Friedman, Scott L.

Fibrosis-dependent mechanisms of hepatocarcinogenesis

Zhang, D. Y., & Friedman, S. L. (2012) · Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 444

Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

Friedman, S. L., & Pinzani, M. (2022) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 430

The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells

Trivedi, P., Wang, S., & Friedman, S. L. (2021) · Cell Metabolism

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 427

Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic

Canbay, A., Taimr, P., Torok, N., Higuchi, H., Friedman, S., & Gores, G. J. (2003) · Laboratory Investigation

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 417

Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice

Saxena, N. K., Ikeda, K., Rockey, D. C., Friedman, S. L., & Anania, F. A. (2002) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 382

Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment

Llovet, J. M., Willoughby, C. E., Singal, A. G., Greten, T. F., Heikenwälder, M., El-Serag, H. B., Finn, R. S., & Friedman, S. L. (2023) · Nature Reviews Gastroenterology & Hepatology

Hepatocellular Carcinoma Treatment and PrognosisLiver Disease Diagnosis and Treatment

Cited by 354

Antifibrotic effects of the dual CCR2/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis

Lefebvre, E., Moyle, G., Reshef, R., Richman, L. P., Thompson, M., Hong, F., Chou, H.-L., Hashiguchi, T., Plato, C., Poulin, D., et al. (2016) · PLOS ONE

Liver physiology and pathologyChemokine receptors and signaling

Cited by 323

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH

Tacke, F., Puengel, T., Loomba, R., & Friedman, S. L. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 321

Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib

Lachenmayer, A., Alsinet, C., Savic, R., Cabellos, L., Toffanin, S., Hoshida, Y., Villanueva, A., Minguez, B., Newell, P., Tsai, H.-W., et al. (2012) · Clinical Cancer Research

Wnt/β-catenin signaling in development and cancerHepatocellular Carcinoma Treatment and Prognosis

Cited by 306

Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture.

Wong, L., Yamasaki, G., Johnson, R. J., & Friedman, S. L. (1994) · Journal of Clinical Investigation

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 304

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Zhan, S.-S., Jiang, J. X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A., & Torok, N. J. (2006) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 284

An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro

Vogel, S., Piantedosi, R., Frank, J., Lalazar, A., Rockey, D. C., Friedman, S. L., & Blaner, W. S. (2000) · Journal of Lipid Research

Retinoids in leukemia and cellular processesLiver physiology and pathology

Cited by 283

Anti-Fibrotic Activity of NK Cells in Experimental Liver Injury Through Killing of Activated HSC

Melhem, A., Muhanna, N., Bishara, A., Alvarez, C. E., Ilan, Y., Bishara, T., Horani, A., Nassar, M., Friedman, S. L., & Safadi, R. (2006) · Journal of Hepatology

Liver physiology and pathologyImmune Cell Function and Interaction

Cited by 270

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Vacca, M., Kamzolas, I., Harder, L. M., Oakley, F., Trautwein, C., Hatting, M., Ross, T., Bernardo, B., Oldenburger, A., Hjuler, S. T., et al. (2024) · Nature Metabolism

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 262

Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification

Montironi, C., Castet, F., Haber, P. K., Pinyol, R., Torres-Martin, M., Torrens, L., Mesropian, A., Wang, H., Puigvehi, M., Maeda, M., et al. (2023) · Gut

Cancer Immunotherapy and BiomarkersHepatocellular Carcinoma Treatment and Prognosis

Cited by 253

Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes

Safadi, R., Ohta, M., Alvarez, C. E., Fiel, M. I., Bansal, M., Mehal, W. Z., & Friedman, S. L. (2004) · Gastroenterology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 239

Discoidin Domain Receptor 2 Regulates Fibroblast Proliferation and Migration through the Extracellular Matrix in Association with Transcriptional Activation of Matrix Metalloproteinase-2

Olaso, E., Labrador, J.-P., Wang, L., Ikeda, K., Eng, F. J., Klein, R., Lovett, D. H., Lin, H. C., & Friedman, S. L. (2002) · Journal of Biological Chemistry

Wound Healing and TreatmentsProtease and Inhibitor Mechanisms

Cited by 238

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

Hernández-Gea, V., Hilscher, M., Rozenfeld, R., Lim, M. P., Nieto, N., Werner, S., Devi, L. A., & Friedman, S. L. (2013) · Journal of Hepatology

Liver physiology and pathologyEndoplasmic Reticulum Stress and Disease

Cited by 236

MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a

Toffanin, S., Hoshida, Y., Lachenmayer, A., Villanueva, A., Cabellos, L., Minguez, B., Savic, R., Ward, S. C., Thung, S., Chiang, D. Y., et al. (2011) · Gastroenterology

MicroRNA in disease regulationHepatocellular Carcinoma Treatment and Prognosis

Cited by 232

Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial

Ratziu, V., de Guevara, L., Safadi, R., Poordad, F., Fuster, F., Flores-Figueroa, J., Arrese, M., Fracanzani, A. L., Ben Bashat, D., Lackner, K., et al. (2021) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 222

Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex

Eng, F. J., & Friedman, S. L. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 222

Functional Linkage of Cirrhosis-Predictive Single Nucleotide Polymorphisms of Toll-Like Receptor 4 to Hepatic Stellate Cell Responses

Guo, J., Loke, J., Zheng, F., Hong, F., Yea, S., Fukata, M., Tarocchi, M., Abar, O. T., Huang, H., Sninsky, J. J., et al. (2009) · Hepatology

Liver physiology and pathologyImmune Response and Inflammation

Cited by 217

Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.

Iredale, J. P., Murphy, G., Hembry, R. M., Friedman, S. L., & Arthur, M. J. (1992) · Journal of Clinical Investigation

Liver physiology and pathologyProtease and Inhibitor Mechanisms

Cited by 202

Inhibition of Rat Hepatic Lipocyte Activation in Culture by Interferon–γ

Rockey, D. C., Maher, J. J., Jarnagin, W. R., Gabbiani, G., & Friedman, S. L. (1992) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 179