagen in Photoaged Skin and by Collagenase-Degraded Collagen in Vitro

Varani, J., Spearman, D., Perone, P., Fligiel, S., Datta, S. C., Wang, Z. Q., Shao, Y., Kang, S., Fisher, G. J., & Voorhees, J. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64040-0 · Cited by 333 · see citing works

Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae

Kirchman, P. A., Kim, S., Lai, C.-Y., & Jazwinski, S. M. (1999) · Genetics · doi:10.1093/genetics/152.1.179 · Cited by 328 · see citing works

Circadian Rhythm Connections to Oxidative Stress: Implications for Human Health

Wilking, M. J., Ndiaye, M. A., Mukhtar, H., & Ahmad, N. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4889 · Cited by 324 · see citing works

Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts

Lee, C.-K., Allison, D. B., Brand, J., Weindruch, R., & Prolla, T. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232308999 · Cited by 314 · see citing works

DNA Methylation Dynamics in Human Induced Pluripotent Stem Cells over Time

Nishino, K., Toyoda, M., Yamazaki‐Inoue, M., Fukawatase, Y., Chikazawa, E., Sakaguchi, H., Akutsu, H., & Umezawa, A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002085 · Cited by 312 · see citing works

Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice

Dell'Agnello, C., Leo, S., Agostino, A., Szabadkai, G., Tiveron, C., Zulian, A., Prelle, A., Roubertoux, P., Rizzuto, R., & Zeviani, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl477 · Cited by 308 · see citing works

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

Cao, K., Blair, C. D., Faddah, D. A., Kieckhaefer, J. E., Olive, M., Erdos, M. R., Nabel, E. G., & Collins, F. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43578 · Cited by 305 · see citing works

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · cited 2× · see citing works

Mitochondrial dynamics in cell death and neurodegeneration

Cho, D., Nakamura, T., & Lipton, S. A. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0435-2 · Cited by 299 · see citing works

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation

Yang, S. H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28968 · Cited by 298 · see citing works

Increase in Mitochondrial Mass in Human Fibroblasts under Oxidative Stress and during Replicative Cell Senescence

Lee, H., Yin, P., Chi, C., & Wei, Y. (2002) · Journal of Biomedical Science · doi:10.1007/bf02254978 · Cited by 294 · see citing works

ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence

Weyemi, U., Lagente-Chevallier, O., Boufraqech, M., Prenois, F., Courtin, F., Caillou, B., Talbot, M., Dardalhon, M., Al Ghuzlan, A., Bidart, J.-M., et al. (2012) · Oncogene · doi:10.1038/onc.2011.327 · Cited by 285 · see citing works

Gene expression changes with age in skin, adipose tissue, blood and brain

Glass, D., Viñuela, A., Davies, M. N., Ramasamy, A., Parts, L., Knowles, D. A., Brown, A. A., Hedman, Å. K., Small, K. S., Buil, A., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-7-r75 · Cited by 281 · see citing works

The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting

Ramsey, M. J., Moore, D. H., Briner, J. F., Lee, D. A., Olsen, L. A., Senft, J. R., & Tucker, J. D. (1995) · Mutation Research/DNAging · doi:10.1016/0921-8734(95)00015-x · Cited by 278 · see citing works

DNA end joining becomes less efficient and more error-prone during cellular senescence

Seluanov, A., Mittelman, D., Pereira-Smith, O. M., Wilson, J. H., & Gorbunova, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400726101 · Cited by 278 · see citing works

Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin

Grönniger, E., Weber, B., Heil, O., Peters, N., Stäb, F., Wenck, H., Korn, B., Winnefeld, M., & Lyko, F. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000971 · Cited by 275 · see citing works

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

Harries, L. W., Hernandez, D. G., Henley, W., Wood, A. R., Holly, A. C., Bradley-Smith, R. M., Yaghootkar, H., Dutta, A., Murray, A., Frayling, T. M., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00726.x · Cited by 274 · see citing works

Aging- and Photoaging-Dependent Changes of Enzymic and Nonenzymic Antioxidants in the Epidermis and Dermis of Human Skin In Vivo

Rhie, G.-E., Shin, M. H., Seo, J. Y., Choi, W. W., Cho, K. H., Kim, K. H., Park, K. C., Eun, H. C., & Chung, J. H. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01469.x · Cited by 274 · see citing works

Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy

Gottlieb, R. A., & Mentzer, R. M. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135757 · Cited by 267 · see citing works

The number of p16INK4a positive cells in human skin reflects biological age

Waaijer, M. E. C., Parish, W. E., Strongitharm, B. H., van Heemst, D., Slagboom, P. E., de Craen, A. J. M., Sedivy, J. M., Westendorp, R. G. J., Gunn, D. A., & Maier, A. B. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00837.x · Cited by 264 · see citing works

How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

Yen, W.-L., & Klionsky, D. J. (2008) · Physiology · doi:10.1152/physiol.00013.2008 · Cited by 264 · see citing works

Cellular senescence controls fibrosis in wound healing

Jun, J.-I., & Lau, L. F. (2010) · Aging · doi:10.18632/aging.100201 · Cited by 255 · see citing works

Hyaluronan in skin: aspects of aging and its pharmacologic modulation

Stern, R., & Maibach, H. I. (2008) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2007.09.013 · Cited by 254 · see citing works

Analysis of alternative splicing associated with aging and neurodegeneration in the human brain

Tollervey, J. R., Wang, Z., Hortobágyi, T., Witten, J. T., Zarnack, K., Kayikci, M., Clark, T. A., Schweitzer, A. C., Rot, G., Curk, T., et al. (2011) · Genome Research · doi:10.1101/gr.122226.111 · Cited by 252 · see citing works

Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillatorsPreprint

Saini, C., Morf, J., Stratmann, M., Gos, P., & Schibler, U. (2012) · Genes & Development · doi:10.1101/gad.183251.111 · Cited by 248 · see citing works

On the Programmed/Non-Programmed Nature of Ageing within the Life History

Kirkwood, T. B. L., & Melov, S. (2011) · Current Biology · doi:10.1016/j.cub.2011.07.020 · Cited by 246 · see citing works

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

Ahlqvist, K. J., Hämäläinen, R. H., Yatsuga, S., Uutela, M., Terzioglu, M., Götz, A., Forsström, S., Salvén, P., Angers‐Loustau, A., Kopra, O., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.012 · Cited by 240 · see citing works

Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and dietary phytonutrients: “Mitohormesis” for health and vitality

Tapia, P. C. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.09.009 · Cited by 239 · see citing works

ROS as a tumour suppressor?

