Bauer, Daniel E.

Akt Stimulates Aerobic Glycolysis in Cancer Cells

Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., et al. (2004) · Cancer Research

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 1,454

ATP citrate lyase inhibition can suppress tumor cell growth

Hatzivassiliou, G., Zhao, F., Bauer, D. E., Andreadis, C., Shaw, A. N., Dhanak, D., Hingorani, S. R., Tuveson, D. A., & Thompson, C. B. (2005) · Cancer Cell

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 1,086

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Richter, M. F., Zhao, K. T., Eton, E., Lapinaite, A., Newby, G. A., Thuronyi, B. W., Wilson, C., Koblan, L. W., Zeng, J., Bauer, D. E., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,020

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Canver, M. C., Smith, E. C., Sher, F., Pinello, L., Sanjana, N. E., Shalem, O., Chen, D. D., Schupp, P. G., Vinjamur, D. S., Garcia, S. P., et al. (2015) · Nature

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 886

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science

Hemoglobinopathies and Related DisordersGenomics and Chromatin Dynamics

Cited by 653

ATP citrate lyase is an important component of cell growth and transformation

Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., & Thompson, C. B. (2005) · Oncogene

Cancer, Lipids, and MetabolismLipid metabolism and biosynthesis

Cited by 537

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Wu, Y., Zeng, J., Roscoe, B. P., Liu, P., Yao, Q., Lazzarotto, C. R., Clement, K., Cole, M. A., Luk, K., Baricordi, C., et al. (2019) · Nature Medicine

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 515

Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch

Liu, N., Hargreaves, V. V., Zhu, Q., Kurland, J. V., Hong, J., Kim, W., Sher, F., Macias-Trevino, C., Rogers, J. M., Kurita, R., et al. (2018) · Cell

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 478

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., et al. (2016) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 373

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., & Orkin, S. H. (2013) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 233

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease

Hoban, M. D., Orkin, S. H., & Bauer, D. E. (2016) · Blood

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 194

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

Métais, J.-Y., Doerfler, P. A., Mayuranathan, T., Bauer, D. E., Fowler, S. C., Hsieh, M. M., Katta, V., Keriwala, S., Lazzarotto, C. R., Luk, K., et al. (2019) · Blood Advances

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 177

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

Bauer, D. E., Kamran, S. C., & Orkin, S. H. (2012) · Blood

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 177

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel, C., Guda, S., Renella, R., Bauer, D. E., Canver, M. C., Kim, Y.-J., Heeney, M. M., Klatt, D., Fogel, J., Milsom, M. D., et al. (2016) · Journal of Clinical Investigation

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 167

Hemoglobin switching’s surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer, D. E., & Orkin, S. H. (2015) · Current Opinion in Genetics & Development

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 143

Functional footprinting of regulatory DNA

Vierstra, J., Reik, A., Chang, K.-H., Stehling-Sun, S., Zhou, Y., Hinkley, S. J., Paschon, D. E., Zhang, L., Psatha, N., Bendana, Y. R., et al. (2015) · Nature Methods

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 133

Emerging genetic therapy for sickle cell disease

Orkin, S. H., & Bauer, D. E. (2019) · Annual Review of Medicine

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 119

Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies

Vinjamur, D. S., Bauer, D. E., & Orkin, S. H. (2018) · British Journal of Haematology

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 114

Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells

Nagpal, N., Wang, J., Zeng, J., Lo, E., Moon, D. H., Luk, K., Braun, R. O., Burroughs, L. M., Keel, S. B., Reilly, C., et al. (2020) · Cell Stem Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 105

Fetal haemoglobin in sickle-cell disease: from genetic epidemiology to new therapeutic strategies

Lettre, G., & Bauer, D. E. (2016) · The Lancet

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 104

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts

Lessard, S., Beaudoin, M., Orkin, S. H., Bauer, D. E., & Lettre, G. (2018) · Human Molecular Genetics

Hemoglobinopathies and Related DisordersMicroRNA in disease regulation

Cited by 38

Technical considerations for the use of CRISPR/Cas9 in hematology research

Gundry, M. C., Dever, D. P., Yudovich, D., Bauer, D. E., Haas, S., Wilkinson, A. C., & Singbrant, S. (2017) · Experimental Hematology

CRISPR and Genetic EngineeringHematopoietic Stem Cell Transplantation

Cited by 26