Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies

Mortality in sickle cell disease. Life expectancy and risk factors for early death

Platt, O. S., Brambilla, D. J., Rosse, W. F., Milner, P. F., Castro, O., Steinberg, M. H., & Klug, P. P. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406093302303 · Cited by 3,320 · see citing works

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

Lozzio, C., & Lozzio, B. (1975) · Blood · doi:10.1182/blood.v45.3.321.bloodjournal453321 · Cited by 2,978 · see citing works

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Pasquinelli, A. E., Reinhart, B. J., Slack, F. J., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B. M., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,568 · see citing works

Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia

Charache, S., Terrin, M. L., Moore, R. D., Dover, G. J., Barton, F. B., Eckert, S. V., McMahon, R. P., & Bonds, D. R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322001 · Cited by 2,340 · cited 1× · see citing works

Global epidemiology of haemoglobin disorders and derived service indicators

Modell, B. (2008) · Bulletin of the World Health Organization · doi:10.2471/blt.06.036673 · Cited by 1,932 · see citing works

Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344 · see citing works

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

Cavazzana-Calvo, M., Payen, E., Negre, O., Wang, G., Hehir, K., Fusil, F., Down, J., Denaro, M., Brady, T., Westerman, K., et al. (2010) · Nature · doi:10.1038/nature09328 · Cited by 1,276 · see citing works

Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates

Piel, F. B., Patil, A. P., Howes, R. E., Nyangiri, O. A., Gething, P. W., Dewi, M., Temperley, W. H., Williams, T. N., Weatherall, D. J., & Hay, S. I. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61229-x · Cited by 1,196 · see citing works

Gene therapy returns to centre stage

Naldini, L. (2015) · Nature · doi:10.1038/nature15818 · Cited by 1,184 · see citing works

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor <i>BCL11A</i>

Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B., & Orkin, S. H. (2008) · Science · doi:10.1126/science.1165409 · Cited by 919 · see citing works

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Canver, M. C., Smith, E. C., Sher, F., Pinello, L., Sanjana, N. E., Shalem, O., Chen, D. D., Schupp, P. G., Vinjamur, D. S., Garcia, S. P., et al. (2015) · Nature · doi:10.1038/nature15521 · Cited by 886 · see citing works

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

Dever, D. P., Bak, R. O., Reinisch, A., Camarena, J., Washington, G., Nicolas, C. E., Pavel-Dinu, M., Saxena, N., Wilkens, A. B., Mantri, S., et al. (2016) · Nature · doi:10.1038/nature20134 · Cited by 864 · see citing works

The LIM‐only protein Lmo2 is a bridging molecule assembling an erythroid, DNA‐binding complex which includes the TAL1, E47, GATA‐1 and Ldb1/NLI proteins

Wadman, I., Osada, H., Grütz, G. G., Agulnick, A. D., Westphal, H., Forster, A., & Rabbitts, T. H. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3145 · Cited by 836 · see citing works

CELL-FREE TRANSMISSION IN ADULT SWISS MICE OF A DISEASE HAVING THE CHARACTER OF A LEUKEMIA

Friend, C. (1957) · The Journal of Experimental Medicine · doi:10.1084/jem.105.4.307 · Cited by 748 · see citing works

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

Deng, W., Lee, J., Wang, H., Miller, J., Reik, A., Gregory, P. D., Dean, A., & Blobel, G. A. (2012) · Cell · doi:10.1016/j.cell.2012.03.051 · Cited by 734 · see citing works

A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

Miller, I. J., & Bieker, J. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2776-2786.1993 · Cited by 725 · see citing works

Gene therapy in a patient with sickle cell disease

Ribeil, J.-A., Hacein-Bey-Abina, S., Payen, E., Magnani, A., Semeraro, M., Magrin, E., Caccavelli, L., Neven, B., Bourget, P., El Nemer, W., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1609677 · Cited by 696 · see citing works

Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias

Weatherall, D. J. (2001) · Nature Reviews Genetics · doi:10.1038/35066048 · Cited by 692 · see citing works

Genome-wide association study shows <i>BCL11A</i> associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia

Uda, M., Galanello, R., Sanna, S., Lettre, G., Sankaran, V. G., Chen, W., Usala, G., Busonero, F., Maschio, A., Albai, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711566105 · Cited by 672 · see citing works

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

der Ploeg, L. H. T. V., & Flavell, R. A. (1980) · Cell · doi:10.1016/0092-8674(80)90086-0 · Cited by 660 · see citing works

An Erythroid Enhancer of <i>BCL11A</i> Subject to Genetic Variation Determines Fetal Hemoglobin Level

Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science · doi:10.1126/science.1242088 · Cited by 653 · see citing works

Lethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

Parkins, A. C., Sharpe, A. H., & Orkin, S. H. (1995) · Nature · doi:10.1038/375318a0 · Cited by 599 · see citing works

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

Mohrin, M., Bourke, E., Alexander, D., Warr, M. R., Barry-Holson, K., Le Beau, M. M., Morrison, C. G., & Passegué, E. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.014 · Cited by 599 · see citing works

ATMOSPHERIC OZONE AND FEMORAL FRACTURES

Burton, J. L., Ensell, F. J., Leach, J. F., & Hall, K. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92450-2 · Cited by 587 · see citing works

DNA polymorphisms at the BCL11A , HBS1L-MYB , and β- globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

Lettre, G., Sankaran, V. G., Bezerra, M., Araujo, A. S., Uda, M., Sanna, S., Cao, A., Schlessinger, D., Costa, F. F., Hirschhorn, J. N., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804799105 · Cited by 560 · see citing works

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

Nuez, B., Michalovich, D., Bygrave, A. E., Ploemacher, R., & Grosveld, F. G. (1995) · Nature · doi:10.1038/375316a0 · Cited by 550 · see citing works

Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians

Pilia, G., Chen, W., Scuteri, A., Orrù, M., Albai, G., Dei, M., Lai, S., Usala, G., Lai, M., Loi, P., et al. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020132 · Cited by 543 · see citing works

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

Zhao, Q., Rank, G., Tan, Y., Li, H., Moritz, R. L., Simpson, R. J., Cerruti, L., Curtis, D. J., Patel, D. J., Allis, C. D., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1568 · Cited by 539 · see citing works

Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.

Platt, O., Orkin, S. H., Dover, G., Beardsley, G. P., Miller, B. A., & Nathan, D. G. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111464 · Cited by 532 · see citing works

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

Menzel, S., Garner, C., Gut, I., Matsuda, F., Yamaguchi, M., Heath, S., Foglio, M., Zelenika, D., Boland, A., Rooks, H., et al. (2007) · Nature Genetics · doi:10.1038/ng2108 · Cited by 529 · see citing works

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Soranzo, N., Spector, T. D., Mangino, M., Kuehnel, B., Rendon, A., Teumer, A., Willenborg, C., Wright, B. J., Chen, L., Li, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.467 · Cited by 520 · see citing works

β-Thalassemia

Origa, R. (2016) · Genetics in Medicine · doi:10.1038/gim.2016.173 · Cited by 511 · see citing works

Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1

Vakoc, C. R., Letting, D. L., Gheldof, N., Sawado, T., Bender, M. A., Groudine, M., Weiss, M. J., Dekker, J., & Blobel, G. A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.12.028 · Cited by 490 · see citing works

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β⁺Thalassemia

Ley, T. J., DeSimone, J., Anagnou, N. P., Keller, G. H., Humphries, R. K., Turner, P. H., Young, N. S., Heller, P., & Nienhuis, A. W. (1982) · New England Journal of Medicine · doi:10.1056/nejm198212093072401 · Cited by 490 · see citing works

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

DeWitt, M. A., Magis, W., Bray, N. L., Wang, T., Berman, J. R., Urbinati, F., Heo, S.-J., Mitros, T., Muñoz, D. P., Boffelli, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf9336 · Cited by 477 · see citing works

Transcription complex stability and chromatin dynamics in vivo

Wijgerde, M., Grosveld, F. G., & Fraser, P. (1995) · Nature · doi:10.1038/377209a0 · Cited by 471 · see citing works

Transgenic Knockout Mice with Exclusively Human Sickle Hemoglobin and Sickle Cell Disease

Pászty, C., Brion, C. M., Manci, E., Witkowska, H. E., Stevens, M. E., Mohandas, N., & Rubin, E. M. (1997) · Science · doi:10.1126/science.278.5339.876 · Cited by 467 · see citing works

Reactivation of developmentally silenced globin genes by forced chromatin looping

Deng, W., Rupon, J. W., Krivega, I., Breda, L., Motta, I., Jahn, K. S., Reik, A., Gregory, P. D., Rivella, S., Dean, A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.050 · Cited by 443 · see citing works

Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells

Kurita, R., Suda, N., Sudo, K., Miharada, K., Hiroyama, T., Miyoshi, H., Tani, K., & Nakamura, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059890 · Cited by 418 · see citing works

Hematopoietic stem cell transplantation in thalassemia major and sickle cell disease: indications and management recommendations from an international expert panel

Angelucci, E., Matthes‐Martin, S., BARONCIANI, D., Bernaudin, F., Bonanomi, S., Cappellini, M. D., Dalle, J., Bartolomeo, P. D., de Heredia, C. D., Dickerhoff, R., et al. (2014) · Haematologica · doi:10.3324/haematol.2013.099747 · Cited by 399 · see citing works

5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.

