Gonzalez, Frank J.

Pregnane X receptor regulates liver size and liver cell fate by yes-associated protein activation in mice

Jiang, Y., Feng, D., Ma, X., Fan, S., Gao, Y., Fu, K., Wang, Y., Sun, J., Yao, X., Liu, C., et al. (2019) · Hepatology

Liver physiology and pathologyHippo pathway signaling and YAP/TAZ

Cited by 103

Transcriptome Analysis of K-877 (a Novel Selective PPARα Modulator (SPPARMα))-Regulated Genes in Primary Human Hepatocytes and the Mouse Liver

Raza-Iqbal, S., Tanaka, T., Anai, M., Inagaki, T., Matsumura, Y., Ikeda, K., Taguchi, A., Gonzalez, F. J., Sakai, J., & Kodama, T. (2015) · Journal of Atherosclerosis and Thrombosis

Peroxisome Proliferator-Activated ReceptorsDrug-Induced Hepatotoxicity and Protection

Cited by 100

Peroxisome Proliferator-activated Receptor β/δ Regulates Very Low Density Lipoprotein Production and Catabolism in Mice on a Western Diet

Akiyama, T. E., Lambert, G., Nicol, C. J., Matsusue, K., Peters, J. M., Brewer, H. B., & Gonzalez, F. J. (2004) · Journal of Biological Chemistry

Peroxisome Proliferator-Activated ReceptorsLipid metabolism and disorders

Cited by 97

Ligand Activation of Peroxisome Proliferator–Activated Receptor β/δ (PPARβ/δ) Attenuates Carbon Tetrachloride Hepatotoxicity by Downregulating Proinflammatory Gene Expression

Shan, W., Palkar, P. S., Murray, I. A., McDevitt, E. I., Kennett, M. J., Kang, B. H., Isom, H. C., Perdew, G. H., Gonzalez, F. J., & Peters, J. M. (2008) · Toxicological Sciences

Peroxisome Proliferator-Activated ReceptorsDrug-Induced Hepatotoxicity and Protection

Cited by 97

Human NADPH-P450 oxidoreductase: complementary DNA cloning, sequence and vaccinia virus-mediated expression and localization of the CYPOR gene to chromosome 7.

Yamano, S., Aoyama, T., McBride, O. W., Hardwick, J. P., Gelboin, H. V., & Gonzalez, F. J. (1989) · Molecular Pharmacology

Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 95

Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from nonparenchymal cells

Brocker, C. N., Yue, J., Kim, D., Qu, A., Bonzo, J. A., & Gonzalez, F. J. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Peroxisome Proliferator-Activated ReceptorsLiver physiology and pathology

Cited by 93

Role of cytochrome P450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity

Abdelmegeed, M. A., Moon, K.-H., Chen, C., Gonzalez, F. J., & Song, B.-J. (2010) · Biochemical Pharmacology

Drug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug Metabolism

Cited by 81

Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice

Tanaka, N., Zhang, X., Sugiyama, E., Kono, H., Horiuchi, A., Nakajima, T., Kanbe, H., Tanaka, E., Gonzalez, F. J., & Aoyama, T. (2010) · Biochemical Pharmacology

Fatty Acid Research and HealthLiver Disease Diagnosis and Treatment

Cited by 78

Role of peroxisome proliferator-activated receptor-α in fasting-mediated oxidative stress

Abdelmegeed, M. A., Moon, K.-H., Hardwick, J. P., Gonzalez, F. J., & Song, B.-J. (2009) · Free Radical Biology and Medicine

Peroxisome Proliferator-Activated ReceptorsAntioxidant Activity and Oxidative Stress

Cited by 74

Hepatocyte Nuclear Factor 4‐Alpha Is Essential for the Active Epigenetic State at Enhancers in Mouse Liver

Thakur, A., Wong, J. C. H., Wang, E. Y., Lotto, J., Kim, D., Cheng, J., Mingay, M., Cullum, R., Moudgil, V., Ahmed, N., et al. (2019) · Hepatology

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 68

Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics

Johnson, C. H., Slanař, O., Krausz, K. W., Kang, D. W., Patterson, A. D., Kim, J.-H., Luecke, H., Gonzalez, F. J., & Idle, J. R. (2012) · The American Journal of Clinical Nutrition

Antioxidant Activity and Oxidative StressMetabolomics and Mass Spectrometry Studies

Cited by 58

Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor α, but not human PPARα

Nakamura, T., Ito, Y., Yanagiba, Y., Ramdhan, D. H., Kono, Y., Naito, H., Hayashi, Y., Li, Y., Aoyama, T., Gonzalez, F. J., et al. (2009) · Toxicology

Per- and polyfluoroalkyl substances researchPeroxisome Proliferator-Activated Receptors

Cited by 57

Noncanonical farnesoid X receptor signaling inhibits apoptosis and impedes liver fibrosis