Ramsey, M. R., & Sharpless, N. E. (2006) · Nature Cell Biology · doi:10.1038/ncb1106-1213 · Cited by 237 · see citing works

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Schmeisser, K., Mansfeld, J., Kuhlow, D., Weimer, S., Priebe, S., Heiland, I., Birringer, M., Groth, M., Segref, A., Kanfi, Y., et al. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1352 · Cited by 236 · see citing works

Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts.

HUTTER, E., RENNER, K., PFISTER, G., STÖCKL, P., JANSEN-DÜRR, P., & GNAIGER, E. (2004) · Biochemical Journal · doi:10.1042/bj20040095 · Cited by 235 · see citing works

Temporal orchestration of circadian autophagy rhythm by C/EBPβ

Ma, D., Panda, S., & Lin, J. D. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.322 · Cited by 234 · see citing works

Control of skin cancer by the circadian rhythm

Gaddameedhi, S., Selby, C. P., Kaufmann, W. K., Smart, R. C., & Sancar, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115249108 · Cited by 234 · see citing works

Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factorPreprint

Reinke, H., Saini, C., Fleury-Olela, F., Dibner, C., Benjamin, I. J., & Schibler, U. (2008) · Genes & Development · doi:10.1101/gad.453808 · Cited by 228 · see citing works

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarelli, E., & Calabrese, E. J. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.007 · Cited by 225 · see citing works

Mitochondrial Oxygen Consumption and Reactive Oxygen Species Production are Independently Modulated: Implications for Aging Studies

Barja, G. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0516 · Cited by 222 · see citing works

Anti-ageing and rejuvenating effects of quercetin

Chondrogianni, N., Kapeta, S., Chinou, İ., Vassilatou, K., Papassideri, I. S., & Gonos, E. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.07.001 · Cited by 220 · see citing works

DNA damage and rpair with age in individual human lymphocytes

Singh, N. P., Danner, D. B., Tice, R. R., Brant, L. J., & Schneider, E. L. (1990) · Mutation Research/DNAging · doi:10.1016/0921-8734(90)90018-m · Cited by 217 · see citing works

Mitochondrial DNA repair in aging and disease

Druzhyna, N., Wilson, G. L., & LeDoux, S. P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.002 · Cited by 217 · see citing works

Widespread splicing changes in human brain development and aging

Mazin, P., Xiong, J., Liu, X., Yan, Z., Zhang, X., Li, M., He, L., Somel, M., Yuan, Y., Phoebe Chen, Y., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2012.67 · Cited by 216 · see citing works

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

Morselli, E., Galluzzi, L., Kepp, O., Criollo, A., Maiuri, M. C., Tavernarakis, N., Madeo, F., & Kroemer, G. (2009) · Aging · doi:10.18632/aging.100110 · Cited by 213 · see citing works

Epidermal stem cells are retained in vivo throughout skin aging

Giangreco, A., Qin, M., Pintar, J. E., & Watt, F. M. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00372.x · Cited by 212 · see citing works

An Age-Induced Switch to a Hyper-Recombinational State

McMurray, M. A., & Gottschling, D. E. (2003) · Science · doi:10.1126/science.1087706 · Cited by 208 · see citing works

The coordination of nuclear and mitochondrial communication during aging and calorie restriction

Finley, L. W. S., & Haigis, M. C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.03.003 · Cited by 207 · see citing works

Smoker's Wrinkles

Daniell, H. (1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-75-6-873 · Cited by 198 · see citing works

Role of Mitochondria in Photoaging of Human Skin: The Defective Powerhouse Model

Krutmann, J., & Schröeder, P. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.1 · Cited by 198 · see citing works

Aging: A revisited theory based on free radicals generated by NOX family NADPH oxidases

Krause, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.10.011 · Cited by 193 · see citing works

A comparative analysis of the cell biology of senescence and aging

Hwang, E. S., Yoon, G., & Kang, H. T. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0034-2 · Cited by 192 · see citing works

Age-related increase of baseline frequencies of sister chromatid exchanges, chromosome aberrations, and micronuclei in human lymphocytes.

Bolognesi, C., Abbondandolo, A., Barale, R., Casalone, R., Dalprà, L., Ferrari, M. D., Degrassi, F., Forni, A., Lamberti, L., Lando, C., et al. (1997) · PubMed · Cited by 190 · see citing works

The Olive Constituent Oleuropein Exhibits Proteasome Stimulatory Properties In Vitro and Confers Life Span Extension of Human Embryonic Fibroblasts

Katsiki, M., Chondrogianni, N., Chinou, İ., Rivett, A. J., & Gonos, E. S. (2007) · Rejuvenation Research · doi:10.1089/rej.2006.0513 · Cited by 188 · see citing works

Decreased Proteasomal Activity Causes Age-Related Phenotypes and Promotes the Development of Metabolic Abnormalities

Tomaru, U., Takahashi, S., Ishizu, A., Miyatake, Y., Gohda, A., Suzuki, S., Ono, A., Ohara, J., Baba, T., Murata, S., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.11.012 · Cited by 185 · see citing works

What Can Progeroid Syndromes Tell Us About Human Aging?

Kipling, D., Davis, T., Ostler, E. L., & Faragher, R. (2004) · Science · doi:10.1126/science.1102587 · Cited by 182 · see citing works

The Frailty Syndrome

Clegg, A. P., & Young, J. B. (2011) · Clinical Medicine · doi:10.7861/clinmedicine.11-1-72 · Cited by 181 · see citing works

Mitochondrial Dynamics in Mammals

Chen, H., & Chan, D. C. (2004) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(04)59005-1 · Cited by 180 · see citing works

Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease

Johnson, T. E., Henderson, S. T., Murakami, S., de Castro, E., de Castro, S. H., Cypser, J. R., Rikke, B. A., Tedesco, P., & Link, C. D. (2002) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1015677828407 · Cited by 174 · see citing works

Aging, tumor suppression and cancer: high wire-act!

