Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Open accessAbstract
In mouse hair follicles, a group of quiescent cells in the bulge is believed to have stem cell activity. Lgr5, a marker of intestinal stem cells, is expressed in actively cycling cells in the bulge and secondary germ of telogen hair follicles and in the lower outer root sheath of anagen hair follicles. Here we show that Lgr5(+) cells comprise an actively proliferating and multipotent stem cell population able to give rise to new hair follicles and maintain all cell lineages of the hair follicle over long periods of time. Lgr5(+) progeny repopulate other stem cell compartments in the hair follicle, supporting the existence of a stem or progenitor cell hierarchy. By marking Lgr5(+) cells during trafficking through the lower outer root sheath, we show that these cells retain stem cell properties and contribute to hair follicle growth during the next anagen. Expression analysis suggests involvement of autocrine Hedgehog signaling in maintaining the Lgr5(+) stem cell population.
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Quiescent stem cells that regenerate hair follicles reside in the bulge.
“Quiescent stem cells that are responsible for regenerating the hair follicles lie within the bulge of the hair follicles21,31,32”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [32]
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- Authors
- Jaks, V., Barker, N., Kasper, M., van Es, J. H., Snippert, H. J., Clevers, H., & Toftgård, R.
- Affiliations
- Karolinska Institutet (SE)
- Hubrecht Institute for Developmental Biology and Stem Cell Research (NL)
- Corresponding author
- Clevers, Hans
- Toftgård, Rune
- Venue
- Nature Genetics
- Published
- 2008-10-12
- Volume
- 40
- Issue
- 11
- Pages
- 1291-1299
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2153027227
- Cited by
- 966
- References
- 36
- Citations by year
- 2026: 20 · 2025: 29 · 2024: 34 · 2023: 28 · 2022: 53 · 2021: 39 · 2020: 45 · 2019: 63 · 2018: 62 · 2017: 63 · 2016: 62 · 2015: 64 · 2014: 62 · 2013: 88 · 2012: 80
- FWCI
- 69.16
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- National Cancer Institute (U01CA105491)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P01AR047898, AR47898)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Keywords
- Lgr5, hair follicle stem cells, G protein-coupled receptors, stem cell proliferation, stem cell hierarchy, outer root sheath, bulge, anagen, telogen, Hedgehog signaling, multipotent progenitors, hair follicle regeneration, stem cell trafficking
- MeSH terms
- Animals, Cell Cycle, Cell Movement, Female, Gene Expression Regulation, Male, Models, Biological, Stem Cells, Time Factors, Signal Transduction, Biomarkers, Cellular Senescence, Hair Follicle, Receptors, G-Protein-Coupled, Cell Proliferation, Mice, Hedgehog Proteins
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