Wang, H., Ge, C., Zhou, J., Guo, Y., Cui, S., Huang, N., Yan, T., Cao, L., Che, Y., Zheng, Q., et al. (2018) · EBioMedicine

Liver physiology and pathologyCell death mechanisms and regulation

Cited by 55

HNF4A modulates glucocorticoid action in the liver

Hunter, A. L., Poolman, T. M., Kim, D., Gonzalez, F. J., Bechtold, D. A., Loudon, A. S. I., Iqbal, M., & Ray, D. W. (2022) · Cell Reports

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 49

Disruption of the Arnt gene in endothelial cells causes hepatic vascular defects and partial embryonic lethality in mice

Yim, S. H., Shah, Y., Tomita, S., Morris, D. H., Gavrilova, O., Lambert, G., Ward, J. M., & Gonzalez, F. J. (2006) · Hepatology

Liver physiology and pathologyAngiogenesis and VEGF in Cancer

Cited by 49

Why Toxic Equivalency Factors Are Not Suitable for Perfluoroalkyl Chemicals

Peters, J. M., & Gonzalez, F. J. (2011) · Chemical Research in Toxicology

Per- and polyfluoroalkyl substances researchToxic Organic Pollutants Impact

Cited by 48

The Nuclear Receptor Peroxisome Proliferator-activated Receptor-β/δ (PPARβ/δ) Promotes Oncogene-induced Cellular Senescence through Repression of Endoplasmic Reticulum Stress

Zhu, B., Ferry, C. H., Markell, L. K., Blazanin, N., Glick, A. B., Gonzalez, F. J., & Peters, J. M. (2014) · Journal of Biological Chemistry

Endoplasmic Reticulum Stress and DiseaseTelomeres, Telomerase, and Senescence

Cited by 47

The Olive Constituent Oleuropein, as a PPARα Agonist, Markedly Reduces Serum Triglycerides

Malliou, F., Andreadou, I., Gonzalez, F. J., Lazou, A., Xepapadaki, E., Vallianou, I., Lambrinidis, G., Mikros, E., Marselos, M., Skaltsounis, A.-L., et al. (2018) · The Journal of Nutritional Biochemistry

Peroxisome Proliferator-Activated ReceptorsEdible Oils Quality and Analysis

Cited by 45

A Species Difference in the Peroxisome Proliferator-Activated Receptor α-Dependent Response to the Developmental Effects of Perfluorooctanoic Acid

Albrecht, P. P., Torsell, N. E., Krishnan, P., Ehresman, D. J., Frame, S. R., Chang, S.-C., Butenhoff, J. L., Kennedy, G. L., Gonzalez, F. J., & Peters, J. M. (2013) · Toxicological Sciences

Per- and polyfluoroalkyl substances researchPeroxisome Proliferator-Activated Receptors

Cited by 44

Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation

Gao, Y., Fan, S., Li, H., Jiang, Y., Yao, X., Zhu, S., Yang, X., Wang, R., Tian, J., Gonzalez, F. J., et al. (2021) · Acta Pharmaceutica Sinica B

Liver physiology and pathologyHippo pathway signaling and YAP/TAZ

Cited by 41

Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity

Murray, I. A., Reen, R. K., Leathery, N., Ramadoss, P., Bonati, L., Gonzalez, F. J., Peters, J. M., & Perdew, G. H. (2005) · Archives of Biochemistry and Biophysics

Toxic Organic Pollutants ImpactPharmacogenetics and Drug Metabolism

Cited by 41

Role of Hypoxia-Inducible Factor 1α in T Cells as a Negative Regulator in Development of Vascular Remodeling

Kurobe, H., Urata, M., Ueno, M., Ueki, M., Ono, S., Izawa-Ishizawa, Y., Fukuhara, Y., Lei, Y., Ripen, A. M., Kanbara, T., et al. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology

Atherosclerosis and Cardiovascular DiseasesCardiac Fibrosis and Remodeling

Cited by 35

Modulation of Ammonium Perfluorooctanoate-Induced Hepatic Damage by Genetically Different PPARα in Mice

Nakagawa, T., Ramdhan, D. H., Tanaka, N., Naito, H., Tamada, H., Ito, Y., Li, Y., Hayashi, Y., Yamagishi, N., Yanagiba, Y., et al. (2012) · Archives of Toxicology

Per- and polyfluoroalkyl substances researchPeroxisome Proliferator-Activated Receptors

Cited by 33

Stable Isotope- and Mass Spectrometry-based Metabolomics as Tools in Drug Metabolism: A Study Expanding Tempol Pharmacology

Li, F., Pang, X., Krausz, K. W., Jiang, C., Chen, C., Cook, J. A., Krishna, M. C., Mitchell, J. B., Gonzalez, F. J., & Patterson, A. D. (2013) · Journal of Proteome Research

Metabolomics and Mass Spectrometry StudiesPharmacogenetics and Drug Metabolism

Cited by 31