Krysan, Damian J.

Drug resistance and tolerance in fungi.

Berman, J., & Krysan, D. J. (2020) · Nature Reviews Microbiology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 642

Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

Roemer, T., & Krysan, D. J. (2014) · Cold Spring Harbor Perspectives in Medicine

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 593

Candida albicans Triggers NLRP3-Mediated Pyroptosis in Macrophages

Wellington, M., Koselny, K., Sutterwala, F. S., & Krysan, D. J. (2014) · Eukaryotic Cell

Inflammasome and immune disordersAntifungal resistance and susceptibility

Cited by 227

Candida albicans mannans mediate Streptococcus mutans exoenzyme GtfB binding to modulate cross-kingdom biofilm development in vivo

Hwang, G., Liu, Y., Kim, D., Li, Y., Krysan, D. J., & Koo, H. (2017) · PLOS Pathogens

Antifungal resistance and susceptibilityBacterial biofilms and quorum sensing

Cited by 214

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Whitesell, L., Robbins, N., Huang, D. S., McLellan, C. A., Shekhar-Guturja, T., LeBlanc, E. V., Nation, C. S., Hui, R., Hutchinson, A., Collins, C., et al. (2019) · Nature Communications

Heat shock proteins researchAntifungal resistance and susceptibility

Cited by 124

Antifungal Activity of Tamoxifen: In Vitro and In Vivo Activities and Mechanistic Characterization

Dolan, K., Montgomery, S., Buchheit, B., DiDone, L., Wellington, M., & Krysan, D. J. (2009) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 112

Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo

Butts, A., Koselny, K., Chabrier-Roselló, Y., Semighini, C. P., Brown, J. C. S., Wang, X., Annadurai, S., DiDone, L., Tabroff, J., Childers, W. E., et al. (2014) · mBio

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 102

A Repurposing Approach Identifies Off-Patent Drugs with Fungicidal Cryptococcal Activity, a Common Structural Chemotype, and Pharmacological Properties Relevant to the Treatment of Cryptococcosis

Butts, A., DiDone, L., Koselny, K., Baxter, B. K., Chabrier-Rosello, Y., Wellington, M., & Krysan, D. J. (2013) · Eukaryotic Cell

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 95

Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics

Brown, J. C. S., Nelson, J., VanderSluis, B., Deshpande, R., Butts, A., Kagan, S., Polacheck, I., Krysan, D. J., Myers, C. L., & Madhani, H. D. (2014) · Cell

Fungal Infections and StudiesFungal and yeast genetics research

Cited by 84

The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis

Koselny, K., Green, J., DiDone, L., Halterman, J. P., Fothergill, A. W., Wiederhold, N. P., Patterson, T. F., Cushion, M. T., Rappelye, C., Wellington, M., et al. (2016) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 83

The RAM network in pathogenic fungi

Saputo, S., Chabrier-Rosello, Y., Luca, F. C., Kumar, A., & Krysan, D. J. (2012) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 65

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation

Xie, J. L., Qin, L., Miao, Z., Grys, B. T., Diaz, J. D. L. C., Ting, K., Krieger, J. R., Tong, J., Tan, K., Leach, M. D., et al. (2017) · Nature Communications

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 60

Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2

Caplan, T., Lorente-Macías, Á., Stogios, P. J., Evdokimova, E., Hyde, S., Wellington, M. A., Liston, S., Iyer, K. R., Puumala, E., Shekhar-Guturja, T., et al. (2020) · Cell Chemical Biology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 57

Derivatives of the Antimalarial Drug Mefloquine Are Broad-Spectrum Antifungal Molecules with Activity against Drug-Resistant Clinical Isolates

Montoya, M. C., Beattie, S., Alden, K. M., & Krysan, D. J. (2020) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 42

Fungal-selective resorcylate aminopyrazole Hsp90 inhibitors: optimization of whole-cell anticryptococcal activity and insights into the structural origins of cryptococcal selectivity

Marcyk, P. T., LeBlanc, E. V., Kuntz, D. A., Xue, A., Ortiz, F., Trilles, R., Bengtson, S., Kenney, T. M. G., Huang, D. S., Robbins, N., et al. (2021) · Journal of Medicinal Chemistry

Heat shock proteins researchFungal Infections and Studies

Cited by 40

The unmet clinical need of novel antifungal drugs

Krysan, D. J. (2017) · Virulence

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 37

Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence

Fu, C., Beattie, S. R., Jezewski, A. J., Robbins, N., Whitesell, L., Krysan, D. J., & Cowen, L. E. (2022) · Genetics

Fungal Infections and StudiesHeat shock proteins research

Cited by 31

A randomized open label trial of tamoxifen combined with amphotericin B and fluconazole for cryptococcal meningitis.

Ngan, N. T. T., Mai, N. T. H., Tung, N. L. N., Lan, N. P. H., Tai, L. T. H., Phu, N. H., Chau, N. V. V., Binh, T. Q., Hung, L. Q., Beardsley, J., et al. (2019) · Wellcome Open Research

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 28

Claims of equivalence in randomized controlled trials of the treatment of bacterial meningitis in children

KRYSAN, D. J., & KEMPER, A. R. (2002) · The Pediatric Infectious Disease Journal

Statistical Methods in Clinical TrialsBacterial Infections and Vaccines

Cited by 27

High-Throughput Screen in Cryptococcus neoformans Identifies a Novel Molecular Scaffold That Inhibits Cell Wall Integrity Pathway Signaling

Hartland, K., Pu, J., Palmer, M., Dandapani, S., Moquist, P. N., Munoz, B., DiDone, L., Schreiber, S. L., & Krysan, D. J. (2016) · ACS Infectious Diseases

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 24

Benzothiourea Derivatives Target the Secretory Pathway of the Human Fungal Pathogen Cryptococcus neoformans

Beattie, S. R., Schnicker, N. J., Murante, T., Kettimuthu, K., Williams, N. S., Gakhar, L., & Krysan, D. J. (2020) · ACS Infectious Diseases

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 10