Kruse, Andrew C.

Crystal structure of the β2 adrenergic receptor–Gs protein complex

Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 3,009

Crystal structure of the human σ1 receptor

Schmidt, H. R., Zheng, S., Gurpinar, E., Koehl, A., Manglik, A., & Kruse, A. C. (2016) · Nature

Pharmacological Receptor Mechanisms and EffectsReceptor Mechanisms and Signaling

Cited by 482

Muscarinic acetylcholine receptors: novel opportunities for drug development

Kruse, A. C., Kobilka, B. K., Gautam, D., Sexton, P. M., Christopoulos, A., & Wess, J. (2014) · Nature Reviews Drug Discovery

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 437

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

Maute, R. L., Gordon, S. R., Mayer, A. T., McCracken, M. N., Natarajan, A., Ring, N. G., Kimura, R., Tsai, J. M., Manglik, A., Kruse, A. C., et al. (2015) · Proceedings of the National Academy of Sciences

Cancer Immunotherapy and BiomarkersMonoclonal and Polyclonal Antibodies Research

Cited by 347

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Staus, D. P., Strachan, R. T., Manglik, A., Pani, B., Kahsai, A. W., Kim, T. H., Wingler, L. M., Ahn, S., Chatterjee, A., Masoudi, A., et al. (2016) · Nature

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 330

Protein design and variant prediction using autoregressive generative models

Shin, J.-E., Riesselman, A. J., Kollasch, A. W., McMahon, C., Simon, E., Sander, C., Manglik, A., Kruse, A. C., & Marks, D. S. (2021) · Nature Communications

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 320

Structures of the σ2 receptor enable docking for bioactive ligand discovery

Alon, A., Lyu, J., Braz, J. M., Tummino, T. A., Craik, V., O’Meara, M. J., Webb, C. M., Radchenko, D. S., Moroz, Y. S., Huang, X.-P., et al. (2021) · Nature

Pharmacological Receptor Mechanisms and EffectsReceptor Mechanisms and Signaling

Cited by 211

Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms

Huseby, M. J., Kruse, A. C., Digre, J., Kohler, P. L., Vocke, J. A., Mann, E. E., Bayles, K. W., Bohach, G. A., Schlievert, P. M., Ohlendorf, D. H., et al. (2010) · Proceedings of the National Academy of Sciences

Bacterial biofilms and quorum sensingAntimicrobial Resistance in Staphylococcus

Cited by 199

Structural Basis of Smoothened Activation in Hedgehog Signaling

Huang, P., Zheng, S., Wierbowski, B. M., Kim, Y., Nedelcu, D., Aravena, L., Liu, J., Kruse, A. C., & Salic, A. (2018) · Cell

Hedgehog Signaling Pathway StudiesReceptor Mechanisms and Signaling

Cited by 176

Goniometer-based femtosecond crystallography with X-ray free electron lasers

Cohen, A. E., Soltis, S. M., González, A., Aguila, L., Alonso-Mori, R., Barnes, C. O., Baxter, E. L., Brehmer, W., Brewster, A. S., Brunger, A. T., et al. (2014) · Proceedings of the National Academy of Sciences

Enzyme Structure and FunctionAdvanced X-ray Imaging Techniques

Cited by 144

Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant

Pascolutti, R., Sun, X., Kao, J., Maute, R. L., Ring, A. M., Bowman, G. R., & Kruse, A. C. (2016) · Structure

Cancer Immunotherapy and BiomarkersProtein Structure and Dynamics

Cited by 102

Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors

Dates, A. N., Jones, D. T. D., Smith, J. S., Skiba, M. A., Rich, M. F., Burruss, M. M., Kruse, A. C., & Blacklow, S. C. (2022) · Cell chemical biology

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 37

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

Page, J. E., Skiba, M. A., Do, T., Kruse, A. C., & Walker, S. (2022) · Proceedings of the National Academy of Sciences

Bacterial Genetics and BiotechnologyBiochemical and Structural Characterization

Cited by 12

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

Page, J. E., Skiba, M. A., Do, T., Kruse, A. C., & Walker, S. (2022) · Proceedings of the National Academy of Sciences

Bacterial Genetics and BiotechnologyBiochemical and Structural Characterization

Cited by 12

In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer

Harvey, E. P., Smith, J. S., Hurley, J. D., Granados, A. J., Schmid, E. W., Liang-Lin, J. G., Zhang, H., Meara, E. M., Wren, E. K., Paul, S., et al. (2026) · Nature Communications

Computational Drug Discovery Methodsvaccines and immunoinformatics approaches

Cited by 7