Gonzalez, Frank J.

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

Singh, A., Happel, C., Manna, S. K., Acquaah-Mensah, G., Carrerero, J., Kumar, S., Nasipuri, P., Krausz, K. W., Wakabayashi, N., Dewi, R., et al. (2013) · Journal of Clinical Investigation

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 333

Metabolism of melatonin by human cytochromes p450

Ma, X., Idle, J. R., Krausz, K. W., & Gonzalez, F. J. (2005) · Drug Metabolism and Disposition

Pharmacogenetics and Drug MetabolismCircadian rhythm and melatonin

Cited by 319

Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity

Watanabe, K., Fujii, H., Takahashi, T., Kodama, M., Aizawa, Y., Ohta, Y., Ono, T., Hasegawa, G., Naito, M., Nakajima, T., et al. (2000) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and Health

Cited by 314

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

Guo, G. L., Lambert, G., Negishi, M., Ward, J. M., Brewer, H. B., Kliewer, S. A., Gonzalez, F. J., & Sinal, C. J. (2003) · Journal of Biological Chemistry

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 312

Plasticity and expanding complexity of the hepatic transcription factor network during liver development

Kyrmizi, I., Hatzis, P., Katrakili, N., Tronche, F., Gonzalez, F. J., & Talianidis, I. (2006) · Genes & Development

Liver physiology and pathologyGenomics and Chromatin Dynamics

Cited by 285

Induction of Rat Hepatic N-Nitrosodimethylamine Demethylase by Acetone Is Due to Protein Stabilization

Song, B. J., Veech, R. L., Park, S. S., Gelboin, H. V., & Gonzalez, F. J. (1989) · Journal of Biological Chemistry

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 277

Hypoxia-Inducible Factor-2α Mediates the Adaptive Increase of Intestinal Ferroportin During Iron Deficiency in Mice

Taylor, M., Qu, A., Anderson, E. R., Matsubara, T., Martin, A., Gonzalez, F. J., & Shah, Y. M. (2011) · Gastroenterology

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 265

Bile Acids Are Substrates for Amine N-Acyl Transferase Activity by Bile Salt Hydrolase

Patterson, A., Rimal, B., Collins, S., Granda, M., Koo, I., Solanka, S., Hoque, N., Gentry, E., Yan, T., Bisanz, J., et al. (2022) · Nature

Gut microbiota and healthDrug Transport and Resistance Mechanisms

Cited by 252

C/EBPα Regulates Hepatic Transcription of Hepcidin, an Antimicrobial Peptide and Regulator of Iron Metabolism

Courselaud, B., Pigeon, C., Inoue, Y., Inoue, J., Gonzalez, F. J., Leroyer, P., Gilot, D., Boudjema, K., Guguen-Guillouzo, C., Brissot, P., et al. (2002) · Journal of Biological Chemistry

Iron Metabolism and DisordersTrace Elements in Health

Cited by 245

Peroxisomal and Mitochondrial Fatty Acid β-Oxidation in Mice Nullizygous for Both Peroxisome Proliferator-activated Receptor α and Peroxisomal Fatty Acyl-CoA Oxidase

Hashimoto, T., Fujita, T., Usuda, N., Cook, W., Qi, C., Peters, J. M., Gonzalez, F. J., Yeldandi, A. V., Rao, M. S., & Reddy, J. K. (1999) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsMetabolism and Genetic Disorders

Cited by 241

PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance

Guerre-Millo, M., Rouault, C., Poulain, P., André, J., Poitout, V., Peters, J. M., Gonzalez, F. J., Fruchart, J.-C., Reach, G., & Staels, B. (2001) · Diabetes

Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Cited by 241

Enzymatic Mechanisms of Ethanol Oxidation in the Brain

Zimatkin, S. M., Pronko, S. P., Vasiliou, V., Gonzalez, F. J., & Deitrich, R. A. (2006) · Alcoholism: Clinical and Experimental Research

Alcohol Consumption and Health EffectsPharmacogenetics and Drug Metabolism

Cited by 241

Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-κB target gene expression

Shah, Y. M., Ma, X., Morimura, K., Kim, I., & Gonzalez, F. J. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Inflammatory Bowel DiseasePeroxisome Proliferator-Activated Receptors

Cited by 231

Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S. M., Hawthorne, W. J., O’Connell, P. J., Loudovaris, T., Kay, T. W., Kulkarni, R. N., et al. (2010) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 230

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

Bonzo, J. A., Ferry, C. H., Matsubara, T., Kim, J.-H., & Gonzalez, F. J. (2012) · Journal of Biological Chemistry

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 193

CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis

Abdelmegeed, M. A., Banerjee, A., Jang, S., Yoo, S.-H., Yun, J.-W., Gonzalez, F. J., Keshavarzian, A., & Song, B.-J. (2013) · Free Radical Biology and Medicine

Alcohol Consumption and Health EffectsDrug-Induced Hepatotoxicity and Protection

Cited by 191

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice

Xu, Y., Li, F., Zalzala, M., Xu, J., Gonzalez, F. J., Adorini, L., Lee, Y., Yin, L., & Zhang, Y. (2016) · Hepatology

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 172

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

Shah, Y. M., Ito, S., Morimura, K., Chen, C., Yim, S., Haase, V. H., & Gonzalez, F. J. (2008) · Gastroenterology

Inflammatory Bowel DiseaseMacrophage Migration Inhibitory Factor

Cited by 168

Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling

Yang, Y., Hao, C., Jiao, T., Yang, Z., Li, H., Zhang, Y., Zhang, W., Doherty, M., Sun, C., Yang, T., et al. (2025) · Science

Gut microbiota and healthOsteoarthritis Treatment and Mechanisms

Cited by 160

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis

Zhou, J., Cui, S., He, Q., Guo, Y., Pan, X., Zhang, P., Huang, N., Ge, C., Wang, G., Gonzalez, F. J., et al. (2020) · Nature Communications

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 154

Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota

Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L., Patel, D., Ma, Y., Brocker, C. N., Yan, T., et al. (2017) · Cell Metabolism

Gut microbiota and healthDietary Effects on Health

Cited by 144

Fibrates Suppress Fibrinogen Gene Expression in Rodents Via Activation of the Peroxisome Proliferator-Activated Receptor-

Kockx, M., Gervois, P. P., Poulain, P., Derudas, B., Peters, J. M., Gonzalez, F. J., Princen, H. M. G., Kooistra, T., & Staels, B. (1999) · Blood

Peroxisome Proliferator-Activated ReceptorsBlood properties and coagulation

Cited by 139

Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450

Sai, Y., Dai, R., Yang, T. J., Krausz, K. W., Gonzalez, F. J., Gelboin, H. V., & Shou, M. (2000) · Xenobiotica

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 138

Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia

Zhang, Y., Yin, L., Anderson, J., Ma, H., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2010) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 112