Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients
Open accessAbstract
Tumor organoids from individual patients with metastatic colorectal cancer can help predict response to irinotecan with or without 5-fluorouracil.
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Prior studies in CRC PDOs have proved them suitable for preclinical drug screening and response prediction.
“Prior studies in CRC PDOs have been proved to be suitable for preclinical drug screening and response prediction (41, 42).”
From Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer (2022) · cites this paper as [41]
Patient-derived tumoroid models show promise in testing drug efficacy and potentially determining a personalized treatment for the patient.
“patient-derived tumoroid models also show promise in testing drug efficacy and potentially determining a personalized treatment for the patient7–12.”
From One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids (2023) · cites this paper as [9]
PDOs have emerged as a promising preclinical model for therapeutic prediction and functional studies across multiple cancer types, including in PDAC.
“PDOs have emerged as a promising preclinical model for therapeutic prediction and functional studies across multiple cancer types, including in PDAC18,19,48–50.”
From Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution (2022) · cites this paper as [50]
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Self-citation
- Authors
- Ooft, S. N., Weeber, F., Dijkstra, K. K., McLean, C. M., Kaing, S., van Werkhoven, E., Schipper, L., Hoes, L., Vis, D. J., van de Haar, J., Prevoo, W., Snaebjornsson, P., van der Velden, D., Klein, M., Chalabi, M., Boot, H., van Leerdam, M., Bloemendal, H. J., Beerepoot, L. V., Wessels, L., Cuppen, E., Clevers, H., & Voest, E. E.
- Affiliations
- The Netherlands Cancer Institute (NL)
- Department of Biometrics, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
- Oncode Institute, 3521 AL Utrecht, Netherlands.
- Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
- Department of Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
- Department of Gastrointestinal Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
- Radboud University Medical Center (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- University Medical Center Utrecht (NL)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Ooft, Salo N.
- Weeber, Fleur
- Dijkstra, Krijn K.
- McLean, Chelsea M.
- Voest, Emile E.
- ORCID
- Ooft, Salo N.
- Weeber, Fleur
- Dijkstra, Krijn K.
- McLean, Chelsea M.
- van Werkhoven, Erik
- Schipper, Luuk
- Hoes, Louisa
- van de Haar, Joris
- Prevoo, Warner
- Snaebjornsson, Petur
- van der Velden, Daphne
- Klein, Michelle
- Chalabi, Myriam
- Boot, Henk
- van Leerdam, Monique
- Bloemendal, Haiko J.
- Beerepoot, Laurens V.
- Wessels, Lodewyk
- Cuppen, Edwin
- Clevers, Hans
- Voest, Emile E.
- Venue
- Science Translational Medicine
- Published
- 2019-10-09
- Volume
- 11
- Issue
- 513
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- OpenAlex
- W2980113327
- Cited by
- 813
- References
- 33
- Citations by year
- 2026: 136 · 2025: 101 · 2024: 114 · 2023: 112 · 2022: 128 · 2021: 144 · 2020: 72 · 2019: 5
- FWCI
- 36.52
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- other-oa
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Research Repository (Delft University of Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (2012-2022)
- KWF Kankerbestrijding (NKI2015-7732, HUBR2014-7006)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Keywords
- patient-derived tumor organoids, metastatic colorectal cancer, chemotherapy response prediction, irinotecan, predictive biomarkers, irinotecan resistance, in vitro drug sensitivity testing
- MeSH terms
- Capecitabine, Irinotecan, Oxaliplatin, Antineoplastic Agents, Female, Fluorouracil, Humans, Organoids, Prospective Studies, Colorectal Neoplasms, Treatment Outcome
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