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MicroRNA (miRNA) as a biomarker for diagnosis, prognosis, and therapeutics molecules in neurodegenerative disease

Alkhazaali-Ali, Z., Negah, S. S., Boroumand, A. R., & Tavakol‐Afshari, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116899 · Cited by 64 · see citing works

Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication

Filannino, F. M., Panaro, M. A., Benameur, T., Pizzolorusso, I., & Porro, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031629 · Cited by 60 · see citing works

Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications

Wang, Z.-Y., Wen, Z.-J., Xu, H.-M., Zhang, Y., & Zhang, Y.-F. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1004221 · Cited by 58 · see citing works

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.

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Biological function of Extracellular Vesicles (EVs): a review of the field

Mohammadipoor, A., Hershfield, M. R., Linsenbardt, H. R., Smith, J., Mack, J., Natesan, S., Averitt, D. L., Stark, T. R., & Sosanya, N. M. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08624-w · Cited by 58 · see citing works

Characterization of human iPSC-derived astrocytes with potential for disease modeling and drug discovery

Soubannier, V., Maussion, G., Chaineau, M., Sigutova, V., Rouleau, G. A., Durcan, T. M., & Stifani, S. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135028 · Cited by 55 · see citing works

Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons

Barbosa, M., Gomes, C., Sequeira, C., Gonçalves‐Ribeiro, J., Pina, C. C., Carvalho, L. A. R., Moreira, R., Vaz, S. H., Vaz, A. R., & Brites, D. M. T. O. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.634355 · Cited by 55 · see citing works

Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases

Wang, L., Zhang, X., Yang, Z., Wang, B., Gong, H., Zhang, K., Lin, Y., & Sun, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00453-6 · Cited by 55 · see citing works

Human and mouse cortical astrocytes: a comparative view from development to morphological and functional characterization

Degl’Innocenti, E., & Dell’Anno, M. T. (2023) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2023.1130729 · Cited by 55 · see citing works

Exosomes in Ageing and Motor Neurone Disease: Biogenesis, Uptake Mechanisms, Modifications in Disease and Uses in the Development of Biomarkers and Therapeutics

Anakor, E., Gall, L. L., Dumonceaux, J., Duddy, W. J., & Duguez, S. (2021) · Cells · doi:10.3390/cells10112930 · Cited by 52 · see citing works

Neuroprotective and Neurotoxic Effects of Glial-Derived Exosomes

Oyarce, K., Cepeda, M. Y., Lagos, R., Garrido, C., Vega-Letter, A. M., García, M. D. L. Á., Luz‐Crawford, P., & Elizondo-Vega, R. J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.920686 · Cited by 53 · see citing works

Extracellular vesicles derived from astrocyte-treated with haFGF14-154 attenuate Alzheimer phenotype in AD mice

Peng, D., Wang, Y., Xiao, Y., Peng, M., Mai, W., Hu, B., Jia, Y., Chen, H., Yang, Y., Xiang, Q., et al. (2022) · Theranostics · doi:10.7150/thno.70951 · Cited by 51 · see citing works

Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential

You, J., Youssef, M., Santos, J. R., Lee, J., & Park, J. (2023) · Biology · doi:10.3390/biology12101307 · Cited by 56 · see citing works

Therapeutic Potential of Extracellular Vesicles in Degenerative Diseases of the Intervertebral Disc

Piazza, N., Dehghani, M., Gaborski, T. R., & Wuertz‐Kozak, K. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00311 · Cited by 49 · see citing works

Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS

Rostalski, H., Leskelä, S., Huber, N., Katisko, K., Cajanus, A., Solje, E., Marttinen, M., Natunen, T., Remes, A. M., Hiltunen, M. O., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00486 · Cited by 45 · see citing works

Plasma microRNA signature in presymptomatic and symptomatic subjects with C9orf72 -associated frontotemporal dementia and amyotrophic lateral sclerosis

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Neuroinflammation in amyotrophic lateral sclerosis: pathogenic insights and therapeutic implications

Calma, A. D., Pavey, N., Menon, P., & Vucic, S. (2024) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001279 · Cited by 47 · see citing works

Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro

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Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS

Provenzano, F., Nyberg, S., Giunti, D., Torazza, C., Parodi, B., Bonifacino, T., Usai, C., de Rosbo, N. K., Milanese, M., Uccelli, A., et al. (2022) · Cells · doi:10.3390/cells11233923 · Cited by 45 · see citing works

Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis

Christoforidou, E., Joilin, G., & Hafezparast, M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01822-4 · Cited by 41 · see citing works

Extracellular Vesicles in Serum and Central Nervous System Tissues Contain microRNA Signatures in Sporadic Amyotrophic Lateral Sclerosis

Lo, T., Figueroa‐Romero, C., Hur, J., Pacut, C. M., Stoll, E., Spring, C., Lewis, R., Nair, A., Goutman, S. A., Sakowski, S. A., et al. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.739016 · Cited by 41 · see citing works

