Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
Open accessAbstract
Hair Today, Skin Tomorrow: The epidermis of mammals contains hair follicles, sebaceous glands, and interfollicular epidermis, but it has not been clear how the development and repair of these structures is regulated. Snippert et al. (p. 1385 ) show that a stem-cell cluster in the hair follicle, characterized by the expression of Lgr6, a close homolog of the Lgr5 marker for stem cells in the small intestine and colon, resides directly above the hair bulge and gives rise to all cell lineages of the skin. Skin wounds in adult mice are repaired by Lgr6 stem cells in the hair follicles that flank the damage. After hair morphogenesis, Lgr6 stem cells give rise to epidermal and sebaceous gland lineages to generate fully differentiated new skin.
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The SG has been proposed to be replenished by distinct pools of stem cells or progenitors located in the HF or base of the SG.
“The SG has been proposed to be replenished by distinct pools of stem cells or progenitors located in the HF or base of the SG3–7.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [5]
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- Authors
- Snippert, H. J., Haegebarth, A., Kasper, M., Jaks, V., van Es, J. H., Barker, N., van de Wetering, M., van den Born, M., Begthel, H., Vries, R. G., Stange, D. E., Toftgård, R., & Clevers, H.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Karolinska Institutet (SE)
- Hubrecht Institute–KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.
- Corresponding author
- Snippert, Hugo J.
- Haegebarth, Andrea
- Clevers, Hans
- ORCID
- Venue
- Science
- Published
- 2010-03-12
- Volume
- 327
- Issue
- 5971
- Pages
- 1385-1389
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021689495
- Cited by
- 751
- References
- 3
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 30 · 2023: 25 · 2022: 38 · 2021: 40 · 2020: 55 · 2019: 43 · 2018: 63 · 2017: 44 · 2016: 46 · 2015: 53 · 2014: 52 · 2013: 69 · 2012: 62
- FWCI
- 94.09
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- other-oa
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Keywords
- LGR6, epidermal stem cells, hair follicle, sebaceous glands, interfollicular epidermis, skin regeneration, wound healing, hair follicle regeneration, Lgr5, self-renewal
- MeSH terms
- Epidermal Cells, Animals, Hair, Mice, Nude, Sebaceous Glands, Skin, Stem Cells, Wound Healing, Signal Transduction, Hair Follicle, Cell Lineage, Gene Expression Profiling, Stem Cell Transplantation, Receptors, G-Protein-Coupled, Mice, Gene Knock-In Techniques
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