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Cited by 187MicroRNA in disease regulationNeuroinflammation and Neurodegeneration MechanismsAmyotrophic Lateral Sclerosis Research

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

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Goodall, Emily F., Heath, Paul R., Bandmann, Oliver, Kirby, Janine, Shaw, Pamela J.·2013·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2013.00178PMC PMC3794211
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Abstract

MicroRNAs (miRNAs) are small, abundant RNA molecules that constitute part of the cell's non-coding RNA "dark matter." In recent years, the discovery of miRNAs has revolutionised the traditional view of gene expression and our understanding of miRNA biogenesis and function has expanded. Altered expression of miRNAs is increasingly recognized as a feature of many disease states, including neurodegeneration. Here, we review the emerging role for miRNA dysfunction in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS) and Huntington's disease pathogenesis. We emphasize the complex nature of gene regulatory networks and the need for systematic studies, with larger sample cohorts than have so far been reported, to reveal the most important miRNA regulators in disease. Finally, miRNA diversity and their potential to target multiple pathways, offers novel clinical applications for miRNAs as biomarkers and therapeutic agents in neurodegenerative diseases.

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Authors
Goodall, E. F., Heath, P. R., Bandmann, O., Kirby, J., & Shaw, P. J.
Affiliations
University of Sheffield (GB)
ORCID
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2013
Volume
7
Pages
178-178
ISSN
1662-5102 (ISSN-L)
DOI
10.3389/fncel.2013.00178
PMC
PMC3794211
OpenAlex
W2033797433
Cited by
187
References
161
Citations by year
2026: 3 · 2025: 5 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 16 · 2020: 13 · 2019: 17 · 2018: 23 · 2017: 18 · 2016: 24 · 2015: 23 · 2014: 19
FWCI
1.82
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Alzheimer's Research Trust
  • National Institute for Health and Care Research (NF-SI-0512-10082)
  • Parkinson's UK (G‐1202)
  • Motor Neurone Disease Association (Goodall/Oct10/6066)
  • European Commission (259867)
  • Directorate for Biological Sciences
  • Medical Research Council (MR/K000039/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
microRNA, neurodegeneration, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, microRNA biogenesis, gene regulatory networks, non-coding RNA, biomarkers, miRNA-based therapy

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