Grossmann, Tom N.

Modulators of Protein–Protein Interactions

Milroy, L.-G., Grossmann, T. N., Hennig, S., Brunsveld, L., & Ottmann, C. (2014) · Chemical Reviews

14-3-3 protein interactionsChemical Synthesis and Analysis

Cited by 497

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

Kim, Y.-W., Grossmann, T. N., & Verdine, G. L. (2011) · Nature Protocols

Chemical Synthesis and AnalysisSynthetic Organic Chemistry Methods

Cited by 376

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Grossmann, T. N., Yeh, J. T.-H., Bowman, B. R., Chu, Q., Moellering, R. E., & Verdine, G. L. (2012) · Proceedings of the National Academy of Sciences

Wnt/β-catenin signaling in development and cancerChemical Synthesis and Analysis

Cited by 268

Constrained Peptides with Target‐Adapted Cross‐Links as Inhibitors of a Pathogenic Protein–Protein Interaction

Glas, A., Bier, D., Hahne, G., Rademacher, C., Ottmann, C., & Grossmann, T. N. (2014) · Angewandte Chemie International Edition

Chemical Synthesis and AnalysisBiochemical and Structural Characterization

Cited by 145

Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets β-Catenin Protein-Protein Interactions

Dietrich, L., Rathmer, B., Ewan, K., Bange, T., Heinrichs, S., Dale, T. C., Schade, D., & Grossmann, T. N. (2017) · Cell Chemical Biology

Chemical Synthesis and AnalysisWnt/β-catenin signaling in development and cancer

Cited by 126

Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling

Koelman, E. M. R., Yeste-Vázquez, A., & Grossmann, T. N. (2022) · Bioorganic & Medicinal Chemistry

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 63

A protein tertiary structure mimetic modulator of the Hippo signalling pathway

Adihou, H., Gopalakrishnan, R., Förster, T., Guéret, S. M., Gasper, R., Geschwindner, S., Carrillo García, C., Karatas, H., Pobbati, A. V., Vazquez‐Chantada, M., et al. (2020) · Nature Communications

Hippo pathway signaling and YAP/TAZChemical Synthesis and Analysis

Cited by 58

Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling

Hahne, G., & Grossmann, T. N. (2013) · Bioorganic & Medicinal Chemistry

Wnt/β-catenin signaling in development and cancerSignaling Pathways in Disease

Cited by 46

Coiled‐Coil Peptide Beacon: A Tunable Conformational Switch for Protein Detection

Mueller, C., & Grossmann, T. N. (2018) · Angewandte Chemie International Edition

Protein Structure and DynamicsChemical Synthesis and Analysis

Cited by 25

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Reissland, M., Hartmann, O., Tauch, S., Bugter, J. M., Prieto-Garcia, C., Schulte, C., Loebbert, S., Solvie, D., Bitman-Lotan, E., Narain, A., et al. (2024) · Oncogene

Wnt/β-catenin signaling in development and cancerUbiquitin and proteasome pathways

Cited by 16