Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae
Open accessAbstract
Genome rearrangements, especially amplifications and deletions, have regularly been observed as responses to sustained application of the same strong selective pressure in microbial populations growing in continuous culture. We studied eight strains of budding yeast ( Saccharomyces cerevisiae ) isolated after 100–500 generations of growth in glucose-limited chemostats. Changes in DNA copy number were assessed at single-gene resolution by using DNA microarray-based comparative genomic hybridization. Six of these evolved strains were aneuploid as the result of gross chromosomal rearrangements. Most of the aneuploid regions were the result of translocations, including three instances of a shared breakpoint on chromosome 14 immediately adjacent to CIT1 , which encodes the citrate synthase that performs a key regulated step in the tricarboxylic acid cycle. Three strains had amplifications in a region of chromosome 4 that includes the high-affinity hexose transporters; one of these also had the aforementioned chromosome 14 break. Three strains had extensive overlapping deletions of the right arm of chromosome 15. Further analysis showed that each of these genome rearrangements was bounded by transposon-related sequences at the breakpoints. The observation of repeated, independent, but nevertheless very similar, chromosomal rearrangements in response to persistent selection of growing cells parallels the genome rearrangements that characteristically accompany tumor progression.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An E. coli population with a rpoS deletion can still develop increased salt tolerance during laboratory evolution by uncoupling of rpoS dependent expression of the otsBA operon, which is important for trehalose synthesis.
“It was shown that an E. coli population with a rpoS deletion can still develop increased salt tolerance during laboratory evolution by uncoupling of rpoS dependent expression of the otsBA operon, which is important for trehalose synthesis [82].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Exploring the metabolic and genetic control of gene expression on a genomic scale.
Derisi, J., Iyer, V., & Brown, P. (1997) · Science · doi:10.1126/science.278.5338.680 · Cited by 4,832 · see citing works
Self-citationFunctional profiling of the Saccharomyces cerevisiae genome
Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316 · see citing works
Sherman, F. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)94004-v · Cited by 4,078 · see citing works
Winzeler, E. A., Shoemaker, D. D., Astromoff, A., Liang, H., Anderson, K., Andre, B., Bangham, R., Benito, R., Boeke, J. D., Bussey, H., et al. (1999) · Science · doi:10.1126/science.285.5429.901 · Cited by 3,953 · see citing works
Hoffman, C. S., & Winston, F. (1987) · Gene · doi:10.1016/0378-1119(87)90131-4 · Cited by 2,492 · see citing works
Pinkel, D., Segraves, R., Sudar, D., Clark, S. M., Poole, I., Kowbel, D., Collins, C. C., Kuo, W.-L., Chen, C., Zhai, Y., et al. (1998) · Nature Genetics · doi:10.1038/2524 · Cited by 2,238 · see citing works
Mutations of mitotic checkpoint genes in human cancers
Cahill, D. P., Christoph Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/32688 · Cited by 1,485 · see citing works
Genome-wide analysis of DNA copy-number changes using cDNA microarrays
Pollack, J. R., Perou, C. M., Alizadeh, A. A., Eisen, M. B., Pergamenschikov, A., Williams, C. F., Jeffrey, S. S., Botstein, D., & Brown, P. O. (1999) · Nature Genetics · doi:10.1038/12640 · Cited by 1,416 · see citing works
Self-citationLiu, Y., Mitsukawa, N., Oosumi, T., & Whittier, R. F. (1995) · The Plant Journal · doi:10.1046/j.1365-313x.1995.08030457.x · Cited by 1,387 · see citing works
Mayr, E. W., & White, M. J. D. (1978) · Systematic Zoology · doi:10.2307/2412932 · Cited by 1,251 · see citing works
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
Iyer, V. R., Horak, C. E., Scafe, C., Botstein, D., Snyder, M. P., & Brown, P. O. (2001) · Nature · doi:10.1038/35054095 · Cited by 1,084 · see citing works
Self-citationOverview of manual and automated DNA sequencing by the dideoxy chain termination method
