Poirier, Guy G.
Université Laval
13 papers on CoChatORCID 0000-0002-4869-1424
Most cited papers
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Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor
Yu, S.-W., Wang, H., Poitras, M. F., Coombs, C., Bowers, W. J., Federoff, H. J., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2002) · Science
Cell death mechanisms and regulationPARP inhibition in cancer therapy
Cited by 1,826
- Verified
PARP inhibition: PARP1 and beyond
Rouleau, M., Patel, A., Hendzel, M. J., Kaufmann, S. H., & Poirier, G. G. (2010) · Nature Reviews Cancer
PARP inhibition in cancer therapyDNA Repair Mechanisms
Cited by 1,298
- Verified
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
Kam, T.-I., Mao, X., Park, H., Chou, S.-C., Karuppagounder, S. S., Umanah, G. E., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., et al. (2018) · Science
Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling
Cited by 476
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Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)
Wang, Y., Kim, N. S., Haince, J.-F., Kang, H. C., David, K. K., Andrabi, S. A., Poirier, G. G., Dawson, V. L., & Dawson, T. M. (2011) · Science Signaling
Cell death mechanisms and regulationPARP inhibition in cancer therapy
Cited by 476
- Verified
Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis
Andrabi, S. A., Umanah, G. K. E., Chang, C., Stevens, D. A., Karuppagounder, S. S., Gagné, J.-P., Poirier, G. G., Dawson, V. L., & Dawson, T. M. (2014) · Proceedings of the National Academy of Sciences
PARP inhibition in cancer therapyCell death mechanisms and regulation
Cited by 307
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Ataxia Telangiectasia Mutated (ATM) Signaling Network Is Modulated by a Novel Poly(ADP-ribose)-dependent Pathway in the Early Response to DNA-damaging Agents
Haince, J.-F., Kozlov, S., Dawson, V. L., Dawson, T. M., Hendzel, M. J., Lavin, M. F., & Poirier, G. G. (2007) · Journal of Biological Chemistry
DNA Repair MechanismsPARP inhibition in cancer therapy
Cited by 261
- Verified
Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration
Cloutier, N., Allaeys, I., Marcoux, G., Machlus, K. R., Mailhot, B., Zufferey, A., Levesque, T., Becker, Y., Tessandier, N., Melki, I., et al. (2018) · Proceedings of the National Academy of Sciences
Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis Mechanisms
Cited by 219
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Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death
Andrabi, S. A., Kang, H. C., Haince, J.-F., Lee, Y.-I., Zhang, J., Chi, Z., West, A. B., Koehler, R. C., Poirier, G. G., Dawson, T. M., et al. (2011) · Nature Medicine
Cell death mechanisms and regulationPARP inhibition in cancer therapy
Cited by 216
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ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
Fouquerel, E., Goellner, E. M., Yu, Z., Gagné, J.-P., Barbi de Moura, M., Feinstein, T., Wheeler, D., Redpath, P., Li, J., Romero, G., et al. (2014) · Cell Reports
PARP inhibition in cancer therapyDNA Repair Mechanisms
Cited by 212
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Platelets release mitochondrial antigens in systemic lupus erythematosus
Melki, I., Allaeys, I., Tessandier, N., Lévesque, T., Cloutier, N., Laroche, A., Vernoux, N., Becker, Y., Benk-Fortin, H., Zufferey, A., et al. (2021) · Science Translational Medicine
Systemic Lupus Erythematosus ResearchPlatelet Disorders and Treatments
Cited by 125
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An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain
Poitras, L., Yu, M., Lesage-Pelletier, C., MacDonald, R. B., Gagné, J.-P., Hatch, G., Kelly, I., Hamilton, S. P., Rubenstein, J. L. R., Poirier, G. G., et al. (2010) · Development
Genetics and Neurodevelopmental DisordersDevelopmental Biology and Gene Regulation
Cited by 69
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Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer’s Disease
Maggiore, A., Casale, A. M., Toscanelli, W., Cappucci, U., Rotili, D., Grieco, M., Gagné, J.-P., Poirier, G. G., d’Erme, M., & Piacentini, L. (2022) · Cells
Alzheimer's disease research and treatmentsNeurobiology and Insect Physiology Research
Cited by 40
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Identification of Mitofusin 1 and Complement Component 1q Subcomponent Binding Protein as Mitochondrial Targets in Systemic Lupus Erythematosus
Becker, Y. L. C., Gagné, J., Julien, A., Lévesque, T., Allaeys, I., Gougeard, N., Rubio, V., Boisvert, F., Jean, D., Wagner, E., et al. (2022) · Arthritis & Rheumatology
Systemic Lupus Erythematosus ResearchSystemic Sclerosis and Related Diseases
Cited by 26
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