DeSimone, J., Heller, P., Hall, L., & Zwiers, D. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.14.4428 · Cited by 384 · see citing works

Developmental and species-divergent globin switching are driven by BCL11A

Sankaran, V. G., Xu, J., Ragoczy, T., Ippolito, G. C., Walkley, C. R., Maika, S. D., Fujiwara, Y., Ito, M., Groudine, M., Bender, M. A., et al. (2009) · Nature · doi:10.1038/nature08243 · Cited by 379 · see citing works

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., et al. (2016) · Science · doi:10.1126/science.aad3312 · Cited by 373 · see citing works

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

Borg, J., Papadopoulos, P., Georgitsi, M., Gutiérrez, L., Grech, G., Fanis, P., Phylactides, M., Verkerk, A. J. M. H., van der Spek, P. J., Scerri, C. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.630 · Cited by 371 · see citing works

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

Zhou, D., Liu, K., Sun, C.-W., Pawlik, K. M., & Townes, T. M. (2010) · Nature Genetics · doi:10.1038/ng.637 · Cited by 367 · see citing works

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

Traxler, E. A., Yao, Y., Wang, Y.-D., Woodard, K. J., Kurita, R., Nakamura, Y., Hughes, J. R., Hardison, R. C., Blobel, G. A., Li, C., et al. (2016) · Nature Medicine · doi:10.1038/nm.4170 · Cited by 366 · see citing works

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

Ganesh, S. K., Zakai, N. A., van Rooij, F. J. A., Soranzo, N., Smith, A. V., Nalls, M. A., Chen, M., Köttgen, A., Glazer, N. L., Dehghan, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.466 · Cited by 356 · see citing works

The active spatial organization of the β-<i>globin</i> locus requires the transcription factor EKLF

Drissen, R., Palstra, R.-J., Gillemans, N., Splinter, E., Grosveld, F., Philipsen, S., & de Laat, W. (2004) · Genes &amp; Development · doi:10.1101/gad.317004 · Cited by 352 · see citing works

Bcl11a is essential for normal lymphoid development

Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G. (2003) · Nature Immunology · doi:10.1038/ni925 · Cited by 351 · see citing works

Human myeloid leukemia cell lines: a review

Koeffler, H., & Golde, D. (1980) · Blood · doi:10.1182/blood.v56.3.344.344 · Cited by 349 · see citing works

Proof of principle for transfusion of in vitro–generated red blood cells

Giarratana, M., Rouard, H., Dumont, A., Kiger, L., Safeukui, I., Pennec, P. L., François, S., Trugnan, G., Peyrard, T., Marie, T., et al. (2011) · Blood · doi:10.1182/blood-2011-06-362038 · Cited by 343 · see citing works

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

Xu, J., Peng, C., Sankaran, V. G., Shao, Z., Esrick, E. B., Chong, B. G., Ippolito, G. C., Fujiwara, Y., Ebert, B. L., Tucker, P. W., et al. (2011) · Science · doi:10.1126/science.1211053 · Cited by 326 · see citing works

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

Hoban, M. D., Cost, G. J., Mendel, M. C., Romero, Z., Kaufman, M. L., Joglekar, A. V., Ho, M., Lumaquin, D., Gray, D., Lill, G. R., et al. (2015) · Blood · doi:10.1182/blood-2014-12-615948 · Cited by 320 · see citing works

In Situ Genetic Correction of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases

Sebastiano, V., Maeder, M. L., Angstman, J. F., Haddad, B., Khayter, C., Yeo, D. T., Goodwin, M. J., Hawkins, J. S., Ramirez, C. L., Batista, L. F. Z., et al. (2011) · Stem Cells · doi:10.1002/stem.718 · Cited by 307 · see citing works

Knockout-Transgenic Mouse Model of Sickle Cell Disease

Ryan, T. M., Ciavatta, D. J., & Townes, T. M. (1997) · Science · doi:10.1126/science.278.5339.873 · Cited by 300 · see citing works

The Amino Acid Sequence of the γ Chain of Human Fetal Hemoglobin*

Schroeder, W. A., Shelton, J. R., Shelton, J. B., Cormick, J., & Jones, R. T. (1963) · Biochemistry · doi:10.1021/bi00905a016 · Cited by 276 · see citing works

Genetic influences on F cells and other hematologic variables: a twin heritability study

Garner, C., Tatu, T., Reittie, J. E., Littlewood, T. J., Darley, J. H., Cervino, S., Farrall, M., Kelly, P. J., Spector, T. D., & Thein, S. L. (2000) · Blood · doi:10.1182/blood.v95.1.342.001k33_342_346 · Cited by 273 · see citing works

Molecular Basis of Hereditary Persistence of Fetal Hemoglobin

Forget, B. G. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10460.x · Cited by 271 · see citing works

Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation

Galarneau, G., Palmer, C. D., Sankaran, V. G., Orkin, S. H., Hirschhorn, J. N., & Lettre, G. (2010) · Nature Genetics · doi:10.1038/ng.707 · Cited by 267 · see citing works

Treating sickle cell disease by targeting HbS polymerization

Eaton, W. A., & Bunn, H. F. (2017) · Blood · doi:10.1182/blood-2017-02-765891 · Cited by 255 · see citing works

The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation

Soler, E., Andrieu-Soler, C., de Boer, E., Bryne, J. C., Thongjuea, S., Stadhouders, R., Palstra, R.-J., Stevens, M., Kockx, C., van IJcken, W., et al. (2010) · Genes &amp; Development · doi:10.1101/gad.551810 · Cited by 245 · see citing works

A positive role for NLI/Ldb1 in long-range β-globin locus control region function

Song, S.-H., Hou, C., & Dean, A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.025 · Cited by 233 · see citing works

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., & Orkin, S. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303976110 · Cited by 233 · cited 3× · see citing works

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cellsPreprint

Tallack, M. R., Whitington, T., Yuen, W. S., Wainwright, E. N., Keys, J. R., Gardiner, B., Nourbakhsh, E., Cloonan, N., Grimmond, S. M., Bailey, T. L., et al. (2010) · Genome Research · doi:10.1101/gr.106575.110 · Cited by 220 · see citing works

CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells

Hoban, M. D., Lumaquin, D., Kuo, C. Y., Romero, Z., Long, J., Ho, M., Young, C. S., Mojadidi, M., Fitz-Gibbon, S., Cooper, A. R., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.148 · Cited by 220 · see citing works

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

Sankaran, V. G., Menne, T., Šćepanović, D., Vergilio, J., Ji, P., Kim, J., Thiru, P., Orkin, S. H., Lander, E. S., & Lodish, H. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018384108 · Cited by 214 · see citing works

A global role for EKLF in definitive and primitive erythropoiesis

Hodge, D. J., Coghill, E., Keys, J. R., Maguire, T. L., Hartmann, B., McDowall, A. W., Weiss, M. J., Grimmond, S. M., & Perkins, A. C. (2005) · Blood · doi:10.1182/blood-2005-07-2888 · Cited by 209 · see citing works

Molecular basis of β thalassemia and potential therapeutic targets

Thein, S. L. (2017) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2017.06.001 · Cited by 208 · see citing works

An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells

Trakarnsanga, K., Griffiths, R. E., Wilson, M. C., Blair, A., Satchwell, T. J., Meinders, M., Cogan, N. M., Kupzig, S., Kurita, R., Nakamura, Y., et al. (2017) · Nature Communications · doi:10.1038/ncomms14750 · Cited by 206 · see citing works

A Dominant Mutation in the Gene Encoding the Erythroid Transcription Factor KLF1 Causes a Congenital Dyserythropoietic Anemia

Arnaud, L., Saison, C., Helias, V., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.10.010 · Cited by 202 · see citing works

Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach

Craig, J. E., Rochette, J., Fisher, C. A., Weatherall, D. J., Marc, S., Lathrop, M. G., Démenais, F., & Thein, S. L. (1996) · Nature Genetics · doi:10.1038/ng0196-58 · Cited by 190 · see citing works

Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia

Ye, L., Wang, J., Tan, Y., Beyer, A. I., Xie, F., Muench, M. O., & Kan, Y. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612075113 · Cited by 190 · see citing works

Mammalian gene targeting with designed zinc finger nucleases

Porteus, M. H. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.08.003 · Cited by 180 · see citing works

The Erythroid Phenotype of EKLF-Null Mice: Defects in Hemoglobin Metabolism and Membrane Stability

Drissen, R., Lindern, M. V., Kolbus, A., Driegen, S., Steinlein, P., Beug, H., Grosveld, F. G., & Philipsen, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5205-5214.2005 · Cited by 168 · see citing works

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel, C., Guda, S., Renella, R., Bauer, D. E., Canver, M. C., Kim, Y.-J., Heeney, M. M., Klatt, D., Fogel, J., Milsom, M. D., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87885 · Cited by 167 · see citing works

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

Perkins, A. C., Xu, X., Higgs, D. R., Patrinos, G. P., Arnaud, L., Bieker, J. J., Philipsen, S., & Workgroup, T. K. C. (2016) · Blood · doi:10.1182/blood-2016-01-694331 · Cited by 165 · see citing works

BCL11A Haploinsufficiency Causes an Intellectual Disability Syndrome and Dysregulates Transcription

Dias, C., Estruch, S. B., Graham, S. A., McRae, J. F., Sawiak, S. J., Hurst, J. A., Joss, S. K., Holder, S., Morton, J. E. V., Turner, C., et al. (2016) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2016.05.030 · Cited by 162 · see citing works

Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype

Singleton, B. K., Burton, N. M., Green, C. A., Brady, R. L., & Anstee, D. J. (2008) · Blood · doi:10.1182/blood-2008-03-145672 · Cited by 161 · see citing works

Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β ^A(T87Q) - <i>Globin</i> Gene

Negre, O., Eggimann, A.-V., Beuzard, Y., Ribeil, J.-A., Bourget, P., Borwornpinyo, S., Hongeng, S., Hacein-Bey, S., Cavazzana, M., Leboulch, P., et al. (2016) · Human Gene Therapy · doi:10.1089/hum.2016.007 · Cited by 159 · see citing works

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia

Liu, D., Zhang, X., Yu, L., Cai, R., Ma, X., Zheng, C., Zhou, Y., Liu, Q., Wei, X., Lin, L., et al. (2014) · Blood · doi:10.1182/blood-2014-03-561779 · Cited by 155 · see citing works

Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34 + Hematopoietic Stem and Progenitor Cells

Chang, K.-H., Smith, S. E., Sullivan, T., Chen, K., Zhou, Q., West, J. A., Liu, M., Liu, Y., Vieira, B. F., Sun, C., et al. (2017) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1016/j.omtm.2016.12.009 · Cited by 155 · see citing works

p66α–MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2–NuRD complex

Gnanapragasam, M. N., Scarsdale, J. N., Amaya, M. L., Webb, H. D., Desai, M. A., Walavalkar, N. M., Wang, S. Z., Zu Zhu, S., Ginder, G. D., & Williams, D. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015341108 · Cited by 148 · see citing works

BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations

Basak, A., Hancarova, M., Ulirsch, J. C., Balci, T. B., Trkova, M., Pelisek, M., Vlckova, M., Muzikova, K., Cermak, J., Trka, J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81163 · Cited by 147 · see citing works

Advances in the use of hydroxyurea

Ware, R. E., & Aygün, B. (2009) · Hematology · doi:10.1182/asheducation-2009.1.62 · Cited by 143 · see citing works

Hemoglobin switching’s surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer, D. E., & Orkin, S. H. (2015) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2015.08.001 · Cited by 143 · see citing works

LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo

Lee, Y. T., de Vasconcellos, J. F., Yuan, J., Byrnes, C., Noh, S.-J., Meier, E. R., Kim, K. S., Rabel, A., Kaushal, M., Muljo, S. A., et al. (2013) · Blood · doi:10.1182/blood-2012-12-472308 · Cited by 142 · see citing works

Conditional c- myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation

Lieu, Y. K., & Reddy, E. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907623106 · Cited by 136 · see citing works

Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice.

Gaensler, K. M. L., Kitamura, M., & Kan, Y. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11381 · Cited by 134 · see citing works

Functional footprinting of regulatory DNA

Vierstra, J., Reik, A., Chang, K.-H., Stehling-Sun, S., Zhou, Y., Hinkley, S. J., Paschon, D. E., Zhang, L., Psatha, N., Bendana, Y. R., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3554 · Cited by 133 · see citing works

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene

Davies, J. M., Hawe, N., Kabarowski, J. H. S., Huang, Q.-H., Zhu, J., Brand, N. J., Leprince, D., Dhordain, P., Cook, M., Morriss‐Kay, G. M., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1202332 · Cited by 128 · see citing works

Dendritic cell fate is determined by BCL11A

Ippolito, G. C., Dekker, J. D., Wang, Y., Lee, B., Shaffer, A. L., Lin, J. X., Wall, J. K., Lee, B.-S., Staudt, L. M., Liu, Y., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319228111 · Cited by 126 · see citing works

In Vitro Mass Production of Human Erythroid Cells from the Blood of Normal Donors and of Thalassemic Patients

Migliaccio, G., Pietro, R. D., di Giacomo, V., Baldassarre, A. D., Migliaccio, A. R., Maccioni, L., Galanello, R., & Papayannopoulou, T. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0502 · Cited by 126 · see citing works

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin

Wienert, B., Funnell, A. P. W., Norton, L. J., Pearson, R. C. M., Wilkinson‐White, L. E., Lester, K. L., Vadolas, J., Porteus, M. H., Matthews, J. M., Quinlan, K. G. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms8085 · Cited by 125 · see citing works

Bcl11a Deficiency Leads to Hematopoietic Stem Cell Defects with an Aging-like Phenotype

Luc, S., Huang, J., McEldoon, J. L., Somuncular, E., Li, D., Rhodes, C., Mamoor, S., Hou, S., Xu, J., & Orkin, S. H. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.064 · Cited by 125 · see citing works