CHEN, E., KUANG, W., & LEE, A. (1991) · Methods · doi:10.1016/s1046-2023(05)80158-6 · Cited by 834 · see citing works
Genetic instability and darwinian selection in tumours
Cahill, D. P., Kinzler, K. W., Vogelstein, B., & Christoph Lengauer, C. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01661-x · Cited by 747 · see citing works
Yeast microarrays for genome wide parallel genetic and gene expression analysis
Lashkari, D. A., DeRisi, J. L., McCusker, J. H., Namath, A., Gentile, C., Hwang, S. Y., Brown, P. O., & Davis, R. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13057 · Cited by 663 · see citing works
Self-citationKim, J. M., Vanguri, S., Boeke, J. D., Gabriel, A., & Voytas, D. F. (1998) · Genome Research · doi:10.1101/gr.8.5.464 · Cited by 534 · see citing works
Widespread aneuploidy revealed by DNA microarray expression profiling
Hughes, T. R., Roberts, C. J., Dai, H. A., Jones, A. R., Meyer, M. R., Slade, D., Burchard, J., Dow, S., Ward, T. R., Kidd, M. J., et al. (2000) · Nature Genetics · doi:10.1038/77116 · Cited by 482 · see citing works
Systematic changes in gene expression patterns following adaptive evolution in yeast
Ferea, T., Botstein, D., Brown, P. O., & Rosenzweig, R. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9721 · Cited by 479 · see citing works
Self-citationA THEORY OF MODULAR EVOLUTION FOR BACTERIOPHAGES*
Botstein, D. (1980) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1980.tb27987.x · Cited by 458 · see citing works
Self-citationATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones
Rita, S., & Kleckner, N. E. (2002) · Science · doi:10.1126/science.1071398 · Cited by 429 · see citing works
Dykhuizen, D. E., & Hartl, D. L. (1983) · Microbiological Reviews · doi:10.1128/mr.47.2.150-168.1983 · Cited by 324 · see citing works
Brown, C. J., Todd, K., & Rosenzweig, R. F. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a026009 · Cited by 307 · see citing works
Chromosomal evolution in Saccharomyces
Fischer, G., James, S. A., Roberts, I. N., Oliver, S. G., & Louis, E. J. (2000) · Nature · doi:10.1038/35013058 · Cited by 304 · see citing works
Genetic architecture of thermal adaptation in Escherichia coli
Riehle, M. M., Bennett, A. F., & Long, A. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.525 · Cited by 255 · see citing works
Stam, K., Heisterkamp, N., Grosveld, G. C., de Klein, A., Verma, R. S., Coleman, M., Dosik, H., & Groffen, J. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512053132301 · Cited by 250 · see citing works
Paquin, C., & Adams, J. (1983) · Nature · doi:10.1038/302495a0 · Cited by 239 · see citing works
Self-citationGENE AMPLIFICATION AND GENOMIC PLASTICITY IN PROKARYOTES
Romero, D., & Palacios, R. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.91 · Cited by 237 · see citing works
Genomic evolution during a 10,000-generation experiment with bacteria
Papadopoulos, D., Schneider, D., Meier-Eiss, J., Arber, W., Lenski, R. E., & Blot, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3807 · Cited by 234 · see citing works
Hendrickson, H. L., Slechta, E. S., Bergthorsson, U., Andersson, D. I., & Roth, J. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032680899 · Cited by 173 · see citing works
Properties of hybrids between Salmonella phage P22 and coliphage λ
Botstein, D., & Herskowitz, I. (1974) · Nature · doi:10.1038/251584a0 · Cited by 145 · see citing works
Self-citationSchneider, D., Duperchy, E., Coursange, E., Lenski, R. E., & Blot, M. (2000) · Genetics · doi:10.1093/genetics/156.2.477 · Cited by 138 · see citing works
Rachidi, N., Barre, P., & Blondin, B. (1999) · Molecular and General Genetics MGG · doi:10.1007/s004380050028 · Cited by 136 · see citing works
Allelic and ectopic recombination between Ty elements in yeast.
Kupiec, M., & Petes, T. D. (1988) · Genetics · doi:10.1093/genetics/119.3.549 · Cited by 126 · see citing works
Adaptation and major chromosomal changes in populations of Saccharomyces cerevisiae
Adams, J., Puskas-Rozsa, S., Simlar, J., & Wilke, C. M. (1992) · Current Genetics · doi:10.1007/bf00351736 · Cited by 123 · see citing works
Self-citationFitness effects of Ty transposition in Saccharomyces cerevisiae.
