Illig, Thomas

Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach

Floegel, A., Stefan, N., Yu, Z., Mühlenbruch, K., Drogan, D., Joost, H.-G., Fritsche, A., Häring, H.-U., Hrabě de Angelis, M., Peters, A., et al. (2013) · Diabetes

Metabolomics and Mass Spectrometry StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 988

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

Wahl, S., Drong, A., Lehne, B., Loh, M., Scott, W. R., Kunze, S., Tsai, P.-C., Ried, J. S., Zhang, W., Yang, Y., et al. (2017) · Nature

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 945

Swarm Learning for decentralized and confidential clinical machine learning

Warnat-Herresthal, S., Schultze, H., Shastry, K. L., Manamohan, S., Mukherjee, S., Garg, V., Sarveswara, R., Händler, K., Pickkers, P., Aziz, N. A., et al. (2021) · Nature

Privacy-Preserving Technologies in DataBlockchain Technology Applications and Security

Cited by 884

Tobacco smoking leads to extensive genome-wide changes in DNA methylation

Zeilinger, S., Kühnel, B., Klopp, N., Baurecht, H., Kleinschmidt, A., Gieger, C., Weidinger, S., Lattka, E., Adamski, J., Peters, A., et al. (2013) · PLoS ONE

Epigenetics and DNA MethylationSmoking Behavior and Cessation

Cited by 824

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum

Gieger, C., Geistlinger, L., Altmaier, E., Hrabé de Angelis, M., Kronenberg, F., Meitinger, T., Mewes, H.-W., Wichmann, H.-E., Weinberger, K. M., Adamski, J., et al. (2008) · PLoS Genetics

Genetic Associations and EpidemiologyMetabolomics and Mass Spectrometry Studies

Cited by 737

Novel biomarkers for pre-diabetes identified by metabolomics

Wang‐Sattler, R., Yu, Z., Herder, C., Messias, A. C., Floegel, A., He, Y., Heim, K., Campillos, M., Holzapfel, C., Thorand, B., et al. (2012) · Molecular Systems Biology

Metabolomics and Mass Spectrometry StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 701

A genome-wide perspective of genetic variation in human metabolism

Illig, T., Gieger, C., Zhai, G., Römisch-Margl, W., Wang-Sattler, R., Prehn, C., Altmaier, E., Kastenmüller, G., Kato, B. S., Mewes, H.-W., et al. (2010) · Nature Genetics

Genetic Associations and EpidemiologyMetabolomics and Mass Spectrometry Studies

Cited by 653

Human serum metabolic profiles are age dependent

Yu, Z., Zhai, G., Singmann, P., He, Y., Xu, T., Prehn, C., Römisch‐Margl, W., Lattka, E., Gieger, C., Soranzo, N., et al. (2012) · Aging Cell

Metabolomics and Mass Spectrometry StudiesGenetics, Aging, and Longevity in Model Organisms

Cited by 340

A common variant on chromosome 11q13 is associated with atopic dermatitis

Esparza-Gordillo, J., Weidinger, S., Fölster-Holst, R., Bauerfeind, A., Ruschendorf, F., Patone, G., Rohde, K., Marenholz, I., Schulz, F., Kerscher, T., et al. (2009) · Nature Genetics

Dermatology and Skin DiseasesGenetic Associations and Epidemiology

Cited by 317

Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors

Müller, S., Martin, S., Koenig, W., Hanifi-Moghaddam, P., Rathmann, W., Haastert, B., Giani, G., Illig, T., Thorand, B., & Kolb, H. (2002) · Diabetologia

Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 311

A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Coviello, A. D., Haring, R., Wellons, M., Vaidya, D., Lehtimäki, T., Keildson, S., Lunetta, K. L., He, C., Fornage, M., Lagou, V., et al. (2012) · PLoS Genetics

Genetic Associations and EpidemiologyHormonal and reproductive studies

Cited by 250

A metabolome-wide association study of kidney function and disease in the general population

Sekula, P., Goek, O.-N., Quaye, L., Barrios, C., Levey, A. S., Römisch-Margl, W., Menni, C., Yet, I., Gieger, C., Inker, L. A., et al. (2016) · Journal of the American Society of Nephrology

Metabolomics and Mass Spectrometry StudiesChronic Kidney Disease and Diabetes

Cited by 203

Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information

Krumsiek, J., Suhre, K., Evans, A. M., Mitchell, M. W., Mohney, R. P., Milburn, M. V., Wägele, B., Römisch-Margl, W., Illig, T., Adamski, J., et al. (2012) · PLoS Genetics

