The RAM network in pathogenic fungi
Open accessAbstract
The r egulation of A ce2 and m orphogenesis (RAM) network is a protein kinase signaling pathway conserved among eukaryotes from yeasts to humans. Among fungi, the RAM network has been most extensively studied in the model yeast Saccharomyces cerevisiae and has been shown to regulate a range of cellular processes, including daughter cell-specific gene expression, cell cycle regulation, cell separation, mating, polarized growth, maintenance of cell wall integrity, and stress signaling. Increasing numbers of recent studies on the role of the RAM network in pathogenic fungal species have revealed that this network also plays an important role in the biology and pathogenesis of these organisms. In addition to providing a brief overview of the RAM network in S. cerevisiae , we summarize recent developments in the understanding of RAM network function in the human fungal pathogens Candida albicans , Candida glabrata , Cryptococcus neoformans , Aspergillus fumigatus , and Pneumocystis spp.
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The RAM pathway in pathogenic fungi is the signaling network of protein kinases that regulate morphology and cellular functions.
“The RAM pathway in pathogenic fungi is the signaling network of protein kinases that regulate morphology and cellular functions.”
From Cell aggregation mediated by <i>ACE2</i> deletion in <i>Candida auris</i> modulates fungal colonization and host immune responses in the skin (2024) · cites this paper as [37]
RAM pathway kinases are usually conserved between species.
“They are usually conserved between the species”
From Cell aggregation mediated by <i>ACE2</i> deletion in <i>Candida auris</i> modulates fungal colonization and host immune responses in the skin (2024) · cites this paper as [37]
Cites
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- Authors
- Saputo, S., Chabrier-Rosello, Y., Luca, F. C., Kumar, A., & Krysan, D. J.
- Affiliations
- University of Rochester Medicine (US)
- Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
- University of Pennsylvania (US)
- University of Michigan (US)
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2012-06
- Volume
- 11
- Issue
- 6
- Pages
- 708-717
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- PMC
- PMC3370468
- OpenAlex
- W2157275967
- Cited by
- 65
- References
- 3
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 1 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 8 · 2012: 3
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eukaryotic Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (1R01AI098450-1A1, R21AI084539, T32AI007464, R01AI098450)
- National Institute of Dental and Craniofacial Research (T90DE021985)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- ACE2, protein kinase signaling, fungal pathogens, fungal pathogenesis, Candida albicans, Candida glabrata, Cryptococcus neoformans, Aspergillus fumigatus, Pneumocystis, Saccharomyces cerevisiae, polarized growth, cell wall integrity, stress signaling
- MeSH terms
- DNA-Binding Proteins, Fungal Proteins, Fungi, Humans, Morphogenesis, Protein Kinases, Saccharomyces cerevisiae, Transcription Factors, Signal Transduction, Saccharomyces cerevisiae Proteins
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