Hereditary Persistence of Fetal Hemoglobin in Greece. A Study and a Comparison

Fessas, P., & Stamatoyannopoulos, G. (1964) · Blood · doi:10.1182/blood.v24.3.223.223 · Cited by 114 · see citing works

LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis

Maeda, T., Ito, K., Merghoub, T., Poliseno, L., Hobbs, R. M., Wang, G., Dong, L., Maeda, M., Doré, L. C., Zelent, A., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.09.005 · Cited by 113 · see citing works

EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression

Renneville, A., van Galen, P., Canver, M. C., McConkey, M. E., Krill-Burger, J. M., Dorfman, D. M., Holson, E. B., Bernstein, B., Orkin, S. H., Bauer, D. E., et al. (2015) · Blood · doi:10.1182/blood-2015-06-649087 · Cited by 110 · see citing works

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

Canver, M. C., Lessard, S., Pinello, L., Wu, Y., Ilboudo, Y., Stern, E. N., Needleman, A. J., Galactéros, F., Brugnara, C., Kutlar, A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3793 · Cited by 105 · see citing works

Fetal haemoglobin in sickle-cell disease: from genetic epidemiology to new therapeutic strategies

Lettre, G., & Bauer, D. E. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01341-0 · Cited by 104 · see citing works

Coordination of erythropoiesis by the transcription factor c-Myb

Vegiopoulos, A., García, P., Emambokus, N. R., & Frampton, J. (2006) · Blood · doi:10.1182/blood-2005-07-2968 · Cited by 103 · see citing works

Mi2β-mediated silencing of the fetal γ-globin gene in adult erythroid cells

Amaya, M., Desai, M., Gnanapragasam, M. N., Wang, S. Z., Zu Zhu, S., Williams, D. C., & Ginder, G. D. (2013) · Blood · doi:10.1182/blood-2012-11-466227 · Cited by 102 · see citing works

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

Lavelle, D., Vaitkus, K., Ling, Y., Ruiz, M. A., Mahfouz, R. Z., Ng, K. P., Negrotto, S., Smith, N. F., Terse, P., Engelke, K. J., et al. (2011) · Blood · doi:10.1182/blood-2011-08-371690 · Cited by 99 · see citing works

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

Cui, S., Lim, K.-C., Shi, L., Lee, M. P., Jearawiriyapaisarn, N., Myers, G., Campbell, A., Harro, D., Iwase, S., Trievel, R. C., et al. (2015) · Blood · doi:10.1182/blood-2015-02-626259 · Cited by 98 · see citing works

Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells

Tsang, J. C. H., Yu, Y., Burke, S., Buettner, F., Wang, C., Kolodziejczyk, A., Teichmann, S., Lu, L.-M., & Liu, P. (2015) · Genome Biology · doi:10.1186/s13059-015-0739-5 · Cited by 98 · see citing works

Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/γ-globin looping

Krivega, I., Byrnes, C., de Vasconcellos, J. F., Lee, Y. T., Kaushal, M., Dean, A., & Miller, J. L. (2015) · Blood · doi:10.1182/blood-2015-02-629972 · Cited by 97 · see citing works

SOME PROPERTIES OF HUMAN FETAL AND MATERNAL BLOOD

Darling, R. C., Smith, C. A., Asmussen, E., et al. (1941) · Journal of Clinical Investigation · doi:10.1172/jci101267 · Cited by 96 · see citing works

Dual role for the methyltransferase G9a in the maintenance of β-globin gene transcription in adult erythroid cells

Chaturvedi, C.-P., Hosey, A. M., Palii, C. G., Perez‐Iratxeta, C., Nakatani, Y., Ranish, J. A., Dilworth, F. J., & Brand, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906769106 · Cited by 95 · see citing works

KLF1 drives the expression of fetal hemoglobin in British HPFH

Wienert, B., Martyn, G. E., Kurita, R., Nakamura, Y., Quinlan, K. G. R., & Crossley, M. (2017) · Blood · doi:10.1182/blood-2017-02-767400 · Cited by 94 · see citing works

KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome

Magor, G. W., Tallack, M. R., Gillinder, K. R., Bell, C. C., McCallum, N., Williams, B., & Perkins, A. C. (2015) · Blood · doi:10.1182/blood-2014-08-590968 · Cited by 92 · see citing works

Nuclease-mediated gene editing by homologous recombination of the human globin locus

Voit, R. A., Hendel, A., Pruett‐Miller, S. M., & Porteus, M. H. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt947 · Cited by 91 · see citing works

Ldb1-nucleated transcription complexes function as primary mediators of global erythroid gene activation

Li, L., Freudenberg, J., Cui, K., Dale, R., Song, S., Dean, A., Zhao, K., Jothi, R., & Love, P. E. (2013) · Blood · doi:10.1182/blood-2013-01-479451 · Cited by 90 · see citing works

