Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-α or its receptors
Open accessAbstract
Aims/hypothesis A population-based sample was studied to define immune abnormalities in individuals at risk of Type II (non-insulin-dependent) diabetes mellitus because of impaired glucose tolerance.Methods A total of 1653 individuals aged 55 to 74 years participated in a population based survey in Southern Germany (KORA Survey 2000). Those without a history of diabetes were subjected to an OGTT. Randomly selected subjects with IGT ( n=80) were compared with non-diabetic control subjects ( n=77) and patients with Type II diabetes ( n=152) of the same population-based sample after matching for age and sex. Immune parameters were analysed in serum with rigidly evaluated ELISA.Results Serum pro-inflammatory cytokine interleukin 6 (IL-6) concentrations were higher in subjects with IGT and Type II diabetes than in the control subjects (median 1.8 and 2.5 vs 0.8 pg/ml, p<0.0001). Soluble IL-6 receptors potentiate IL-6 bioactivity and their concentrations were mildly increased in Type II diabetes ( p<0.05). These immune changes seem relevant because IL-6 dependent acute-phase proteins C-reactive protein, serum amyloid A protein and fibrinogen were also increased in IGT and Type II diabetes. Circulating concentrations of TNF-alpha and its two receptors sTNF-R60 and sTNF-R80 were not increased in IGT subjects compared with the control subjects.Conclusion/interpretation Our study shows systemic up-regulation of selected inflammatory mediators in patients with Type II diabetes and IGT. The pattern observed is non-random and fits with an IL-6 associated rather than TNF-alpha associated response.
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Elderly people have higher basal levels of inflammation independently of disease status.
“Elderly people have higher basal levels of inflammation independently of disease status, and a considerable number of studies have been carried out in this population to assess associations between physical activity and inflammatory markers (190,223 -230) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [226]
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- Authors
- Müller, S., Martin, S., Koenig, W., Hanifi-Moghaddam, P., Rathmann, W., Haastert, B., Giani, G., Illig, T., Thorand, B., & Kolb, H.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Venue
- Diabetologia
- Published
- 2002-05-08
- Volume
- 45
- Issue
- 6
- Pages
- 805-812
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2024144587
- Cited by
- 311
- References
- 50
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 11 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 3 · 2016: 9 · 2015: 18 · 2014: 19 · 2013: 10 · 2012: 26
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Gesundheit
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- impaired glucose tolerance, type 2 diabetes, interleukin-6, soluble IL-6 receptor, acute phase proteins, C-reactive protein, serum amyloid A, fibrinogen, TNF-α, soluble TNF receptors, systemic inflammation, immune abnormalities
- MeSH terms
- Acute-Phase Proteins, Aged, Blood Glucose, Blood Pressure, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Lipids, Male, Reference Values, Tumor Necrosis Factor-alpha, Interleukin-6, Receptors, Tumor Necrosis Factor, Glucose Intolerance
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