Friedman, Scott L.

An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis

Wang, S., Li, K., Pickholz, E., Dobie, R., Matchett, K. P., Henderson, N. C., Carrico, C., Driver, I., Borch Jensen, M., Chen, L., et al. (2023) · Science Translational Medicine

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 176

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Lee, Y. A., Noon, L. A., Akat, K. M., Ybanez, M. D., Lee, T.-F., Berres, M.-L., Fujiwara, N., Goossens, N., Chou, H.-I., Parvin-Nejad, F. P., et al. (2018) · Nature Communications

Autophagy in Disease and TherapyHippo pathway signaling and YAP/TAZ

Cited by 161

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)

Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 158

Dendritic Cell Regulation of Carbon Tetrachloride–Induced Murine Liver Fibrosis Regression

Jiao, J., Sastre, D., Fiel, M. I., Lee, U. E., Ghiassi–Nejad, Z., Ginhoux, F., Vivier, E., Friedman, S. L., Merad, M., & Aloman, C. (2012) · Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 154

IL-17A enhances the expression of profibrotic genes through upregulation of the TGF-β receptor on hepatic stellate cells in a JNK-dependent manner

Fabre, T., Kared, H., Friedman, S. L., & Shoukry, N. H. (2014) · The Journal of Immunology

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 150

NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity

Lu, J., He, L., Behrends, C., Araki, M., Araki, K., Jun Wang, Q., Catanzaro, J. M., Friedman, S. L., Zong, W.-X., Fiel, M. I., et al. (2014) · Nature Communications

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 148

Transplantation trends in primary biliary cirrhosis

Lee, J., Belanger, A., Doucette, J. T., Stanca, C., Friedman, S., & Bach, N. (2007) · Clinical Gastroenterology and Hepatology

Liver Diseases and ImmunityOrgan Transplantation Techniques and Outcomes

Cited by 147

A Novel Murine Model to Deplete Hepatic Stellate Cells Uncovers Their Role in Amplifying Liver Damage in Mice

Puche, J. E., Lee, Y. A., Jiao, J., Aloman, C., Fiel, M. I., Muñoz, U., Kraus, T., Lee, T., Yee, H. F., & Friedman, S. L. (2013) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 136

Altered Microbiota Diversity and Bile Acid Signaling in Cirrhotic and Noncirrhotic NASH-HCC

Sydor, S., Best, J., Messerschmidt, I., Manka, P., Vilchez-Vargas, R., Brodesser, S., Lucas, C., Wegehaupt, A., Wenning, C., Aßmuth, S., et al. (2020) · Clinical and Translational Gastroenterology

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 127

Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases

Bansal, R., Nakagawa, S., Yazdani, S., van Baarlen, J., Venkatesh, A., Koh, A. P., Song, W.-M., Goossens, N., Watanabe, H., Beasley, M. B., et al. (2017) · Experimental & Molecular Medicine

Liver physiology and pathologyCell Adhesion Molecules Research

Cited by 96

Lhx2 –/– mice develop liver fibrosis

Wandzioch, E., Kolterud, Å., Jacobsson, M., Friedman, S. L., & Carlsson, L. (2004) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 95

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents

Moeini, A., Torrecilla, S., Tovar, V., Montironi, C., Andreu-Oller, C., Peix, J., Higuera, M., Pfister, D., Ramadori, P., Pinyol, R., et al. (2019) · Gastroenterology

Hepatocellular Carcinoma Treatment and PrognosisLiver physiology and pathology

Cited by 92

Hepatic Stellate Cells and Liver Fibrosis

Puche, J. E., Saiman, Y., & Friedman, S. L. (2013) · Comprehensive Physiology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 89

Why Do So Many Nonalcoholic Steatohepatitis Trials Fail?

Ratziu, V., & Friedman, S. L. (2023) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 88

Hepatic Stellate Cell-Immune Interactions in NASH

Carter, J. K., & Friedman, S. L. (2022) · Frontiers in Endocrinology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 79

Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: implication for a potential link between retinoid loss and TGF-β mediated fibrogenesis in vivo

Okuno, M., Sato, T., Kitamoto, T., Imai, S., Kawada, N., Suzuki, Y., Yoshimura, H., Moriwaki, H., Onuki, K., Masushige, S., et al. (1999) · Journal of Hepatology

Liver physiology and pathologyRetinoids in leukemia and cellular processes

Cited by 79

In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma

Narla, G., Kremer-Tal, S., Matsumoto, N., Zhao, X., Yao, S., Kelley, K., Tarocchi, M., & Friedman, S. L. (2007) · Oncogene

Kruppel-like factors researchCancer-related Molecular Pathways

Cited by 77

Antifibrotic Agents for Liver Disease

Albanis, E., & Friedman, S. L. (2006) · American Journal of Transplantation

Liver physiology and pathologyHepatitis C virus research

Cited by 68

Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis

Zhang, H., Ma, Y., Cheng, X., Wu, D., Huang, X., Chen, B., Ren, Y., Jiang, W., Tang, X., Bai, T., et al. (2021) · Science Translational Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 65

Hepatic fibrosis: A convergent response to liver injury that is reversible

Wang, S., & Friedman, S. L. (2020) · Journal of Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 62

Modeling Dysbiosis of Human NASH in Mice: Loss of Gut Microbiome Diversity and Overgrowth of Erysipelotrichales

Carter, J. K., Bhattacharya, D., Borgerding, J. N., Fiel, M. I., Faith, J. J., & Friedman, S. L. (2021) · PLOS ONE

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 52

Hepatic stellate cells maintain liver homeostasis through paracrine neurotrophin-3 signaling that induces hepatocyte proliferation

Trinh, V. Q.-H., Lee, T.-F., Lemoinne, S., Ray, K. C., Ybanez, M. D., Tsuchida, T., Carter, J. K., Agudo, J., Brown, B. D., Akat, K. M., et al. (2023) · Science Signaling

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 45

EHBP1 suppresses liver fibrosis in metabolic dysfunction-associated steatohepatitis

Ma, F., Longo, M., Meroni, M., Bhattacharya, D., Paolini, E., Mughal, S., Hussain, S., Anand, S. K., Gupta, N., Zhu, Y., et al. (2025) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 29

Fighting cardiac fibrosis with CAR T cells

Friedman, S. L. (2022) · New England Journal of Medicine

Cardiac Fibrosis and RemodelingCAR-T cell therapy research

Cited by 28