Heath, Paul R.

The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins

Harrison, P. J., Heath, P. R., Eastwood, S. L., Burnet, P. W. J., McDonald, B., & Pearson, R. C. A. (1995) · Neuroscience Letters

Molecular Biology Techniques and ApplicationsRNA Research and Splicing

Cited by 342

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

Cox, L. E., Ferraiuolo, L., Goodall, E. F., Heath, P. R., Higginbottom, A., Mortiboys, H., Hollinger, H. C., Hartley, J. A., Brockington, A., Burness, C. E., et al. (2010) · PLoS ONE

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 262

Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role

Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 233

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

Varcianna, A., Myszczynska, M. A., Castelli, L. M., O'Neill, B., Kim, Y., Talbot, J., Nyberg, S., Nyamali, I., Heath, P. R., Stopford, M. J., et al. (2019) · EBioMedicine

Amyotrophic Lateral Sclerosis ResearchExtracellular vesicles in disease

Cited by 194

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

Goodall, E. F., Heath, P. R., Bandmann, O., Kirby, J., & Shaw, P. J. (2013) · Frontiers in Cellular Neuroscience

MicroRNA in disease regulationNeuroinflammation and Neurodegeneration Mechanisms

Cited by 187

Value of systematic genetic screening of patients with amyotrophic lateral sclerosis

Shepheard, S. R., Parker, M. D., Cooper-Knock, J., Verber, N. S., Tuddenham, L., Heath, P., Beauchamp, N., Place, E., Sollars, E. S. A., Turner, M. R., et al. (2021) · Journal of Neurology, Neurosurgery & Psychiatry

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 116

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

Garwood, C. J., Ratcliffe, L. E., Morgan, S. V., Simpson, J. E., Owens, H., Vazquez-Villaseñor, I., Heath, P. R., Romero, I. A., Ince, P. G., & Wharton, S. B. (2015) · Molecular Brain

Growth Hormone and Insulin-like Growth FactorsAlzheimer's disease research and treatments

Cited by 101

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

Al‐Mashhadi, S., Simpson, J. E., Heath, P. R., Dickman, M., Forster, G., Matthews, F. E., Brayne, C., Ince, P. G., Wharton, S. B., & Medical Research Council Cognitive Function and Ageing Study (2015) · Brain Pathology

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 85

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis

Cooper-Knock, J., Green, C., Altschuler, G., Wei, W., Bury, J. J., Heath, P. R., Wyles, M., Gelsthorpe, C., Highley, J. R., Lorente-Pons, A., et al. (2017) · Acta Neuropathologica Communications

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 80

The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain

Fluteau, A., Ince, P. G., Minett, T., Matthews, F. E., Brayne, C., Garwood, C. J., Ratcliffe, L. E., Morgan, S., Heath, P. R., Shaw, P. J., et al. (2015) · Neuroscience Letters

FOXO transcription factor regulationAlzheimer's disease research and treatments

Cited by 66

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

Simpson, J. E., Ince, P. G., Matthews, F. E., Shaw, P. J., Heath, P. R., Brayne, C., Garwood, C., Higginbottom, A., Wharton, S. B., & MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · Neuropathology and Applied Neurobiology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 56

Calcium dysregulation in relation to Alzheimer‐type pathology in the ageing brain

Garwood, C., Faizullabhoy, A., Wharton, S. B., Ince, P. G., Heath, P. R., Shaw, P. J., Baxter, L., Gelsthorpe, C., Forster, G., Matthews, F. E., et al. (2013) · Neuropathology and Applied Neurobiology

Alzheimer's disease research and treatmentsCalpain Protease Function and Regulation

Cited by 47

Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease

Shabir, O., Pendry, B., Lee, L., Eyre, B., Sharp, P. S., Rebollar, M. A., Drew, D., Howarth, C., Heath, P. R., Wharton, S. B., et al. (2022) · eLife

Neurological Disease Mechanisms and TreatmentsBarrier Structure and Function Studies

Cited by 40