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Cited by 83Effects of Radiation ExposureSpaceflight effects on biologyRadiation Therapy and Dosimetry

Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

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Cortese, Franco, Klokov, Dmitry, Osipov, Andreyan, Stefaniak, Jakub, Moskalev, Alexey, Schastnaya, Jane, Cantor, Charles, Aliper, Alexander +22 more·2018·Oncotarget
DOI 10.18632/oncotarget.24461PMC PMC5865701
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Abstract

While many efforts have been made to pave the way toward human space colonization, little consideration has been given to the methods of protecting spacefarers against harsh cosmic and local radioactive environments and the high costs associated with protection from the deleterious physiological effects of exposure to high-Linear energy transfer (high-LET) radiation. Herein, we lay the foundations of a roadmap toward enhancing human radioresistance for the purposes of deep space colonization and exploration. We outline future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, and methods of slowing metabolic activity while preserving cognitive function. We conclude by presenting the known associations between radioresistance and longevity, and articulating the position that enhancing human radioresistance is likely to extend the healthspan of human spacefarers as well.

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  • Promising strategies are the inducible expression of endogenous antioxidants, DNA repair genes or radioprotective transgenes resulting in controlled reduction in early and late-stage irradiation damage.

    “Promising strategies are the inducible expression of endogenous antioxidants, DNA repair genes or radioprotective transgenes resulting in controlled reduction in early and late-stage irradiation damage44.”

    From Towards sustainable human space exploration—priorities for radiation research to quantify and mitigate radiation risks (2023) · cites this paper as [44]

    The “Gene therapy for deep space exploration” section (page unavailable) recommends inducible expression for endogenous antioxidants and DNA repair genes, and identifies radioprotective transgenes as promising. But its reported reduction in early- and late-stage irradiation damage concerns MnSOD antioxidant transgenes specifically; the Dsup radioprotective transgene example used a constitutive promoter. It does not establish that inducible expression of all three strategies produces that outcome. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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200 of 257 shown

Authors
Cortese, F., Klokov, D., Osipov, A., Stefaniak, J., Moskalev, A., Schastnaya, J., Cantor, C., Aliper, A., Mamoshina, P., Ushakov, I., Sapetsky, A., Vanhaelen, Q., Alchinova, I., Karganov, M., Kovalchuk, O., Wilkins, R., Shtemberg, A., Moreels, M., Baatout, S., Izumchenko, E., de Magalhães, J. P., Artemov, A. V., Costes, S. V., Beheshti, A., Mao, X. W., Pecaut, M. J., Kaminskiy, D., Ozerov, I. V., Scheibye-Knudsen, M., & Zhavoronkov, A.
Affiliations
  • Queen's University (CA)
  • University of Ottawa (CA)
  • Johns Hopkins University (US)
  • University of Oxford (GB)
  • Engelhardt Institute of Molecular Biology (RU)
  • Boston University (US)
  • State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russia
  • Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
  • University of Lethbridge (CA)
  • Health Canada (CA)
  • Russian Academy of Sciences (RU)
  • Belgian Nuclear Research Centre (BE)
  • Ghent University (BE)
  • Biogerontology Research Foundation, London, UK
  • Ames Research Center (US)
  • Loma Linda University (US)
  • Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark
ORCID
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2018-02-12
Volume
9
Issue
18
Pages
14692-14722
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.24461
PMC
PMC5865701
OpenAlex
W2792124893
Cited by
83
References
288
Citations by year
2026: 4 · 2025: 5 · 2024: 10 · 2023: 13 · 2022: 8 · 2021: 12 · 2020: 11 · 2019: 17 · 2018: 3
FWCI
1.68
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Oncotarget (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
Funders
Russian Foundation for Basic Research (17–29–01002)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Physiology › Spaceflight effects on biology
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
Keywords
radioresistance (biology), deep space exploration, space colonization, high-LET radiation, cosmic rays, DNA repair, radiation protection, gene therapy, metabolic rate reduction, cognitive function, longevity, healthspan

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