Joining the loops: β‐Globin gene regulation

Noordermeer, D., & de Laat, W. L. (2008) · IUBMB Life · doi:10.1002/iub.129 · Cited by 89 · see citing works

Messenger RNA population analysis during erythroid differentiation: A kinetical approach

Bastos, R. N., Volloch, Z., & Aviv, H. (1977) · Journal of Molecular Biology · doi:10.1016/s0022-2836(77)80068-5 · Cited by 87 · see citing works

Regulation of hematopoietic development by ZBTB transcription factors

Maeda, T. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2035-x · Cited by 85 · see citing works

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

Breda, L., Motta, I., Lourenco, S., Gemmo, C., Deng, W., Rupon, J. W., Abdulmalik, O. Y., Manwani, D., Blobel, G. A., & Rivella, S. (2016) · Blood · doi:10.1182/blood-2016-01-691089 · Cited by 83 · see citing works

The LDB1 Complex Co-opts CTCF for Erythroid Lineage-Specific Long-Range Enhancer Interactions

Lee, J., Krivega, I. V., Dale, R., & Dean, A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.072 · Cited by 82 · see citing works

A Common Human β Globin Splicing Mutation Modeled in Mice

Lewis, J., Yang, B., Kim, R., et al. (1998) · Blood · doi:10.1182/blood.v91.6.2152 · Cited by 81 · see citing works

The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice

Porcu, S., Kitamura, M., Witkowska, E., Zhang, Z., Mutero, A., Lin, C. J., Chang, J., & Gaensler, K. M. L. (1997) · Blood · doi:10.1182/blood.v90.11.4602 · Cited by 79 · see citing works

A Form of Hereditary Persistence of Fetal Haemoglobin Characterized by Uneven Cellular Distribution of Haemoglobin F and the Production of Haemoglobins A and A2 in Homozygotes

Weatherall, D. J., Cartner, R., Clegg, J. B., Wood, W. G., Macrae, I. A., & Mackenzie, A. (1975) · British Journal of Haematology · doi:10.1111/j.1365-2141.1975.tb01815.x · Cited by 74 · see citing works

2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment

Funnell, A. P. W., Prontera, P., Ottaviani, V., Piccione, M., Giambona, A., Maggio, A., Ciaffoni, F., Stehling-Sun, S., Marra, M., Masiello, F., et al. (2015) · Blood · doi:10.1182/blood-2015-04-638528 · Cited by 70 · see citing works

Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex

Greig, L. C., Woodworth, M. B., Greppi, C., & Macklis, J. D. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.008 · Cited by 66 · see citing works

Distal CCAAT box deletion in the A globin gene of two black adolescents with elevated fetal A globin

Gilman, J. G., Mishima, N., Wen, X., Stoming, T. A., Lobel, J. S., & Huisman, T. H. J. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.22.10635 · Cited by 61 · see citing works

Distinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells

Kiefer, C. M., Lee, J., Hou, C., Dale, R. K., Lee, Y. T., Meier, E. R., Miller, J. L., & Dean, A. (2011) · Blood · doi:10.1182/blood-2011-06-363101 · Cited by 59 · see citing works

The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription

Yun, W. J., Kim, Y. W., Kang, Y., Lee, J., Dean, A., & Kim, A. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku072 · Cited by 58 · see citing works

Let-7 microRNAs are developmentally regulated in circulating human erythroid cells

Noh, S.-J., Miller, S. H., Lee, Y. T., et al. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-98 · Cited by 58 · see citing works

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis)

Rivers, A. E., Vaitkus, K., Ibanez, V., Ruiz, M. A., Jagadeeswaran, R., Saunthararajah, Y., Cui, S., Engel, J. D., DeSimone, J., & Lavelle, D. (2016) · Haematologica · doi:10.3324/haematol.2015.140749 · Cited by 56 · see citing works

Paying for future success in gene therapy

Orkin, S. H., & Reilly, P. R. (2016) · Science · doi:10.1126/science.aaf4770 · Cited by 56 · see citing works

Fetal expression of a human Aγ globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

Perkins, A. C., Peterson, K. R., Stamatoyannopoulos, G., Witkowska, H. E., & Orkin, S. H. (2000) · Blood · doi:10.1182/blood.v95.5.1827.004k10_1827_1833 · Cited by 55 · see citing works

Gene Therapy in a Patient with Sickle Cell Disease

Badat, M., & Davies, J. (2017) · New England Journal of Medicine · doi:10.1056/nejmc1704009 · Cited by 54 · see citing works

IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts

de Vasconcellos, J. F., Tumburu, L., Byrnes, C., Lee, Y. T., Xu, P. C., Li, M., Rabel, A., Clarke, B. A., Guydosh, N. R., Proia, R. L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609552114 · Cited by 50 · see citing works