Extracellular Vesicles in Amyotrophic Lateral Sclerosis

McCluskey, G., Morrison, K. E., Donaghy, C. G., René, F., Duddy, W. J., & Duguez, S. (2022) · Life · doi:10.3390/life13010121 · Cited by 41 · see citing works

How Degeneration of Cells Surrounding Motoneurons Contributes to Amyotrophic Lateral Sclerosis

Crabé, R., Aimond, F., Gosset, P., Scamps, F., & Raoul, C. (2020) · Cells · doi:10.3390/cells9122550 · Cited by 40 · see citing works

Role of brain extracellular vesicles in air pollution-related cognitive impairment and neurodegeneration

Nicholson, S. M., Baccarelli, A., & Prada, D. (2021) · Environmental Research · doi:10.1016/j.envres.2021.112316 · Cited by 40 · see citing works

Emerging targets in drug discovery against neurodegenerative diseases: Control of synapsis disfunction by the RhoA/ROCK pathway

Martín-Cámara, O., Cores, Á., López‐Alvarado, P., & Menéndez, J. C. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113742 · Cited by 39 · see citing works

Therapeutic Potential of Astrocyte Transplantation

Hastings, N., Kuan, W., Osborne, A., & Kotter, M. (2022) · Cell Transplantation · doi:10.1177/09636897221105499 · Cited by 38 · see citing works

Astrocytes: The Stars in Neurodegeneration?

Dittlau, K. S., & Freude, K. (2024) · Biomolecules · doi:10.3390/biom14030289 · Cited by 38 · see citing works

Emerging Role of Genetic Alterations Affecting Exosome Biology in Neurodegenerative Diseases

Riva, P., Battaglia, C., & Venturin, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174113 · Cited by 37 · see citing works

Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice

Jury, N., Abarzúa, S., Díaz, I. D. P., Guerra, M. V., Ampuero, E., Cubillos, P., Martínez, P., Herrera-Soto, A., Arredondo, C., Rojas, F., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-0816-9 · Cited by 35 · see citing works

Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases

He, M., Zhang, H., Tang, Z., & Gao, S. (2021) · Neural Plasticity · doi:10.1155/2021/8884642 · Cited by 35 · see citing works

Astrocyte regional diversity in ALS includes distinct aberrant phenotypes with common and causal pathological processes

Gomes, C., Sequeira, C., Barbosa, M., Cunha, C., Vaz, A. R., & Brites, D. M. T. O. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112209 · Cited by 36 · see citing works

Involvement of Astrocytes and microRNA Dysregulation in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Potential

Bai, Y., Su, X., Piao, L., Jin, Z., & Jin, R. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.556215 · Cited by 34 · see citing works

A review on the current literature regarding the value of exosome miRNAs in various diseases

Li, S., Lv, D., Yang, H. J., Lü, Y., & Jia, Y. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2232993 · Cited by 34 · see citing works

Increasing hexokinase 1 expression improves mitochondrial and glycolytic functional deficits seen in sporadic Alzheimer’s disease astrocytes

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Mechanisms of Immune Activation by c9orf72-Expansions in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Trageser, K. J., Smith, C., Herman, F. J., Ono, K., & Pasinetti, G. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01298 · Cited by 31 · see citing works

Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions

Harcha, P. A., Garcés, P., Arredondo, C., Fernández, G. R., Sáez, J. C., & van Zundert, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041924 · Cited by 33 · see citing works

Role of Glia-Derived Extracellular Vesicles in Neurodegenerative Diseases

Li, T., Tan, X., Li, S., Al-Nusaif, M., & Le, W. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.765395 · Cited by 33 · see citing works

Extracellular Vesicles as Innovative Treatment Strategy for Amyotrophic Lateral Sclerosis

Wang, K., Yu, L., Ren, C., Wang, Y., He, W., & Jiang, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.754630 · Cited by 33 · see citing works

RNA Deregulation in Amyotrophic Lateral Sclerosis: The Noncoding Perspective

Laneve, P., Tollis, P., & Caffarelli, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910285 · Cited by 32 · see citing works

Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes

Gomes, C., Sequeira, C., Likhite, S. B., Dennys, C. N., Kolb, S. J., Shaw, P. J., Vaz, A. R., Kaspar, B. K., Meyer, K., & Brites, D. M. T. O. (2022) · Cells · doi:10.3390/cells11071186 · Cited by 31 · see citing works

C9orf72 hexanucleotide repeat expansions impair microglial response in ALS

Masrori, P., Bijnens, B., Fumagalli, L., Davie, K., Poovathingal, S. K., Meese, T. S., Storm, A., Hersmus, N., Fazal, R., van den Biggelaar, D., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02075-1 · Cited by 30 · see citing works

Glial Cell Dysfunction in C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Ghasemi, M., Keyhanian, K., & Douthwright, C. L. (2021) · Cells · doi:10.3390/cells10020249 · Cited by 31 · see citing works

Transcriptome analysis reveals disparate expression of inflammation-related miRNAs and their gene targets in iPSC-astrocytes from people with schizophrenia

Akkouh, I. A., Hughes, T., Steen, V. M., Glover, J. C., Andreassen, O. A., Djurovic, S., & Szabó, A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.037 · Cited by 31 · see citing works

