Botstein, David

Gene Ontology: tool for the unification of biology

Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics

Biomedical Text Mining and OntologiesBioinformatics and Genomic Networks

Cited by 43,206

Cluster analysis and display of genome-wide expression patterns

Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 16,184

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature

Lymphoma Diagnosis and TreatmentBreast Cancer Treatment Studies

Cited by 9,925

Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes

Gasch, A. P., Spellman, P. T., Kao, C. M., Carmel-Harel, O., Eisen, M. B., Storz, G., Botstein, D., & Brown, P. O. (2000) · Molecular Biology of the Cell

Fungal and yeast genetics researchBacterial Genetics and Biotechnology

Cited by 4,815

Missing Value Estimation Methods for DNA Microarrays

Troyanskaya, O., Cantor, M., Sherlock, G., Brown, P., Hastie, T., Tibshirani, R., Botstein, D., & Altman, R. B. (2001) · Bioinformatics

Gene expression and cancer classificationGenomics and Phylogenetic Studies

Cited by 4,230

Systematic variation in gene expression patterns in human cancer cell lines

Ross, D. T., Scherf, U., Eisen, M. B., Perou, C. M., Rees, C., Spellman, P., Iyer, V., Jeffrey, S. S., Van de Rijn, M., Waltham, M., et al. (2000) · Nature Genetics

Gene expression and cancer classificationBreast Cancer Treatment Studies

Cited by 2,088

GO::TermFinder–open source software for accessing gene ontology information and finding significantly enriched gene ontology terms associated with a list of genes

Boyle, E. I., Weng, S., Gollub, J., Jin, H., Botstein, D., Cherry, J. M., & Sherlock, G. (2004) · Bioinformatics

Bioinformatics and Genomic NetworksBiomedical Text Mining and Ontologies

Cited by 2,067

Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell

Gene expression and cancer classificationCancer-related Molecular Pathways

Cited by 1,527

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

Botstein, D., & Risch, N. (2003) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 1,503

Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae

Dunham, M. J., Badrane, H., Ferea, T., Adams, J., Brown, P. O., Rosenzweig, F., & Botstein, D. (2002) · Proceedings of the National Academy of Sciences

Evolution and Genetic DynamicsFungal and yeast genetics research

Cited by 564

Coordination of Growth Rate, Cell Cycle, Stress Response, and Metabolic Activity in Yeast

Brauer, M. J., Huttenhower, C., Airoldi, E. M., Rosenstein, R., Matese, J. C., Gresham, D., Boer, V. M., Troyanskaya, O. G., & Botstein, D. (2008) · Molecular Biology of the Cell

Fungal and yeast genetics researchGene Regulatory Network Analysis

Cited by 558

'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns

Hastie, T., Tibshirani, R., Eisen, M. B., Alizadeh, A., Levy, R., Staudt, L., Chan, W. C., Botstein, D., & Brown, P. (2000) · Genome Biology

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 547

Genomic Expression Responses to DNA-damaging Agents and the Regulatory Role of the Yeast ATR Homolog Mec1p

Gasch, A. P., Huang, M., Metzner, S., Botstein, D., Elledge, S. J., & Brown, P. O. (2001) · Molecular Biology of the Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 542

The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast

Gresham, D., Desai, M. M., Tucker, C. M., Jenq, H. T., Pai, D. A., Ward, A., DeSevo, C. G., Botstein, D., & Dunham, M. J. (2008) · PLoS Genetics

Evolution and Genetic DynamicsFungal and yeast genetics research

Cited by 482

Genome-wide Analysis of Gene Expression Regulated by the Calcineurin/Crz1p Signaling Pathway in Saccharomyces cerevisiae

Yoshimoto, H., Saltsman, K., Gasch, A. P., Li, H. X., Ogawa, N., Botstein, D., Brown, P. O., & Cyert, M. S. (2002) · Journal of Biological Chemistry

Fungal and yeast genetics researchSignaling Pathways in Disease

Cited by 404

Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae

Reguly, T., Breitkreutz, A., Boucher, L., Breitkreutz, B.-J., Hon, G. C., Myers, C. L., Parsons, A., Friesen, H., Oughtred, R., Tong, A., et al. (2006) · Journal of Biology

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 326

Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms

Alter, O., Brown, P. O., & Botstein, D. (2003) · Proceedings of the National Academy of Sciences

Gene expression and cancer classificationBioinformatics and Genomic Networks

Cited by 304

Diverse and Specific Gene Expression Responses to Stresses in Cultured Human Cells

Murray, J. I., Whitfield, M. L., Trinklein, N. D., Myers, R. M., Brown, P. O., & Botstein, D. (2004) · Molecular Biology of the Cell

Heat shock proteins researchFungal and yeast genetics research

Cited by 300

Transcriptional Remodeling in Response to Iron Deprivation in Saccharomyces cerevisiae

Shakoury-Elizeh, M., Tiedeman, J., Rashford, J., Ferea, T., Demeter, J., Garcia, E., Rolfes, R., Brown, P. O., Botstein, D., & Philpott, C. C. (2004) · Molecular Biology of the Cell

Fungal and yeast genetics researchIron Metabolism and Disorders

Cited by 204

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

Di Francesco, A., Deighan, A. G., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Schott, W., Wright, K. M., et al. (2023) · Nature

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 194

Regulators of health and lifespan extension in genetically diverse mice on dietary restriction

Churchill, G., Francesco, A. D., Deighan, A., Litichevskiy, L., Chen, Z., Luciano, A., Robinson, L., Garland, G., Donato, H., Schott, W., et al. (2024) · Nature

Genetics, Aging, and Longevity in Model OrganismsDietary Effects on Health

Cited by 194

Novel insights from a multiomics dissection of the Hayflick limit

Chan, M., Yuan, H., Soifer, I., Maile, T. M., Wang, R. Y., Ireland, A., O'Brien, J. J., Goudeau, J., Chan, L. J., Vijay, T., et al. (2022) · eLife

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 99