Campisi, J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.024 · Cited by 171 · see citing works

Morpho-dynamic changes of mitochondria during ageing of human endothelial cells

Jendrach, M., Pohl, S., Vöth, M., Kowald, A., Hammerstein, P., & Bereiter‐Hahn, J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.002 · Cited by 170 · see citing works

Chronic Ultraviolet B Irradiation Causes Loss of Hyaluronic Acid from Mouse Dermis Because of Down-Regulation of Hyaluronic Acid Synthases

Dai, G., Freudenberger, T., Zipper, P., Melchior, A., Grether‐Beck, S., Rabausch, B., de Groot, J., Twarock, S., Hanenberg, H., Homey, B., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070136 · Cited by 162 · see citing works

Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment

Columbaro, M., Capanni, C., Mattioli, E., Novelli, G., Parnaik, V. K., Squarzoni, S., Maraldi, N. M., & Lattanzi, G. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5318-6 · Cited by 160 · see citing works

The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine

Richards, S. A., Muter, J., Ritchie, P., Lattanzi, G., & Hutchison, C. J. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr327 · Cited by 157 · see citing works

The alternative splicing of fibronectin pre-mRNA is altered during aging and in response to growth factors

Magnuson, V. L., Young, M. E., Schattenberg, D. G., Mancini, M. A., Chen, D. L., Steffensen, B., & Klebe, R. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98735-1 · Cited by 154 · see citing works

Age‐associated increase in heterochromatic marks in murine and primate tissues

Kreiling, J. A., Tamamori‐Adachi, M., Sexton, A. N., Jeyapalan, J. C., Munoz‐Najar, U., Peterson, A. L., Manivannan, J., Rogers, E. S., Pchelintsev, N. A., Adams, P. D., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00666.x · Cited by 152 · see citing works

p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation

Brosh, R., Shalgi, R., Liran, A., Landan, G., Korotayev, K., Nguyen, G. H., Enerly, E., Johnsen, H., Buganim, Y., Solomon, H., et al. (2008) · Molecular Systems Biology · doi:10.1038/msb.2008.65 · Cited by 152 · see citing works

mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex

Dillman, A. A., Hauser, D. N., Gibbs, J. R., Nalls, M. A., McCoy, M. K., Rudenko, I. N., Galter, D., & Cookson, M. R. (2013) · Nature Neuroscience · doi:10.1038/nn.3332 · Cited by 148 · see citing works

Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression

Shin, M. H., Moon, Y. J., Seo, J., Lee, Y., Kim, K. H., & Chung, J. H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.10.053 · Cited by 147 · see citing works

Tissue-specific splicing pattern of fibronectin messenger RNA precursor during development and aging in rat.

Pagani, F., Zagato, L., Vergani, C., Casari, G., Sidoli, A., & Baralle, F. E. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.5.1223 · Cited by 146 · see citing works

Sun Exposure: What Molecular Photodermatology Tells Us About Its Good and Bad Sides

Krutmann, J., Morita, A., & Chung, J. H. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.394 · Cited by 144 · see citing works

Hormesis and aging in Caenorhabditis elegans

Cypser, J. R., Tedesco, P., & Johnson, T. E. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.09.004 · Cited by 143 · see citing works

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

Garinis, G. A., Uittenboogaard, L. M., Stachelscheid, H., Fousteri, M., van Ijcken, W., Breit, T. M., van Steeg, H., Mullenders, L. H. F., van der Horst, G. T. J., Brüning, J. C., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1866 · Cited by 138 · see citing works

Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity

van Ham, T. J., Holmberg, M. A., van der Goot, A. T., Teuling, E., Garcı́a-Arencibia, M., Kim, H.-E., Du, D., Thijssen, K. L., Wiersma, M., Burggraaff, R. C., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.020 · Cited by 137 · see citing works

The Role of Autophagy in Aging

Bergamini, E., Cavallini, G., Donati, A., & Gori, Z. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.020 · Cited by 136 · see citing works

Molecular Basis of Tobacco Smoke-Induced Premature Skin Aging

Morita, A., Torii, K., Maeda, A., & Yamaguchi, Y. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.13 · Cited by 135 · see citing works

Heterochromatin and the DNA damage response: the need to relaxThis paper is one of a selection of papers in a Special Issue entitled 31st Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

Cann, K. L., & Dellaire, G. (2011) · Biochemistry and Cell Biology · doi:10.1139/o10-113 · Cited by 135 · see citing works

Vimentin Is the Specific Target in Skin Glycation

Kueper, T., Grune, T., Prahl, S., Lenz, H., Welge, V., Biernoth, T., Vogt, Y., Muhr, G., Gaemlich, A., Jung, T., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701586200 · Cited by 133 · see citing works

Phase Resetting of the Mammalian Circadian Clock by DNA Damage

Oklejewicz, M., Destici, E., Tamanini, F., Hut, R. A., Janssens, R. C., & van der Horst, G. T. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.01.047 · Cited by 132 · see citing works

Hormesis, cell death and aging

Martins, I., Galluzzi, L., & Kroemer, G. (2011) · Aging · doi:10.18632/aging.100380 · Cited by 128 · see citing works

EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration

Cao, C., Sun, Y. W., Healey, S., Zhi-gang, B., Hu, G., Wan, S., KOUTTAB, N. M., Chu, W., & Wan, Y. (2006) · Biochemical Journal · doi:10.1042/bj20060816 · Cited by 127 · see citing works

Marked aging‐related decline in efficiency of oxidative phosphorylation in human skin fibroblasts

Gréco, M., Villani, G., Mazzucchelli, F., Bresolin, N., Papa, S., & Attardi, G. M. (2003) · The FASEB Journal · doi:10.1096/fj.02-1009fje · Cited by 122 · see citing works

Pluripotent stem cells escape from senescence-associated DNA methylation changesPreprint

Koch, C., Reck, K., Shao, K., Lin, Q., Joussen, S., Ziegler, P., Walenda, G., Drescher, W., Opalka, B., May, T., et al. (2012) · Genome Research · doi:10.1101/gr.141945.112 · Cited by 121 · see citing works