Wilke, C. M., & Adams, J. (1992) · Genetics · doi:10.1093/genetics/131.1.31 · Cited by 106 · see citing works
Self-citationGENE DUPLICATION IN SACCHAROMYCES CEREVISIAE
Hansche, P. E., Beres, V., & Lange, P. (1978) · Genetics · doi:10.1093/genetics/88.4.673 · Cited by 74 · see citing works
The population biology and evolutionary significance of Ty elements in Saccharomyces cerevisiae
Wilke, C. M., Maimer, E., & Adams, J. (1992) · Genetica · doi:10.1007/bf00133718 · Cited by 54 · see citing works
Self-citationAdams, J., Paquin, C. E., Oeller, P. W., & Lee, L. W. (1985) · Genetics · doi:10.1093/genetics/110.2.173 · Cited by 53 · see citing works
Self-citationTy elements are involved in the formation of deletions in DEL1 strains of saccharomyces cerevisiae
Liebman, S. W., Shalit, P., & Picologlou, S. (1981) · Cell · doi:10.1016/0092-8674(81)90209-9 · Cited by 53 · see citing works
Smith, C. A., Pollice, A. A., Gu, L. P., Brown, K. A., Singh, S., Janocko, L. E., Johnson, R. C., Julian, T. B., Hyams, D. M., Wolmark, N., et al. (2000) · PubMed · Cited by 47 · see citing works
GENE DUPLICATION AS A MECHANISM OF GENETIC ADAPTATION IN SACCHAROMYCES CEREVISIAE
Hansche, P. E. (1975) · Genetics · doi:10.1093/genetics/79.4.661 · Cited by 43 · see citing works
Recombination between sequences in nonhomologous positions.
Sugawara, N., & Szostak, J. W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.18.5675 · Cited by 41 · see citing works
Adams, J., & Oeller, P. W. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.7124 · Cited by 34 · see citing works
Self-citationChromosomes XIV and XVII of Saccharomyces cerevisiae Constitute a Single Linkage Group
Klapholz, S., & Esposito, R. E. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.11.1399-1409.1982 · Cited by 20 · see citing works
Isolation of Sets of a, α, a/α, a/a and α/α isogenic strains in Saccharomyces cerevisiae
Paquin, C. E., & Adams, J. (1982) · Current Genetics · doi:10.1007/bf00397636 · Cited by 18 · see citing works
Self-citationChromosomal Changes during Experimental Evolution in Laboratory Populations of Escherichia coli
Bergthorsson, U., & Ochman, H. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.4.1360-1363.1999 · Cited by 17 · see citing works
Chisholm, G., & Cooper, T. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.8.2548-2559.1992 · Cited by 7 · see citing works
Camasses, A. (1996) · Current Genetics · doi:10.1007/s002940050124 · Cited by 7 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- [28]Lashkari, D. A., DeRisi, J. L., McCusker, J. H., Namath, A. F., Gentile, C., Hwang, S. Y., Brown, P. O. & Davis, R. W. (1997) Proc. Natl. Acad. Sci. USA 94, 13057-13062.
- [41]Sugawara, N. & Szostak, J. W. (1983) Proc. Natl. Acad. Sci. USA 80, 5675-5679.
- [46]Adams, J. & Oeller, P. W. (1986) Proc. Natl. Acad. Sci. USA 83, 7124-7127.
- [49]Campbell, A. & Botstein, D. (1983) in Lambda II , eds. Hendrix, R., Roberts, J., Stahl, F. & Weisberg, R. (Cold Spring Harbor Lab. Press, Plainview, NY), pp. 365-380.
Cited by
Sorted by citations
The Genetic Landscape of a Cell
Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L. Y., Toufighi, K., Mostafavi, S., et al. (2010) · Science · doi:10.1126/science.1180823 · Cited by 2,162 · see citing works
Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation
Elena, S. F., & Lenski, R. E. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1088 · Cited by 1,386 · see citing works
Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast
Torres, E. M., Sokolsky, T., Tucker, C. M., Chan, L. Y., Boselli, M., Dunham, M. J., & Amon, A. (2007) · Science · doi:10.1126/science.1142210 · Cited by 935 · see citing works
Self-citationAdaptive laboratory evolution—Principles and applications for biotechnology
Dragosits, M., & Mattanovich, D. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-64 · Cited by 827 · see citing works
A genome-wide view of the spectrum of spontaneous mutations in yeast.