Strict in vivo specificity of the Bcl11a erythroid enhancer

Smith, E. C., Luc, S., Croney, D. M., Woodworth, M. B., Greig, L. C., Fujiwara, Y., Nguyen, M., Sher, F., Macklis, J. D., Bauer, D. E., et al. (2016) · Blood · doi:10.1182/blood-2016-08-736249 · Cited by 49 · see citing works

Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines

Antoniou, M. N. (2003) · Humana Press eBooks · doi:10.1385/0-89603-178-0:421 · Cited by 47 · see citing works

Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2

Shearstone, J. R., Golonzhka, O., Chonkar, A., Tamang, D., van Duzer, J. H., Jones, S. S., & Jarpe, M. B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153767 · Cited by 43 · see citing works

A G gamma type of the hereditary persistence of fetal hemoglobin with beta chain production in cis.

Huisman, T. H. J., Miller, A. L., & Schroeder, W. A. (1975) · PubMed · Cited by 42 · see citing works

The regulation of human globin promoters by CCAAT box elements and the recruitment of NF-Y

Martyn, G. E., Quinlan, K. G. R., & Crossley, M. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.10.002 · Cited by 41 · see citing works

Humanized β-Thalassemia Mouse Model Containing the Common IVSI-110 Splicing Mutation

Vadolas, J., Nefedov, M. D., Wardan, H., Mansooriderakshan, S., Voullaire, L. E., Jamsai, D., Williamson, R., & Ioannou, P. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512931200 · Cited by 35 · see citing works

Animal models of β-hemoglobinopathies: utility and limitations

McColl, B., & Vadolas, J. (2016) · Journal of Blood Medicine · doi:10.2147/jbm.s87955 · Cited by 34 · see citing works

The British type of non‐deletion HPFH: characterization of developmental changes in vivo and erythroid growth in vitro

Wood, W. G., Macrae, I. A., Darbre, P. D., et al. (1982) · British Journal of Haematology · doi:10.1111/j.1365-2141.1982.tb01935.x · Cited by 31 · see citing works

Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice

Costa, F. C., Fedosyuk, H., Chazelle, A. M., Neades, R. Y., & Peterson, K. R. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003155 · Cited by 30 · see citing works

HETEROCELLULAR HEREDITARY PERSISTENCE OF FETAL HÆMOGLOBIN AND HOMOZYGOUS SICKLE-CELL DISEASE

Serjeant, G., Serjeant, B. E., & Mason, K. P. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92976-2 · Cited by 24 · see citing works

Utility of CRISPR/Cas9 systems in hematology research

Lucas, D., O’Leary, H. A., Ebert, B. L., Cowan, C. A., & Tremblay, C. S. (2017) · Experimental Hematology · doi:10.1016/j.exphem.2017.06.006 · Cited by 13 · see citing works

HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts

de Vasconcellos, J. F., Lee, Y. T., Byrnes, C., Tumburu, L., Rabel, A., & Miller, J. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166928 · Cited by 12 · see citing works

Fundamental and clinical aspects of hemoglobin and bile pigment metabolism.

Watson, C. J. E. (1948) · PubMed · Cited by 1 · see citing works

Fetal hemoglobin in sickle cell anemia

Steinberg, M. H. (2020) · Blood · doi:10.1182/blood.2020007645 · Cited by 136 · see citing works

Robust clinical and laboratory response to hydroxyurea using pharmacokinetically guided dosing for young children with sickle cell anemia

McGann, P. T., Niss, O., Dong, M., Marahatta, A., Howard, T. A., Mizuno, T., Lane, A., Kalfa, T. A., Malik, P., Quinn, C. T., et al. (2019) · American Journal of Hematology · doi:10.1002/ajh.25510 · Cited by 105 · see citing works

Epigenetic Modifiers as Game Changers for Healthy Aging

Sharma, S., & Bhonde, R. R. (2023) · Rejuvenation Research · doi:10.1089/rej.2022.0059 · Cited by 10 · see citing works

Mouse Models of Epigenetic Inheritance

Bernal, A. J., Murphy, S. K., & Jirtle, R. L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375709-8.00015-0 · Cited by 32 · see citing works

Epigenetic Responses to Diet in Aging

Ford, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00016-9 · Cited by 3 · see citing works

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

Xu, J., Peng, C., Sankaran, V. G., Shao, Z., Esrick, E. B., Chong, B. G., Ippolito, G. C., Fujiwara, Y., Ebert, B. L., Tucker, P. W., et al. (2011) · Science · doi:10.1126/science.1211053 · Cited by 326 · see citing works

Transcriptional silencing of fetal hemoglobin by BCL11A

Sankaran, V. G., Xu, J., & Orkin, S. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05574.x · Cited by 67 · see citing works