ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
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ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of poly(ADP-ribose) (PAR) in response to strand breaks, and it plays an important role in cell death following excessive DNA damage. ARTD1-induced cell death is associated with NAD(+) depletion and ATP loss; however, the molecular mechanism of ARTD1-mediated energy collapse remains elusive. Using real-time metabolic measurements, we compared the effects of ARTD1 activation and direct NAD(+) depletion. We found that ARTD1-mediated PAR synthesis, but not direct NAD(+) depletion, resulted in a block to glycolysis and ATP loss. We then established a proteomics-based PAR interactome after DNA damage and identified hexokinase 1 (HK1) as a PAR binding protein. HK1 activity is suppressed following nuclear ARTD1 activation and binding by PAR. These findings help explain how prolonged activation of ARTD1 triggers energy collapse and cell death, revealing insight into the importance of nucleus-to-mitochondria communication via ARTD1 activation.
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HK1 binding to poly(ADP-ribose) polymers inhibits glycolysis to cause a bioenergetic collapse that precipitates RCD.
“hexokinase 1 (HK1), whose binding to poly(ADP-ribose) polymers inhibits glycolysis to cause a bioenergetic collapse that precipitates RCD [680, 681].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [681]
Excessive PARP1 activation induces ATP depletion via PAR-dependent inhibition of hexokinase, causing dysfunctional glycolysis, likely independently of NAD+ depletion.
“Notably, excessive PARP1 activation induces ATP depletion through PAR-dependent inhibition of hexokinase activity, resulting in dysfunctional glycolysis, a mechanism likely independent of NAD+ depletion (Andrabi et al., 2014; Fouquerel et al., 2014).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Fouquerel et al., 2014
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- Authors
- Fouquerel, E., Goellner, E. M., Yu, Z., Gagné, J.-P., Barbi de Moura, M., Feinstein, T., Wheeler, D., Redpath, P., Li, J., Romero, G., Migaud, M., Van Houten, B., Poirier, G. G., & Sobol, R. W.
- Affiliations
- University of Pittsburgh (US)
- UPMC Hillman Cancer Center (US)
- Centre de recherche du CHU de Québec-Université Laval (CA)
- Queen's University Belfast (GB)
- Corresponding author
- Sobol, Robert W.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 8
- Issue
- 6
- Pages
- 1819-1831
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC4177344
- OpenAlex
- W2122545253
- Cited by
- 212
- References
- 64
- Citations by year
- 2026: 12 · 2025: 16 · 2024: 20 · 2023: 23 · 2022: 18 · 2021: 21 · 2020: 19 · 2019: 18 · 2018: 21 · 2017: 13 · 2016: 18 · 2015: 9 · 2014: 3 · 2013: 1
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- University of Pittsburgh (P30 CA047904)
- Max-Planck-Gesellschaft
- National Institutes of Health (ES021116, GM087798)
- Cancer Institute, University of Pittsburgh (P30CA047904)
- Canadian Institutes of Health Research (MOP209278, 178013_1)
- National Cancer Institute (CA148629, R01CA148629, CA148629-04S1, P30CA047904)
- National Institute of General Medical Sciences (R43GM087798, GM099213, GM087798, R43GM099213, R44GM087798)
- National Institute of Environmental Health Sciences (ES021116, R21ES019498, R44ES021116, ES019498, R43ES021116)
- Topics
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- PARP1, poly(ADP-ribose), hexokinase 1, glycolysis inhibition, NAD+ depletion, DNA damage, cell death
- MeSH terms
- Adenosine Triphosphate, Amino Acid Sequence, DNA Damage, DNA Repair, Energy Metabolism, Glycolysis, Glycoside Hydrolases, Hexokinase, Humans, Mitochondria, Molecular Sequence Data, NAD, Poly(ADP-ribose) Polymerases, Sequence Alignment, Proteomics, Cell Line, Tumor, Protein Interaction Domains and Motifs
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