Lynch, M., Sung, W., Morris, K., Coffey, N., Landry, C. R., Dopman, E. B., Dickinson, W. J., Okamoto, K., Kulkarni, S., Hartl, D. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803466105 · Cited by 708 · see citing works
Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts
Gallone, B., Steensels, J., Prahl, T., Soriaga, L., Saels, V., Herrera-Malaver, B., Merlevede, A., Roncoroni, M., Voordeckers, K., Miraglia, L., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.020 · Cited by 679 · see citing works
Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast
Pavelka, N., Rancati, G., Zhu, J., Bradford, W. D., Saraf, A., Florens, L., Sanderson, B. W., Hattem, G. L., & Li, R. (2010) · Nature · doi:10.1038/nature09529 · Cited by 577 · see citing works
Genome-wide analysis of a long-term evolution experiment with Drosophila
Burke, M. K., Dunham, J. P., Shahrestani, P., Thornton, K. R., Rose, M. R., & Long, A. D. (2010) · Nature · doi:10.1038/nature09352 · Cited by 448 · see citing works
Gresham, D., Desai, M. M., Tucker, C. M., Jenq, H. T., Pai, D. A., Ward, A., DeSevo, C. G., Botstein, D., & Dunham, M. J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000303 · Cited by 482 · see citing works
Self-citationOhno's dilemma: Evolution of new genes under continuous selection
Bergthorsson, U., Andersson, D. I., & Roth, J. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707158104 · Cited by 405 · see citing works
Chromosomal duplication is a transient evolutionary solution to stress
Yona, A. H., Manor, Y. S., Herbst, R. H., Romano, G. H., Mitchell, A., Kupiec, M., Pilpel, Y., & Dahan, O. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211150109 · Cited by 376 · see citing works
Gene Copy-Number Alterations: A Cost-Benefit Analysis
Tang, Y.-C., & Amon, A. (2013) · Cell · doi:10.1016/j.cell.2012.11.043 · Cited by 348 · see citing works
Selmecki, A. M., Dulmage, K., Cowen, L. E., Anderson, J. B., & Berman, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000705 · Cited by 319 · see citing works
Forche, A., Alby, K., Schaefer, D., Johnson, A. D., Berman, J., & Bennett, R. J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060110 · Cited by 338 · see citing works
Genomic Plasticity of the Human Fungal Pathogen Candida albicans
Selmecki, A., Forche, A., & Berman, J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00060-10 · Cited by 247 · see citing works
Evolution of Evolvability in Gene Regulatory Networks
Crombach, A., & Hogeweg, P. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000112 · Cited by 256 · see citing works
Larkin, D. M., Pape, G., Donthu, R., Auvil, L., Welge, M., & Lewin, H. A. (2009) · Genome Research · doi:10.1101/gr.086546.108 · Cited by 184 · see citing works
Adaptation of<i>Saccharomyces cerevisiae</i>to saline stress through laboratory evolution
DHAR, R., SÄGESSER, R., WEIKERT, C., YUAN, J., & WAGNER, A. (2011) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2011.02249.x · Cited by 165 · see citing works
Evolutionary insight from whole‐genome sequencing of experimentally evolved microbes
DETTMAN, J. R., RODRIGUE, N., MELNYK, A. H., WONG, A., BAILEY, S. F., & KASSEN, R. (2012) · Molecular Ecology · doi:10.1111/j.1365-294x.2012.05484.x · Cited by 160 · see citing works
Evolution in<i>Candida albicans</i>Populations During a Single Passage Through a Mouse Host
Forche, A., Magee, P. T., Selmecki, A., Berman, J., & May, G. (2009) · Genetics · doi:10.1534/genetics.109.103325 · Cited by 147 · see citing works
Selmecki, A., Bergmann, S., & Berman, J. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04492.x · Cited by 157 · see citing works
Hunger Artists: Yeast Adapted to Carbon Limitation Show Trade-Offs under Carbon Sufficiency
Wenger, J. W., Piotrowski, J., Nagarajan, S., Chiotti, K., Sherlock, G., & Rosenzweig, F. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002202 · Cited by 154 · see citing works
Self-citationRetrotransposition is associated with genome instability during chronological aging
Maxwell, P. H., Burhans, W. C., & Curcio, M. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100271108 · Cited by 132 · see citing works
