Kordower, Jeffrey H.

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B., & Olanow, C. W. (2008) · Nature Medicine

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 1,722

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

Tuszynski, M. H., Thal, L., Pay, M., Salmon, D. P., U, H. S., Bakay, R., Patel, P., Blesch, A., Vahlsing, H. L., Ho, G., et al. (2005) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,050

Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease

Forsyth, C. B., Shannon, K. M., Kordower, J. H., Voigt, R. M., Shaikh, M., Jaglin, J. A., Estes, J. D., Dodiya, H. B., & Keshavarzian, A. (2011) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disorders

Cited by 974

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsNeurology and Historical Studies

Cited by 859

Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment

DeKosky, S. T., Ikonomovic, M. D., Styren, S. D., Beckett, L., Wisniewski, S., Bennett, D. A., Cochran, E. J., Kordower, J. H., & Mufson, E. J. (2002) · Annals of Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 686

Alpha-synuclein in colonic submucosa in early untreated Parkinson’s disease

Shannon, K. M., Keshavarzian, A., Mutlu, E., Dodiya, H. B., Daian, D., Jaglin, J. A., & Kordower, J. H. (2012) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 469

Role of TLR4 in the gut-brain axis in Parkinson's disease: A translational study from men to mice

Perez-Pardo, P., Dodiya, H. B., Engen, P. A., Forsyth, C. B., Huschens, A. M., Shaikh, M., Voigt, R. M., Naqib, A., Green, S. J., Kordower, J. H., et al. (2019) · Gut

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 467

Is alpha-synuclein in the colon a biomarker for premotor Parkinson’s disease? Evidence from 3 cases

Shannon, K. M., Keshavarzian, A., Dodiya, H. B., Jakate, S., & Kordower, J. H. (2012) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 464

Progression of intestinal permeability changes and alpha-synuclein expression in a mouse model of Parkinson's disease

Kelly, L. P., Carvey, P. M., Keshavarzian, A., Shannon, K. M., Shaikh, M., Bakay, R. A. E., & Kordower, J. H. (2014) · Movement Disorders

Parkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disorders

Cited by 308

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

Dodiya, H. B., Forsyth, C. B., Voigt, R. M., Engen, P. A., Patel, J., Shaikh, M., Green, S. J., Naqib, A., Roy, A., Kordower, J. H., et al. (2020) · Neurobiology of Disease

Parkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disorders

Cited by 305

A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer’s disease

Rafii, M. S., Baumann, T. L., Bakay, R. A. E., Ostrove, J. M., Siffert, J., Fleisher, A. S., Herzog, C. D., Barba, D., Pay, M., Salmon, D. P., et al. (2014) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsVirus-based gene therapy research

Cited by 223

Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology

Manfredsson, F. P., Luk, K. C., Benskey, M. J., Gezer, A., Garcia, J., Kuhn, N. C., Sandoval, I. M., Patterson, J. R., O'Mara, A., Yonkers, R., et al. (2018) · Neurobiology of Disease

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 199

Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: Diminished compensatory mechanisms as a prelude to parkinsonism

Collier, T. J., Lipton, J., Daley, B. F., Palfi, S., Chu, Y., Sortwell, C., Bakay, R. A. E., Sladek, J. R., & Kordower, J. H. (2007) · Neurobiology of Disease

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 162

Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys

Kordower, J. H., Kanaan, N. M., Chu, Y., Suresh Babu, R., Stansell, J., Terpstra, B. T., Sortwell, C. E., Steece-Collier, K., & Collier, T. J. (2006) · Annals of Neurology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 141

Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson’s disease

Olanow, C. W., Savolainen, M., Chu, Y., Halliday, G. M., & Kordower, J. H. (2019) · Brain

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 112

The Critical Role of Nonhuman Primates in Medical Research - White Paper

Friedman, H., Haigwood, N., Ator, N., Newsome, W., Allan, J. S., Golos, T. G., Kordower, J. H., Shade, R. E., Goldberg, M. E., Bailey, M. R., et al. (2017) · Pathogens and Immunity

Animal testing and alternativesPrimate Behavior and Ecology

Cited by 108

T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease

Williams, G. P., Marmion, D. J., Schonhoff, A. M., Jurkuvenaite, A., Won, W.-J., Standaert, D. G., Kordower, J. H., & Harms, A. S. (2020) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 102

Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson’s disease

Chu, Y., Bartus, R. T., Manfredsson, F. P., Olanow, C. W., & Kordower, J. H. (2020) · Brain

Parkinson's Disease Mechanisms and TreatmentsVirus-based gene therapy research

Cited by 88

Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates

Dodiya, H. B., Bjorklund, T., Stansell III, J., Mandel, R. J., Kirik, D., & Kordower, J. H. (2010) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 86

Transgene Expression, Bioactivity, and Safety of CERE-120 (AAV2-Neurturin) Following Delivery to the Monkey Striatum

Herzog, C. D., Dass, B., Gasmi, M., Bakay, R., Stansell, J. E., Tuszynski, M., Bankiewicz, K., Chen, E.-Y., Chu, Y., Bishop, K., et al. (2008) · Molecular Therapy

Virus-based gene therapy researchParkinson's Disease Mechanisms and Treatments

Cited by 72

Trophic factors therapy in Parkinson's disease

Ramaswamy, S., Soderstrom, K. E., & Kordower, J. H. (2009) · Progress in Brain Research

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

Cited by 72

Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease

Marchionini, D. M., Lehrmann, E., Chu, Y., He, B., Sortwell, C. E., Becker, K. G., Freed, W. J., Kordower, J. H., & Collier, T. J. (2007) · Brain Research

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

Cited by 69

Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates

Mandel, R. J., Marmion, D. J., Kirik, D., Chu, Y., Heindel, C., McCown, T., Gray, S. J., & Kordower, J. H. (2017) · Acta Neuropathologica Communications

Parkinson's Disease Mechanisms and TreatmentsVirus-based gene therapy research

Cited by 55

Gene transfer provides a practical means for safe, long-term, targeted delivery of biologically active neurotrophic factor proteins for neurodegenerative diseases

Herzog, C. D., Bishop, K. M., Brown, L., Wilson, A., Kordower, J. H., & Bartus, R. T. (2011) · Drug Delivery and Translational Research

Virus-based gene therapy researchAlzheimer's disease research and treatments

Cited by 29