Zhu, Lihua Julie

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

Yin, H., Song, C.-Q., Dorkin, J. R., Zhu, L. J., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., et al. (2016) · Nature Biotechnology

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 876

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

Yin, H., Song, C.-Q., Suresh, S., Wu, Q., Walsh, S., Rhym, L. H., Mintzer, E., Bolukbasi, M. F., Zhu, L. J., Kauffman, K., et al. (2017) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 499

Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants

Bansal, A., Zhu, L. J., Yen, K., & Tissenbaum, H. A. (2015) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 367

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

Yin, H., Song, C.-Q., Suresh, S., Kwan, S.-Y., Wu, Q., Walsh, S., Ding, J., Bogorad, R. L., Zhu, L. J., Wolfe, S. A., et al. (2018) · Nature Chemical Biology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 240

Adenine base editing in an adult mouse model of tyrosinaemia

Song, C.-Q., Jiang, T., Richter, M., Rhym, L. H., Koblan, L. W., Zafra, M. P., Schatoff, E. M., Doman, J. L., Cao, Y., Dow, L. E., et al. (2019) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 200

Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

Li, Q., Sun, Y., Jarugumilli, G. K., Liu, S., Dang, K., Cotton, J. L., Xiol, J., Chan, P. Y., DeRan, M., Ma, L., et al. (2020) · Cell Stem Cell

Hippo pathway signaling and YAP/TAZWnt/β-catenin signaling in development and cancer

Cited by 180

Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis

Lopes da Rosa, J., Boyartchuk, V. L., Zhu, L. J., & Kaufman, P. D. (2010) · Proceedings of the National Academy of Sciences

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 132

Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity

Rahman, M., Nirala, N. K., Singh, A., Zhu, L. J., Taguchi, K., Bamba, T., Fukusaki, E., Shaw, L. M., Lambright, D. G., Acharya, J. K., et al. (2014) · Journal of Cell Biology

Sirtuins and Resveratrol in MedicineATP Synthase and ATPases Research

Cited by 116

Ki-67 Contributes to Normal Cell Cycle Progression and Inactive X Heterochromatin in p21 Checkpoint-Proficient Human Cells

Sun, X., Bizhanova, A., Matheson, T. D., Yu, J., Zhu, L. J., & Kaufman, P. D. (2017) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsCancer-related Molecular Pathways

Cited by 76

Consequences of aneuploidy in human fibroblasts with trisomy 21

Hwang, S., Cavaliere, P., Li, R., Zhu, L. J., Dephoure, N., & Torres, E. M. (2021) · Proceedings of the National Academy of Sciences

Down syndrome and intellectual disability researchMicrotubule and mitosis dynamics

Cited by 67

Genome-wide detection of CRISPR editing in vivo using GUIDE-tag

Liang, S.-Q., Liu, P., Smith, J. L., Mintzer, E., Maitland, S., Dong, X., Yang, Q., Lee, J., Haynes, C. M., Zhu, L. J., et al. (2022) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 54