Metabolomics and Mass Spectrometry StudiesBioinformatics and Genomic Networks

Cited by 197

Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms

Baurecht, H., Hotze, M., Brand, S., Büning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Fölster-Holst, R., et al. (2015) · The American Journal of Human Genetics

Dermatology and Skin DiseasesPsoriasis: Treatment and Pathogenesis

Cited by 193

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits

Petersen, A.-K., Zeilinger, S., Kastenmüller, G., Römisch-Margl, W., Brugger, M., Peters, A., Meisinger, C., Strauch, K., Hengstenberg, C., Pagel, P., et al. (2014) · Human Molecular Genetics

Epigenetics and DNA MethylationGenetic Associations and Epidemiology

Cited by 183

Metabolites associate with kidney function decline and incident chronic kidney disease in the general population

Goek, O.-N., Prehn, C., Sekula, P., Römisch-Margl, W., Döring, A., Gieger, C., Heier, M., Koenig, W., Wang-Sattler, R., Illig, T., et al. (2013) · Nephrology Dialysis Transplantation

Metabolomics and Mass Spectrometry StudiesChronic Kidney Disease and Diabetes

Cited by 143

Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits

Horn, D., Kapeller, J., Rivera-Brugués, N., Moog, U., Lorenz-Depiereux, B., Eck, S., Hempel, M., Wagenstaller, J., Gawthrope, A., Monaco, A. P., et al. (2010) · Human Mutation

Genetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities

Cited by 140

Reliability of serum metabolite concentrations over a 4-month period using a targeted metabolomic approach

Floegel, A., Drogan, D., Wang-Sattler, R., Prehn, C., Illig, T., Adamski, J., Joost, H.-G., Boeing, H., & Pischon, T. (2011) · PLoS ONE

Metabolomics and Mass Spectrometry StudiesClinical Laboratory Practices and Quality Control

Cited by 135

Serum Metabolite Concentrations and Decreased GFR in the General Population

Goek, O.-N., Döring, A., Gieger, C., Heier, M., Koenig, W., Prehn, C., Römisch-Margl, W., Wang-Sattler, R., Illig, T., Suhre, K., et al. (2012) · American Journal of Kidney Diseases

Metabolomics and Mass Spectrometry StudiesChronic Kidney Disease and Diabetes

Cited by 121

Increased efficacy of omalizumab in atopic dermatitis patients with wild‐type filaggrin status and higher serum levels of phosphatidylcholines

Hotze, M., Baurecht, H., Rodríguez, E., Chapman‐Rothe, N., Ollert, M., Fölster‐Holst, R., Adamski, J., Illig, T., Ring, J., & Weidinger, S. (2014) · Allergy

Dermatology and Skin DiseasesAsthma and respiratory diseases

Cited by 107

Questionnaire-based self-reported nutrition habits associate with serum metabolism as revealed by quantitative targeted metabolomics

Altmaier, E., Kastenmüller, G., Römisch-Margl, W., Thorand, B., Weinberger, K. M., Illig, T., Adamski, J., Döring, A., & Suhre, K. (2011) · European Journal of Epidemiology

Metabolomics and Mass Spectrometry StudiesNutritional Studies and Diet

Cited by 84

Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues

Adam, J., Brandmaier, S., Leonhardt, J., Scheerer, M. F., Mohney, R. P., Xu, T., Bi, J., Rotter, M., Troll, M., Chi, S., et al. (2016) · Diabetes

Metabolism, Diabetes, and CancerMetabolomics and Mass Spectrometry Studies

Cited by 68

Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk

Kormann, M. S. D., Ferstl, R., Depner, M., Klopp, N., Spiller, S., Illig, T., Vogelberg, C., Von Mutius, E., Kirschning, C. J., & Kabesch, M. (2009) · Allergy

Immune Response and InflammationDermatology and Skin Diseases

Cited by 39

N-acetyltransferase 2 phenotype, occupation, and bladder cancer risk: results from the EPIC cohort

Pesch, B., Gawrych, K., Rabstein, S., Weiss, T., Casjens, S., Rihs, H.-P., Ding, H., Angerer, J., Illig, T., Klopp, N., et al. (2013) · Cancer Epidemiology, Biomarkers & Prevention

Pharmacogenetics and Drug MetabolismCarcinogens and Genotoxicity Assessment

Cited by 35