Molkentin, Jeffery D.

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation

Cell death mechanisms and regulationAutophagy in Disease and Therapy

Cited by 6,680

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 2,280

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

Baines, C. P., Kaiser, R. A., Sheiko, T., Craigen, W. J., & Molkentin, J. D. (2007) · Nature Cell Biology

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 971

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

Khalil, H., Kanisicak, O., Prasad, V., Correll, R. N., Fu, X., Schips, T., Vagnozzi, R. J., Liu, R., Huynh, T., Lee, S.-J., et al. (2017) · Journal of Clinical Investigation

Cardiac Fibrosis and RemodelingTGF-β signaling in diseases

Cited by 905

Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

Molkentin, J. D., Black, B. L., Martin, J. F., & Olson, E. N. (1995) · Cell

Muscle Physiology and DisordersGenomics and Chromatin Dynamics

Cited by 819

The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury

Kempf, T., Eden, M., Strelau, J., Naguib, M., Willenbockel, C., Tongers, J., Heineke, J., Kotlarz, D., Xu, J., Molkentin, J. D., et al. (2006) · Circulation Research

GDF15 and Related BiomarkersCardiac Ischemia and Reperfusion

Cited by 651

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

Fu, X., Khalil, H., Kanisicak, O., Boyer, J. G., Vagnozzi, R. J., Maliken, B. D., Sargent, M. A., Prasad, V., Valiente-Alandi, I., Blaxall, B. C., et al. (2018) · Journal of Clinical Investigation

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 636

Redefining the identity of cardiac fibroblasts

Tallquist, M. D., & Molkentin, J. D. (2017) · Nature Reviews Cardiology

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 581

Molecular basis of physiological heart growth: fundamental concepts and new players

Maillet, M., van Berlo, J. H., & Molkentin, J. D. (2013) · Nature Reviews Molecular Cell Biology

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 536

Animal Models of Heart Failure: A Scientific Statement From the American Heart Association

Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., Rockman, H. A., Kass, D. A., Molkentin, J. D., Sussman, M. A., et al. (2012) · Circulation Research

Cardiac Fibrosis and RemodelingHeart Failure Treatment and Management

Cited by 435

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

Luongo, T. S., Lambert, J. P., Gross, P., Nwokedi, M., Lombardi, A. A., Shanmughapriya, S., Carpenter, A. C., Kolmetzky, D., Gao, E., van Berlo, J. H., et al. (2017) · Nature

Mitochondrial Function and PathologyCardiac Ischemia and Reperfusion

Cited by 396

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

Elrod, J. W., Wong, R., Mishra, S., Vagnozzi, R. J., Sakthievel, B., Goonasekera, S. A., Karch, J., Gabel, S., Farber, J., Force, T., et al. (2010) · Journal of Clinical Investigation

Mitochondrial Function and PathologySignaling Pathways in Disease

Cited by 384

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice

Karch, J., Kwong, J. Q., Burr, A. R., Sargent, M. A., Elrod, J. W., Peixoto, P. M., Martinez-Caballero, S., Osinska, H., Cheng, E. H.-Y., Robbins, J., et al. (2013) · eLife

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 290

Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD

Karch, J., Bround, M. J., Khalil, H., Sargent, M. A., Latchman, N., Terada, N., Peixoto, P. M., & Molkentin, J. D. (2019) · Science Advances

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 250

Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure

Heineke, J., Auger-Messier, M., Xu, J., Sargent, M., York, A., Welle, S., & Molkentin, J. D. (2010) · Circulation

Muscle Physiology and DisordersCardiac Fibrosis and Remodeling

Cited by 238

Cardiac-Specific Loss of N-Cadherin Leads to Alteration in Connexins With Conduction Slowing and Arrhythmogenesis

Li, J., Patel, V. V., Kostetskii, I., Xiong, Y., Chu, A. F., Jacobson, J. T., Yu, C., Morley, G. E., Molkentin, J. D., & Radice, G. L. (2005) · Circulation Research

Connexins and lens biologyCardiac electrophysiology and arrhythmias

Cited by 223

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

Kwong, J. Q., Davis, J., Baines, C. P., Sargent, M. A., Karch, J., Wang, X., Huang, T., & Molkentin, J. D. (2014) · Cell Death & Differentiation

Mitochondrial Function and PathologyCardiac Ischemia and Reperfusion

Cited by 174

Autophagic cell death is dependent on lysosomal membrane permeability through bax and bak

Karch, J., Schips, T. G., Maliken, B. D., Brody, M. J., Sargent, M. A., Kanisicak, O., & Molkentin, J. D. (2017) · eLife

Autophagy in Disease and TherapyCell death mechanisms and regulation

Cited by 91

A 20/20 view of ANT function in mitochondrial biology and necrotic cell death

Bround, M. J., Bers, D. M., & Molkentin, J. D. (2020) · Journal of Molecular and Cellular Cardiology

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 83

Postnatal Ablation of Foxm1 from Cardiomyocytes Causes Late Onset Cardiac Hypertrophy and Fibrosis without Exacerbating Pressure Overload-Induced Cardiac Remodeling

Bolte, C., Zhang, Y., York, A., Kalin, T. V., Schultz, J. E. J., Molkentin, J. D., & Kalinichenko, V. V. (2012) · PLoS ONE

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 35

MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy

Bround, M. J., Abay, E., Huo, J., Havens, J. R., York, A. J., Bers, D. M., & Molkentin, J. D. (2024) · Scientific Reports

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 20

Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart

Liu, R., Khalil, H., Lin, S.-C. J., Sargent, M. A., York, A. J., & Molkentin, J. D. (2016) · PLOS ONE

Cardiac Fibrosis and RemodelingSignaling Pathways in Disease

Cited by 10