The AhR–Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention?
Open accessAbstract
The ligand-activated transcription factor AhR mediates the cutaneous stress response toward a variety of environmental noxae and is therefore currently of interest for modern preventive medicine. In this issue, Tsuji et al. identify the antifungal agent ketoconazole as an inducer of AhR signaling and the Nrf2 antioxidant response in human keratinocytes. Ketoconazole-stimulated nuclear translocation of Nrf2 and its cytoprotective effects against oxidative stress strongly depend on a functional AhR. This newly identified AhR-Nrf2 pathway opens up new opportunities to prevent and treat inflammatory skin diseases.
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AHR is a ligand-dependent transcription factor activated by multiple compounds that can induce either epidermal differentiation or oxidative stress.
“AHR, a ligand-dependent transcription factor, is activated by multiple compounds that can induce either epidermal differentiation or oxidative stress (43, 44).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [43]
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“AHR, a ligand-dependent transcription factor, is activated by multiple compounds that can either induce epidermal differentiation or oxidative stress (43, 44).”
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- Authors
- Haarmann-Stemmann, T., Abel, J., Fritsche, E., & Krutmann, J.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Corresponding author
- Krutmann, Jean
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 132
- Issue
- 1
- Pages
- 7-9
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1974818802
- Cited by
- 85
- References
- 16
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 14 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 7 · 2012: 1
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- aryl hydrocarbon receptor, Nrf2, keratinocytes, ketoconazole, oxidative stress, chemoprevention, skin inflammation, antifungal agents, nuclear translocation
- MeSH terms
- Anti-Inflammatory Agents, Humans, Ketoconazole, Keratinocytes, Receptors, Aryl Hydrocarbon, NF-E2-Related Factor 2
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