Aging Fibroblasts Present Reduced Epidermal Growth Factor (EGF) Responsiveness Due to Preferential Loss of EGF Receptors

Shiraha, H., Gupta, K. B., Drabik, K., & Wells, A. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000008200 · Cited by 120 · see citing works

Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts

Nishio, K., Inoue, A., Qiao, S., Kondo, H., & Mimura, A. (2001) · Histochemistry and Cell Biology · doi:10.1007/s004180100325 · Cited by 115 · see citing works

Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

Figge, M. T., Reichert, A. S., Meyer‐Hermann, M., & Osiewacz, H. D. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002576 · Cited by 112 · see citing works

p53/CEP‐1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress

Ventura, N., Rea, S. L., Schiavi, A., Torgovnick, A., Testi, R., & Johnson, T. E. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00482.x · Cited by 111 · see citing works

Aneuploidy in health, disease, and aging

Ricke, R. M., & van Deursen, J. M. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201301061 · Cited by 111 · see citing works

Recent advances in the cell biology of aging

Hayflick, L. (1980) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(80)90106-2 · Cited by 108 · see citing works

Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease

Thomas, P., & Fenech, M. F. (2007) · Mutagenesis · doi:10.1093/mutage/gem044 · Cited by 107 · see citing works

Aging and oxidatively damaged nuclear DNA in animal organs

Möller, P., Løhr, M., Folkmann, J. K., Mikkelsen, L., & Loft, S. H. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.003 · Cited by 105 · see citing works

Circadian autophagy rhythm: a link between clock and metabolism?

Ma, D., Li, S., Molusky, M. M., & Lin, J. D. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.03.004 · Cited by 103 · see citing works

Age and gender effects on DNA strand break repair in peripheral blood mononuclear cells

Garm, C., Moreno‐Villanueva, M., Bürkle, A., Petersen, I., Bohr, V. A., Christensen, K., & Stevnsner, T. (2012) · Aging Cell · doi:10.1111/acel.12019 · Cited by 102 · see citing works

Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblasts

Nishio, K., & Inoue, A. (2005) · Histochemistry and Cell Biology · doi:10.1007/s00418-005-0766-5 · Cited by 100 · see citing works

MicroRNAs and the Genetic Network in Aging

Inukai, S., & Slack, F. J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.01.023 · Cited by 99 · see citing works

A conserved splicing mechanism of the LMNA gene controls premature aging

López‐Mejía, I. C., Vautrot, V., de Toledo, M., Behm‐Ansmant, I., Bourgeois, C. F., Navarro, C. L., Osorio, F. G., Freije, J. M. P., Stévenin, J., Sandre‐Giovannoli, A. D., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr385 · Cited by 99 · see citing works

Mitochondrial dynamics in model organisms: What yeasts, worms and flies have taught us about fusion and fission of mitochondria

Westermann, B. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.12.003 · Cited by 98 · see citing works

Photoaging and DNA repair

Moriwaki, S., & Takahashi, Y. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2007.08.011 · Cited by 98 · see citing works

The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells

Lener, B., Kozieł, R., Pircher, H., Hütter, E., Greussing, R., Herndler‐Brandstetter, D., Hermann, M., Unterluggauer, H., & Jansen‐Dürr, P. (2009) · Biochemical Journal · doi:10.1042/bj20090666 · Cited by 97 · see citing works

Expression profiling of aging in the human skin

Lener, T., Moll, P. R., Rinnerthaler, M., Bauer, J. W., Aberger, F., & Richter, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.01.012 · Cited by 96 · see citing works

Stem cells: past, present, and future

Zakrzewski, W., Dobrzyński, M., Szymonowicz, M. K., & Rybak, Z. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1165-5 · Cited by 1,886 · see citing works

Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming

Solé-Boldo, L., Raddatz, G., Schütz, S., Mallm, J.-P., Rippe, K., Lonsdorf, A. S., Rodríguez-Paredes, M., & Lyko, F. (2020) · Communications Biology · doi:10.1038/s42003-020-0922-4 · Cited by 559 · see citing works

Activated fibroblasts in cancer: Perspectives and challenges

Caligiuri, G., & Tuveson, D. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.015 · Cited by 431 · see citing works

Immune ageing at single-cell resolution

Mogilenko, D. A., Shchukina, I., & Artyomov, M. N. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00646-4 · Cited by 392 · see citing works

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

Sladitschek, H. L., Guarnieri, A., Brumana, G., Zanconato, F., Battilana, G., Xiccato, R. L., Panciera, T., Forcato, M., Bicciato, S., Guzzardo, V., et al. (2022) · Nature · doi:10.1038/s41586-022-04924-6 · Cited by 346 · see citing works

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

Lukjanenko, L., Jung, M. J., Hegde, N., Perruisseau-Carrier, C., Migliavacca, E., Rozo, M., Karaz, S., Jacot, G. E., Schmidt, M., Li, L., et al. (2016) · Nature Medicine · doi:10.1038/nm.4126 · Cited by 337 · see citing works

Exosomes Derived from Human Induced Pluripotent Stem Cells Ameliorate the Aging of Skin Fibroblasts

Oh, M., Lee, J., Kim, Y. J., Rhee, W. J., & Park, J. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061715 · Cited by 258 · see citing works

Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms

Krutmann, J., Schikowski, T., Morita, A., & Berneburg, M. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.12.011 · Cited by 253 · see citing works

Marine collagen and its derivatives: Versatile and sustainable bio-resources for healthcare

Salvatore, L., Gallo, N., Natali, M. L., Campa, L., Lunetti, P., Madaghiele, M., Blasi, F. S., Corallo, A., Capobianco, L., & Sannino, A. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.110963 · Cited by 235 · see citing works

Predicting age from the transcriptome of human dermal fibroblasts

Fleischer, J. G., Schulte, R., Tsai, H. H., Tyagi, S., Ibarra, A., Shokhirev, M. N., Huang, L., Hetzer, M. W., & Navlakha, S. (2018) · Genome Biology · doi:10.1186/s13059-018-1599-6 · Cited by 232 · see citing works

Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin

Waldera Lupa, D. M., Kalfalah, F., Safferling, K., Boukamp, P., Poschmann, G., Volpi, E., Götz-Rösch, C., Bernerd, F., Haag, L., Huebenthal, U., et al. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.120 · Cited by 224 · see citing works

Diet and Skin Aging—From the Perspective of Food Nutrition

Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works

Origin and functional heterogeneity of fibroblasts

LeBleu, V. S., & Neilson, E. G. (2020) · The FASEB Journal · doi:10.1096/fj.201903188r · Cited by 218 · see citing works

Alterations in extracellular matrix composition during aging and photoaging of the skin

McCabe, M. C., Hill, R. C., Calderone, K., Cui, Y., Yan, Y., Quan, T., Fisher, G. J., & Hansen, K. C. (2020) · Matrix Biology Plus · doi:10.1016/j.mbplus.2020.100041 · Cited by 189 · see citing works

Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds

Wilkinson, H. N., & Hardman, M. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00773 · Cited by 173 · see citing works

Cell aging and cellular senescence in skin aging - Recent advances in fibroblast and keratinocyte biology

Gruber, F., Kremslehner, C., Eckhart, L., & Tschachler, E. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2019.110780 · Cited by 166 · see citing works

Lineage Identity and Location within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin

Korosec, A., Frech, S., Geßlbauer, B., Vierhapper, M. F., Radtke, C., Petzelbauer, P., & Lichtenberger, B. M. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.07.033 · Cited by 163 · see citing works

The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics

Xiong, M., Zhang, Q., Hu, W., Zhao, C., Lv, W., Yi, Y., Wang, Y., Tang, H., Wu, M., & Wu, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105490 · Cited by 155 · see citing works

Mechanisms of lung aging

Brandenberger, C., & Mühlfeld, C. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2511-x · Cited by 152 · see citing works

SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy

Lang, A., Anand, R., Altinoluk-Hambüchen, S., Ezzahoini, H., Stefanski, A., Iram, A., Bergmann, L., Urbach, J., Böhler, P., Hänsel, J., et al. (2017) · Aging · doi:10.18632/aging.101307 · Cited by 145 · see citing works

Epigenetic Regulation of Skin Cells in Natural Aging and Premature Aging Diseases

Orioli, D., & Dellambra, E. (2018) · Cells · doi:10.3390/cells7120268 · Cited by 144 · see citing works

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

Lang, A., Grether‐Beck, S., Singh, M., Kuck, F., Jakob, S., Kefalas, A., Altinoluk-Hambüchen, S., Graffmann, N., Schneider, M., Lindecke, A., et al. (2016) · Aging · doi:10.18632/aging.100905 · Cited by 138 · see citing works

Neuroendocrine Aspects of Skin Aging

Bocheva, G., Slominski, R. M., & Slominski, A. T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112798 · Cited by 137 · see citing works

Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo

Yoon, J. E., Kim, Y., Kwon, S., Kim, M., Kim, Y. H., Kim, J., Park, T. J., & Kang, H. Y. (2018) · Theranostics · doi:10.7150/thno.26975 · Cited by 134 · see citing works

Protective Role of Melatonin and Its Metabolites in Skin Aging

Bocheva, G., Slominski, R. M., Janjetović, Z., Kim, T., Böhm, M., Steinbrink, K., Reiter, R. J., Kleszczyński, K., & Slominski, A. T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031238 · Cited by 133 · see citing works

The Impact of Vitamin D on Skin Aging

Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22169097 · Cited by 129 · see citing works

SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

Xu, Z., Zhang, L., Zhang, W., Du, M., Zhang, H., Jiang, Y., Xu, X., Meter, M. V., Seluanov, A., Gorbunova, V. A., et al. (2015) · Cell Cycle · doi:10.4161/15384101.2014.980641 · Cited by 118 · see citing works

The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER

Schinzel, R. T., Higuchi‐Sanabria, R., Shalem, O., Moehle, E. A., Webster, B. M., Joe, L. K., Bar‐Ziv, R., Frankino, P. A., Durieux, J., Pender, C. L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.018 · Cited by 115 · see citing works

Hyaluronan as tunable drug delivery system

Passi, A. G., & Vigetti, D. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.08.006 · Cited by 112 · see citing works

3′ UTR lengthening as a novel mechanism in regulating cellular senescence.

Chen, M., Lyu, G., Han, M., Nie, H., Shen, T., Chen, W., Niu, Y., Song, Y., Li, X., Li, H., et al. (2018) · Genome Research · doi:10.1101/gr.224451.117 · Cited by 111 · see citing works

Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans

Li, Z., Zhang, W., Chen, Y., Guo, W., Zhang, J., Tang, H., Xu, Z., Zhang, H., Yi, T., Wang, F., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.65 · Cited by 104 · see citing works

The Role of microRNAs in Organismal and Skin Aging

Gerasymchuk, M., Cherkasova, V., Kovalchuk, O., & Kovalchuk, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155281 · Cited by 111 · see citing works

How good is the evidence that cellular senescence causes skin ageing?

Low, E., Alimohammadiha, G., Smith, L. A., Costello, L., Przyborski, S. A., von Zglinicki, T., & Miwa, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101456 · Cited by 114 · see citing works

The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies

Toutfaire, M., Bauwens, É., & Debacq‐Chainiaux, F. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.011 · Cited by 104 · see citing works

Short- and long-term polystyrene nano- and microplastic exposure promotes oxidative stress and divergently affects skin cell architecture and Wnt/beta-catenin signaling

Schmidt, A., Brito, W. A. D. S., Singer, D., Mühl, M., Berner, J., Saadati, F., Wolff, C. M., Miebach, L., Wende, K., & Bekeschus, S. (2023) · Particle and Fibre Toxicology · doi:10.1186/s12989-023-00513-1 · Cited by 103 · see citing works

Loss of Metabolic Plasticity Underlies Metformin Toxicity in Aged Caenorhabditis Elegans

Espada, L., Dakhovnik, A., Chaudhari, P., Martirosyan, A., Miek, L., Poliezhaieva, T., Schaub, Y., Nair, A., Döring, N., Rahnis, N., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00307-1 · Cited by 100 · see citing works

Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity

Statzer, C., Park, J. Y. C., & Ewald, C. Y. (2023) · Aging and Disease · doi:10.14336/ad.2022.1116 · Cited by 102 · see citing works

Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy

Iannetti, E. F., Smeitink, J. A. M., Beyrath, J., Willems, P. H. G. M., & Koopman, W. J. H. (2016) · Nature Protocols · doi:10.1038/nprot.2016.094 · Cited by 97 · see citing works

Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy

Hao, D., Wen, X., Liu, L., Wang, L., Zhou, X., Li, Y., Zeng, X., He, G., & Jiang, X. L. (2019) · Cell Death and Disease · doi:10.1038/s41419-018-1261-y · Cited by 99 · see citing works

The Role of Fibroblasts in Skin Homeostasis and Repair

Boraldi, F., Lofaro, F. D., Bonacorsi, S., Mazzilli, A., Garcia‐Fernandez, M. I., & Quaglino, D. (2024) · Biomedicines · doi:10.3390/biomedicines12071586 · Cited by 94 · see citing works

A Trickster in Disguise: Hyaluronan’s Ambivalent Roles in the Matrix

Bohaumilitzky, L., Huber, A., Stork, E. M., Wengert, S., Woelfl, F., & Boehm, H. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00242 · Cited by 91 · see citing works

Autophagic Control of Skin Aging

Eckhart, L., Tschachler, E., & Грубер, Ф. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00143 · Cited by 90 · see citing works

Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts

Waldera-Lupa, D. M., Kalfalah, F. M., Florea, A., Sass, S., Kruse, F., Rieder, V., Tigges, J., Fritsche, E., Krutmann, J., Busch, H. S., et al. (2014) · Aging · doi:10.18632/aging.100698 · Cited by 77 · see citing works

Thermal stress resistance and aging effects of Panax notoginseng polysaccharides on Caenorhabditis elegans

Feng, S., Cheng, H., Zhou, X., Shen, S., Yuan, M., Liu, J., & Ding, C. (2015) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2015.07.057 · Cited by 75 · see citing works

Phenotypic and functional changes in dermal primary fibroblasts isolated from intrinsically aged human skin

Brun, C., Jean‐Louis, F., Oddos, T., Bagot, M., Bensussan, A., & Michel, L. (2015) · Experimental Dermatology · doi:10.1111/exd.12874 · Cited by 75 · see citing works

Urolithin A protects human dermal fibroblasts from UVA-induced photoaging through NRF2 activation and mitophagy

Liu, W., Yan, F., Xu, Z., Chen, Q., Ren, J., Wang, Q., Chen, L., Ying, J., Liu, Z., Zhao, J., et al. (2022) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2022.112462 · Cited by 73 · see citing works

The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor

Brinkmann, V., Ale-Agha, N., Haendeler, J., & Ventura, N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01561 · Cited by 71 · see citing works

A role for estrogen in skin ageing and dermal biomechanics

Wilkinson, H. N., & Hardman, M. J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111513 · Cited by 71 · see citing works

In Vitro Models for Anti-Aging Efficacy Assessment: A Critical Update in Dermocosmetic Research

Cruz, A. M., Gonçalves, M. C., Marques, M. S., Veiga, F., Paiva‐Santos, A. C., & Pires, P. C. (2023) · Cosmetics · doi:10.3390/cosmetics10020066 · Cited by 64 · see citing works

Dihydrocaffeic Acid Prevents UVB-Induced Oxidative Stress Leading to the Inhibition of Apoptosis and MMP-1 Expression via p38 Signaling Pathway

de Oliveira, M. M., Ratti, B. A., Daré, R. G., Silva, S. D. O., Truiti, M. D. C. T., Ueda‐Nakamura, T., Auzély‐Velty, R., & Nakamura, C. V. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2419096 · Cited by 68 · see citing works

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Sturm, G., Cardenas, A., Bind, M.-A., Horvath, S., Wang, S., Wang, Y., Hägg, S., Hirano, M., & Picard, M. (2019) · Epigenetics · doi:10.1080/15592294.2019.1626651 · Cited by 61 · see citing works

Cellulose Nanocrystals as a Sustainable Raw Material: Cytotoxicity and Applications on Healthcare Technology

Pelegrini, B. L., Ré, F., de Oliveira, M. M., Fernandes, T., de Oliveira, J. H., de Oliveira, A. G., Girotto, E. M., Nakamura, C. V., Sampaio, A. R., Valim, A., et al. (2019) · Macromolecular Materials and Engineering · doi:10.1002/mame.201900092 · Cited by 62 · see citing works

Fibroblast heterogeneity: Keystone of tissue homeostasis and pathology in inflammation and ageing

Gauthier, V., Kyriazi, M., Nefla, M., Pucino, V., Raza, K., Buckley, C. D., & Alsaleh, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1137659 · Cited by 61 · see citing works

Polycomponent mesotherapy formulations for the treatment of skin aging and improvement of skin quality

Dalens, M., & Prikhnenko, S. (2015) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s76721 · Cited by 60 · see citing works

Novel approaches for managing aged skin and nonmelanoma skin cancer

Todorova, K. A., & Mandinova, A. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.004 · Cited by 59 · see citing works

Stem Cell-Derived Exosomes: A New Method for Reversing Skin Aging

Wu, J., Wu, S., Zhang, L.-P., Zhao, X., Li, Y., Yang, Q.-Y., Yuan, R., Liu, J.-L., Mao, H., & Zhu, N. (2022) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-022-00461-5 · Cited by 60 · see citing works

Derivation of Cell-Engineered Nanovesicles from Human Induced Pluripotent Stem Cells and Their Protective Effect on the Senescence of Dermal Fibroblasts

Lee, H., Cha, H., & Park, J. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010343 · Cited by 56 · see citing works

Emerging roles of exosomes in oral diseases progression

Wang, J., Jing, J., Zhou, C., & Fan, Y. (2024) · International Journal of Oral Science · doi:10.1038/s41368-023-00274-9 · Cited by 57 · see citing works

Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction

Clementi, E., Inglin, L., Beebe, E., Gsell, C., Garajovà, Z., & Markkanen, E. (2020) · BMC Biology · doi:10.1186/s12915-020-00771-x · Cited by 48 · see citing works

Myotonic Dystrophy type 1 cells display impaired metabolism and mitochondrial dysfunction that are reversed by metformin

