Schafer, Dorothy P.

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 4,089

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

Absinta, M., Maric, D., Gharagozloo, M., Garton, T., Smith, M. D., Jin, J., Fitzgerald, K. C., Song, A., Liu, P., Lin, J.-P., et al. (2021) · Nature

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 768

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 638

Neuronal vulnerability and multilineage diversity in multiple sclerosis

Schirmer, L., Velmeshev, D., Holmqvist, S., Kaufmann, M., Werneburg, S., Jung, D., Vistnes, S., Stockley, J. H., Young, A., Steindel, M., et al. (2019) · Nature

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 638

The “quad‐partite” synapse: Microglia‐synapse interactions in the developing and mature CNS

Schafer, D. P., Lehrman, E. K., & Stevens, B. (2013) · Glia

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 570

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

Werneburg, S., Jung, J., Kunjamma, R. B., Ha, S.-K., Luciano, N. J., Willis, C. M., Gao, G., Biscola, N. P., Havton, L. A., Crocker, S. J., et al. (2020) · Immunity

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 440

Microglia Function in Central Nervous System Development and Plasticity

Schafer, D. P., & Stevens, B. (2015) · Cold Spring Harbor Perspectives in Biology

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 353

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

Schafer, D. P., & Stevens, B. (2013) · Current Opinion in Neurobiology

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 174

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

Schafer, D. P., Heller, C. T., Gunner, G., Heller, M., Gordon, C., Hammond, T., Wolf, Y., Jung, S., & Stevens, B. (2016) · eLife

Genetics and Neurodevelopmental DisordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 147

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons

Schafer, D. P., Lehrman, E. K., Heller, C. T., & Stevens, B. (2014) · Journal of Visualized Experiments

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 108

A comparative analysis of microglial inducible Cre lines

Faust, T. E., Feinberg, P. A., O’Connor, C., Kawaguchi, R., Chan, A., Strasburger, H., Frosch, M., Boyle, M. A., Masuda, T., Amann, L., et al. (2023) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsCRISPR and Genetic Engineering

Cited by 103

Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy

Beccari, S., Sierra-Torre, V., Valero, J., Pereira-Iglesias, M., García-Zaballa, M., Soria, F. N., De Las Heras-Garcia, L., Carretero-Guillen, A., Capetillo-Zarate, E., Domercq, M., et al. (2023) · Autophagy

Neuroinflammation and Neurodegeneration MechanismsAutophagy in Disease and Therapy

Cited by 89

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Gross, P. S., Durán-Laforet, V., Ho, L. T., Melchor, G. S., Zia, S., Manavi, Z., Barclay, W. E., Lee, S. H., Shults, N., Selva, S., et al. (2025) · Nature Communications

Multiple Sclerosis Research StudiesTelomeres, Telomerase, and Senescence

Cited by 62

Transforming growth factor‐beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors

Baror, R., Neumann, B., Segel, M., Chalut, K. J., Fancy, S. P. J., Schafer, D. P., & Franklin, R. J. M. (2019) · Glia

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 54

Microglia phagocytic mechanisms: Development informing disease

Beiter, R. M., Sheehan, P. W., & Schafer, D. P. (2024) · Current Opinion in Neurobiology

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 44

Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS

Eitan, C., Siany, A., Barkan, E., Olender, T., van Eijk, K. R., Moisse, M., Farhan, S. M. K., Danino, Y. M., Yanowski, E., Marmor-Kollet, H., et al. (2022) · Nature Neuroscience

Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research Studies

Cited by 38

4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis–like lesions

Lin, J.-P., Brake, A., Donadieu, M., Lee, A., Smith, G., Hu, K., Nair, G., Kawaguchi, R., Sati, P., Geschwind, D. H., et al. (2025) · Science

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 35

Microglia: Activity‐dependent regulators of neural circuits

Durán Laforet, V., & Schafer, D. P. (2024) · Annals of the New York Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 32

Lymphoid gene expression supports neuroprotective microglia function

Ayata, P., Crowley, J. M., Challman, M. F., Sahasrabuddhe, V., Gratuze, M., Werneburg, S., Ribeiro, D., Hays, E. C., Durán-Laforet, V., Faust, T. E., et al. (2025) · Nature

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 32