Jansen, M. L. A., Diderich, J. A., Mashego, M., Hassane, A., de Winde, J. H., Daran-Lapujade, P., & Pronk, J. T. (2005) · Microbiology · doi:10.1099/mic.0.27577-0 · Cited by 126 · see citing works
Genome plasticity in Candida albicans is driven by long repeat sequences
Todd, R. T., Wikoff, T. D., Forche, A., & Selmecki, A. (2019) · eLife · doi:10.7554/elife.45954 · Cited by 118 · see citing works
The functional basis of adaptive evolution in chemostats
Gresham, D., & Hong, J. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12082 · Cited by 122 · see citing works
Whole-genome sequencing of a laboratory-evolved yeast strain
Araya, C. L., Payen, C., Dunham, M. J., & Fields, S. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-88 · Cited by 113 · see citing works
Self-citationDeatherage, D. E., Traverse, C. C., Wolf, L. N., & Barrick, J. E. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2014.00468 · Cited by 93 · see citing works
Ploidy controls the success of mutators and nature of mutations during budding yeast evolution
Thompson, D. A., Desai, M. M., & Murray, A. W. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.070 · Cited by 89 · see citing works
Oud, B., Maris, A. J. A., Daran, J.-M., & Pronk, J. T. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2011.00776.x · Cited by 82 · see citing works
Muller, H., Thierry, A., Coppée, J.-Y., Gouyette, C., Hennequin, C., Sismeiro, O., Talla, E., Dujon, B., & Fairhead, C. (2009) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.11.006 · Cited by 78 · see citing works
The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress
Vande Zande, P., Zhou, X., & Selmecki, A. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-041320-112443 · Cited by 70 · see citing works
A Double-Edged Sword: Aneuploidy is a Prevalent Strategy in Fungal Adaptation
Tsai, H.-J., & Nelliat, A. (2019) · Genes · doi:10.3390/genes10100787 · Cited by 60 · see citing works
Kok, S., Nijkamp, J. F., Oud, B., Roque, F. C., Ridder, D., Daran, J.-M., Pronk, J. T., & Maris, A. J. A. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2011.00787.x · Cited by 65 · see citing works
Mba, I. E., Nweze, E. I., Eze, E. A., & Anyaegbunam, Z. K. G. (2022) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2022.105256 · Cited by 46 · see citing works
Mitotic Recombination and Adaptive Genomic Changes in Human Pathogenic Fungi
Gusa, A., & Jinks-Robertson, S. (2019) · Genes · doi:10.3390/genes10110901 · Cited by 38 · see citing works
Evolutionary Dynamics of Candida albicans during <i>In Vitro</i> Evolution
Huang, M., McClellan, M., Berman, J., & Kao, K. C. (2011) · Eukaryotic Cell · doi:10.1128/ec.05168-11 · Cited by 34 · see citing works
- Authors
- Dunham, M. J., Badrane, H., Ferea, T., Adams, J., Brown, P. O., Rosenzweig, F., & Botstein, D.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Botstein, David
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-11-21
- Volume
- 99
- Issue
- 25
- Pages
- 16144-16149
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC138579
- OpenAlex
- W2164832298
- Cited by
- 564
- References
- 47
- Citations by year
- 2026: 11 · 2025: 6 · 2024: 20 · 2023: 15 · 2022: 12 · 2021: 10 · 2020: 23 · 2019: 30 · 2018: 19 · 2017: 29 · 2016: 19 · 2015: 32 · 2014: 31 · 2013: 32 · 2012: 25
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Mathematics Enthusiast (submittedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- National Institutes of Health (5r01hg000983-06)
- National Human Genome Research Institute (HG-00983)
- National Institute of General Medical Sciences (GM46406, R37GM046406, R01GM046406)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genome Rearrangement Algorithms
- Keywords
- genome rearrangement, Saccharomyces cerevisiae, experimental evolution, aneuploidy, chromosomal translocation, DNA copy number, glucose-limited chemostat, chromosome 15 deletion, TCA cycle
- MeSH terms
- Aneuploidy, DNA Transposable Elements, DNA, Fungal, Gene Amplification, Genes, Fungal, Phenotype, Saccharomyces cerevisiae, Selection, Genetic, Chromosomes, Fungal, Genome, Fungal, Gene Deletion, Gene Dosage, Evolution, Molecular, Oligonucleotide Array Sequence Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