García-Puga, M., Saenz‐Antoñanzas, A., Fernández‐Torrón, R., de Munaín, A. L., & Matheu, A. (2020) · Aging · doi:10.18632/aging.103022 · Cited by 50 · see citing works

Immunological Aspects of Skin Aging in Atopic Dermatitis

Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115729 · Cited by 50 · see citing works

Tissue fibroblasts are versatile immune regulators: An evaluation of their impact on the aging process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102296 · Cited by 49 · see citing works

Effect of oral administration of collagen hydrolysates from Nile tilapia on the chronologically aged skin

Wang, L., Jiang, Y. C., Wang, X., Zhou, J., Cui, H., Xu, W., He, Y., Ma, H., & Gao, R. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.03.005 · Cited by 47 · see citing works

A review of exosomes and their application in cutaneous medical aesthetics

Olumesi, K. R., & Goldberg, D. J. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.15930 · Cited by 45 · see citing works

Eriodictyol Attenuates H2O2-Induced Oxidative Damage in Human Dermal Fibroblasts through Enhanced Capacity of Antioxidant Machinery

Buranasudja, V., Muangnoi, C., Sanookpan, K., Halim, H., Sritularak, B., & Rojsitthisak, P. (2022) · Nutrients · doi:10.3390/nu14122553 · Cited by 44 · see citing works

Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)

Huang, L., Zhao, Z., Wen, J., Ling, W., Miao, Y., & Wu, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11339 · Cited by 43 · see citing works

A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vessels

Pauty, J., Nakano, S., Usuba, R., Nakajima, T., Johmura, Y., Omori, S., Sakamoto, N., Kikuchi, A., Nakanishi, M., & Matsunaga, Y. T. (2020) · Biomaterials Science · doi:10.1039/d0bm01297a · Cited by 39 · see citing works

Maintenance of Chronological Aging Features in Culture of Normal Human Dermal Fibroblasts from Old Donors

Rorteau, J., Chevalier, F. P., Bonnet, S., Barthélemy, T., Lopez-Gaydon, A., Martin, L. S., Béchetoille, N., & Lamartine, J. (2022) · Cells · doi:10.3390/cells11050858 · Cited by 39 · see citing works

Human dermal fibroblasts in psychiatry research

Kalman, J. L., Garbett, K. A., Janka, Z., & Mirnics, K. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.067 · Cited by 38 · see citing works

Effects of Lycium barbarum Polysaccharides on Health and Aging of C. elegans Depend on daf-12/daf-16

Zhang, Z., Zhou, Y., Fan, H., Kirunda, J. B., Zhao, Y., Zhan, X., Yang, L., & Jia, Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6379493 · Cited by 36 · see citing works

Post-Translational Modifications Evoked by Reactive Carbonyl Species in Ultraviolet-A-Exposed Skin: Implication in Fibroblast Senescence and Skin Photoaging

Nègre‐Salvayre, A., & Salvayre, R. (2022) · Antioxidants · doi:10.3390/antiox11112281 · Cited by 38 · see citing works

Current Understanding of the Role of Senescent Melanocytes in Skin Ageing

Hughes, B. K., & Bishop, C. L. (2022) · Biomedicines · doi:10.3390/biomedicines10123111 · Cited by 35 · see citing works

Osteogenic differentiation of human mesenchymal stromal cells and fibroblasts differs depending on tissue origin and replicative senescence

Grotheer, V., Skrynecki, N., Oezel, L., Windolf, J., & Grassmann, J. P. (2021) · Scientific Reports · doi:10.1038/s41598-021-91501-y · Cited by 35 · see citing works

Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives

Acín‐Pérez, R., Benincá, C., Shabane, B., Shirihai, O. S., & Stiles, L. (2021) · Life · doi:10.3390/life11090949 · Cited by 34 · see citing works

Alternative test models for skin ageing research

Nakamura, M., Haarmann‐Stemmann, T., Krutmann, J., & Morita, A. (2018) · Experimental Dermatology · doi:10.1111/exd.13519 · Cited by 34 · see citing works

Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors

Kalfalah, F. M., Seggewiß, S., Walter, R., Tigges, J., Moreno‐Villanueva, M., Bürkle, A., Ohse, S., Busch, H. S., Boerries, M., Hildebrandt, B., et al. (2015) · Aging · doi:10.18632/aging.100723 · Cited by 33 · see citing works

Toward the Standardization of Mitochondrial Proteomics: The Italian Mitochondrial Human Proteome Project Initiative

Alberio, T., Pieroni, L., Ronci, M., Banfi, C., Bongarzone, I., Bottoni, P., Brioschi, M., Caterino, M., Chinello, C., Cormio, A., et al. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00350 · Cited by 33 · see citing works

The anti-skin-aging effect of oral administration of gelatin from the swim bladder of Amur sturgeon ( Acipenser schrenckii )

Wang, L., Wang, X., Bai, F., Fang, Y., Wang, J., & Gao, R. (2019) · Food & Function · doi:10.1039/c9fo00661c · Cited by 32 · see citing works

The plasticity of fibroblasts: A forgotten player in the aging process

Salminen, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101995 · Cited by 34 · see citing works

Anti-aging activity and their mechanisms of natural food-derived peptides: current advancements

Li, J., Wang, J., Zhang, N., Li, Y., Cai, Z., Li, G., Liu, Z., Liu, Z., Wang, Y., Shao, X., et al. (2023) · Food Innovation and Advances · doi:10.48130/fia-2023-0028 · Cited by 32 · see citing works

4-Hydroxynonenal Contributes to Fibroblast Senescence in Skin Photoaging Evoked by UV-A Radiation

Swiader, A., Camaré, C., Guerby, P., Salvayre, R., & Nègre‐Salvayre, A. (2021) · Antioxidants · doi:10.3390/antiox10030365 · Cited by 29 · see citing works

Promises and challenges of senolytics in skin regeneration, pathology and ageing

Pils, V., Ring, N., Valdivieso, K., Lämmermann, I., Грубер, Ф., Schosserer, M., Grillari, J., & Ogrodnik, M. B. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111588 · Cited by 32 · see citing works

