Barker, Nick

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 7,204

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 5,687

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature

Wnt/β-catenin signaling in development and cancerDigestive system and related health

Cited by 2,510

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell

Developmental Biology and Gene RegulationCancer Cells and Metastasis

Cited by 1,951

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es, J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., et al. (2010) · Cell Stem Cell

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 1,547

Organoids as an in vitro model of human development and disease

Fatehullah, A., Tan, S. H., & Barker, N. (2016) · Nature Cell Biology

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 1,508

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R. (2008) · Nature Genetics

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 966

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., et al. (2010) · Science

Hair Growth and DisordersSkin and Cellular Biology Research

Cited by 751

The intestinal stem cell

Barker, N., van de Wetering, M., & Clevers, H. (2008) · Genes & Development

Digestive system and related healthWnt/β-catenin signaling in development and cancer

Cited by 629

The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H., et al. (1999) · Nature

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 621

The inner nuclear membrane protein Emerin regulates β‐catenin activity by restricting its accumulation in the nucleus

Markiewicz, E., Tilgner, K., Barker, N., van de Wetering, M., Clevers, H., Dorobek, M., Hausmanowa‐Petrusewicz, I., Ramaekers, F. C., Broers, J. L., Blankesteijn, W. M., et al. (2006) · The EMBO Journal

Nuclear Structure and FunctionWnt/β-catenin signaling in development and cancer

Cited by 246

Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue

Quyn, A. J., Appleton, P. L., Carey, F. A., Steele, R. J. C., Barker, N., Clevers, H., Ridgway, R. A., Sansom, O. J., & Näthke, I. S. (2010) · Cell Stem Cell

Microtubule and mitosis dynamicsDevelopmental Biology and Gene Regulation

Cited by 242

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

Szenker-Ravi, E., Altunoglu, U., Leushacke, M., Bosso-Lefèvre, C., Khatoo, M., Thi Tran, H., Naert, T., Noelanders, R., Hajamohideen, A., Beneteau, C., et al. (2018) · Nature

Wnt/β-catenin signaling in development and cancerCongenital limb and hand anomalies

Cited by 190

A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells

Murakami, K., Terakado, Y., Saito, K., Jomen, Y., Takeda, H., Oshima, M., & Barker, N. (2021) · Proceedings of the National Academy of Sciences

Wnt/β-catenin signaling in development and cancerCRISPR and Genetic Engineering

Cited by 62

Stemming Colorectal Cancer Growth and Metastasis: HOXA5 Forces Cancer Stem Cells to Differentiate

Tan, S. H., & Barker, N. (2015) · Cancer Cell

Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancer

Cited by 29