Costes, Sylvain V.

The Transformation Suppressor Pdcd4 Is a Novel Eukaryotic Translation Initiation Factor 4A Binding Protein That Inhibits Translation

Yang, H.-S., Jansen, A. P., Komar, A. A., Zheng, X., Merrick, W. C., Costes, S., Lockett, S. J., Sonenberg, N., & Colburn, N. H. (2003) · Molecular and Cellular Biology

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

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Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., Kidane, Y., Rathi, K. S., Smith, S. M., Stear, B., et al. (2020) · Cell

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Understanding Cancer Development Processes after HZE-Particle Exposure: Roles of ROS, DNA Damage Repair and Inflammation

Sridharan, D. M., Asaithamby, A., Bailey, S. M., Costes, S. V., Doetsch, P. W., Dynan, W. S., Kronenberg, A., Rithidech, K. N., Saha, J., Snijders, A. M., et al. (2015) · Radiation Research

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The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information

Morris, J. H., Soman, K., Akbas, R. E., Zhou, X., Smith, B., Meng, E. C., Huang, C. C., Cerono, G., Schenk, G., Rizk-Jackson, A., et al. (2023) · Bioinformatics

Biomedical Text Mining and OntologiesSemantic Web and Ontologies

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Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver

Beheshti, A., Chakravarty, K., Fogle, H., Fazelinia, H., Silveira, W. A. D., Boyko, V., Polo, S.-H. L., Saravia-Butler, A. M., Hardiman, G., Taylor, D., et al. (2019) · Scientific Reports

Spaceflight effects on biologyLipid metabolism and biosynthesis

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Targeted and nontargeted effects of ionizing radiation that impact genomic instability

Maxwell, C. A., Fleisch, M. C., Costes, S. V., Erickson, A. C., Boissière, A., Gupta, R., Ravani, S. A., Parvin, B., & Barcellos-Hoff, M. H. (2008) · Cancer Research

Effects of Radiation ExposureDNA Repair Mechanisms

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Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., Cantor, C., Aliper, A., Mamoshina, P., Ushakov, I., et al. (2018) · Oncotarget

Effects of Radiation ExposureSpaceflight effects on biology

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Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study

Beheshti, A., Cekanaviciute, E., Smith, D. J., & Costes, S. V. (2018) · Scientific Reports

Spaceflight effects on biologySpace exploration and regulation

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DNA Damage Baseline Predicts Resilience to Space Radiation and Radiotherapy

Pariset, E., Bertucci, A., Petay, M., Malkani, S., Lopez Macha, A., Paulino Lima, I. G., Gomez Gonzalez, V., Tin, A. S., Tang, J., Plante, I., et al. (2020) · Cell Reports

Effects of Radiation ExposureDNA Repair Mechanisms

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Evaluating biomarkers to model cancer risk post cosmic ray exposure

Sridharan, D. M., Asaithamby, A., Blattnig, S. R., Costes, S. V., Doetsch, P. W., Dynan, W. S., Hahnfeldt, P., Hlatky, L., Kidane, Y., Kronenberg, A., et al. (2016) · Life Sciences in Space Research

Effects of Radiation ExposureRadiation Therapy and Dosimetry

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Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53 -Null Mammary Carcinomas

Illa-Bochaca, I., Ouyang, H., Tang, J., Sebastiano, C., Mao, J.-H., Costes, S. V., Demaria, S., & Barcellos-Hoff, M. H. (2014) · Cancer Research

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