Astrocytes: Dissecting Their Diverse Roles in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Valori, C. F., Sulmona, C., Brambilla, L., & Rossi, D. (2023) · Cells · doi:10.3390/cells12111450 · Cited by 30 · see citing works

Immunology of amyotrophic lateral sclerosis – role of the innate and adaptive immunity

Mimic, S., Aru, B., Pehlivanoğlu, C., Sleiman, H., Anđjus, P. R., & Demirel, G. Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1277399 · Cited by 28 · see citing works

Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS

Ciervo, Y., Gatto, N., Allen, C. F., Grierson, A. J., Ferraiuolo, L., Mead, R. J., & Shaw, P. J. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.03.017 · Cited by 29 · see citing works

Autism-associated synaptic vesicle transcripts are differentially expressed in maternal plasma exosomes of physiopathologic pregnancies

Fang, Y., Wan, C., Wen, Y., Wu, Z., Pan, J., Zhong, M., & Zhong, N. A. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02821-6 · Cited by 29 · see citing works

Modelling frontotemporal dementia using patient-derived induced pluripotent stem cells

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Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs

Halpern, M., Brennand, K., & Gregory, J. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104562 · Cited by 28 · see citing works

Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives

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MicroRNAs in amyotrophic lateral sclerosis: from pathogenetic involvement to diagnostic biomarker and therapeutic agent development

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Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity

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Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets

Ferraiuolo, L., & Maragakis, N. J. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135911 · Cited by 24 · see citing works

Autophagy‐Mediated Inflammatory Cytokine Secretion in Sporadic ALS Patient iPSC‐Derived Astrocytes

BaofengFeng, Amponsah, A. E., Guo, R., Liu, X., Zhang, J., Du, X., Zhou, Z., He, J., Ma, J., & Cui, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6483582 · Cited by 24 · see citing works

Epigenetic Changes in Prion and Prion-like Neurodegenerative Diseases: Recent Advances, Potential as Biomarkers, and Future Perspectives

Hernaiz, A., Toivonen, J. M., Bolea, R., & Martín‐Burriel, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012609 · Cited by 24 · see citing works

Neural Differentiation and spinal cord organoid generation from induced pluripotent stem cells (iPSCs) for ALS modelling and inflammatory screening

Guo, R., Chen, Y., Zhang, J., Zhou, Z., Feng, B., Du, X., Liu, X., Ma, J., & Cui, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03836-4 · Cited by 23 · see citing works

Diagnostic Circulating miRNAs in Sporadic Amyotrophic Lateral Sclerosis

Panio, A., Cava, C., D’Antona, S., Bertoli, G. R., & Porro, D. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.861960 · Cited by 24 · see citing works

Astrocytic MicroRNA in Ageing, Inflammation, and Neurodegenerative Disease

Chu, A. J., & Williams, J. M. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.826697 · Cited by 21 · see citing works

The Neurotoxicity of Vesicles Secreted by ALS Patient Myotubes Is Specific to Exosome-Like and Not Larger Subtypes

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SOD1 G93A Astrocyte-Derived Extracellular Vesicles Induce Motor Neuron Death by a miRNA-155-5p-Mediated Mechanism

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Astrocyte Activation Markers

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Why should we care about astrocytes in a motor neuron disease?

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Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity

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Astrocytes in ischemic stroke: Crosstalk in central nervous system and therapeutic potential

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Dysregulation of extracellular vesicle formation and release in patient amyotrophic lateral sclerosis astrocytes.

Varcianna, A. (2024) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)

Micro-RNAs Shuttled by Extracellular Vesicles Secreted from Mesenchymal Stem Cells Dampen Astrocyte Pathological Activation and Support Neuroprotection in In-Vitro Models of ALS

Provenzano, F., Nyberg, S., Giunti, D., Torazza, C., Parodi, B., Bonifacino, T., Usai, C., de Rosbo, N. K., Milanese, M., Uccelli, A., et al. (2022) · Cells · doi:10.3390/cells11233923 · Cited by 45 · see citing works

SOD1 G93A Astrocyte-Derived Extracellular Vesicles Induce Motor Neuron Death by a miRNA-155-5p-Mediated Mechanism

Marton, S., Miquel, E., Acosta-Rodríguez, J., Fontenla, S., Libisch, G., & Cassina, P. (2023) · ASN NEURO · doi:10.1177/17590914231197527 · Cited by 22 · see citing works

Characterization of the extracellular vesicles released by astrocytes cultured from the spinal cord of late symptomatic SOD1G93A mice, a model of amyotrophic lateral sclerosis

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microRNAs shuttled by extracellular vesicles derived from mesenchymal stem cells revert glial activation and neurotoxicity in in-vitro models of amyotrophic lateral sclerosis

Milanese, M., Balbi, M., Giunti, D., Provenzano, F., Sophye, N., Parodi, B., Bacchetti, F., Carola, T., Bonifacino, T., Usai, C., et al. (2023) · CINECA IRIS Institutial Research Information System (University of Genoa)