The role of cytokines/chemokines in an aging skin immune microenvironment

Lin, Z., Hsu, C., Hwang, E., Wang, P., & Fang, J. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111761 · Cited by 29 · see citing works

Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney

Arai, H., Sato, Y., & Yanagita, M. (2021) · Immunological Reviews · doi:10.1111/imr.12969 · Cited by 27 · see citing works

Shining Light on Autophagy in Skin Pigmentation and Pigmentary Disorders

Kovacs, D., Cardinali, G., Picardo, M., & Bastonini, E. (2022) · Cells · doi:10.3390/cells11192999 · Cited by 29 · see citing works

Strategic outline of interventions targeting extracellular matrix for promoting healthy longevity

Park, J. Y. C., King, A., Björk, V., English, B. W., Fedintsev, A., & Ewald, C. Y. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00060.2023 · Cited by 29 · see citing works

A Holistic Approach to Antiaging as an Adjunct to Antiaging Procedures: A Review of the Literature

Saluja, S. S., & Fabi, S. G. (2017) · Dermatologic Surgery · doi:10.1097/dss.0000000000001027 · Cited by 26 · see citing works

The Growth Differentiation Factor 11 is Involved in Skin Fibroblast Ageing and is Induced by a Preparation of Peptides and Sugars Derived from Plant Cell Cultures

Tito, A., Barbulova, A., Zappelli, C., Leone, M., Ruvo, M., Mercurio, F. A., Chambery, A., Russo, R., Colucci, M. G., & Apone, F. (2019) · Molecular Biotechnology · doi:10.1007/s12033-019-00154-w · Cited by 26 · see citing works

AMPK signaling inhibits the differentiation of myofibroblasts: impact on age-related tissue fibrosis and degeneration

Salminen, A. (2023) · Biogerontology · doi:10.1007/s10522-023-10072-9 · Cited by 25 · see citing works

A Zingerone Analog, Acetyl Zingerone, Bolsters Matrisome Synthesis, Inhibits Matrix Metallopeptidases, and Represses IL-17A Target Gene Expression

Swindell, W. R., Bojanowski, K., & Chaudhuri, R. K. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.07.715 · Cited by 25 · see citing works

Tracing skin aging process: a mini- review of in vitro approaches

Letsiou, S. (2021) · Biogerontology · doi:10.1007/s10522-021-09916-z · Cited by 25 · see citing works

Extracellular Vesicles (Secretomes) from Human Trophoblasts Promote the Regeneration of Skin Fibroblasts

Go, Y. Y., Lee, C. M., Ju, W. M., Chae, S.-W., & Song, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136959 · Cited by 25 · see citing works

The role of immunosuppressive myofibroblasts in the aging process and age-related diseases

Salminen, A. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02360-1 · Cited by 26 · see citing works

Replicative senescence of human dermal fibroblasts affects structural and functional aspects of the Golgi apparatus

Despres, J., Ramdani, Y., Giovanni, M. D., Bénard, M., Zahid, A., Montero‐Hadjadje, M., Yvergnaux, F., Saguet, T., Driouich, A., & Follet‐Gueye, M. (2019) · Experimental Dermatology · doi:10.1111/exd.13886 · Cited by 24 · see citing works

Exposing human primary dermal fibroblasts to particulate matter induces changes associated with skin aging

Reynolds, W. J., Hanson, P. S., Critchley, A. C., Griffiths, B., Chavan, B., & Birch‐Machin, M. A. (2020) · The FASEB Journal · doi:10.1096/fj.202001357r · Cited by 23 · see citing works

Raman and infrared spectroscopy differentiate senescent from proliferating cells in a human dermal fibroblast 3D skin model

Eberhardt, K., Matthäus, C., Winter, D., Wiegand, C., Hipler, U., Diekmann, S., & Popp, J. (2017) · The Analyst · doi:10.1039/c7an00592j · Cited by 24 · see citing works

Senescence plays a role in myotonic dystrophy type 1

García-Puga, M., Saenz‐Antoñanzas, A., Gereñu, G., Arrieta-Legorburu, A., Fernández‐Torrón, R., Zulaica, M., Sáenz, A., Elizazu, J., Nogales‐Gadea, G., Gadalla, S. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.159357 · Cited by 23 · see citing works

Increased permeability of reconstructed human epidermis from UVB-irradiated keratinocytes

Löwenau, L. J., Zoschke, C., Brodwolf, R., Volz, P., Hausmann, C., Wattanapitayakul, S. K., Boreham, A., Alexiev, U., & Schäfer‐Korting, M. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.12.017 · Cited by 23 · see citing works

Quantitative evaluation of collagen and elastic fibers after intense pulsed light treatment of mouse skin

Faucz, L. R. L., Will, S., Rodrigues, C. J., Hesse, H., Moraes, A. C., & Maria, D. A. (2018) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22782 · Cited by 22 · see citing works

Do senescence markers correlate in vitro and in situ within individual human donors?

Waaijer, M., Gunn, D., van Heemst, D., Slagboom, P., Sedivy, J., Dirks, R., Tanke, H., Westendorp, R., & Maier, A. B. (2018) · Aging · doi:10.18632/aging.101389 · Cited by 21 · see citing works

Proteome-wide analysis of in situ aged fibroblasts

Waldera-Lupa, D. M., & Stühler, K. (2015) · Oncotarget · doi:10.18632/oncotarget.3176 · Cited by 1 · see citing works

The curious case of dermal fibroblasts: cell identity loss may be a mechanism underlying cardiovascular aging

Badi, I. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz012 · Cited by 6 · see citing works

The ageing dermis: the main cause for the appearance of 'old' skin

Lapiere, C. M. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb16119.x · Cited by 135 · see citing works

Maintenance of Chronological Aging Features in Culture of Normal Human Dermal Fibroblasts from Old Donors

Rorteau, J., Chevalier, F. P., Bonnet, S., Barthélemy, T., Lopez-Gaydon, A., Martin, L. S., Béchetoille, N., & Lamartine, J. (2022) · Cells · doi:10.3390/cells11050858 · Cited by 39 · see citing works

Mise en place d'un modèle in vitro d'étude du vieillissement cellulaire sur fibroblaste dermique humain

Lafforgue, C., Zabot, M. T., & COTTE, J. (1991) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.1991.tb00551.x